alexa A Case Report of Immunoglobulin A-dominant Acute Postinfectious Glomerulonephritis in a Patient with a Horseshoe Kidney | OMICS International
ISSN: 2472-1220
Journal of Kidney
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

A Case Report of Immunoglobulin A-dominant Acute Postinfectious Glomerulonephritis in a Patient with a Horseshoe Kidney

Woods SA1,*, Trivedi DD2, Naseer A2,3, Huch KM1,2,3 and Gyamlani G2,3

1Department of Internal Medicine, University of Tennessee Health Science, Memphis, USA

2Division of Nephrology, The University of Tennessee Health Science, Memphis, USA

3Veterans Affairs Medical Center, Nephrology Section, Memphis, USA

*Corresponding Author:
S. Alexander Woods
University of Tennessee Health Science Center
956 Court Street, Suite H314, Memphis, TN 38163, USA
E-mail: [email protected]

Received date: October 19, 2015; Accepted date: November 23, 2015; Published date: November 30, 2015

Citation: Woods SA, Trivedi DD, Naseer A, Huch KM, Gyamlani G (2015) A Case Report of Immunoglobulin A-dominant Acute Postinfectious Glomerulonephritis in a Patient with a Horseshoe Kidney. J Kidney 1:104. doi:10.4172/2472-1220.1000104

Copyright: © 2015 Woods SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Kidney

Abstract

Immunoglobulin A-dominant acute postinfectious glomerulonephritis (IgA-dominant APIGN) is an increasingly recognized morphologic variant of APIGN. In contrast to classic APIGN, in which there is glomerular deposition of IgG and/or C3, IgA is the sole or dominant immunoglobulin deposited in IgA-dominant APIGN. Patients present with declining glomerular filtration rate (GFR), proteinuria, and microscopic hematuria. Horseshoe kidney (HSK) is a relatively common renal anomaly. To this point, the co-occurrence of HSK and IgA-dominant APIGN has not been reported in the literature. Here, we report a case of IgA-dominant APIGN in a patient with HSK resulting in the need for temporary hemodialysis.

Keywords

Immunoglobulin A; Postinfectious glomerulonephritis; Horseshoe kidney

Introduction

Acute post-infectious glomerulonephritis (APIGN) is an immune-complex mediated glomerulonephritis that follows an extrarenal infection. Classically, APIGN has been a post-streptococcal glomerulonephritis (PSGN) occurring predominantly in children following pharyngitis or impetigo. This is still the predominant scenario in developing countries [1]. However, over the years, the spectrum of disease in developed countries has changed such that the disease is more likely to occur in persons older than 60 years (0.9 cases per million versus 0.4 cases per million) [2] and the inciting pathogen is more likely to be Staphylococcus than Streptococcus with incidences of 46% and 16%, respectively [3]. Within the last 15 years, there has been discovery of a new morphological variant of APIGN known as immunoglobulin A-dominant acute postinfectious glomerulonephritis (IgA-dominant APIGN), which is characterized by diffuse endocapillary proliferative glomerulonephritis with dominance or sole deposition of IgA rather than the classic IgG immunoglobulin in the subepithelial layer of the glomerulus [4,5]. Factors associated with IgA-dominant APIGN appear to be male gender, older age, and staphylococcal infection [6]. It often manifests as acute or rapidly progressive renal failure with proteinuria, and the mainstays of treatment are antimicrobial therapy, steroids, and supportive care with outcomes including complete renal recovery (16- 38%), persistent renal dysfunction without renal replacement therapy (20-43%), progression to ESRD (27-41%), and death (4-13%) [5,6].

In contrast to APIGN, there has been no significant evolution in the epidemiology of the horseshoe kidney (HSK). It remains the most common renal fusion abnormality with an incidence ranging from 1:400-1:700 persons [7-9]. HSK results from fusion of the right and left metanephros during fetal development, and evidence suggests that defects in genes involved in the development of the renal capsule, namely Foxd-1, are responsible for the failure of the early metanephros to separate from the midline and body wall to form two distinct kidneys flanking the midline [10,11].

