alexa A Concise Review on Biological Activity of Tridax procumbens Linn | OMICS International
ISSN: 2161-0401
Organic Chemistry: Current Research

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

A Concise Review on Biological Activity of Tridax procumbens Linn

Shahnawaz Ahmad Mir1,2*, Zubair Jan3, Shafia Mir1, Ayaz Mahmood Dar1 and Gouri Chitale2

1Department of Chemistry, Government Degree College Kulgam, University of Kashmir, Jammu and Kashmir, India

2Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

3Islamic University of Science and Technology, Awantipora, Jammu and Kashmir, India

*Corresponding Author:
Shahnawaz Ahmad Mir
Department of Chemistry, Government
Degree College Kulgam, University of Kashmir
Jammu and Kashmir, India
Tel: +919906785942
E-mail: [email protected]

Received date: December 28, 2016; Accepted date: January 11, 2017; Published date: January 28, 2017

Citation: Mir SA, Jan Z, Mir S, Dar AM, Chitale G (2017) A Concise Review on Biological Activity of Tridax procumbens Linn. Organic Chem Curr Res 6:177. doi:10.4172/2161-0401.1000177

Copyright: © 2017 Mir SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Organic Chemistry: Current Research


Tridax procumbens Linn belongs to the family asteraceae. The extracts of Tridax procumbens have been used as indigenous medicine for a variety of ailments. It has been extensively used in Indian traditional medicine for wound healing, as anticoagulant, antifungal and insect repellent, in diarrhea and dysentery. Leaf extracts are used to treat infectious skin diseases in folk medicines. It is also dispensed as ‘Bhringraj’ which is well known ayurvedic medicine for liver disorders. Antioxidant, antimicrobial, anti-inflammatory and immune modulatory properties have also been demonstrated. Plants have strong ability to synthesize aromatic substances, most of which are phenols or their oxygen substituted derivatives which are mostly secondary metabolites. At least 12,000 have been isolated, a number estimated to be less than 10% of the total. These substances serve as plant defense mechanisms against predation by microbes, insects, herbivores. Some terpenoids are plant pigment, some are plant flavoring agents and some are having medicinal properties.


Tridax procumbens; Biological activity; Plant extract; Medicinal plants


Tridax procumbens is a species of flowering plant belonging to family asteraceae and is the most potent species among 30 species. It is best known as widespread weed and pest plant. It is native to the tropical Americas but it has been introduced to tropical, subtropical and mild temperate regions worldwide. It is listed as a noxious weed in the United States and has a pest status. Some of the medicinally important species of the genus Tridax are: T. angustifolia, T. serboana, T. bicolor, T. accedens, T. dubia, T. erecta and T. rosea.

Scientific classification

Kingdom: Plantae

Division: Angiosperms

Order: Asterales

Family: Asteraceae

Genus: Tridax

Species: Procumbens

Binomial name: Tridax procumbens Linn.

The plant bears white or yellow flowers with three toothed ray florets. The leaves are toothed and generally anchor shaped. Its fruit is hard achene covered with stiff hairs and having a feathery, plume like white pappus at one end. Calyx is represented by scales or reduced to pappus. The plant is invasive in part because it produces so many of these achenes, up to 1500 per plant and each achene can catch the wind in its pappus and be carried to some distance. This weed can be found in fields, meadows, crop lands, disturbed areas, lawns and roadsides in areas with tropical or semitropical climate [1].

A survey of literature revealed isolation of tannins, flavonoids, glycosides, isoflavonoids, steroids, saponins, lipids, phospholipids, resins, sterols, reducing sugars, phenols, anthraquinone and catechol [2].

Tridax procumbens is employed as indigenous medicine for a variety of ailments. It has been extensively used in Indian traditional medicine for wound healing, as anticoagulant, antifungal and insect repellent, in diarrhea and dysentery [3]. Leaf extracts are used to treat infectious skin diseases in folk medicines. It is also dispensed as ‘Bhringraj’ which is well known ayurvedic medicine for liver disorders [4]. Antioxidant properties have been demonstrated [5], also hair growth promoting activity have been analyzed [6].

Biological studies

As Tridax procumbens is employed as indigenous medicine for the variety of ailments, the biological activities surveyed are: During the antiinflammatory activity of Tridax procumbens extracts, the significantly reduced parameters like exudate volume leukocyte migration, edema fluid, grannuloma tissue and γ-glutamyl transpeptidase depicted the good anti-inflammatory action of this plant. Furthermore, the results suggest that Tridax procumbens has negligible ulcerogenic property and causes anti-inflammatory activity through inhibiting SRs and PGs [7].

