alexa A Computational Approach for Identifying the Impact of Pharmacogenomics in Regulatory Networks to Understand Disease Pathology | Open Access Journals
ISSN: 2155-9538
Journal of Bioengineering & Biomedical Science
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A Computational Approach for Identifying the Impact of Pharmacogenomics in Regulatory Networks to Understand Disease Pathology

Harishchander A*

Department of Bioinformatics, Sathyabama University, Chennai, Tamil Nadu, India

*Corresponding Author:
Harishchander A
Department of Bioinformatics
Sathyabama University, Chennai
Tamil Nadu, India
Tel: 9940066227
E-mail: [email protected]

Received date: June 25, 2017; Accepted date: July 20, 2017; Published date: July 30, 2017

Citation: Harishchander A (2017) A Computational Approach for Identifying the Impact of Pharmacogenomics in Regulatory Networks to Understand Disease Pathology. J Bioengineer & Biomedical Sci 7: 235. doi: 10.4172/2155-9538.1000235

Copyright: © 2017 Harishchander A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

In the current era of post genomics, there exist a varity of computational methodologies to understand the nature of disease pathology like RegNetworks, DisgiNet, pharmGkb, pharmacomiR and etc. In most of these computational methodologies either a seed pairing approach or a base pair complement is being followed. Hence there exists a gap in understanding the nature of disease pathology in a holistic view point. In this manuscript we combine the approach of seed pairing and graph theory to illustrate the impact of Pharmacogenomics in Regulatory Networks to understand disease Pathology

Keywords

Pharmacogenomics; Macromolecules; Phenotypes

Introduction

Events in gene regulation play vital roles in a various developmental and physiological processes in a cell, in which macromolecules such as RNAs, genes and proteins to coordinate and organize responses under various conditions [1]. Therefore, substantial efforts were made to reveal the gene regulatory structures of gene from the transcriptomic datasets generated by microarray [2], ChIP-Seq [3] and RNA-Seq [4]. Although, there were a number of reverse engineering techniques the driven data were previously proposed to identify the regulatory relationships between regulators and their targets (e.g. Transcription Factors and downstream genes) [5]. In order to reduce the low accuracy of these existing methods the dimensionality limits their applications in practice [6]. However, recent studies suggest a promising alternative for identifying the structures of regulatory network by combining the high-throughput data with the prior knowledge on known or predicted regulatory relationships in various databases and literature [7-9]. For instance, the frame work can significantly improve the accuracy of regulatory relationship by incorporating prior knowledge into the transcriptomic profiling in data [10]. Also, the results from several independent studies suggest that the incorporation of prior knowledge can help to identify the context-specific regulatory interactions corresponding to phenotypes [11,12]. Hence, the interest to collect, organize and share such prior information with the related communities is required for future research biomedical science.

Literature Review

Knowledge about the relationships in gene regulation from multiple sources (e.g. conserved co-expression of genes in a high-throughput experiment) was available in various databases and literature. It is vital to develop a unified database and provide the necessary tools to users for retrieving information. However, only limited sources such as RegulonDB for Escherichia coli [13] were available previously and the information on the genome-wide regulatory relationships for other species were still lacking. After considering the importance of pharmacogenomics and regulatory networks in biomedical studies, the implementation of genome-wide relationships in regulation was illustrated. It should be clear that, the experimentally observed or discovered regulatory relationships were also curated in public databases such as TRED [14], KEGG [15] and TF binding site (TFBS) information for Transcription Factor–gene regulatory interaction potentials [16,17]. This information can still be used to predict the new regulatory relationships between TFs and genes by matching the binding motifs in DNA sequences. Hence, these predictions were based on TFBS to integrate into PharmacoReg to provide a more comprehensive landscape in gene regulation. Moreover, to include the post- transcriptional regulatory relationship, consideration of miRNAs (small non-coding RNA molecules with ∼22 nucleotides) becomes vital in initiating the gene regulation. Initially the genes associated with Pharmacogenomics of Psoriasis were identified from pharmGkb. Then, the miRNAs associated with Pharmacogenomics of Psoriasis were identified from pharmcomiR. Further, the transcription factors were identified RegNetworks (Figure 1). Finally, a pharmacogenomic based regulatory network was constructed and analyzed in Cytoscape (Table 1).

bioengineering-biomedical-science-psoriasis-clustering-analysis

Figure 1: RegNetwork in psoriasis (clustering analysis).

