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Antiretroviral Therapy: Level of Adherence and Its Determinants Among Patients on Treatment in Different Health Facilities. A Cross Sectional Study in Oromia Regional State, Ethiopia
ISSN 2155-6113
Journal of AIDS & Clinical Research

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Antiretroviral Therapy: Level of Adherence and Its Determinants Among Patients on Treatment in Different Health Facilities. A Cross Sectional Study in Oromia Regional State, Ethiopia

Tolossa E Chaka1*, Sileshi G Abeya1, Abebe M Adlo1, Tilaye W Abebe1, Shalo D Hamuse2, Mihretu T Lencha2 and Zelalem H Jemal2

1Adama Hospital Medical College, Adama, Ethiopia

2Oromia Regional Health Bureau, Addis Ababa, Ethiopia

*Corresponding Author:
Tolossa E Chaka
Consultant Pediatrician
Department of Pediatrics and Child Health Adama Hospital Medical College
P.O. Box: 84, Adama, Ethiopia
Tel: +251911413135
E-mail: [email protected]

Received date: October 06, 2016; Accepted date: October 18, 2016; Published date: October 25, 2016

Citation: Chaka TE, Abeya SG, Adlo AM, Abebe TW, Hamuse SD, et al. (2016) Antiretroviral Therapy: Level of Adherence and Its Determinants Among Patients on Treatment in Different Health Facilities. A Cross Sectional Study in Oromia Regional State, Ethiopia. J AIDS Clin Res 7:629. doi:10.4172/2155-6113.1000629

Copyright: © 2016 Chaka TE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

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Abstract

Background: HIV/AIDS pandemic is the world’s most deadly disease that has killed more than 25 million people so far. Appropriate antiretroviral viral treatment (ART) reduces mortality and morbidity and enhances quality of life. Adherence to both follow up clinics and drugs is crucial to this effect. Objective: To assess level of adherence to antiretroviral treatment and its determinants among patients on ART in Oromia regional state, Ethiopia. Methods: Cross-sectional study design was used. For the study purpose, the region was divided into four strata so that different socioeconomic characteristics of the study population will be represented. List of health facilities that had a case load of >500 patients across the strata was used as sampling frame and health facilities were randomly selected. The Sample size was proportionally assigned to health facilities and every other patient visiting the selected health facility was included and a total of 1632 study participants (age 15 years and above) were interviewed. The patients’ follow up chart was used to extract baseline clinical data. Epi Info 7 was used for data entry and analyzed using SPSS 20. Descriptive statistics were used to determine sociodemographic characteristics and level of adherence. Logistic regression model was used to identify predictors of adherence. Results: Ninety seven percent of patients had good adherence to ART. Factors associated with better adherence were housewives (AOR, 5.10; 95% CI, 1.30, 19.98), baseline CD4 count <350 cells/ml (AOR: 2.21; 95% CI: 1.13, 4.34) and patients free of addictive substances (AOR: 7.42; 95% CI: 1.46, 37.81). Significant proportions of patients believe that worshiping and holy water (“Tsebel”) can cure HIV/AIDS. Conclusion: The vast majority (97%) of the respondents were in optimum adherence to the treatment. Various factors were associated with optimum adherence to antiretroviral treatment. Knowledge and attitude of PLWHA towards ART should be addressed carefully.

Keywords

Antiretroviral treatment; Adherence; Associated factors; Oromia; Ethiopia

Abbreviations

ART: Antiretroviral Therapy; ARV: Antiretroviral; CD4: Cluster of Differentiation; HIV/AIDS: Human Immunodeficiency Virus/ Acquired Immunodeficiency Syndrome; IDI: In-Depth Interview; IPT: Isoniazid Prophylactic Treatment; LTFU: Lost to Follow-Up; OIs: Opportunistic Infections; PLWHA: People Living with HIV/AIDS; PLWHIV: People Living with HIV; PMTCT: Prevention of Mother to Child Transmission; WHO: World Health Organization

Introduction

Sub-Saharan countries contribute most (63% of the 24.7 million PLWHA) of the HIV/AIDS patients to the world [1]. The initial challenge in combating HIV/AIDS epidemic was an access to antiretroviral (ARV) medicines [1,2]. However, increasing production and decrease in the cost of the ARVs dramatically facilitated the scaling up of antiretroviral therapy (ART) programs worldwide [1]. In the late 1990s,combinations of ART medications were introduced even though patient adherence had emerged as a program challenge [3].