The hypoglycemic rats in 95% ethanolic extract of Tridax procumbens (TP) were tested. In addition some of TP-1 extract was suspended in water and was then partitioned with ether and n-butanol, respectively. After solvents were evaporated, four fractions of T.P. were obtained, ether (TP-2.1), n-butanol (TP-2.2), emulsion (TP-2.3) and aqueous fraction (TP-2.4). The hypoglycemic properties of the ethanolic extract (TP-1) and its fraction were evaluated. The search was persued in normoglycemic and alloxan-diabetic rats. The blood sugar level of diabetic rats were reduced by 10-17%, however this extract has no effect on fasted blood sugar level of the normal rats. Moreover, oral administration of TP-2-1 could improve both oral and intraperitoneal glucose tolerance of normoglycemic rats. Taken together, these results suggest that Tridax procumbens contains hypoglycemic compound(s) which could be isolated by solvent fractionation [8].

The n-hexane extract of the flowers of Tridax procumbens exhibited activity against Escherichia coli while that of ethyl acetate extract was active against Bacillus cereus and Klebsiella sp. The same extract of the whole aerial parts were active against Mycobecterium smegmatis, Escherichia coli, Salmonella group and Salmonella paratyphi. The aerial part extract also showed activity only against M. smegmatis and S. aurens, while the aqueous extract showed no antimicrobial activity [9].

Study on the cardiovascular effects of aqueous extract from the leaves of Tridax procumbens on anaesthetized Sprague-Dawlay rat showed that the intravenous administration of 3, 6 and 9 mg/kg of the aqueous extract caused significant decrease in the mean arterial blood pressure in a dose related manner that is the extract caused greater decrease in the mean arterial blood pressure at higher dose than at lower dose. Also, higher doses of the extract 6 mg/kg and 9 mg/kg caused significant reductions in the heart rate while lower dose of the extract 3 mg/kg did not cause any significant change in the heart rate. The hypotensive and the bradycardiac effects were immediate. These results therefore seemed to support the claim that the leaves of Tridax procumbens has hypotensive effect and that the mechanism of its action is possibly through activation of mascarinic cholinergic receptors [10].

A study was carried out to assess the effect of chloroform insoluble fraction of ethanolic extract of Tridax procumbens against D-galactosamine/ lippopolysacharide (D-galn/LPS)-induced hepatitis in rats. Induction of rats with D-galn/LPS (300 mg/kg body weight) leads to a marked increase in lipid peroxidation as measured by thiobarbituric acid: a reactive substance in liver. Further there was a decline in the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione s-transferase and the levels of non-enzymatic antioxidants namely reduced glutathione, vitamin C and vitamin E. These biochemical alterations were normalized upon pre-treatment with Tridax procumbens extract. The results suggest that Tridax procumbens is very effective in allievating the D-galn/LPS-induced oxidative stress suggesting its antioxidant property [11].

The immune modulatory properties of ethanolic leaf extract of Tridax procumbens on swiss albino rats orogastrically dosed with Pseudomonas aeruginosa was analysed. The results showed that ethanolic leaf extract of Tridax procumbents has immunomodulatory properties and it is able to inhibit proliferation of Pseudomonas aeruginosa [12]

The essential oils extracted by steam distillation from leaves of Tridax procumbens were found to be promising as repellents against Anopheles stephensi and could be useful in the search for new natural repellent compounds [13].

Dried aqueous, alcoholic and pet-ether extract of leaves of Tridax procumbens were subjected for hypoglycemic activity in wistar rats (150-200 g) and blood sugar level was determined by glucometer. The oral administration of leaf extract at doses of 200 mg/kg body weight. leads to sufficient blood sugar reduction. These results show that Tridax procumbens is anti-diabetic in nature [14].

The haemostatic activity of various extracts of leaves of Tridax procumbens were screened by studying at a time of ten human volunteers employing Lee-White’s method performed in vitro. Out of ethanolic and petroleum ether extract, ethanolic extract showed positive activity. The results suggest that the Tridax procumbens plant possesses haemostatic activity [15].

Aqueous methanolic extracts of Tridax procumbens exhibited inhibitory activity against Staphylococcus aurens strains indicating good antimicrobial activity. The activity was done by agar-disc and well diffusion method [16].