Genes (pharmGkb) miRNAs (pharmacomiR) Transcription Factor (EnrichR)
ABCB1 hsa-miR-222, hsa-miR-338-5p and hsa-miR-451 AR, CEBPA, CEBPB, EGR1, EGR2, ETS1, HAX1, HIF1A, JUN, NFKB1RARARNF2, SP1, TFAP2A, TP53 and WT1
CYP3A4 hsa-miR-221 SP1 and TFAP2A
CTLA4 hsa-miR-200C, hsa-miR-101, hsa-miR-105, hsa-miR-155, hsa-miR-205, hsa-miR-380, hsa-miR-384, hsa-miR-429, hsa-miR-432, hsa-miR-449b, hsa-miR-451, hsa-miR-496, hsa-miR-516a-3p, hsa-miR-517a, hsa-miR-651 and hsa-miR-656 BPTF, STAT5A and STAT5B
TNF hsa-miR-27a, hsa-miR-130a, hsa-miR-130b, hsa-miR-149, hsa-miR-187, hsa-miR-19a, hsa-miR-296-3p, hsa-miR-409-5p, hsa-miR-454
hsa-miR-516a-5p, hsa-miR-516b, hsa-miR-519b-3p, hsa-miR-542-3p, hsa-miR-581, hsa-miR-592, hsa-miR-599, hsa-miR-654-3p, hsa-miR-770-5p, hsa-miR-875-3p, hsa-miR-875-5p and hsa-miR-939
AHR, ARNT, ATF1, ATF2, CEBPB, CEBPD, CREB1, EBF1, EGR1, EGR4, ELK1, ETS1, ETV4, FOS, IKBKB, IRF5, JUN, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFE2L1, NFKB1, NFKB1, NFKB2, POU2F1, RELA, RELA, SMAD6, SMAD7, SP1, SP3, SPI1, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TBP, TFAP2A and TP53
MTHFR hsa-miR-331-5p, hsa-miR-103, hsa-miR-107, hsa-miR-125a-3p, hsa-miR-138, hsa-miR-16, hsa-miR-195, hsa-miR-214, hsa-miR-22, hsa-miR-220b, hsa-miR-24, hsa-miR-424, hsa-miR-486-3p, hsa-miR-497, hsa-miR-516a-5p, hsa-miR-565, hsa-miR-642 and hsa-miR-646 AHR, ARNT, CUX1, E2F1, EP300, JUN, MAX, MXI1::CLEC5A, MYC, REST, SP1, SREBF1, SREBF2, TFAP2A, USF1, XBP1 and YY1
VDR hsa-miR-451, hsa-miR-124 hsa-miR-125b, hsa-miR-506 and hsa-miR-544 BACH2, CREBBP, CTCF, FOS, FOSB, FOSL1, GTF2B, HMGN3, HNF4A, HR, JUN, JUNB, JUND, KDM5A, LMO2, MAX, MED1, NCOA1, NCOA2, NCOA6, NR0B2, NR1H2, NRIP1, RXRA, RXRB, RXRG, SMAD3, SNW1, STAT1 and TRIM24
CREBBP hsa-miR-27b AIRE, ALX1, AR, ATF1, ATF4, BCL3, BRCA1, CALCOCO1, CDX2, CEBPA, CEBPB, CEBPD, CITED1, CITED2, CNOT3, CREB1, CREB3, CREB3L1, CREB3L3, CREB3L4 and CREB5
ABCC2 hsa-miR-155, hsa-miR-339-5p CEBPB, HNF4A,PPARG::RXRA, RXRA and TP53
UGT1A8 hsa-miR-181a MYB and SRF
UGT1A9 hsa-miR-181c CUX1, MYB and SRF
NR1I2 hsa-miR-181d, hsa-miR-148a and hsa-miR-148a NCOA1, NCOA3, NCOR2, POU1F1, PPARGC1A, RXRA, RXRB and RXRG
AKT1 hsa-miR-181b, hsa-miR-125b, hsa-miR-149*, hsa-miR-185, hsa-miR-409-3p, hsa-miR-451and hsa-miR-625 AR, BRCA1, CREB1, EGR1
EP300, ESR1, ESR2, EZH2
FOXO1, FOXO3, FOXO4
GATA1, GATA2, HIST2, H2BE, HTT, IKBKB, IKBKG, MDM4
NFKB1, NFKBIA, NFKBIB
NKX3-1, NR4A1, PATZ1
PHB2, PPARA, PPARG, PPARGC1B, RELA, SMAD2
SMAD3, SMAD4, SMAD7
SP1, STAT1, STAT5A, TP53, TRIB3, XBP1, YBX1 and YY1
MAP2K1 hsa-miR-19a, hsa-miR-103, hsa-miR-107, hsa-miR-1271, hsa-miR-130a, hsa-miR-130b, hsa-miR-144, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-181a, hsa-miR-181c, hsa-miR-195, hsa-miR-301a
hsa-miR-335, hsa-miR-34a,
hsa-miR-34c, hsa-miR-34c-5p,
hsa-miR-411, hsa-miR-424, hsa-miR-449a, hsa-miR-497, hsa-miR-501-5p, hsa-miR-506, hsa-miR-516a-3p, hsa-miR-545, hsa-miR-575, hsa-miR-620, hsa-miR-889 and hsa-miR-96
ATF1, ATF2, ATF3, ATF4, ATF5
ATF6, ATF7, CREB1, ELK1, EP300, MYC, POU3F2 and SP1
PIK3CA hsa-miR-19b, hsa-miR-10a, hsa-miR-10b, hsa-miR-124, hsa-miR-135a, hsa-miR-135b, hsa-miR-148a, hsa-miR-148b, hsa-miR-152, hsa-miR-155, hsa-miR-193a-5p, hsa-miR-19a, hsa-miR-19b, hsa-miR-203, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-370, hsa-miR-372, hsa-miR-373, hsa-miR-422a, hsa-miR-490-5p, hsa-miR-506, hsa-miR-512-3p, hsa-miR-520a-3p, hsa-miR-520a-5p, hsa-miR-520b, hsa-miR-520d-3p, hsa-miR-520e, hsa-miR-525-5p, hsa-miR-561, hsa-miR-576-5p and hsa-miR-942 CTCF, ESR1, FOXI1, FOXO1, FOXO3, FOXO3B, FOXO4, PGR and TP53
BCL2 hsa-miR-301b, hsa-let-7a, hsa-miR-1, hsa-miR-103, hsa-miR-106a, hsa-miR-107, hsa-miR-125a-5p, hsa-miR-125b, hsa-miR-139-5p, hsa-miR-140-3p, hsa-miR-143, hsa-miR-153, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c
hsa-miR-181d, hsa-miR-182, hsa-miR-192, hsa-miR-195, hsa-miR-204, hsa-miR-20a, hsa-miR-21, hsa-miR-211, hsa-miR-217, hsa-miR-23a, hsa-miR-23b, hsa-miR-296-5p, hsa-miR-29a, hsa-miR-29b
hsa-miR-29c, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-338-5p, hsa-miR-34a, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c, hsa-miR-34c-5p, hsa-miR-365, hsa-miR-424, hsa-miR-429, hsa-miR-448, hsa-miR-451, hsa-miR-495, hsa-miR-497, hsa-miR-503, hsa-miR-504, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-548b-5p, hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-587, hsa-miR-630, hsa-miR-641, hsa-miR-646 and hsa-miR-96
AR, ATF1, BCLAF1, BRCA1, CEBPA, CREB1, CTCF, CUX1, DDIT3, EGR1, ETS1, GLI1, GLI2
MYB, MYBL1, MYC, NFKB1, NFKB2, NR4A1, PARP1, PML
PPARG, RARA, RARB, RARG
RELA, SF1, SP1, STAT3, STAT5A
TP53 and WT1
SLC30A8 hsa-miR-454, hsa-miR-143,hsa-miR-183, hsa-miR-186, hsa-miR-194, hsa-miR-205, hsa-miR-25
hsa-miR-298, hsa-miR-378, hsa-miR-422a, hsa-miR-501-3p, hsa-miR-502-3p, hsa-miR-543, hsa-miR-563, hsa-miR-577, hsa-miR-874
and hsa-miR-9
CEBPB, FOXO3, FOXO3B and HNF1A
CD3G hsa-miR-301a, hsa-miR-136, hsa-miR-28-5p, hsa-miR-33b and hsa-miR-619 JUN
CD4 hsa-miR-130a, hsa-miR-181c
hsa-miR-181d, hsa-miR-221
hsa-miR-222 and hsa-miR-765
CREB1, ETS1, ETS2 and MYB
CHN1 hsa-miR-130b, hsa-miR-194, hsa-miR-205, hsa-miR-210, hsa-miR-224, hsa-miR-300, hsa-miR-30a, hsa-miR-30d, hsa-miR-30e, hsa-miR-335, hsa-miR-452, hsa-miR-494, hsa-miR-502-5p, hsa-miR-543, hsa-miR-570 and hsa-miR-802 CUX1, FOXO3, FOXO3B, FOXO4
GTF3C1, NKX6-1, POU3F1, POU3F2, SREBF1, SREBF2
SRY and TCF3
ELK1 hsa-miR-24, hsa-miR-135a, hsa-miR-135b, hsa-miR-136, hsa-miR-150, hsa-miR-185, hsa-miR-205, hsa-miR-326, hsa-miR-330-5p, hsa-miR-34b, hsa-miR-34c-3p
hsa-miR-361-3p, hsa-miR-495
hsa-miR-498, hsa-miR-539, hsa-miR-542-5p, hsa-miR-626, hsa-miR-660 and hsa-miR-873
AR, ARNT, BRCA1, BRCA1, CEBPA, CEBPB, CREBBP, CUX1, EGR1, EP300, FOS, ID1, ID2, ID3, KLF4, MAX, MXI1::CLEC5A, MYB, MYC, NFKB1, NFYA, PIAS2, SP1, SRF, STAT1, STAT2, TFAP2A, TFAP2C and USF1
FYN hsa-miR-15b, hsa-miR-125a-3p, hsa-miR-1271, hsa-miR-183, hsa-miR-326, hsa-miR-330-5p, hsa-miR-369-3p, hsa-miR-370, hsa-miR-376a
hsa-miR-376b, hsa-miR-380, hsa-miR-452, hsa-miR-486-3p, hsa-miR-489, hsa-miR-569, hsa-miR-583
hsa-miR-586, hsa-miR-604, hsa-miR-624, hsa-miR-639, hsa-miR-646, hsa-miR-889, hsa-miR-921
hsa-miR-939, hsa-miR-944and hsa-miR-96
ALX1, BCL3, CREB1, CTNNB1
EGR1, HLF, HNRNPK, KHDRBS1
NFIL3, NFKB1, NKX2-2, NR3C1
PAX5, RFX1, RREB1, SP1, STAT1
VSX2 and YTHDC1
