alexa An Assessment on the Ultrasound Guided Dextrose Prolotherapy for Persistent Coccygeal Pain: A Case Series and Review of Literature | OMICS International
ISSN: 2327-5162
Alternative & Integrative Medicine
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

An Assessment on the Ultrasound Guided Dextrose Prolotherapy for Persistent Coccygeal Pain: A Case Series and Review of Literature

Felix Linetsky1* and Francisco Torres2

1Department of Osteopathic Principles & Practice, Clearwater FL, USA

2Florida Spine Institute, Clearwater FL, USA

*Corresponding Author:
Felix Linetsky
Clinical Associate Professor Department of Osteopathic Principles & Practice 611 Druid Rd E, Clearwater FL 33756, USA
Tel: 727-787-5555
E-mail: [email protected]

Received date December 05, 2013; Accepted date March 03, 2014; Published date March 05, 2014

Citation: Linetsky F, Torres F (2014) An Assessment on the Ultrasound Guided Dextrose Prolotherapy for Persistent Coccygeal Pain: A Case Series and Review of Literature. Altern Integr Med 3:155. doi:10.4172/2327-5162.1000155

Copyright: © 2014 Linetsky F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Alternative & Integrative Medicine

As physicians practicing prolotherapy regularly, we read Dr. Yin Ting Chen et al. article with great interest. However, there are a number of issues raised that require further clarification.

Ultrasound guidance is a good tool for those who are not comfortable with palpation guided injection techniques. Dr. Hackett described his original case report on the treatment of persistent coccygeal pain with prolotherapy in the first edition of his textbook in 1956 (Case 19), and in the four subsequent editions, the latest published in 1991 [1-3]. Ever since the first publication, a large group of physicians have been using this treatment method.

The authors of the article published in this journal describe three cases of persistent coccydynia, successfully treated with ultrasound guided dextrose “prolotherapy.” The first two patients had posttraumatic coccydynia with a definite tenderness to palpation of coccyx.

The third patient reported the sudden onset of back, bilateral leg, hip and tail bone pain, paresthesia to the left medial thigh down to the heel which was initially associated with incontinence. Three years later she had tenderness over the hips, posterior superior iliac spines, sacroiliac joints, Piriformis muscles and mid gluteal regions bilaterally. Palpation of the coccyx revealed minimal tenderness. From the description of the case it appears that she had low back pain with radiculopathy and referred coccydynia of unknown etiology. The authors described improvement of her coccydynia; however, it is not clear whether or not any of the remaining symptoms were resolved.

In none of the cases was a rectal exam performed or described with a direct palpation of the ventral coccyx. MRI studies were also not completed; therefore, it is impossible to know if there was any damage to the ligaments, cartilage of the sacrococcygeal joints or tendinosis of Coccygeus and Gluteus maximus muscles or bone marrow edema in these cases. Further ultrasound evaluation did not reveal abnormalities in the ligaments but what about the muscles? The Doppler study was not done, thus one cannot determine whether any neovascularity was present, which would signify the neurovascular ingrowth and partially explain pain in chronic tendinosis or ligamentosis. These unanswered questions suggest that the three cases described in the article belong in the category of coccydynia of unknown origin.

Dr. Hackett’s original definition of prolotherapy describes the procedure as “the rehabilitation of incompetent structure by the generation of new cellular tissue.” Classic applications for prolotherapy are painful hypermobility and ligament laxity. But the authors did not find any of these symptoms or any evidence of tissue compromise in the three cases they have described; therefore there was no indication for prolotherapy under the classical definition [2].

Collagenous connective tissues, despite slightly different biochemical content, blend at their boundaries and at the osseous structures, functioning as a single unit [4]. Ingrowth of small sensory and sympathetic fibers in degenerated connective tissue with release of the nociceptive substances is well described in the current literature. Therefore, the denervation by any means is indicated to treat pain [4].

Ex juvantibus the treatment was successful, as in many cases described by Khan et al. [5] but the remaining questions are why it was successful and was it Prolotherapy?

Naming every hyperosmolar dextrose injection prolotherapy is arbitrary. In spinal anesthesia it is called a hyperosmolar or hyperbaric block, albeit smaller concentrations of dextrose are used.

It is not clear how: “In our case series, the use ultrasound allowed us to visually confirm the site of pathology…” where earlier in the text the authors write: “Ultrasound examination of her coccyx did not reveal any notable ligamentous and osseous abnormalities”.

Experimental studies have demonstrated that any solution with osmolality greater than a 1000 mOsm/l is neurolytic, causing separation of the myelin lamellae in myelinated nerve fibers and total destruction in unmyelinated fibers, after soaking for one hour in solutions with osmolality greater than 1000 mOsm/l or distilled water. Pharmacologic properties of phenol, glycerin and hypertonic dextrose are both neurolytic and inflammatory. A 1:1 dilution of 50% dextrose with 1% lidocaine as used by the authors produces a hyperosmolar 0.5% lidocaine with a 25% dextrose concentration and osmolality of 1388 mOsm/l; (which is a hyperosmolar neurolytic block [4,6].

In conclusion, the treatment described by Yin-Ting Chen, MD et al. falls into the category of hyperosmolar neurolytic blocks of the ingrown sensitive and sympathetic fibers detectable only by biopsy and special staining, but not into category of prolotherapy.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11818
  • [From(publication date):
    May-2014 - May 25, 2018]
  • Breakdown by view type
  • HTML page views : 7994
  • PDF downloads : 3824

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7