The anti-inflammatory activity of Tridax procumbens was carried out on carrageenin-induced paw edema along with standard drug, Ibuprofen. The ibuprofen significantly reduced paw edema. The oral administration equi-effective dose of Tridax procumbens revealed about 20-35% more activity than the one rendered by Ibuprofen. The effect of Tridax procumbens along with various dose regimen of Ibuprofen showed greater anti-inflammatory activity than the Ibuprofen alone [17,18].

The anti-hyperglycemic potential of Tridax procumbens was also evaluated during which oral administration of acute and sub-chronic doses (250 and 500 mg/kg body weight) of ethanolic extract of Tridax procumbens showed a significant reduction in fasting blood glucose levels in diabetic rats. The results were compared with the standard drug Glibenclamide (10 mg/kg body weight) [19].

The free and bound flavonoids of different parts of Tridax procumbens for their antimicrobial activity using “disc diffusion” assay against two gram negative bacteria (Escherichia coli and Proteus mirabilis), one gram positive bacteria (Staphylococcus aurens) and a fungus (Candida albicans) were studied. This plant exhibited broad spectrum antimicrobial activity and the results indicate that Tridax procumbens can be exploited for future antimicrobial drugs [20].

The anti-bacterial analysis of Tridax procumbens against different bacterial strains was analysed by comparing minimum inhibitory concentration and zone of inhibition with that of standard antibiotic discs of Vancomycin. The results suggest that extract of Tridax procumbens has anti-bacterial properties [20].

The results from the investigation of the effect of Tridax procumbens on the weight, packed cell volume and plasma electrolyte profiles of salt loaded rats. The results suggest that the anti-hypertensive action of Tridax procumbens may be mediated via reduction of weight and alteration of plasma sodium and potassium levels and in addition suggests its use in the management of obesity and diabetes mellitus [21].

The reducing power ability analysed for antioxidant activity using the 1, 1-diphenyl-2-picrylhdrazyl (DPPH) assay and for total phenolics using Follian-ciocalteu method. The ethanolic extract showed that Tridax procumbens has a percentage antioxidant activity of 96.70 which was observed to be higher than that of gallic acid (92.92) and ascorbic acid (94.81) used as standards. The total phenolic determination shows that Tridax procumbens has a phenolic content of 12 mg/g GAE (Gallic acid equivalent). The reductive potential determination shows that Tridax procumbens has very significant reductive potential of 0.89 nm at the same concentration with gallic acid whose reductive potential was 0.99 nm. The results of these analyses revealed the fact that plants are rich source of natural antioxidant [5].

The toxicity of ethanolic extract of Tridax procumbens in rats at a dose level of 300 mg/kg body weight was designed to study. It was observed that daily administration of extract showed significant decrease in level of blood sugar. Simultaneously, percent of haemoglobin was also determined and it was observed that percent of haemoglobin does not show significant changes after daily and single administration of dose [22].

A protocol for the callus induction in Tridax procumbens from various explants like leaf, internodes and shoot apical buds was developed. The sterilized explants were inoculated in MS-media containing various combination of auxins such as 2-4-dichlorophenoxy acetic acid (2, 4-DPA), naphthalene acetic acid (NAA) and cytokinins such as kinetin and 6-benzyl amino purine (BAP). Leaf and apical bud explants showed early and profuse callus induction whereas internodal explants showed comparatively delayed but profuse callus induction. In vitro, generated callus can be used as source for the isolation of secondary metabolites from Tridax procumbens [23].

The antifungal effect of Tridax procumbens against Helminthosporium oryzae, Rhizoctonia solani and Pyricularia oryzae were checked. The radial growth of these fungal pathogens was significantly effected by 0.1% concentration of extract. The leaf extract has shown higher zone of inhibition in H. oryzae in comparision to the zone of inhibition values of R. solani and P. oryzae [24].

It was analysed that the standardized EtOAc, MeOH and 70% EtOH extracts of Tridax procumbens aerial parts showed significant inhibition of rat paw edema at a medium dose of 200 mg/kg and the EtOAc extract was the most active. The extracts were evaluated for COX-1 and COX-2 (cyclooxygenase) inhibitory activity and EtOAc extract exhibited the highest inhibition of COX-1 and COX-2 at 50 μg/ ml. The results showed that the anti-inflammatory activity of Tridax procumbens of aerial parts could be at least in part due to COX-1 and COX-2 enzyme inhibition and free radical scavenging activities may be attributed to the presence of flavonoids and other polyphenols in the extract [25].