LAT hsa-miR-497, hsa-miR-216b, hsa-miR-296-3p, hsa-miR-376c, hsa-miR-574-3p, hsa-miR-602, hsa-miR-604, hsa-miR-608, hsa-miR-631 and hsa-miR-941 CTCF, PAX2, PPARG, TFAP4 and YY1
LCK hsa-miR-424 and hsa-miR-202 ARNT, CTCF, EBF1, ELK1
ESR1, ESR2, ETS1, HNF4A
KHDRBS1, MIF, MYB, NFKBIA
NR3C1, RXRA, SP1, STAT1, STAT3, STAT5A, TAL1, TCF3 and USF1
MAP2K4 hsa-miR-16, hsa-miR-124, hsa-miR-128, hsa-miR-128a, hsa-miR-128b
hsa-miR-136, hsa-miR-137, hsa-miR-141, hsa-miR-15b, hsa-miR-16
hsa-miR-195, hsa-miR-200a, hsa-miR-218, hsa-miR-22, hsa-miR-24
hsa-miR-25, hsa-miR-27a, hsa-miR-27b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30b, hsa-miR-30d, hsa-miR-30e, hsa-miR-32
hsa-miR-363, hsa-miR-367, has-miR-374a, hsa-miR-424, hsa-miR-487b, hsa-miR-497, hsa-miR-503, hsa-miR-505, hsa-miR-506, hsa-miR-580, hsa-miR-892a, hsa-miR-92, hsa-miR-92a, hsa-miR-92b and hsa-miR-938
AHR, ARID5B, ARNT, PAX5 and YY1
MAP3K1 hsa-miR-195, hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e,
hsa-let-7f, hsa-let-7g, hsa-let-7i,
hsa-miR-1, hsa-miR-106a, hsa-miR-106b, hsa-miR-124, hsa-miR-129-3p
hsa-miR-129-5p, hsa-miR-136,
hsa-miR-137, hsa-miR-17, hsa-miR-18a, hsa-miR-18b, hsa-miR-190, hsa-miR-192, hsa-miR-193a-3p, hsa-miR-193b, hsa-miR-19a, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-203, hsa-miR-206, hsa-miR-20a, hsa-miR-20b, hsa-miR-21, hsa-miR-23a, hsa-miR-23b
hsa-miR-30a, hsa-miR-31, hsa-miR-340, hsa-miR-371-5p, hsa-miR-372
hsa-miR-411, hsa-miR-429, hsa-miR-433, hsa-miR-488, hsa-miR-495, hsa-miR-499-3p, hsa-miR-506
hsa-miR-517b, hsa-miR-519d,
hsa-miR-520d-5p, hsa-miR-524-5p,
hsa-miR-544, hsa-miR-548c-3p,
hsa-miR-557, hsa-miR-582-5p, hsa-miR-590-5p, hsa-miR-607, hsa-miR-613, hsa-miR-643, hsa-miR-892b, hsa-miR-9, hsa-miR-93 and hsa-miR-98
CEBPB, EGR1, IKBKB, IKBKG
NFKB1, RELA and SPI1
PTPN7 hsa-miR-15a and hsa-miR-126 E2F1, EGR1, GATA1 and MXI1::CLEC5A
RAC1 hsa-miR-214, hsa-miR-101, hsa-miR-122, hsa-miR-137, hsa-miR-142-3p, hsa-miR-144, hsa-miR-155, hsa-miR-182, hsa-miR-194
hsa-miR-200c, hsa-miR-217
hsa-miR-299-5p, hsa-miR-300
hsa-miR-320, hsa-miR-361-5p
hsa-miR-369-3p, hsa-miR-374a
hsa-miR-429, hsa-miR-485-3p
hsa-miR-518f, hsa-miR-655
and hsa-miR-96
ABL1, E2F1, EIF2AK2, ELK1, GABPA, NFKB1, RELA, STAT1
STAT3 and YY1
RAF1 hsa-miR-22, hsa-miR-125b, hsa-miR-135a, hsa-miR-135b, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-195, hsa-miR-19a, hsa-miR-19b, hsa-miR-424, hsa-miR-497, hsa-miR-516a-3p, hsa-miR-516b, hsa-miR-634, hsa-miR-646, hsa-miR-649 and hsa-miR-7 AR, MYC, NR3C1, RB1, RBL2, RFXANK, TSC22D3 and YY1
RELA hsa-miR-544, hsa-miR-124, hsa-miR-138, hsa-miR-22, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c
hsa-miR-302d, hsa-miR-329, hsa-miR-362-3p, hsa-miR-371-5p, hsa-miR-373, hsa-miR-506, hsa-miR-512-3p, hsa-miR-520f, hsa-miR-569
hsa-miR-596, hsa-miR-7, hsa-miR-769-5p and hsa-miR-891b
AATF, AES, AHR, AR, BRCA1, CEBPB, CEBPD, CREBBP, EGR1, EGR1, EP300, ESR1, FOS, FUS, GTF2B, HDAC1, HDAC2, HDAC3, HEXIM1, HMGA2, IKBKB, IKBKG, ING4, IRF1, IRF2, IRF3, JUN, KAT2B, MEN1, MYC, NCOA3, NCOR2, NFKB1, NFKB2, NFKB2, NFKBIA, NFKBIB, NKRF, NKX2-1, NR3C1, PARP1, PAX6, PDCD11, PGR, PIAS1, PIAS3, PML, POU2F1, PPARA, PPARD, REL, RELB, RFC1, RXRA, SIN3A, SIRT1, SNIP1, SP1, SRF, STAT1, STAT3, STAT6, TAF1, TAF11, TAF4B, TAF6, TBP, TP53, TP53BP1, TRIB3, TRIP4, TSC22D3 and TWIST1
CLAR hsa-miR-302e, hsa-miR-324-3p, hsa-miR-361-3p, hsa-miR-450b-3p, hsa-miR-516a-5p, hsa-miR-627, hsa-miR-660 and hsa-miR-768-5p AR, E2F1, E2F4, GABPA, MYC
NFYA, NKX2-1, NR3C1, RREB1
SP1, TFAP2A, TFAP2C, USF1
VSX2 and YY1
CAMK4 hsa-miR-302d, hsa-miR-106a, hsa-miR-129-5p, hsa-miR-17, hsa-miR-187, hsa-miR-191, hsa-miR-20a
hsa-miR-299-3p, hsa-miR-30a
hsa-miR-30b, hsa-miR-30c, hsa-miR-33a and hsa-miR-33b, hsa-miR-34b, hsa-miR-34c-3p, hsa-miR-455-5p, hsa-miR-507, hsa-miR-511, hsa-miR-567, hsa-miR-586, hsa-miR-885-5p and hsa-miR-96
ATF4, BACH1, BACH2, CREBBP
EP300, HDAC4, MAX, MEF2A
MYC, PPARG and RELA
CA1KK1 hsa-miR-302b, hsa-miR-103, hsa-miR-107, hsa-miR-145, hsa-miR-221, hsa-miR-222, hsa-miR-361-3p, hsa-miR-515-5p, hsa-miR-574-5p, hsa-miR-596, hsa-miR-619, hsa-miR-631, hsa-miR-634, hsa-miR-671-5p, hsa-miR-769-5p, hsa-miR-921 and hsa-miR-943 ARNT, BACH1, BACH2, E2F1, MAX, MXI1::CLEC5A, MYC, NFYA, PAX6, PPARG, TFAP2A
TFAP2C and USF1
EDN1 hsa-miR-302a, hsa-let-7b, hsa-let-7c, hsa-miR-1, hsa-miR-147, hsa-miR-155, hsa-miR-185, hsa-miR-199a-5p, hsa-miR-203, hsa-miR-206, hsa-miR-220c, hsa-miR-454, hsa-miR-517b, hsa-miR-574-5p, hsa-miR-613
hsa-miR-648, hsa-miR-892a
and hsa-miR-935
AR, CEBPA, CREB1, E2F1, FOXJ2
FOXO1, HIF1A, HLF, JUN, MEF2A, NFIC, NFKB1, PPARA, PPARG, SMAD1, SMAD3, SMAD4, TCF3 and ZEB1
GATA4 hsa-miR-302c, hsa-miR-1, hsa-miR-200b, hsa-miR-200c, hsa-miR-208b and hsa-miR-429 ATF1,ATF2, ATF3, ATF4, ATF5
ATF6,ATF7, CEBPA, CREB1, CUX1, EP300, FOS, FOSB, HAND2, JARID2, JUN, JUNB
JUND, MED1, MEF2C, NFATC4
NFKB1, NFKB2, NKX2-5
NR5A1, PIAS1, RELA, SRF, TBX5
USF1and ZFPM2
GSK3B hsa-miR-181d, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-224, hsa-miR-26a, hsa-miR-26b, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-582-3p, hsa-miR-647 and hsa-miR-876-3p APC, AR, ARNT, ATF4, BCL3, CDX2, CEBPA, CEBPA, CREB1,
CREB3, CREB3L1, CREB3L3,
CREB3L4, CREB5, CREM, CSDA, CTNNB1, CUX1, E2F1, E2F1, FOXO1, GLI1, GLI2, GLI3, HNRNPD, HOXA9, IKBKG, MEIS1, MITF, MYC, MYOCD, NFAT5, NFATC1
NFATC2, NFATC3, NFATC4
NFKB1, NFYA, NFYB, NFYC
NKX2-2, NOTCH2, PAX5, POU2F1, PPARGC1A, SNAI1
SOX9, SPI1, STAT5A, TP53 and YBX1
HAND1 hsa-miR-520a-3p, hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7g, hsa-let-7i
hsa-miR-196a, hsa-miR-196b, hsa-miR-25, hsa-miR-32, hsa-miR-335, hsa-miR-363, hsa-miR-367, hsa-miR-92, hsa-miR-92a, hsa-miR-98
FHL2, FOXD1, FOXF2, HEY2, HEYL, HOXA9, MEIS1, MYOD1, POU3F1, RORA, TCF12 and TCF3
HAND2 hsa-miR-520e, hsa-miR-1, hsa-miR-128, hsa-miR-135b, hsa-miR-140-5p, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d, hsa-miR-202, hsa-miR-206, hsa-miR-25
hsa-miR-296-5p, hsa-miR-32, hsa-miR-363, hsa-miR-367, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-543, hsa-miR-566
hsa-miR-615-5p, hsa-miR-661, hsa-miR-767-3p, hsa-miR-876-3p, hsa-miR-92, hsa-miR-92a and hsa-miR-92b
AHR, ARNT, BPTF, CENPB, COPS5, EP300, FOXD3, GATA4
HEY2, HEYL, NPM1, PHOX2A
SRY, TCF3 and VSX2
HDAC5 hsa-miR-373, hsa-miR-124, hsa-miR-128, hsa-miR-134, hsa-miR-30a, hsa-miR-30b, hsa-miR-506, hsa-miR-589, hsa-miR-629, hsa-miR-653, hsa-miR-765, hsa-miR-768-3p and hsa-miR-9 ANKRA2, BCL6, BCOR, CIITA,