Although the association has not been formally investigated, there does not appear to be an increased risk of glomerular disease associated with horseshoe kidney. A recent literature review by Hu et al delineated the glomerular pathologies which have been identified in a HSK thus far [12]. Here, we add to that list with a case report of IgA dominant APIGN in a patient with a HSK. To our knowledge, this is the first case described in the literature.

Case Report

A 63 year-old African American male with a past medical history of diabetes mellitus, hypertension, and dermatitis presented with complaints of dyspnea upon exertion and anasarca for five days. The nephrology service was consulted for evaluation of non-oliguric acute kidney injury as evidenced by a serum creatinine increase to 2.7 mg/dL from 1.2 mg/dL measured five months prior to admission, associated with microscopic hematuria and nephrotic-range proteinuria with a urine protein to creatinine (UPC) ratio of 7243 mg/g. The patient had a recent flare of his dermatitis which was treated with a short course of steroids.

Examination revealed a hypertensive patient with anasarca, an erythematous, scaly rash on the neck, shoulders, and chest, and a nonerythematous, ichthyotic rash of his lower extremities.

Serologic studies were unremarkable with the exception of an elevated anti-DNase level. Serum complement levels were within normal limits (C3 127 mg/d and C4 36 mg/dL). Blood and urine cultures had no growth. Renal ultrasound revealed a horseshoe kidney without other abnormalities. The dermatology service diagnosed the rash as acquired ichthyosis. Because of progressively worsening renal failure necessitating hemodialysis without a clear etiology, a percutaneous renal biopsy was obtained under CT guidance.

Light microsopy (LM) (Figure 1A and 1B) revealed 21 glomeruli including five with segmental cellular crescents and three with global sclerosis. The glomeruli had minimal mesangial proliferation, scattered neutrophils within the capillary lumina, and extensive tubular damage. Immunofluorescence (IF) (Figure 1C) demonstrated 2+ segmental granular mesangial staining with IgA and C3, 1+ kappa light chain staining, and trace IgM and lambda light chain staining. IgG and C1q staining were absent in the glomeruli. Electron microscopy (EM) (Figure 1D) demonstrated electron-dense deposits in the mesangial distribution and scattered hump-like electron-dense deposits in the subepithelial distribution.

kidney-Abdominal-Light-microscopy

Figure 1: (A) Light microscopy revealing a glomerulus with mesangial proliferation and infiltrating neutrophils. (B) Light microscopy revealing a glomerulus with segmental fibrocellular crescent. (C) Immunofluorescence microscopy demonstrating IgA immunostaining in a coarsely granular staining pattern in the mesangium and segmental pattern in the glomerular capillary walls. (D) Electron microscopy demonstrating a large hump-shaped subepithelial electron-dense deposit (arrow).

These findings were consistent with IgA-dominant APIGN due to a presumed staphylococcal skin infection superimposed upon a streptococcal skin infection. The patient received two weeks of antibiotic therapy consisting of piperacillin/tazobactam for 5 days and ampicillin/ sulbactam for 9 days. He underwent hemodialysis for two weeks after which he regained sufficient renal function for discontinuation of dialysis. Follow-up of the patient in the clinic four weeks later revealed continued renal convalescence with a creatinine of 2.5 mg/dL and a UPC ratio of 2236 mg/g. At one-year follow-up, the patient’s creatinine had improved to 1.4 mg/dL with a UPC ratio of 700mg/g.

Discussion

IgA-dominant APIGN is an increasingly recognized morphologic variant of APIGN, particularly in persons greater than 65 years of age (17% of cases) [3]. Skin is the most common site of infection (26-51% of cases) followed by lung and abscesses from sites other than skin. Additional sites of infection reported include the urinary tract, bone, heart, and upper respiratory tract. Staphylococcal species account for the majority of infections (70%). Streptococcus, enterococcus, and gram-negative species are responsible for 6-9% of cases, and the remainder of cases have no identifiable pathogen (21-24%) [3,5,6]. Often, the source of infection is not clinically obvious because of long latency periods between the time of infection and the development of glomerulonephritis (up to 16 weeks). Previous studies have reported an association between IgA-dominant APIGN and diabetes, noting that the higher circulating concentrations of IgA in diabetics may predispose them to the IgA-dominant variant [3-6]. However, based upon the analysis of cases identified by Nasr et al and Koo et al. the incidence of diabetes in patients with IgA-dominant APIGN is 34-55%, revealing that diabetics likely do not have a greater predisposition to IgA-dominant APIGN than non-diabetics [3,5,6].

