alexa Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia | Open Access Journals
ISSN: 2167-0951
Hair Therapy & Transplantation
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Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia

Inui S, Tohyama C and Itami S*

Department of Regenerative Dermatology, Osaka University School of Medicine, Osaka, Japan

*Corresponding Author:
Itami S
Department of Regenerative Dermatology
Osaka University, Osaka, Japan
E-mail: [email protected]

Received date: September 10, 2016; Accepted date: October 05, 2016; Published date: October 13, 2016

Citation: Inui S, Tohyama C, Itami S (2016) Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia. Hair Ther Transplant 6:145. doi: 10.4172/2167-0951.1000145

Copyright: © 2016 Inui S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Because we previously found that cepharanthine (CEP) induces production of IGF-I, one of anagen inducers, from dermal papilla cells, we investigated clinical effect of topical lipoid CEP (lipo-CEP) on hair growth of male androgenetic alopecia (AGA). Twenty-three males with early AGA applied 0.1% lipo-CEP lotion once a day on the vertex area for 6 months. As a result, hair growth rate was significantly accelerated from 0.243 to 0.281 mm/day (p<0.01). Likewise, hair density and thickness increased but the changes were not statistically significant (p<0.1). From these results, lipo-CEP lotion can stimulate hair growth mainly through accelerating growth rate, representing a hopeful reagent for treating AGA.

Keywords

Alopecia; Androgenetic; Male pattern baldness; Cepharanthine

Introduction

Cepharanthine (CEP) is a biscoclaurine alkaloid extracted from the plant Stephania cepharantha Hayata. Japanese Ministry of Health approved oral CEP as a therapeutic reagent for radiation-induced leukopenia, alopecia areata and pityrodes and it has been clinically utilized for more than 40 years [1]. Although CEP has been suggested to have simulative effect on hair growth, its mechanism was yet unknown. Then, we found that CEP induces production of IGF-I, one of anagen inducers, from dermal papilla cells [2]. Because IGF-I is an androgen-inducible positive growth mediator for beard growth stimulation [3] and an increased expression of IGF-1 mRNA in the DPCs positively correlates with patient response to finasteride [4], we investigate here clinical effect of topical lipoid CEP (lipo-CEP) on hair growth of male androgenetic alopecia (AGA).

Methods

Twenty-three males from twenties to fifties with early AGA (Norwood-Hamilton scale II or III, median age: 39.5 year-old) were enrolled in this study after informed consents were obtained. They applied 0.1% lipo-CEP lotion once a day on the vertex area for 6 months. Hair density, growth rate, thickness and anagen ratio were analyzed using Folliscope® system (Lead M Corporation, Seoul, Korea) before and after the 6-month treatment. Statistical analysis was performed by paired t-test.

Results

Hair growth rate was significantly accelerated from 0.243+0.054 to 0.281+0.049 mm/day (p<0.01, Figure 1) by the application of lipo-CEP lotion. Hair density and thickness increased from 161.3+19.5 to 167.2+17.0/cm2 and 79.0+13.4 to 81.4+15.2 μm, respectively, while these changes were not statistically significant (p<0.1). From these results, lipo-CEP lotion can stimulate hair growth mainly through accelerating growth rate. On the other hand, there was no significant effect on anagen ratio probably because the enrolled patients had early stage of AGA.

Hair-Therapy-Effect-topical-application-lipoid-cepharanthine

Figure 1: Effect of topical application of 0.1% lipoid cepharanthine on the vertex for 6 months on hair density, growth rate and thickness.

Discussion

Our previous study showed that the concentration of CEP was 0.1 and 1.0 μg/ml stimulated IGF-I production from dermal papilla cells. However, serum concentration after taking 10 mg oral CEP is only 1 ng/ml [5] and therefore topical application of CEP is more likely to be effective for AGA. Accordingly, our trial here tested the effect of topical CEP. To achieve high concentration of CEP in the skin, enhancement of its penetrance is necessary. For this purpose, we synthesized lipo- CEP and resultantly found that lipo-CEP solution is a hopeful reagent for treating AGA. Although standard therapies such as finasteride [6], dutasteride [7] and minoxidil [8] significantly increased hair density of AGA patients, lipo-CEP did not alter it. Therefore, its effect may be mild and additive compared with the standard therapies.

References

  1. Rogosnitzky M, Danks R (2011) Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions. Pharmacol Rep 63: 337-347.
  2. Inui S, Itami S (2013) Induction of insulin-like growth factor-I by cepharanthine from dermal papilla cells: a novel potential pathway for hair growth stimulation. J Dermatol 40: 1054-1055
  3. Itami S, Kurata S, Takayasu S (1995) Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells. Biochem Biophys Res Commun 212: 988-994.
  4. Tang L, Bernardo O, Bolduc C, Lui H, Madani S, et al. (2003) The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia. J Am Acad Dermatol 49: 229-233.
  5. Yasuda K, Moro M, Ohnishi A, Akasu M, Shishido A, et al. (1989) Pharmacokinetic study of cepharanthin following single oral doses in healthy subjects. Jpn J Clin Pharmacol 20: 735-740.
  6. Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, et al. (1998) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol 39: 578-589.
  7. Harcha WG, Martinez JB, Tsai TF, Katsuoka K, Kawashima M, et al. (2014) A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol 70: 489-498.
  8. Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, et al. (2002) A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 47: 377-385.
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