alexa A Study to find out the Prevalence of Hypothyroidism among Pregnant Women Visiting ESI Hospital Sanathnagar Hyderabad | Open Access Journals
ISSN: 2161-0932
Gynecology & Obstetrics
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

A Study to find out the Prevalence of Hypothyroidism among Pregnant Women Visiting ESI Hospital Sanathnagar Hyderabad

Srinivas Rao and Anitha Patibandla*

Department of OBG, ESI Hospital Sanathnagar, Hyderabad, India

*Corresponding Author:
Anitha Patibandla
Department of OBG, ESI Hospital Sanathnagar
Hyderabad, India
Tel: 0091-9490190411
E-mail: [email protected]

Received date: January 05, 2016 Accepted date: March 02, 2016 Published date: March 08, 2016

Citation: Rao S, Patibandla A (2016) A Study to find out the Prevalence of Hypothyroidism among Pregnant Women Visiting ESI Hospital Sanathnagar Hyderabad. Gynecol Obstet (Sunnyvale) 6:363. doi:10.4172/2161-0932.1000363

Copyright: © 2016 Rao S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Gynecology & Obstetrics


Aim: To study the prevalence of hypothyroidism in low income, urban pregnant women.

Study design: This is a retrospective study that includes 1062 pregnant women attending the antenatal clinic at ESI hospital, Sanathnagar, Hyderabad. Thyroid profile is being done as a routine test along with other antenatal profile tests in our hospital. Thyroid profile test includes serum T3, serum T4 and serum TSH. Hospital Ethics committee permission was granted for the study.

Results: A total of 1062 pregnant women were enrolled for this study. Results showed 20.1% prevalence of hypothyroidism of which 14.9% being subclinical hypothyroidism and 6.6% overt hypothyroidism.

Conclusion: The study shows a very high prevalence rate of hypothyroidism in the patients attending the antenatal outpatient department at ESI hospital, Sanathnagar, Hyderabad. This justifies the inclusion of thyroid profile test as a routine test in the antenatal profile.


Pregnancy; Hypothyroidism; Subclinical hypothyroidism; Prevalence; India


Hypothyroidism is a condition which affects both maternal and fetal outcome. Children born to untreated or undertreated mothers have profound effect on future intellectual development [1].

Pregnancy is associated with reversible changes in the maternal thyroid physiology. There is moderate enlargement of thyroid gland. There is increase in the levels of thyroid binding globulin which is estrogen mediated. The thyroid stimulation is due to the “spill effect” by HCG, which shares structural similarity with TSH. There is a relative decline in the availability of iodine due to increased renal clearance and losses to fetus and placenta [2].

The fetal thyroid gland begins synthesizing thyroid hormone after 12 weeks of gestation. Thyroid hormone is supplied to the fetus by the mother before this time, and it is at this time that thyroid hormones are most important for fetal brain development. However significant fetal brain development continues beyond first trimester, making thyroid hormone also important in later gestation [2].

It has been suggested that the babies of women with hypothyroidism in pregnancy are at increased risk of impaired neurological development [2]. Various studies have showed that in women with normal thyrotropin (TSH) and free thyroxin (fT4), elevated titers of TPOAbs (Thyroid peroxidase antibodies) are associated with complications like preterm birth, abnormal fetal growth, and prenatal/ postnatal depression symptoms [3]. Maternal thyroid dysfunction in early pregnancy leads to impaired cognition and attention deficit/ hyperactivity problems in preschool children [3].

Women with overt hypothyroidism are at an increased risk for pregnancy complications such as early pregnancy failure, preeclampsia, placental abruption, low birth weight and still birth [4-6]. Treatment of women with overt hypothyroidism has been associated with improved pregnancy outcomes.

According to The American Congress of Obstetricians and Gynecologists (ACOG), the prevalence of hypothyroidism in pregnancy is 2 to 5%. There are a few studies from India which show the prevalence of hypothyroidism during pregnancy ranging from 4.8% to 11% [7]. Therefore this retrospective study was conducted to study the prevalence of hypothyroidism in pregnancy in women attending antenatal clinic at ESI hospital, Hyderabad.

Materials and Methods

This study was conducted in the department of obstetrics and gynecology in ESI hospital, Sanathnagar, Hyderabad from April 2015 to July 2015 after clearance from ethics committee. Thyroid profile is being done for all pregnant women as a routine antenatal test in our hospital. We collected the results of thyroid function tests of 1062 women who attended the antenatal OPD during this period. The tests included in our antenatal profile are: Complete blood picture, Complete urine examination, Blood grouping and Rh typing, RBS, Blood urea, S. Creatinine, HIV, HbsAg and T3, T4 and TSH.


