# Analysis of Prey-Predator Model in Chemostat When the Predator Produces Inhibitor

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**Corresponding Author:**Moniem AA, University College in Al-Jamoum, Umm Al-Qura University, Mecca, Saudi Arabia, Tel: 966 12 550 1000, Email: [email protected]

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Received Date: Jun 15, 2017 /
Accepted Date: Oct 03, 2017 /
Published Date: Oct 27, 2017 *

### Abstract

In this work, a prey-predator model in chemostat is considered when the predator produces inhibitor. This inhibitor is lethal to the prey by results in decrease of growth rate of the predator at some cost to its reproductive abilities. A Lyapunov function in the study of the global stability of a predator-free steady state is analysed. Local and global stability of other steady states, persistence analysis, as well as numerical simulations are also presented.

**Keywords:**
Persistence; Inhibitor; Chemostat; Prey; Predator; Lyapunov function

#### Introduction

The chemostat is one of the standard models of an open system in ecology [1-5]. The monograph of Hsu and Waltman has various mathematical methods for analyzing chemostat models [4]. So, it is quite natural that it should be used as a model for studying detoxification problems. Many authors have studied those models [6-12]. Recently, the inhibitor has been introduced in the models for prey - predator in chemostat when the prey produces unaffected inhibitor which is lethal to neither predator nor nutrient [1]. Moniem [2] has considered a model of simple food chain in chemostat when the predator produces unaffected inhibitor which is lethal to neither prey nor nutrient.

In this paper, we consider a prey-predator model in chemo stat when the predator produces inhibitor. This inhibitor is lethal to the prey by results in decrease of growth rate of the predator at some cost to its reproductive abilities.

This paper is organized as follows: In the next section, the model is presented and some simplifications are achieved. Section 3 deals with the existence and local stability of steady states. In section 4, we shall provide global analysis, including global stability of the boundary steady states and persistence analysis. Discussion, comments and numerical simulation are found in final section.

#### The Model

The interested equations are

(1.1)

Where s(t), x(t), y(t) and p(t) are the concentration of the nutrient, prey, predator and inhibitor at time t respectively. s° denotes the input concentration of the nutrient, D denotes the washout rate, and the parameter γ represents the coefficient of the interaction between the inhibitor and the prey. γ_{i}, i=1,2 are the Yield constants. The constant k∈(0,1) represents the fraction of potential growth devoted to producing the inhibitor [3].

Also we have and, where m_{i}, i=1,2 are the maximal growth rates, and a_{i}, i=1,2 are the Michaels- Menten constants.

Now to perform the usual scaling for the chemostat, let

Substituting in eqn. 1.1 and dropping the bars, the mathematical model will be reduced to the form

(1.2)

#### Existence and Local Stability

Let T=s+x+y+p then we have . Since each component is non-negative, the system in eqn. 1.2 is dissipative and thus, has a compact, global attractor. To simplify in eqn. 1.2, let , we find that the system in eqn. 1.2 will take the form

(2.1)

Clearly z(t)→0 as t→∞ so the system in eqn. (2.1) may be viewed as an asymptotically autonomous system with the following equations

(2.2)

The equilibrium point E_{0}=(1,0,0) always exists. If 1<*f*_{1}(1) then there is an equilibrium of in eqn. (2.2) of the form E_{1}=(λ_{s},1-λ_{s},0) where _{s} is the unique solution of f_{1}(λ_{s})-1=0. Similarly, if , there is an equilibrium of the form E_{2}=(s^{*}λ_{s}, y^{*}) where s^{*} is the unique value of s such that is the unique solution of (1-k) f_{2}(x)-1=0 and

Since the limit plane in (eqn. 2.2) is Σ: s+y+z=1 , then by dropping *S* equation, the system of equations eqn. (2.2) will be reduced to the form

(2.3)

It is easy to show that in eqn. 2.3 in positive plane. As a consequence, the global attractor in eqn. (2.1) lies in the set z=0 and Σ plane where in eqn. (2.3) is satisfied. When the analysis of in eqn. (2.3) is completed in this paper, the work of Thieme (11), relates the corresponding dynamics in eqns. (2.1) and (2.3), and hence in eqn. (1.2). We will show that all solutions in eqn. (2.3) tend to rest points and hence, using Thieme (10), we can find the rest points of the system in eqn. (1.2).