The ARV drugs suppress viral replication, restore the immune status, halt progression of disease, increase survival rates, reduce morbidity and improve quality of life [1,2]. Thus, the use of ART revitalized communities and transformed perceptions on HIV/AIDS from a plague to a manageable chronic illness [4]. Even though there are many benefits of ART, very high level of adherence (at least 95%) is needed to ensure the optimal benefits [2,5]. Poor adherence along with other factors can lead to virological, immunological and clinical failures with ultimate emergence of drug resistant strains [1,2,4,6,7]. When an individual develops resistance to the first-line ARVs, they have to be treated with second line ARVs which are more expensive [8].

Theoretical framework of ART adherence predictors

Studies showed that different factors affect ART adherence and lost to follow up. These factors can be related and not limited to: sociodemographic, treatment regimen related, disease characteristics, patient-provider relationship, clinical setting, individual patient related and the quality of healthcare services [9,10].

Socio-demographic factors: Lack of transport and transportation costs, food shortage, stigma and discrimination and lack of social/ family support are some of the socio-demographic predictors of ART adherence. In a study conducted in Yirgalem Hospital, respondents who lived more than 47 km away from ART site (AOR, 2.48; 95% CI: 1.24 to 4.98) were more likely to be lost from treatment [10]. In another qualitative study, financial constraints, lack of transport and inability to pay costs for tests and OI drugs were a great distress to the vast majority of patients [11]. In the study done in Ethiopia, most ART patients are poor and many discontinue treatment because they do not have adequate food with which to take medication [12]. The study done by Ayala et al. showed that patients who got family support were two times more likely to adhere than others [13].

Treatment and disease related factors: Antiretroviral treatment consists of a complex regimen that can include multiple pills a day, with multiple dosing throughout the day and specific food and fluid related instructions. These are often difficult to follow for patients and contribute to poor adherence. The higher the pill burden, the lower is the adherence [14]. Patients with higher CD4 counts tend to be less adherent. In a systemic review and meta analysis by Bock Peter et.al, the odds of being adherent was marginally lower for patients in the higher CD4 count group (pooled OR 0.9; 95% CI 0.84-0.96) [15]. On the other hand, antiretroviral medications often have many side effects, some of which are temporary: diarrhea, fatigue, nausea and vomiting; while others may be permanent or long lasting: peripheral neuropathy, physical changes in body appearance, lipoatrophy/lipodystrophy, metabolic changes. Studies have shown that when patients experience side-effects, they tend to stop treatment or take it irregularly [14].

Health care system and health care team factors

Access to care and the patient health care provider relationship were found to be important factors that determined satisfactory adherence to ART [16]. Meaningful and supportive relationship between the patient and health care provider can help to overcome significant barriers to adherence [1]. Patients become frustrated with health care providers when misunderstandings occur, treatment becomes complex, sideeffects go unmanaged and the patient is blamed for being a “bad patient”. One study showed that, difficulty in following physician’s instructions was a significant barrier to medications adherence [17]. Satisfaction in the health care service is an important indicator of the quality of the patient-provider relationship. As Bosworth et al. pointed out, patients who are not satisfied with their health care provider are more likely to reject medical advice [18]. Another study also revealed that dissatisfaction with the health services is a predictor of nonadherence [19].

Individual patient related factors

In a qualitative study done in Ethiopia, the majority of patients had disclosed their status to their close family and friends, but very few had disclosed it to the community [20]. The fear and experience of stigma and discrimination often prevents PLHIV from disclosing their HIV status. Low rates of HIV disclosure and high levels of perceived HIV associated stigma can pose a barrier to adherence [21]. Some PLHIV do not have a good understanding of HIV and the common beliefs about the causes of HIV and basic etiology of HIV can reduce motivation for treatment. In addition, misconceptions and rumors related to ARVs can affect adherence [22]. In Ethiopia, religious PLHA often take holy water as treatment for HIV instead of ARVs [12]. Drinking alcohol (AOR, 0.21; 95% CI, 0.07 to 0.62) was also associated with nonadherence to doses of ARVs [23].

Different facility based studies across the country showed that the level of ART adherence varies between 87-94% [4,10,24-26]. There is no national or regional study done to determine prevalence of ART adherence and its predictors. The aim of this study is to assess the prevalence of ART adherences and associated factors at regional level.

Methods

Study area

Oromia regional state is the largest and populous region located at the central part of the country, Ethiopia [27,28]. Being the largest region that covers the central land mass of the country, it includes high HIV prevalence corridors. According to the national HIV/AIDS projections for Ethiopia, the prevalence of HIV infection in 2014 was 1.2% (1.6% and 0.8% for women and men, respectively) among the adult population. The Oromia region HIV/AIDS situation is similar with that of national data. There are 42 Hospitals and over 1,300 Health Centers in the region [28]. Of these health facilities, 318 (All Hospitals and 276 Health Centers) are providing ART service for over 80,000 clients.