A total of 1062 cases were studied. All the subjects belonged to either poor or middle socioeconomic status.

Out of 1062 cases, 149 (14.03%) cases demonstrated subclinical hypothyroidism, 66 cases (6.2%) had overt hypothyroidism and 7 cases (0.6%) had hyperthyroidism (Figure 1).


Figure 1: Pie chart depicting thyroid dysfunction in pregnancy.

The mean age of the mothers were 22.1 years and the subjects belonged to either poor or middle socioeconomic status.

Distribution of patient to trimester in which hypothyroidism was detected

Nineteen percent had hypothyroidism prior to pregnancy, 45% had hypothyroidism on routine screening in 1st trimester and 21% in 2nd trimester and 14% in 3rd trimester (Figure 2).


Figure 2: Distribution of patient to trimester in which hypothyroidism was detected.

Spectrum of hypothyroidism

Present study shows 70% subclinical hypothyroidism and 30% overt hypothyroidism out of total hypothyroid cases (Figure 3).


Figure 3: Spectrum of hypothyroidism.


This retrospective study was aimed to know the prevalence of hypothyroidism in pregnant women attending antenatal clinic of ESI Hospital. The results showed 20.1% prevalence, 14.03% being subclinical hypothyroidism and 6.6% overt hypothyroidism. The upper limit of TSH is taken as 2.5 mIU/L in 1st trimester and 3 mIU/L in 2nd and 3rd trimester.

Subclinical Hypothyroidism is defined as an elevated TSH level with a normal level of circulating free T4. The prevalence of Subclinical Hypothyroidism during pregnancy in the US is estimated to be 0.25–2.5% [8].

According to ACOG, the prevalence of subclinical hypothyroidism has been anticipated to be between 2% and 5%. It has been stated that benefit of treatment to either mother or fetus has not yet been demonstrated in pregnant women with subclinical hypothyroidism and routine screening for subclinical hypothyroidism is not currently recommended [9].

Targeted case finding has been the preferred method due to its practicality, cost-effectiveness, and lack of any studies which conclusively demonstrate the superiority of universal screening over targeted case finding [10]. Targeted screening includes women who either have a positive family history, goiter, Type I diabetes, preexisting thyroid disorder, preterm delivery, antibody positivity, or prior therapeutic head or neck irradiation, and so on [10]. Currently, position statements issued by the Thyroid, Endocrine and Obstetric organizations do not recommend universal screening.

A study done by Vaidya et al., reported that by targeted thyroid screening testing of only the high-risk group would miss about one third of pregnant women with overt/subclinical hypothyroidism [11].

A study done in North India to know the prevalence of subclinical hypothyroidism concludes that there is a high prevalence of hypothyroidism (14.3%), majority being subclinical in pregnant women during first trimester [1]. Another study done in southern urban population of India has shown the prevalence of subclinical hypothyroidism to be 9.2% [12].

Sahu et al. have done thyroid function during second trimester in high-risk pregnant women and reported that prevalence of thyroid disorders, especially overt and subclinical hypothyroidism, was 6.47%. Further, significant adverse effects on maternal and fetal outcome were seen emphasizing the importance of routine antenatal thyroid screening [13].

Study done by Rao et al. demonstrates that hypothyroidism has a statistically significant relationship with recurrent pregnancy loss in the first trimester and suggests that diagnosis of hypothyroidism could help couples with recurrent pregnancy loss to have a successful outcome in subsequent pregnancies [14].

Subclinical Hypothyroidism in pregnancy has been associated with adverse maternal outcomes in observational studies including eclampsia, pre-eclampsia, placental abnormalities, miscarriages, preterm labor, and low birth weights [4,5,15,16].

There has been a wide geographic variation in prevalence of hypothyroidism during pregnancy; it varies from 2.5% from the west to 11% from India. It seems the prevalence is more in Asian countries compared with west.

All the above studies have shown a very high prevalence of hypothyroidism in Indian population. Universal screening for hypothyroidism may benefit both mother and the fetus. The present study supports universal thyroid screening to improve maternal and fetal outcomes.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 8452
  • [From(publication date):
    March-2016 - Oct 19, 2017]
  • Breakdown by view type
  • HTML page views : 8325
  • PDF downloads :127

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version