We now discuss the existence of steady state. The washout steady state E0 always exists. A predator-free steady state E_{1} exists when λ_{S}2 exists when _{S}S+λ_{x}s)=1-_{s}- λ_{x} *f*_{1}(s) is decreasing function in s with 0<H(0)=1, H(s^{*})=0 and . If and only if λ_{S}+λ_{x}<1.

Next theorem will discuss the local stability of this steady state by finding the eigenvalues of the associated variation matrices.

**Theorem 1**

If 1<λ_{S} then only E_{0} exists and E_{0} is locally asymptotically stable. If λ_{S}S+λ_{x} then only E_{0} and E_{1} exist, E_{0} is unstable, and E_{1} is locally asymptotically stable. If λ_{S}S+λ_{x}0, E_{1}, E_{2} exist, E_{0}, E_{1} are unstable and E_{2} is locally asymptotically stable if

and consequently by an application of the Poincare-Bendixson theorem there is a periodic solution in Σ.

**Proof:** The Jacobian matrix in eqn. (2.3) is taken the form

The eigenvalues are on the diagonal and the washout steady state will be locally asymptotically stable if and only if *f*_{1}-1S.

At (λ_{S},(1-λ_{S}),0) the Jacobian matrix becomes

The two eigenvalues are and Therefore the predator – free steady state is asymptotically stable if and only if

At E_{2} the Jacobian matrix takes the form

Then E_{2} is locally asymptotically stable if the determinant of this matrix is positive and its trace is negative, it means that

#### Global Analysis

**Theorem 2**

For 1<λ_{S} and for large t all solutions in eqn. 2.2 tends to E_{0}.

**Proof:** For1<λS and for large t we get s(t)<1 and *f*_{1}(1)<1Therefore, the second equation 2.2 gives , which imply The third eqn. (2.2) becomes , which leads to . The first equation (2.2) has a solution s=1+(constant) e^{-t}→1 as t→∞.

**Theorem 3**

If λ_{S}<1 ,1<λ_{S}+λ_{x} and for large t then all solutions in eqn. 2.2 tend to E_{1}

**Proof**

Let

(3.1)

and

(3.2)

Let C(u) be a continuously differentiable function and *C*′(*u*) be defined by

(3.3)

Note that *C*′(*u*) is linear on [1-λ_{S}, λ_{x}] We may construct a Lyapunov function as follows:

(3.4)

on the set Ψ ={(s,x,y):0<s+x+y<1} where x=1-λ_{S}

Differentiate in eqn. 3.4 with respect to time t, we obtain

(3.5)

The term is non-positive for 0<s<1 and equal zero for s∈[0,1) if and only if s=λ_{S} or x=0 Since *C*′(*x*) = 0 for and *C*′(*u*) ≥ 0 for *u* ≥ 0, then the term is nonpositive for s∈[0,1).

Define

(3.6)

If then and .

Using the definition of η we find that *h*(*s*, *x*, *y*) ≤ 0 . If 1-λ_{s}<x<λ_{x} then all terms of h(s,x,y) are non-positive. If , then *C*′(*x*) = *β* and making use of definition of β and η we find that h(s,x,y) will be non-positive and the second term of V vanishes at y=0 therefore V is non-positive on Ψ.