The phytoconstituents of Tridax procumbens responsible for effect on cellular and hormonal functions in mice were attempted to explore. The in vitro (phagocytosis) and in vivo (haemagglutination and delayed hypersensitivity) were used to study the effect of extract and fraction on the cellular and hormonal immunity. The results obtained indicate the ability of flavonoidal and saponin fraction of Tridax procumbens to modulate both cell mediated and the hormonal components of the immune system and explored the phytoconstituents responsible for immunomodulatory potential of Tridax procumbens [26].

The anti-microbial effect of aqueous and ethanolic leaf extracts of Tridax procumbens on rot causing fungi isolated from the infected tomato fruit parts viz: Aspergillus nigar, Rhizopus stolonifer, Fusarium oxysporium, Geotrichum candidium revealed all the plant extracts both aqueous and ethanolic showed significant reduction of mycelia growth of isolated pathogens. Higher concentration of both the extracts favoured higher mycelia growth reduction [27].

Phytochemical studies

The compounds isolated from various parts of Tridax procumbens (Figure 1) are listed in Table 1.

Compounds Plant part
Luteolin (I) and Glucoluteolin; β–sitosterol (II) and Tannins (III). Flowers
A flavones glycoside:- 5,7,4-trihydroxy-6,3-dimethoxy flavone 5-O-alpha-L-rhamnopyranoside and 3,6-dimethoxy-5,7,2́́,3́́,4́́-pentahy droxyflavone 7-O- β-glucopyranoside; 3S- 16-17-didehydro falcarinol. Leaves
A flavonoldiglycoside:- quercetagetin-3,6,4́-trimethoxy-7-O-neohe speridoside (3S, 5R, 6S, 7E)-5,6-epoxy-3-hydroxy-7-megastigmene-9-one and Icariside. A polyacetylene:- 1,2-dihydrodendroarboreal B, an enonederivatve:- ( 3S, 5R, 6S, 7E )-3-tetradecanoate-5,6-epoxy- β-ionone along with Sodium, potassium, calcium, quercetin and isoquercetin.   Whole plant
Bis-bithiophene- tribisbiothiophene (IV), taraxasteryl acetate (V), beta-amyrenone (VI), lupeol (VII), oleanolic acid (VIII).
β-Sitosterol-3-O-β –D-xylopyranoside
Methyl 14-oxooctadecanoate, Methyl 14-oxononacosa-noate, 3-methyl nonadecylbenzene, Heptacosanyl cyclohaxane carolylate, 1(2, 2-dimethyl-3-hydroxypropyl)-2-isobutylphthalate, 12-hydroxytetracosan -15-one, 32-methyl-30-oxotetratriacon-31-en-1-ol and 30-methyl-28-oxodotriacont-29-en-1-oic acid (IX).
Water soluble novel polysaccharides; Sterols, Hydrocarbons, Saturated & Unsaturated fatty acids.
Alkoloids, carotenoids, flavonoids, saponins and tannins and lipids.

Table 1: Compounds isolated from Tridax procumbens.


Figure 1: Structure of some compounds isolated from Tridax procumbens.


The use of plants, both the wild and domesticated species has been recorded since ancient times in almost all major civilizations. Ayurveda has been known to be practiced in the Indian subcontinent since long. The specimen under consideration has also come to notice due to its already predominant use as wound healing, anticoagulant, antimicrobial, insect repellent, in diarrhea and dysentery. Leaf extracts are used to treat infectious skin diseases in folk medicines. It is also dispensed as ‘Bhringraj’ which is well known ayurvedic medicine for liver disorders. Antioxidant, antimicrobial, anti-inflammatory and immune modulatory properties have also been demonstrated.


Authors thank Head of Department of Chemistry, Bundelkhand University, Jhansi for providing the necessary research facilities. Author (SAM) specially thank Gauri Chitali for constant support during the completion of the work.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • International Conference on Organic and Inorganic Chemistry
    July 12-13, 2018 Paris, France
  • 5th International Conference on Organic and Inorganic Chemistry
    July 12-13, 2018 Paris, France
  • International Conference on Organic & Inorganic Chemistry
    July 18-19 , 2018 Atlanta, USA
  • International conference on Organic Farming & Biological Treatment
    September 19-20, 2018 Dallas, USA
  • 10th Europian Organic Chemistry Congress
    March 21-22, 2019 Rome, Italy

Article Usage

  • Total views: 4867
  • [From(publication date):
    March-2017 - May 25, 2018]
  • Breakdown by view type
  • HTML page views : 4510
  • PDF downloads : 357

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7