The etiology of uveitis is often idiopathic,however, genetic, traumatic, or infectious mechanisms are known to promote or trigger uveitis. Diseases that predispose a patient to uveitis and are likely to present to the emergency department include inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus (SLE), sarcoidosis, tuberculosis, syphilis, and AIDS.
It is well established in the medical community that uveitis can be a sign of Multiple sclerosis and it is estimated that 1 to 10 percent of Multiple sclerosis patients have uveitis. MS affects approximately 2.3 million people worldwide, causes irreversible nerve deterioration, and is notoriously difficult to diagnose.
Researchers from Casey Eye Institute at the Oregon Health and Science University and the University of Heidelberg, Germany conducted a database search of approximately 3,000 patients with uveitis from the Casey Eye Institute and 5,319 patients from the University of Heidelberg between 1985 and 2013.