Patients often present with hypertension, renal failure, nephroticrange proteinuria, and hematuria. Hypocomplementemia has been identified in up to 69% of patients [5].

Diagnosis is made by renal biopsy. Histologic patterns identified on LM include endocapillary proliferative and exudative GN (63% of patients), pure mesangial proliferative GN (33%), and crescentic GN (4%). Immunofluorescence reveals IgA as the sole or dominant immunoglobulin deposited in 96% of cases, and staining for C3 is of higher intensity relative to IgA in 55% of cases and of equal intensity in 36% of cases. Additionally, staining for kappa light chains is equal to or stronger than staining for lambda light chains in 69% of reported cases. Electron microscopy reveals mesangial electron-dense deposits and subepithelial humps in 96% and 83% of cases, respectively [5].

The differential in staining of IgA, C3, and light chains aids in the differentiation of IgA-dominant APIGN from IgA nephropathy. The former more frequently has lower-intensity staining for IgA than C3 and less mesangial staining for lambda rather than kappa light chains [3,13].

Our patient was an elderly diabetic male who presented with hypertension, anasarca, and non-oliguric acute kidney injury. Renal biopsy showed features of crescentic and mesangial proliferative GN on LM (Figure 1A and 1B). Immunofluorescence staining of IgA and C3 was equivalent at 2+ staining, and light-chain stain demonstrated greater kappa light chain deposition relative to lambda light chain thus differentiating IgA-dominant APIGN from IgA nephropathy (Figure 1C). EM revealed subepithelial and mesangial electron dense deposits. There were only scant subepithelial deposits seen on EM which may have resulted in a negative IF staining in the area of glomerular basement membrane. These pathological findings were consistent with other reported cases of IgA-dominant APIGN.

Our patient also had a horseshoe kidney (HSK). This is a common congenital anomaly and has been associated with an increased incidence of hydronephrosis [14,15], nephrolithiasis [9,14,16-18], UTI [14] and certain malignancies [19-21]. Several types of glomerular diseases have been reported to occur in HSK [12,22-29] and though there has not been a formal study designed to specifically address this association, studies addressing either HSK or glomerulonephritis individually have not identified an association of the two [1-7,9]. In light of the frequent incidence of HSK and the need for renal imaging prior to biopsy for diagnosis of glomerular disease, we might expect that if an association existed, it would have presented itself in the studies of glomerular disease conducted thus far. The lack of association may reflect the fact that HSK malformation results from abnormalities of the renal capsule, not the parenchyma. For this reason, the renal parenchyma of a HSK may be at the same risk for glomerular disease as that of a normal kidney. However, because HSK poses a relative contraindication to renal biopsy, providers may be hesitant to pursue a definitive diagnosis, and thus the incidence of biopsy-proven glomerular disease in HSK may be underestimated [25].

In our case, we suspect that the occurrence of IgA-dominant APIGN in a HSK is a matter of coincidence, and that this case supports the supposition that the renal malformation of HSK neither protects nor predisposes to glomerular disease, but rather holds the same risk for glomerular disease as that of the general population. However, a formal study to address the incidence of glomerular disease in patients with HSK relative to the general population is needed to elucidate the true association between the two entities.

In conclusion, IgA-dominant APIGN is an increasingly recognized morphologic variant of APIGN, and HSK remains a common renal malformation. We report a case of IgA-dominant APIGN occurring in a patient with a HSK. To our knowledge, this is the first case reported in the literature.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • Global Physicians and Healthcare Congress
    June 25-27, 2018 Dubai, UAE
  • International Conference on Medical and Health Science
    August 24-25, 2018 Tokyo, Japan
  • 11th International Conference on Clinical and Medical Case Reports
    October 22-23, 2018 Istanbul, Turkey

Article Usage

  • Total views: 8380
  • [From(publication date):
    December-2015 - Dec 18, 2017]
  • Breakdown by view type
  • HTML page views : 8306
  • PDF downloads : 74
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version