HR, KLF4, MAX, MEF2A, MEF2C
MEF2D, NCOR1, NCOR2, NFKB2
NRIP1, PHB2, RFXANK, RUNX3
USF1 and ZBTB16
HDAC9 hsa-miR-520c-3p, hsa-miR-124, hsa-miR-147, hsa-miR-182, hsa-miR-190b, hsa-miR-199b-5p, hsa-miR-19a, hsa-miR-26a, hsa-miR-26b, hsa-miR-27a, hsa-miR-27b, hsa-miR-299-5p, hsa-miR-302b, hsa-miR-302c, hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-32, hsa-miR-338-5p, hsa-miR-365, hsa-miR-377, hsa-miR-383, hsa-miR-409-5p,hsa-miR-452,hsa-miR-506,hsa-miR-514, hsa-miR-515-5p, hsa-miR-542-5p, hsa-miR-558, hsa-miR-768-3p, hsa-miR-891a and hsa-miR-96 KLF12, MEF2A, MEF2A, NCOR1
REST, SIN3A, SIN3B, USF1, ZBTB16 and ZEB1
LIF hsa-miR-520b, hsa-miR-125a-5p, hsa-miR-125b, hsa-miR-1297, hsa-miR-181b, hsa-miR-181d, hsa-miR-199a, hsa-miR-199a-5p, hsa-miR-26a, hsa-miR-28-5p, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-328, hsa-miR-331-3p, hsa-miR-346, hsa-miR-494, hsa-miR-504, hsa-miR-654-5p, hsa-miR-874 and hsa-miR-93 CTCF, EGR3, ETS1, ETS2, MZF1
NFKB1, PBX1, RREB1, STAT1
STAT2 and TBP
MEF2C hsa-miR-520d-3p, hsa-miR-135a, hsa-miR-135b, hsa-miR-137, hsa-miR-153, hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-18b, hsa-miR-190, hsa-miR-190b, hsa-miR-194, hsa-miR-19a, hsa-miR-19b, hsa-miR-203, hsa-miR-21, hsa-miR-223, hsa-miR-23a, hsa-miR-23b, hsa-miR-27b, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-330-3p, hsa-miR-331-5p, hsa-miR-33a, hsa-miR-340, hsa-miR-372, hsa-miR-421, hsa-miR-448, hsa-miR-450b-5p, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520d-5p, hsa-miR-520e, hsa-miR-520f, hsa-miR-524-5p, hsa-miR-556-3p, hsa-miR-603, hsa-miR-621 and hsa-miR-656 ATF2, BPTF, CDC5L, CREB1, CUX1, EP300, ESR1, FOXD3, FOXI1, FOXJ2, GATA4, HDAC4
HDAC5, HLF, IRF1, KLF12, MEF2A, MEF2D, NCOA2, NKX2-2
NKX3-1, PAX6, PBX1, POU2F1, POU2F2, POU3F1, POU3F2, POU3F3
POU5F1, SMAD2, SP1, SP1, SPI1, STAT5A, STAT5B, TCF3, TEAD1
TFAP4, TGIF1, TWIST2 and VGLL2
MYL2 hsa-miR-124, hsa-miR-490-5p
hsa-miR-593 and hsa-miR-876-5p
HNF1A and MEF2A
ACTA1 hsa-miR-506, hsa-let-7a,hsa-let-7b
hsa-let-7c,hsa-let-7d,hsa-let-7e, hsa-let-7f, hsa-let-7g, hsa-let-7i, hsa-miR-122,hsa-miR-155,hsa-miR-21
hsa-miR-220c,hsa-miR-569, hsa-miR-574-5p and hsa-miR-98
ABL1, E2F4, ELK1, HCLS1, MEF2A, NR3C2, REST, SRF, TBP
TP53 and ZEB1
PDPK1 hsa-miR-23a, hsa-miR-147, hsa-miR-181a, hsa-miR-181c, hsa-miR-214, hsa-miR-27a, hsa-miR-27b, hsa-miR-323-5p, hsa-miR-374b, hsa-miR-375, hsa-miR-382, hsa-miR-410, hsa-miR-486-3p, hsa-miR-499-3p, hsa-miR-504, hsa-miR-885-3p and hsa-miR-944 EGR1, EGR3, GABPA, PPARD
RXRA, RXRB, RXRG and SP1
RPS6KB1 hsa-miR-23b, hsa-miR-103, hsa-miR-107, hsa-miR-124, hsa-miR-128, hsa-miR-129-5p, hsa-miR-130a
hsa-miR-130b, hsa-miR-135a, hsa-miR-135b, hsa-miR-137, hsa-miR-142-5p, hsa-miR-145, hsa-miR-153
hsa-miR-155, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d, hsa-miR-186, hsa-miR-200b
hsa-miR-200c, hsa-miR-218, hsa-miR-223, hsa-miR-27a, hsa-miR-27b, hsa-miR-301a, hsa-miR-301b
hsa-miR-340, hsa-miR-369-3p, hsa-miR-377, hsa-miR-429, hsa-miR-506, hsa-miR-507, hsa-miR-548c-3p, hsa-miR-557, hsa-miR-561, hsa-miR-568, hsa-miR-579, hsa-miR-590-3p, hsa-miR-605, hsa-miR-607, hsa-miR-641, hsa-miR-655, hsa-miR-7 and hsa-miR-944
E2F1, E2F2 and LMO2
YWHAH hsa-miR-125b, hsa-miR-103, has-miR-107, hsa-miR-137, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-195, hsa-miR-25, hsa-miR-28-3p, hsa-miR-33, hsa-miR-33a, hsa-miR-33b, hsa-miR-361-5p, hsa-miR-365, hsa-miR-381, hsa-miR-421, hsa-miR-424, hsa-miR-490-5p, hsa-miR-497, hsa-miR-519d, hsa-miR-521, hsa-miR-523,hsa-miR-563, hsa-miR-576-5p,hsa-miR-583, hsa-miR-584, hsa-miR-586, hsa-miR-598, hsa-miR-652, hsa-miR-660, hsa-miR-708, hsa-miR-885-5p, hsa-miR-888, hsa-miR-95and hsa-miR-96 ABL1, ATF2, CREB1, CREBBP, E2F4, EGR3, ESR1, ESR2, ING1, JUN, MDM4, MED1, MEF2A, MYC, NCOA1, NCOA2, NCOA3, NR3C1, NRIP1, TFAP2A, THRA, TLX2, TNFAIP3, YY1 and ZFP36
ADSS hsa-miR-125a-5p, hsa-miR-1, hsa-miR-16, hsa-miR-182, hsa-miR-19a
hsa-miR-19b, hsa-miR-206, hsa-miR-28-3p, hsa-miR-383, hsa-miR-503, hsa-miR-514, hsa-miR-548a-3p
hsa-miR-548a-5p, hsa-miR-548b-5p
hsa-miR-548c-5p, hsa-miR-548d-5p
hsa-miR-561, hsa-miR-609, hsa-miR-642, hsa-miR-922, hsa-miR-923 and hsa-miR-96
CTCF, EGR1, EGR2, EGR3
KLF12, SP1, TFAP2A and TFAP2C
CDKN1A hsa-miR-590-3p, hsa-miR-449a, hsa-miR-449b, hsa-let-7a, hsa-let-7e, hsa-let-7f, hsa-miR-106a, hsa-miR-106b, hsa-miR-125a-5p, hsa-miR-130a, hsa-miR-130b, hsa-miR-132, hsa-miR-145, hsa-miR-146a, hsa-miR-146b-5p, hsa-miR-17, hsa-miR-17-5p,hsa-miR-182, hsa-miR-193a-5p,hsa-miR-20, hsa-miR-208a
hsa-miR-208b, hsa-miR-20a, hsa-miR-20b, hsa-miR-21, hsa-miR-212, hsa-miR-22, hsa-miR-224, hsa-miR-28-5p, hsa-miR-298, hsa-miR-299-5p, hsa-miR-301a, hsa-miR-301b
hsa-miR-302a, hsa-miR-345, hsa-miR-363, hsa-miR-370, hsa-miR-372, hsa-miR-423-3p,
hsa-miR-454, hsa-miR-503, hsa-miR-509-3-5p, hsa-miR-515-3p, hsa-miR-516a-3p, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520g, hsa-miR-520h, hsa-miR-572, hsa-miR-608, hsa-miR-639, hsa-miR-641, hsa-miR-654-3p, hsa-miR-657, hsa-miR-93, hsa-miR-939
hsa-miR-942 and hsa-miR-96
AR, ATF2, CDC5L, CEBPA, CEBPA, ESR1, ESR1, ETS1, FLI1, FOS, FOXC1, FOXD1, FOXF2, FOXJ2, HDAC11, HIF1A, HNF4A, JUN, PARP1, PPARG, RARA, RB1, RELB, SMAD1, SMAD2, SMAD3, SMAD4, SP1, SP3, SP4, SRF, STAT1, STAT3, TFAP2A, TP53, TP53, TP63, TP73, TSG101, WT1 and XRCC6
GNAQ hsa-miR-381, hsa-miR-142-3p, hsa-miR-182, hsa-miR-423-5p, hsa-miR-491-3p, hsa-miR-574-3p, hsa-miR-581, hsa-miR-587, hsa-miR-642, hsa-miR-886-3p and hsa-miR-96 CTCF, CUX1, EGR1, MEF2A and PPARG
MARCKS hsa-miR-300, hsa-miR-1, hsa-miR-128a, hsa-miR-128b, hsa-miR-138, hsa-miR-142-3p, hsa-miR-143, hsa-miR-144, hsa-miR-182, hsa-miR-200b, hsa-miR-200c, hsa-miR-205,
hsa-miR-206, hsa-miR-21, hsa-miR-216a, hsa-miR-218, hsa-miR-222,
hsa-miR-23a, hsa-miR-25, hsa-miR-27a, hsa-miR-27b, hsa-miR-300, hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-370, hsa-miR-429, hsa-miR-491-5p, hsa-miR-495, hsa-miR-499-5p, hsa-miR-561, hsa-miR-655, hsa-miR-770-5p and hsa-miR-876-3p
AHR, ALX1, ARNT, HNF1A
MZF1, NFKB1, PAX6, POU2F1
TOB1 and YY1
SP1 hsa-miR-153, hsa-miR-1, hsa-miR-105, hsa-miR-124, hsa-miR-128, hsa-miR-128a, hsa-miR-128b, hsa-miR-135a, hsa-miR-135b, hsa-miR-137, hsa-miR-138, hsa-miR-149, hsa-miR-150, hsa-miR-155, hsa-miR-203, hsa-miR-204, hsa-miR-206, hsa-miR-211, hsa-miR-216a,
hsa-miR-218, hsa-miR-22, hsa-miR-223, hsa-miR-24, hsa-miR-27a,