Let M be the largest invariant subset of φ={(s,x,y)∈Ψ:V=0} such that V=0 at S= λ_{s} or x=0 and y=0. More further,V is bounded above, any point of the form (s,0,0) cannot be in the limit set of any solution initiating in the interior of R^{3}_{+}. (λs,x,0)M implies that S=_{s} and from the first equation (2.2 ), we get x=1-λ_{s}

Therefore M={E_{1}}. This completes the proof.

**Theorem 4**

If λ_{s}<1 and λ_{s}+λ_{X}<1 then the system in eqn. (2.2) is uniformly persistence.

**Proof**

Let Z_{1}={(s,x,y):s∈[0,1] ,x,y∈(0,1]},

Z_{2} represents *sx*− *plane* : 0 ≤ *s*, *x* ≤ 1,

Z_{3} represents *sy* − *plane* : 0 ≤ *s*, *y* ≤ 1, and

Z = Z_{2} ∪ Z_{3}

We want to show that Z is a uniformly strong repeller for Z_{1} Since E_{0} and E_{1} are the only steady states in Z. E_{0} is saddle in R^{3}and its stable manifold is {( *s*,0, *y* ) : 0 ≤ *y*}. Also, E_{1} is saddle in R^{3} and its stable manifold is {( *s*, *x*,0) : 0 < *x*}.Then, they are weak reppelers for Z_{1}.The stable manifold structures of E_{0} and E_{1} imply that they are not cyclically chained to each other on the boundary Z. Therefore Z is a uniform strong repeller for Z_{1} (see proposition in eqn.(1.2) of Thieme [12]).

So, there are ε_{1}>0 and ε_{2}>0. such that and where _{1} and ε_{2} are not depending on the initial values in Z_{1}. By using (Thieme [12]), the first eqn. (2.2) yields that there is ε_{3}>0 such that where _{3} is not depending on the initial values in Z_{1}Proof is completed.

#### Conclusion And Numerical Simulation

In this paper, we consider a prey-predator model in chemostat when the predator produces inhibitor. This inhibitor is lethal to the prey by results in decrease of growth rate of the predator at some cost to its reproductive abilities. We found that the washout steady state is the global attractor, if it is the only steady state and . When the washout and the predator free steady states are the only steady states, we found that E_{0} is unstable and *E*_{1} is locally asymptotically stable. E_{1}is global attractor by constructing a Lyapunov function under condition that . We also showed that E_{2} exists in the sense that the system is uniformly persistent and E_{2} is locally asymptotically stable if the determinant of this matrix is positive and its trace is negative, it means that

We find by numerical simulation that eight iterative examples are presented here to show the influence of increasing the parameter k on the dynamical behaviour. In all examples, parameters values in eqn. (2.2) are as follows [2]:

(s(0),x(0),y(0))=(0.1,0.7,0.8),m_{1}=4.0,m_{2}=5.0,a_{1}=0.6,a_{2}=0.5,γ=0.2

And we deduce that when k ∈[0,0.4] the solution appears to approach a periodic solution. So, E_{0}, E_{1} and E_{2} lose their stability (**Figures 1-3**). Those oscillatory solutions appear to be the results of Hopf bifurcations. The numerical simulation shows that the system in eqn. (2.2) has an attracting limit cycle.

Also, at k ∈[0.4,6.5] the solution approaches a positive steady state. Both E_{0} and E_{1} are unstable and E_{2} is globally asymptotically stable (**Figures 4-7**).

For k ∈[6.5,1] the solution approaches the predator-free steady state. E_{0} is unstable and E_{1} is globally asymptotically stable (**Figure 8**). All left figures plot in time courses and all right figurers plot the trajectory in (s,x,y) space. We also, deduce that no difference between this paper and Moniem [2] as numerical simulation, even γ changes its value on interval [0,1[for each value of k.

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Citation: Moniem AA (2017) Analysis of Prey-Predator Model in Chemostat When the Predator Produces Inhibitor. J Appl Computat Math 6: 367. Doi: 10.4172/2168-9679.1000367

Copyright: © 2017 Moniem AA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.