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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     (MN) can be primary/‘idiopathic’ (IMN) or secondary. Identification and eradication of secondary causes is important in all patients. The immune system causes some damage to the kidney. In some cases of membranous nephritis there is an identifiable cause for the immune stimulation, for example lupus, hepatitis, or a tumour somewhere in the body but more often the cause is not clear.

  • Membranous nephropathy

    Disease pathophysiology:

    In membranous nephropathy extremely small complexes get stuck in the tiny parts of the kidney. The process activates or triggers your own body's immune system causing inflamation. This is what damages your kidney. The complexes and damage can only be seen on akidney biopsy where a tiny part of the kidney is examined under a very powerful microscope.

     

  • Membranous nephropathy

    Disease Statistics: 

    Saudi Center for Organ Transplantation, Riyadh, Kingdom of Saudi Arabia Glomerulonephritis (GN) constitutes a major cause of morbidity and mortality from renal disease. It accounts for 16-18% of patients on dialysis in the United States, 9-15% in Europe and 23.2-58.4% in the tropics. Also, various factors including genetic, racial and environmental have been incriminated in the pathogenesis of GN .

     

  • Membranous nephropathy

    Disease treatment: 

    Treatments include: Observation for patients with asymptomatic proteinuria Immunosuppressive therapy for progressive disease or symptomatic nephrotic syndrome - Chlorambucil, cyclosporine, tacrolimus, cyclophosphamide Corticosteroids - not effective when used alone, but used in combination with immunosuppressants Diuretics - may be used in situation of volume overload".

     

  • Membranous nephropathy

    Major research on disease:

    Membranous nephropathy – role of steroids. There was a male preponderance. Significant graft dysfunction, directly attributable to recurrent disease, was evident in 31% of cases at 10 years. 

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