hsa-miR-27b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-300, hsa-miR-32, hsa-miR-320,
hsa-miR-324-5p, hsa-miR-335,
hsa-miR-361-5p, hsa-miR-362-3p,
hsa-miR-374b, hsa-miR-375, hsa-miR-377, hsa-miR-381, hsa-miR-384, hsa-miR-410, hsa-miR-429
hsa-miR-487a, hsa-miR-488, hsa-miR-495, hsa-miR-506, hsa-miR-539, hsa-miR-548a-5p, hsa-miR-548b-3p, hsa-miR-548b-5p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-570, hsa-miR-590-3p,
hsa-miR-603, hsa-miR-607, hsa-miR-613, hsa-miR-625 and hsa-miR-7
AATF, AHR, AR, ARNT, ATF7IP
BCL6, BCOR, BRCA1, CEBPA, CEBPB, E2F1, E2F2, E2F3, E2F4, EGR1, EGR1, EGR3, ELF1, EP300, ESR1, ESR2, ETS1, GABPA, GATA1, HCFC1, HDAC1, HDAC2, HIF1A, HMGA1, HNF4A, HTT, JUN, KLF10, KLF4, KLF6, MEF2A, MEF2C, MEF2D, MIS18BP1, MSX1, MYB, MYC, MYOD1, MYOG, NCOR1, NCOR2,
NFYA, NFYB, NR2F1, NR5A1,
PAX6, PER3, PML, POU2F1, POU2F1, PURA, RARA, RB1, RBBP4, RBL1, REL, RELA,
RREB1, RXRA, SMAD2, SMAD3
SMAD4, SOX10 and SOX8
SP3 hsa-miR-361-5p, hsa-miR-105, hsa-miR-124,hsa-miR-133a, hsa-miR-133b, hsa-miR-135a, hsa-miR-135b
hsa-miR-145, hsa-miR-153, hsa-miR-155, hsa-miR-182, hsa-miR-223, hsa-miR-27a, hsa-miR-338-5p
hsa-miR-369-3p, hsa-miR-374a
hsa-miR-374b, hsa-miR-410, hsa-miR-421, hsa-miR-448, hsa-miR-487a, hsa-miR-487b, hsa-miR-506
hsa-miR-507, hsa-miR-520d-5p,
hsa-miR-522, hsa-miR-524-5p,
hsa-miR-548a-5p, hsa-miR-548b-5p
hsa-miR-548c-5p, hsa-miR-548d-5p
hsa-miR-568, hsa-miR-580, hsa-miR-590-3p, hsa-miR-634, hsa-miR-655, hsa-miR-889 and hsa-miR-96
E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, EGR1, EP300, ESR1
GABPA, HDAC1, HDAC2, MEF2A
NFYA, PAX6, PBX1, PIAS1, RB1,
RBBP4 and SP1
MAPK3 hsa-miR-429, hsa-miR-132, hsa-miR-212, hsa-miR-497 and hsa-miR-613 AR, BCL3, CEBPB, ELK1, ELK4, ESR1,ETS1,ETS2,ETV6, ETV7, FOS, GATA1, GATA4, GTF2I, HDAC4, HIF1A, HSF1, HSF4, JUN, JUND, MAX, MITF, MYC, NR3C1, PPARA, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD9, SNAI2, SP1, SPIB, SREBF1, SREBF2, STAT3, STAT5A, TAL1, TAL2, TCF3, TGIF1, TOP2B, TP53, UBTF, USF1, YY1 and ZNF7
PRKCA hsa-miR-200b, hsa-miR-147, hsa-miR-183, hsa-miR-186, hsa-miR-200c, hsa-miR-203, hsa-miR-205, hsa-miR-25, hsa-miR-340, hsa-miR-362-5p, hsa-miR-495, hsa-miR-522
hsa-miR-545, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-5p
hsa-miR-548d-5p, hsa-miR-590-3p
hsa-miR-603, hsa-miR-9 and hsa-miR-15a
AR, BTG2, CREM, DDX5, DLX3, EDF1, EWSR1, HABP4, HAND1
HAND2, HES1, HMGN1, HMGN2
MAX, MXI1::CLEC5A, MYOD1
NFATC1, NFKB1, PA2G4, PPARA
RARA, RARA, SP1, TFAP2A
TP53, TRIM29 and USF1
FOS hsa-miR-340, hsa-miR-345-3p, hsa-miR-4771, hsa-miR-4765, hsa-miR-4749-5p, hsa-miR-4749-3p, hsa-miR-4742-5p, hsa-miR-4742-3p, hsa-miR-4732-5p, hsa-miR-4732-3p
hsa-miR-4692, hsa-miR-4659b-5p
hsa-miR-4659b-3p, hsa-miR-4657
hsa-miR-4645-5p, hsa-miR-4645-3p, hsa-miR-4534, hsa-miR-4533, hsa-miR-4522, hsa-miR-4521, hsa-miR-451a, hsa-miR-4519, hsa-miR-4518, hsa-miR-449c-5p, hsa-miR-449c-3p, hsa-miR-449b-5p, hsa-miR-449b-3p
hsa-miR-449a, hsa-miR-4484, hsa-miR-4479, hsa-miR-4457, hsa-miR-4425, hsa-miR-4419a, hsa-miR-4317, hsa-miR-4310, hsa-miR-4292
hsa-miR-4288, hsa-miR-4282, hsa-miR-4274, hsa-miR-4258, hsa-miR-4256, hsa-miR-383, hsa-miR-3690,
hsa-miR-3676-5p, hsa-miR-3676-3p, hsa-miR-3670, hsa-miR-3616-5p, hsa-miR-3616-3p, hsa-miR-3179, hsa-miR-3117-5p, hsa-miR-3117-3p, hsa-miR-30a-5p, hsa-miR-30a-3p, hsa-miR-301b, hsa-miR-29b-3p, hsa-miR-22-5p, hsa-miR-22-3p, hsa-miR-212-5p, hsa-miR-212-3p, hsa-miR-2116-5p, hsa-miR-2116-3p, hsa-miR-1827, hsa-miR-1470, hsa-miR-144-5p, hsa-miR-144-3p, hsa-miR-139-5p, hsa-miR-139-3p, hsa-miR-132-5p, hsa-miR-132-3p, hsa-miR-130b-5p, hsa-miR-130b-3p, hsa-miR-130a-5p, hsa-miR-130a-3p, hsa-miR-1302, hsa-miR-1283, hsa-miR-1269a, hsa-miR-125b-5p, hsa-miR-1255b-5p
hsa-miR-1252, hsa-miR-1249
hsa-miR-1227 and hsa-let-7a-5p
ATF1, ATF2, ATF7, BACH2, BATF, BCL3, CEBPB, CEBPG, COBRA1, CREB1, DDIT3, EGR1
EGR2, ELK1, ELK3, ELK4, ESR1
ESR2, ETS1, ETS2, ETV4 and FLI1
JUN hsa-miR-324-3p, hsa-miR-139-5p, hsa-miR-141, hsa-miR-15a, hsa-miR-16, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, hsa-miR-216b,
hsa-miR-297, hsa-miR-30a, hsa-miR-340, hsa-miR-429, hsa-miR-495, hsa-miR-496, hsa-miR-517c, hsa-miR-520d-5p, hsa-miR-522, hsa-miR-524-5p, hsa-miR-612, hsa-miR-642, hsa-miR-758, hsa-miR-890, hsa-miR-889, hsa-miR-802, hsa-miR-766-5p, hsa-miR-766-3p, hsa-miR-661, hsa-miR-645, hsa-miR-614, hsa-miR-5706, hsa-miR-5684, hsa-miR-5587-5p, hsa-miR-5587-3p, hsa-miR-5586-5p, hsa-miR-5586-3p, hsa-miR-553, hsa-miR-548z, hsa-miR-548ao-3p, hsa-miR-548aj-3p, hsa-miR-544a, hsa-miR-539-3p, hsa-miR-520b, hsa-miR-519a-3p, hsa-miR-518e-5p, hsa-miR-518e-3p, hsa-miR-518a-5p,
hsa-miR-518a-3p, hsa-miR-516a-5p,
hsa-miR-516a-3p, hsa-miR-5008-5p,
hsa-miR-5008-3p, hsa-miR-5000-5p, hsa-miR-5000-3p, hsa-miR-487b, hsa-miR-487a, hsa-miR-4792,
hsa-miR-4784, hsa-miR-4771, hsa-miR-4763-5p, hsa-miR-4763-3p,
hsa-miR-4732-5p, hsa-miR-4732-3p
hsa-miR-4716-5p, hsa-miR-4716-3p
hsa-miR-4696, hsa-miR-4692
hsa-miR-4687-5p, hsa-miR-4687-3p
hsa-miR-4683, hsa-miR-4665-5p
hsa-miR-4665-3p, hsa-miR-4659b-5p, hsa-miR-4659b-3p, hsa-miR-4640-5p, hsa-miR-4640-3p, hsa-miR-4534, hsa-miR-4521, hsa-miR-451a, hsa-miR-4519, hsa-miR-449c-5p, hsa-miR-449c-3p, hsa-miR-449b-5p, hsa-miR-449b-3p, hsa-miR-449a, hsa-miR-4457, hsa-miR-4434 and hsa-miR-4425
ABL1, AR, ATF1, ATF2, ATF3, ATF4, BATF, BCL3, BCL6, BRCA1, COBRA1, COPS5, CREB1, CREB5
CREBBP, DDIT3, E2F1, E2F4, EGR1, ELF3, EN1, EP300, ERG, ESR1, ESR2, ETS1, ETS2, FOS
FOSL1, FOSL2, GATA1, GATA2
GATA3, GTF2B, GTF2F2, HCFC1
HDAC3, HHEX, HIF1A, HMGA1
HOXA9, HOXC8, LEF1, MAF
MAFB, MEF2A, MYBBP1A
MYC, MYOD1, NCOA1, NCOA2
NCOA3, NFE2L1, NFE2L2, NFIC
NFYA, NR3C1, NR5A1, NRIP1
PGR, PIAS1, POU1F1, RARA, RARB, RARG, RB1, RBM39
REL, RELA, RUNX1, RUNX2
SKI, SMAD2, SMAD3, SMAD4
SMARCD1, SMARCD3, SNAPC5
SOX10, SOX8, SP1, SPI1, SPIB
SREBF1, SREBF2, STAT1, STAT2
STAT3, STAT4, STAT5A, STAT6
TAF1, TBP, TCF20, TCF4, TCF7
TCF7L1, TCF7L2, TGIF1, TRIP4
TSC22D3, VDR, HSF2 and JDP2
MAPK8 hsa-miR-26a, hsa-miR-103, hsa-miR-107, hsa-miR-196b, hsa-miR-214, hsa-miR-548c-3p and hsa-miR-641 ATF2, COPS2, ELK1, ELK3, FOS HSF1, HSF4, JDP2, JUN, JUNB, JUND, IL8, MECOM, MYC, NFATC2, NFATC4, NR3C1, PAX2
PGR, PPARG, REL, SMAD2, SMAD3, SPIB, STAT3, TP53, TP73
and XRCC6
SRC hsa-miR-1297, hsa-miR-137, hsa-miR-141, hsa-miR-144, hsa-miR-149, hsa-miR-153, hsa-miR-200a, hsa-miR-203, hsa-miR-220c, hsa-miR-31, hsa-miR-34a, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b,
