Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone and have noted that this late peak in pagetic osteosarcomas was absent in Norway, where Paget’s disease is rarely seen. No Paget’s disease wasidentified in a recent series from Japan looking at osteosar-comas in persons >50 years of age.
Although initially diagnosed by a primary care physician, Endocrinologists, rheumatologists, orthopedic specialists, neurosurgeons, neurologists, oral and maxillofacial specialists, podiatrists, and otolaryngologists are by and large learned about treating Paget's malady, and may be called upon to assess particular indications. The goal of treatment is to relieve bone pain and prevent the progression of the disease.