Ocular rosacea is a manifestation of rosacea that affects the eyes and eyelids. Signs and symptoms generally consist of redness, irritation or burning of the eyes. Affected individuals may also feel that there is something, such as an eyelash, in the eye and frequently have redness of the nose and cheeks as well. The precise pathophysiology of rosacea remains unclear but is comprised of both vascular dysregulation and altered immune system responses and inflammatory changes. Recent research has shown an upregulation of proinflammatory and vasoregulatory genes in rosacea patients. Alterations in the innate immune system responses include an overabundance of cathelicidin (an antimicrobial peptide), along with kallikrein-5, an enzyme involved in processing cathelicidin. Moreover, toll-like receptor 2 activity in the innate immune system is increased in patients with rosacea.
It was examined that approximately 60% of patients with rosacea develop related problems affecting the eye (ocular rosacea). Out of which 20% experienced in Netherlands. Researches are focusing on the use of facial modeling and analysis to objectively quantify facial redness.Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature.Tear Osmolarity and Tear Film Parameters in Patients With Ocular Rosacea.