hsa-miR-9, hsa-miR-940, hsa-miR-145 and hsa-miR-143
ABL1,AR, ARHGAP35,CTNNB1, DAB2, ESR1, ESR2, ETS1, ETS2, FOXO1, GTF2I, HCLS1, HNF1A,
HNRNPK, IKBKB, KHDRBS1, MAX, MXI1::CLEC5A, MYC,
NFKBIA, NR1I2, PAX5, PGR,
PPARD, RXRA, SMARCB1, SMARCE1, SP1, SRF, STAT1,
STAT3, STAT5A, STAT5B,
STAT6, TFAP2A, THRA, TRIP6
WBP11 and YTHDC1
GRB2 hsa-miR-26b, hsa-miR-124, hsa-miR-128a, hsa-miR-128b, hsa-miR-141, hsa-miR-153, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-182, hsa-miR-195, hsa-miR-200a
hsa-miR-208b, hsa-miR-220c, hsa-miR-27a, hsa-miR-27b, hsa-miR-320, hsa-miR-329, hsa-miR-376c
hsa-miR-424, hsa-miR-433, hsa-miR-497, hsa-miR-506, hsa-miR-520g, hsa-miR-520h, hsa-miR-532-3p, hsa-miR-941 and hsa-miR-96
ABL1, DAB2, DTX1, EGR1, ELK1,
ESR1, FOXA2, FOXO1, FOXO3, FOXO3B, GABPA, HTT, KHDRBS1, KHDRBS2, MTA1
MTA3, NPM1, PAX5 and TP63
PIK3R1 hsa-miR-376c, hsa-miR-103, hsa-miR-107, hsa-miR-128, hsa-miR-132, hsa-miR-136, hsa-miR-150, hsa-miR-153, hsa-miR-155, hsa-miR-15a, hsa-miR-15b, hsa-miR-16
hsa-miR-186, hsa-miR-195, hsa-miR-21, hsa-miR-212, hsa-miR-218
hsa-miR-221, hsa-miR-222, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-361-5p, hsa-miR-424
hsa-miR-448, hsa-miR-455-3p, hsa-miR-486-5p, hsa-miR-488, hsa-miR-495, hsa-miR-497, hsa-miR-503, hsa-miR-520a-5p, hsa-miR-525-5p, hsa-miR-532-3p, hsa-miR-542-3p, hsa-miR-545, hsa-miR-548a-3p, hsa-miR-548c-3p, hsa-miR-579, hsa-miR-590-5p, hsa-miR-603, hsa-miR-630, hsa-miR-655, hsa-miR-656, hsa-miR-767-5p, hsa-miR-891b
hsa-miR-93 and hsa-miR-96
ABL1, CTCF, CTNNB1, EBF1, EGR1, EGR2, EGR3, ELK1, ESR1, GABPA, GATA3, GTF2H1, HNF1A, HOXA9, IRF1, KHDRBS1
KLF12, MEF2A, MEIS1, NFE2L1
NFIL3, NFKBIA, NFYA, NFYB
NFYC, NR2F2, PBX1, PGR, POU3F1, POU3F2, RB1, SP1, USF1 and WBP11
ABCG2 hsa-miR-496, hsa-miR-192, hsa-mir-328, hsa-miR-328, hsa-miR-519c-3p
hsa-miR-519d, hsa-miR-520a-3p
hsa-miR-520b, hsa-miR-520c-3p
hsa-miR-520d-3p, hsa-miR-520e
hsa-miR-520f, hsa-miR-520g and hsa-miR-520h
FOS, JUN, MAX and USF1
SHC1 hsa-miR-186, hsa-miR-124, hsa-miR-1271, hsa-miR-127-5p, hsa-miR-140-3p, hsa-miR-140-5p, hsa-miR-198, hsa-miR-204, hsa-miR-211, hsa-miR-219, hsa-miR-219-5p
hsa-miR-330-5p, hsa-miR-452, hsa-miR-506, hsa-miR-518e, hsa-miR-568, hsa-miR-572, hsa-miR-650, hsa-miR-9 and hsa-miR-96
ABL1, BCL3, ELK1, EP300, ESR1
ESR1, FOS, GABPA, JUN, NPM1
POU2F1, REL, RELA, SP1, STAT5A, STAT5B, TOPORS
and TP53
SOS1 hsa-miR-495, hsa-miR-124, hsa-miR-132, hsa-miR-148b, hsa-miR-152, hsa-miR-155, hsa-miR-181a, hsa-miR-181b, hsa-miR-181d, hsa-miR-204, hsa-miR-211, hsa-miR-212, hsa-miR-217, hsa-miR-302c, hsa-miR-30a, hsa-miR-30b, hsa-miR-30d, hsa-miR-30e, hsa-miR-506, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-520e, hsa-miR-520f, hsa-miR-9
and hsa-miR-96
AR, BIN1, CTCF, EGR1, ESR1, NFIC, RARA, SP1, STAT3, TFAP2A, USF1, NFIC, RARA, SPRY1, SPRY2, CCND1, SPRY4
SPRY3, BCL2L1, CCND2, CCND3
MYC, SPRED1 and SPRED2
CREB1 hsa-miR-653, hsa-miR-103, hsa-miR-124, hsa-miR-128a, hsa-miR-128b, hsa-miR-141, hsa-miR-181a
hsa-miR-181b, hsa-miR-181c
hsa-miR-181d, hsa-miR-182, hsa-miR-200a, hsa-miR-223, hsa-miR-25, hsa-miR-27a, hsa-miR-27b, hsa-miR-32, hsa-miR-34b*, hsa-miR-363, hsa-miR-367, hsa-miR-433, hsa-miR-519b-3p, hsa-miR-526b
hsa-miR-543, hsa-miR-552, hsa-miR-576-5p, hsa-miR-92a, hsa-miR-92b, hsa-miR-944 and hsa-miR-96
ABL1, AHR, ARNT, ATF1, ATM, CEBPA, CEBPB, CIITA, CREBBP, CREM, EDF1, EGR1, EP300, FHL5, GLI2, GTF2F2, KAT5, KCNIP3, MYC, NFKB1, NFKB2,
NR3C1, PDX1, REL, RELA, RELB,
SMARCA4, SMARCA5, SOX9,
SRF, STAT3, THRA and TLX2
PLCG1 hsa-miR-543, hsa-miR-101, hsa-miR-129, hsa-miR-129-5p, hsa-miR-149, hsa-miR-182, hsa-miR-200b, hsa-miR-218, hsa-miR-221, hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d
hsa-miR-30e, hsa-miR-34a, hsa-miR-429, hsa-miR-455-5p, hsa-miR-874 and hsa-miR-96
ABL1, ATF2, CREB1, CTCF, E2F4
EEF1A1, EGR1, ESR1, GTF2H1
KHDRBS1, NFYA, SREBF1, SREBF2, TOPORS, USF1 and YY1
CD247 hsa-miR-410, hsa-miR-214 and hsa-miR-346 EP300, FOS, JUN, SLA2, STAT5A
STAT5B and YY1
ZAP70 hsa-miR-297, hsa-miR-331-3p, hsa-miR-34a, hsa-miR-34b, hsa-miR-34c-5p, hsa-miR-484, hsa-miR-629
hsa-miR-885-3p and hsa-miR-939
ABL1, ATF6, CTCF, HNF4A, NFYA, NR2F1, NR2F2, SLA2, USF1 and XBP1
CSNK2A1 hsa-miR-520h, hsa-miR-125b
hsa-miR-141, hsa-miR-186, hsa-miR-200a, hsa-miR-216b and hsa-miR-221
AIP, APEX1, ARNT, ATF1, ATF2,
BDP1, BRCA1, BRF1, CREBBP,
CREM, CTDP1, CTNNB1, CUX2,
DDIT3, EGR1, ETS1, FOS, GTF2A1, GTF2A1L, HCLS1, HDAC1, HDAC2, HDAC3, HES6,
HIF1A, HMGA1, HMGA2, HOXB7
HSF1, IFI16, IRF2, JUN, KLF1, MAX, MAZ, MEF2C, MYB, MYC,
MYCN, MYF5, NAP1L4, NFIC,
NFKB1, NFKBIA, NKX2-5, PGR,
PML, RELA, SHOX, SP1, SPIB,
SRF, SSRP1, SUB1, TCF7L2, TOPORS, TP53, UBTF, VDR, YY1 and ZHX1
PTK2B hsa-miR-519c-3p, hsa-miR-19a, hsa-miR-205, hsa-miR-23a, hsa-miR-23b, hsa-miR-345, hsa-miR-515-5p
hsa-miR-647, hsa-miR-892b and hsa-miR-940
CTCF, EGR1, EWSR1, GABPA
HNF4A, MYC, NFKB1, REST
SP1, SPI1, SRF, STAT3, TGFB1I1 and TP53
CAMK2B hsa-miR-544 AHR, ARNT, ATF4, CTCF, E2F1
E2F2, E2F3, E2F4, E2F5, E2F6
E2F7, EGR1, EGR2, EGR3, ETS1
MEF2A, NFE2L1, PAX5, RORA
RREB1, RXRG, SP1, THRB, USF1 and XBP1
HBXIP hsa-miR-192, hsa-miR-106a, hsa-miR-106b, hsa-miR-140-5p, hsa-miR-145, hsa-miR-16, hsa-miR-17,
hsa-miR-18a, hsa-miR-18b, hsa-miR-20a, hsa-miR-20b, hsa-miR-370, hsa-miR-378, hsa-miR-492, hsa-miR-496, hsa-miR-515-3p, hsa-miR-519d, hsa-miR-519e, hsa-miR-520d-5p, hsa-miR-520g, hsa-miR-520h, hsa-miR-524-5p, hsa-miR-545, hsa-miR-590-3p, hsa-miR-606, hsa-miR-619, hsa-miR-631, hsa-miR-876-3p and hsa-miR-93
EEF1A1, GABPA, HNF1A, HNF4A MAF1, MAX, POU2F1, USF1 and ZBTB16
PPP3CA hsa-miR-328, hsa-let-7a, hsa-let-7b
hsa-let-7c, hsa-let-7e, hsa-let-7f,
hsa-let-7g, hsa-let-7i, hsa-miR-100, hsa-miR-106a, hsa-miR-106b, hsa-miR-142-3p, hsa-miR-145, hsa-miR-153, hsa-miR-17, hsa-miR-182, hsa-miR-20b, hsa-miR-21, hsa-miR-300
hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-31, hsa-miR-340, hsa-miR-34b, hsa-miR-372, hsa-miR-381, hsa-miR-410, hsa-miR-495, hsa-miR-499-5p, hsa-miR-501-3p,hsa-miR-502-3p, hsa-miR-519a, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-520d-3p, hsa-miR-520d-5p, hsa-miR-520e, hsa-miR-520g, hsa-miR-520h, hsa-miR-524-5p, hsa-miR-590-5p, hsa-miR-635, hsa-miR-93, hsa-miR-96
hsa-miR-98 and hsa-miR-99a
AHR, ARNT, CEBPB, CUX1, E2F1
E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, EGR1, FOXC1, FOXJ2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFYA, PPARG and ZBTB6
NFATC1 hsa-miR-519c, hsa-miR-122, hsa-miR-124, hsa-miR-137, hsa-miR-143, hsa-miR-155, hsa-miR-506 and hsa-miR-611 AHR, ARNT, ATF2, CDC5L, EP300, FOXC1, FOXF2, FOXI1, FOXO1, FOXO3, FOXO3B, FOXO4, NFKB1, PAX5, REL, RELA, SPI1, SRF and USF1
PPP3CB hsa-miR-371-5p, hsa-miR-101, hsa-miR-103, hsa-miR-107, hsa-miR-1297, hsa-miR-137, hsa-miR-140-3p
hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-192, hsa-miR-195
hsa-miR-196b, hsa-miR-19b, hsa-miR-215, hsa-miR-222, hsa-miR-26a, hsa-miR-26b, hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b, hsa-miR-30e, hsa-miR-326, hsa-miR-424, hsa-miR-506, hsa-miR-559, hsa-miR-613, hsa-miR-645, hsa-miR-646, hsa-miR-660, hsa-miR-768-3p and hsa-miR-802
CEBPA, CEBPB, DDIT3, EGR1,
EP300, NFAT5, NFATC1, NFATC2
NFATC3, NFATC4, NR3C1 and PAX2
RCAN1 hsa-miR-148a, hsa-let-7b, hsa-miR -103, hsa-miR-107, hsa-miR-124, hsa-miR-323-3p, hsa-miR-34a, hsa-miR-34c-5p and hsa-miR-506 ALX1, CREB1, EBF1, EGR1, IRF1
JUN, MAX, POU3F1, SP1, SPI1
STAT5A, TGIF1, USF1 and VSX2
PPARG hsa-miR-196a, hsa-miR-128a, hsa-miR-130a, hsa-miR-130b, hsa-miR-138, hsa-miR-144, hsa-miR-20b, hsa-miR-27a, hsa-miR-27b, hsa-miR-301, hsa-miR-338-5p, hsa-miR-34a, hsa-miR-409-3p, hsa-miR-449a, hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520d-3p, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-5p, hsa-miR-548d-5p and hsa-miR-559 AR, BRD8, CEBPA, CEBPB, COPS5, CREB1, EDF1, EGR1, ESR1, ESR2, FOXO1, GATA1, HDAC3, HMGA1, MED1, NCOA1
NCOA2, NCOA3, NCOA4, NCOA6
NCOR1, NCOR2, NFE2L1, NFE2L2, NR0B1 and NR0B2
NOS3 hsa-miR-10b BACH1, CTCF, EPAS1, ERG, ESR1, ESR2, ETS1, ETV4, GABPA
GATA1, GATA2, GATA3, JUN, NR2F2, RORA, SP1, SP1, SP3, SPI1, TAL1::GATA1, TFAP2A and TP53
ADRB2 hsa-miR-142-3p, hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e
hsa-let-7f, hsa-let-7g, hsa-let-7i, hsa-miR-155, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-195, hsa-miR-216b, hsa-miR-27a, hsa-miR-30a, hsa-miR-30a-5p, hsa-miR-30b
hsa-miR-30d, hsa-miR-30e, hsa-miR-424, hsa-miR-497, hsa-miR-556-3p, hsa-miR-605, hsa-miR-607
hsa-miR-625, hsa-miR-634, hsa-miR-7, hsa-miR-888 and hsa-miR-98
CEBPA, CEBPB, CREB1, CUX1
ELK1, GATA1, HLF, NFIC, NFIL3
PBX1, RORA, STAT5A and TBP
CORIN hsa-miR-873, hsa-miR-106a, hsa-miR-106b, hsa-miR-138, hsa-miR-148a, hsa-miR-152, hsa-miR-17, hsa-miR-20a, hsa-miR-20b, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-373, hsa-miR-495, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-520c-3p
hsa-miR-520d-3p, hsa-miR-520e
hsa-miR-520f, hsa-miR-548a-3p, hsa-miR-561, hsa-miR-582-3p and hsa-miR-93
CTCF
GNAS hsa-miR-139-5p, hsa-let-7i, hsa-miR-105, hsa-miR-136, hsa-miR-138, hsa-miR-143, hsa-miR-155, hsa-miR-15b, hsa-miR-18a, hsa-miR-205, hsa-miR-218, hsa-miR-219-2-3p, hsa-miR-219-5p, hsa-miR-221, hsa-miR-223, hsa-miR-338-3p, hsa-miR-34b, hsa-miR-361-3p, hsa-miR-361-5p, hsa-miR-362-5p, hsa-miR-452, hsa-miR-453, hsa-miR-489, hsa-miR-494, hsa-miR-502-5p, hsa-miR-512-3p, hsa-miR-532-5p, hsa-miR-582-3p, hsa-miR-588, hsa-miR-596, hsa-miR-624, hsa-miR-625, hsa-miR-629, hsa-miR-630, hsa-miR-660, hsa-miR-876-3p and hsa-miR-943 CEBPA, CTCF, CUX1, E2F2, E2F4
HSF1, NFIL3, REST, TFAP2A, TFAP2C, USF1, VSX2 and YY1
HSP90AA1 hsa-miR-133b AHR, AIP, AR, ARNT, ARNTL, CREB1, CTCF, EGR1, EIF2AK2, ESR1, HIF1A, HSF1, HSF2, IKBKB, IKBKG, MAX, MXI1::CLEC5A, MYC, MYOD1, NPAS2, NR2C2, NR3C1, NR3C2, PPARA, REST, RUNX1T1, SRF, STAT1, STAT3, TFAP2A, TFAP2C, TP53, USF1 and YY1
GTF2A1 hsa-miR-9, hsa-miR-142-3p, hsa-miR-196a, hsa-miR-196b, hsa-miR-25, hsa-miR-32, hsa-miR-493 and hsa-miR-92a ARNT, BACH2, BCL3, ELK1, EP300, ESR1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, MAX, MXI1::CLEC5A, MYC, TAF1, TAF4, TBP, TBPL1, TRIP4 and USF1
GTF2E1 hsa-miR-145, hsa-miR-124, hsa-miR-155, hsa-miR-200b, hsa-miR-200c, hsa-miR-221, hsa-miR-222, hsa-miR-300, hsa-miR-361-5p, hsa-miR-381, hsa-miR-429, hsa-miR-494, hsa-miR-506, hsa-miR-654-5p
and hsa-miR-944
AES, E2F2, ERCC3, GTF2A1, GTF2A2, GTF2B, GTF2E2, GTF2F2, GTF2H1, GTF2H4, NFYA
SND1, SP1, TAF6, TBP, TCEA1, TRIM24, YY1 and ZEB1
NR3C1 hsa-miR-384, hsa-miR-1, hsa-miR-124, hsa-miR-137, hsa-miR-141, hsa-miR-142-3p, hsa-miR-144, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-181d, hsa-miR-182, hsa-miR-183, hsa-miR-18a, hsa-miR-18b, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, hsa-miR-204
hsa-miR-206, hsa-miR-211, hsa-miR-22, hsa-miR-29a, hsa-miR-29b
hsa-miR-29c, hsa-miR-300, hsa-miR-30a, hsa-miR-30b, hsa-miR-320, hsa-miR-328, hsa-miR-340, hsa-miR-377, hsa-miR-381, hsa-miR-410, hsa-miR-429, hsa-miR-506, hsa-miR-515-5p, hsa-miR-518d-5p, hsa-miR-543, hsa-miR-548c-3p, hsa-miR-582-5p, hsa-miR-603 and hsa-miR-889
AHR, AR, ARNT, ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ATF7,
CEBPA, CEBPB, CREB1, CREBBP, CTCF, DDX54, E2F1, ECD, EGR1, EGR2, EGR3, ETS1, ETS2, HIF1A, JUN, KDM5A, MED14, NCOA1, NCOA2, NCOA6
NCOR1, NCOR2, NFIA, NFIC, NFKB1, NFKB2,NR2F2 and NR2F6
POLR2A hsa-miR-28-5p , hsa-miR-214, hsa-miR-542-5p and hsa-miR-873 ABL1, ALX1, ATF2, BARD1, BRCA1, CREB1, CREBBP, CTCF, CTDP1, ELL, ERCC6, FUS, GTF2B, HTATSF1, KLF12, MCM3
MED21, NFIL3, NONO, NR3C1, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2L, POU2F1, PQBP1, SAFB, SND1, SP1, STAT1, STAT3, SUPT5H, TAF10, TBP, TCEA1, TCERG1, TFAP2A, UPF1, USF1
XAB2, XRCC5, YY1 and ZNF74
GNB1 hsa-let-7g, hsa-miR-101, hsa-miR-139-5p, hsa-miR-218, hsa-miR-570 and hsa-miR-598 CREB1, EGR1, EGR2, EP300, HDAC5, MZF1, NFKB1, PATZ1
RELA, SP1 and VSX2
RXRA hsa-miR-98, hsa-miR-124, hsa-miR-219-5p, hsa-miR-27a, hsa-miR-27b, hsa-miR-506, hsa-miR-626, hsa-miR-876-5p and hsa-miR-9 BCL3, BRD8, COPS2, CTNNB1, EDF1, EGR1, ESR1, FOXO1, FUS, GATA2, HMGA1, JMJD1C, MED1, MYC, MYOD1, NCOA1, NCOA2, NCOA3, NCOA4, NCOA6, NCOR2, NFKB1, NFKBIB, NPAS2, NR0B2, NR1H2, NR1H3, NR1H4, NR1I2, NR1I3, NR2F1, NR4A2, NRBF2, NRIP1, NSD1, PARP1, PAX8, POU2F1, PPARA, PPARD, PPARG, PPARGC1A, RARA, RARB, RARG and RELA
SMARCD1 hsa-let-7c, hsa-miR-101, hsa-miR-127-5p, hsa-miR-133a, hsa-miR-133b, hsa-miR-141, hsa-miR-148a,
hsa-miR-148b, hsa-miR-150, hsa-miR-152, hsa-miR-191, hsa-miR-200a, hsa-miR-21, hsa-miR-223, hsa-miR-324-5p, hsa-miR-325, hsa-miR-369-5p, hsa-miR-370, hsa-miR-421, hsa-miR-490-3p, hsa-miR-515-5p, hsa-miR-552, hsa-miR-556-3p, hsa-miR-590-5p, hsa-miR-624, hsa-miR-7 and hsa-miR-940
ATF1, ATF2, ATF3, ATF4, ATF5
ATF6, ATF7, CREB1, FOS, GATA1, JUN, MAX, MEIS1, MXI1::CLEC5A, MYC, NR3C1and REL
SMARCE1 hsa-let-7a, hsa-miR-103, hsa-miR-107, hsa-miR-134, hsa-miR-135a, hsa-miR-135b, hsa-miR-22, hsa-miR-485-3p, hsa-miR-494, hsa-miR-512-5p, hsa-miR-520a-5p, hsa-miR-548a-5p, hsa-miR-548b-5p, hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548d-5p, hsa-miR-555, hsa-miR-603, hsa-miR-609, hsa-miR-760 and hsa-miR-9 BAZ1B, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, ESR1, ESR2, IRF7, NCOA1, NCOA2, NCOA3, NR3C1, PAX5, RELB and SMAD1
ANXA1 hsa-let-7i , hsa-miR-196a, hsa-miR-221, hsa-miR-222, hsa-miR-376c, hsa-miR-598 and hsa-miR-758 FOS, FOXL1, POU3F1 and TBP
CAV1 hsa-let-7b, hsa-miR-106b, hsa-miR-124, hsa-miR-125a-3p, hsa-miR-203
hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-377, hsa-miR-409-3p, hsa-miR-494, hsa-miR-506, hsa-miR-548c-3p, hsa-miR-628-5p, hsa-miR-768-3p and hsa-miR-96
ABL1, AR, ATF6, E2F1, E2F4, EGR1, ESR1, NFIC, PAX2, RFX1
SP1, TFDP1, TP53 and XBP1
LPL hsa-let-7e, hsa-miR-138, hsa-miR-155, hsa-miR-27a, hsa-miR-27b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-452, hsa-miR-588, hsa-miR-590-3p and hsa-miR-768-5p AR, ARNT, ASCC2, E2F1, E2F2,
E2F3, E2F4, E2F5, E2F6, E2F7, ESR1, POU2F1, POU2F2, POU3F1,
POU3F2, POU3F3, POU5F1, PPARA, PPARD, PPARG, RXRA,
RXRB and RXRG
ACTB hsa-let-7d, hsa-miR-145, hsa-miR-216a, hsa-miR-221, hsa-miR-412, hsa-miR-582-3p, hsa-miR-647 and hsa-miR-648 ATF7IP, EEF1A1, EGR1, EGR3, ELK1, EP300, GABPA, HNF4A, HNRNPAB, NFKB1, NFKB2, NFYA, NFYB, NFYC, POLR2A, POU3F2, PPARG, REL, RELA, SMAD3, SMAD9, SMARCA4, SP1, SRF, STAT1, STAT3, TBP, TFAP2A and USF1
ARID1A hsa-let-7f, hsa-miR-1, hsa-miR-101, hsa-miR-132, hsa-miR-144, hsa-miR-153, hsa-miR-185, hsa-miR-19a, hsa-miR-19b, hsa-miR-203, hsa-miR-212, hsa-miR-216, hsa-miR-216a, hsa-miR-221, hsa-miR-222, hsa-miR-223, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-31
hsa-miR-324-5p, hsa-miR-340, hsa-miR-377, hsa-miR-485-3p, hsa-miR-486-5p, hsa-miR-548c-3p, hsa-miR-555, hsa-miR-568, hsa-miR-576-5p, hsa-miR-583, hsa-miR-625, hsa-miR-765, hsa-miR-876-3p, hsa-miR-885-3p and hsa-miR-9
ARNT, CREB1, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, FOXD3, FOXI1, GATA2, HNF4A, MAX, MLLT1, MXI1::CLEC5A, MYC, MZF1, PAX5, POU2F1, POU3F1, PPARG, SMARCA4, SOX9, SP1, SRF, TFAP2A, TFAP2C, TP53, USF1 and YY1
GTF2B hsa-miR-202, hsa-miR-1, hsa-miR-103, hsa-miR-107, hsa-miR-122, hsa-miR-187, hsa-miR-190, hsa-miR-190b, hsa-miR-199a-3p, hsa-miR-206, hsa-miR-214, hsa-miR-22
hsa-miR-24, hsa-miR-26a, hsa-miR-26b, hsa-miR-338-3p, hsa-miR-384
hsa-miR-488, hsa-miR-511, hsa-miR-520d-5p, hsa-miR-524-5p, hsa-miR-561, hsa-miR-582-5p, hsa-miR-607 and hsa-miR-633
BCL3, CREBBP, EGR1, EP300, ESR1, ESRRA, FOXF2, GTF2E1, GTF2E2, GTF2F1, GTF2F2, HSF1, IKZF1, JUN, MAX, MCM2, MXI1::CLEC5A, MYC, NCOA1, NCOA3, NCOA4, NR2F1, NR5A1, POLR2A, POU2F1, POU2F2, POU3F2, REL, RELA, TAF9, TBP, TBPL1, TCEA2, THRA, USF1 and VDR
NF1 hsa-miR-30e , hsa-miR-103, has-miR-107, hsa-miR-10b, hsa-miR-125a-3p, hsa-miR-128, hsa-miR-135a, hsa-miR-135b, hsa-miR-137
hsa-miR-144, hsa-miR-153, hsa-miR-15a, hsa-miR-15b, hsa-miR-16
hsa-miR-182, hsa-miR-195, hsa-miR-19a, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-217
hsa-miR-219-1-3p, hsa-miR-25, hsa-miR-27a, hsa-miR-27b, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-338-5p, hsa-miR-340, hsa-miR-363, hsa-miR-369-3p, hsa-miR-370
hsa-miR-374a, hsa-miR-374b, hsa-miR-424, hsa-miR-448, hsa-miR-497, hsa-miR-519b-3p, hsa-miR-519c-3p, hsa-miR-543, hsa-miR-548d-3p, hsa-miR-552, hsa-miR-561
hsa-miR-571, hsa-miR-582-5p, hsa-miR-590-3p, hsa-miR-617, hsa-miR-625, hsa-miR-655, hsa-miR-876-5p, hsa-miR-944 and hsa-miR-96
ATF2, CREB1, CTCF, JUN, PATZ1
PAX5, SP1, TBPL1 and TFAP2A
SMARCA4 hsa-miR-30c, hsa-miR-1, hsa-miR-101, hsa-miR-132, hsa-miR-139-5p,
hsa-miR-144, hsa-miR-155, hsa-miR-191, hsa-miR-206, hsa-miR-212, hsa-miR-221, hsa-miR-222, hsa-miR-296-5p, hsa-miR-301a, hsa-miR-30c, hsa-miR-452, hsa-miR-489, hsa-miR-495, hsa-miR-503, hsa-miR-508-5p, hsa-miR-512-3p, hsa-miR-517b, hsa-miR-568, hsa-miR-569, hsa-miR-574-3p, hsa-miR-582-5p, hsa-miR-613, hsa-miR-765 and hsa-miR-942
AHR, ARID1A, ARID1B, BRCA1, BRWD1, CEBPB, CHD4, CREB1, CTNNB1, E2F1, E2F4, EGR1, ESR1, ETS2, GABPA, HSF1, IKZF1, MYC, MZF1, NR3C1, PAX6, PBRM1, RB1, RELB, RFXAP, SMARCB1, SMARCC1, SMARCE1, STAT2, TMF1, TP53, YY1 and ZMYND11
SMARCB1 hsa-miR-30d, hsa-miR-1, hsa-miR-192, hsa-miR-206 and hsa-miR-300 CEBPB, E2F4, FOS, FOSB, FOSL1
HNF4A, JUN, JUNB, JUND, KLF1
MECP2, MYC, NR3C1, RB1, RELB
SMARCA4, TCF3, TFAP2A, TP53
and YEATS4
SMARCC1 hsa-miR-30a, hsa-let-7a, hsa-let-7b,
hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7g, hsa-let-7i, hsa-miR-1, hsa-miR-124, hsa-miR-129-5p, hsa-miR-144, hsa-miR-153, hsa-miR-196a, hsa-miR-196b, hsa-miR-202, hsa-miR-206, hsa-miR-208b, hsa-miR-214, hsa-miR-23a, hsa-miR-23b, hsa-miR-29b, hsa-miR-29c, hsa-miR-330-3p, hsa-miR-339-3p, hsa-miR-488, hsa-miR-506, hsa-miR-548d-3p, hsa-miR-567, hsa-miR-610, hsa-miR-641 and hsa-miR-98
CEBPB, FOXC1, GABPA, HOXA9
KLF1, MEIS1, NR3C1, RELB, SIN3A and SMARCA4
SMARCC2 hsa-miR-30b, hsa-miR-28-5p, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-30e, hsa-miR-519a,
hsa-miR-519b-3p, hsa-miR-519c-3p,
hsa-miR-519d, hsa-miR-568, hsa-miR-608, hsa-miR-708 and hsa-miR-938
BAZ1B, CTCF, ESR1, GABPA
POLR2C and RELB
HRH1 hsa-miR-196b, hsa-miR-192, hsa-miR-324-5p, hsa-miR-518a-5p, hsa-miR-527, hsa-miR-583 FOS, HNF4A, JUN, MAX, NR2F1,
NR3C1, POU2F1, POU2F2, POU3F1,
POU3F2, POU3F3, POU5F1 and TFAP2A

Table 1: Pharmacoreg of psoriasis.

Discussion

Based on Clustering Analysis of Taget (Gene) and interactors (miRNA and Transcription factors), it is clear that hsa-miR-362-3p, SOX 10, SOX8, AATF and GTF2A2 regulates most of the vital process in disease pathology and this result will have a vital impact in the research areas of Biomarker and Personalised medicine for disorders in auto immunity.

Conclusion

The approach in this manuscript is to have a different view point to approach the disease pathology of Psoriasis and hence an ensemble of associated gene. miRNAs and transcription factors from available sources were retrieved and analyzed on the basis of Network Biology (An emerging field with prominent significance). In this manuscript PharmacoReg is implemented for Psoriasis but in future it will be implemented to understand the pathology of other diseases.

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