Study design

Facility based cross sectional study was conducted to assess the level of antiretroviral treatment adherence and associated factors. Stratified sampling method was used. First, Oromia region was stratified into four strata based on geographical and socio-cultural relative similarity.

Second, based on the latest regional health bureau report [28], we identified all health facilities with at least 500 patients on ART. We used this case load as inclusion criteria for the health facilities in the study to be able to get the required sample from the facility. The latest regional health bureau ART data were also used to identify the proportion of patients currently on ART to be included in the study per stratum. The health facilities to be included in the study were randomly selected from the list of health facilities with patient load of 500 and above in the four strata.

The third step was determining the number of patients to be interviewed per health facility. This was done by proportionally dividing the sample size allocated to the respective stratum to the health facilities based on the caseload each health facility had. Finally, all patients visiting the selected health facility during the study period were consecutively interviewed until the allocated sample is obtained. Fear of information contamination is avoided by interviewing every other patient where the caseload is high. Baseline and treatment information was extracted from electronic medical records for all interviewed patients. Single population proportion formula was used to calculate sample size with design effect to increase the power of the study. Sampling procedure is indicated by Figure 1.

Data collection

After written consent was obtained, a semi-structured questionnaire was used to interview all study participants. Data extraction format was used to extract baseline clinical data from the medical records. Data collectors and supervisors were trained for three days prior to the data collection. The data from questionnaires and medical records were linked by using the unique ART number.

Data management and analysis

aids-clinical-sampling-procedure

Figure 1: Schematic presentation of sampling procedure.

Epi Info version 7.1.4 was used for data entry. The data were exported to SPSS version 20 for cleaning and analysis. Univariate, bivariate and multivariate analyses were performed. Stratified analysis by predictors of ART adherence was conducted. Proportions, tables and graphs were used to describe the study population. Appropriate statistical analysis models were used after checking for assumptions. Binary logistic regression was used to identify the independent predictors of adherence. Multicolinearity was checked to rule out interactions among the independent variables and any independent variable with greater than 60% of Colinearity was dropped from the analysis. Colinearity between categorical variables was assessed by looking at the values of variance inflation factor (VIF) and those larger than 10 were excluded from the fitted model [29,30]. A Confidence level of 95% was used to determine statistical significance and p-value of less than or equal to 0.05 was considered as statistically significant association.

Ethical Consideration

The ethical approval was secured from Adama Hospital Medical College ethical review committee. An accompanying letter of permission was also obtained from the Regional Health Bureau for all included health facilities. Written informed consent was obtained and participants/care givers were informed that they have the right to decline from the study. The study participants’ Confidentiality of the information was assured and privacy of the respondents’ was maintained.

Result

Description of the study subjects

A total of 1631 adult patients living with HIV/AIDS and on ART were included in the study. Two third (66.1%) of the respondents were females. Sixty eight percent of the participants were between 25-44 years of age with the median age of 36 years (IQR=14 years). The majorities (82.3%) were urban residents and more than half (52.0%) were married. However, about one in six (14.0%) of the study participants were never married at the time of the interview. The predominant ethnic group (64.1%) in the study area was Oromo followed by Amhara (27.7%). About two third of the respondents were Orthodox Christian by religion followed by Muslims (12.6%). One quarter (25%) of the respondents were unable to read and write, while about one in five were educated to the level of elementary (1-8th grade) school. Day laborers comprise 27%, followed by governmental or NGO employees (15.3%) (Table1).

The median estimated monthly income was calculated to be 700 ETB (IQR=900 ETB), and nearly half of participants were earning below 600 ETB (Figure 2). Most of the respondents (68.6%) live with their families, while one out of five are living alone. More than one in ten (13.2%) of the respondents never disclosed their HIV statuses to their relatives or friends. About 611 respondents (38%) reported no social support during the study period. Nearly eleven percent of the respondents reported using addictive substances like Khat, Cigarette and alcohol (Table 2).

Clinical background and ART adherences of the study participants

At baseline, the vast majority (95%) of the respondent’s functional status was working. Two third (66.8%) of the respondents started ART because their baseline CD4 count was <350 cells/ml. When asked about the number of pills taken per day during the last one month prior to the study, two out of five (39.9%) of the respondents reported that they took two pills and 5% of the study participants took four and more pills per day. Out of all respondents, 171 (10.5%) missed at least one dose in the last one month prior to the survey and 246 (16.3%) reported to have the side effects of the regimen (Table 3).

Level of ART adherence

The result of this study showed that ART adherence status of 1608 (98.8%) participants from the Logbook was good. Similarly, ART adherence status according to the data from the interviews, 1586 (97%) of the respondents had a good adherence status for one month prior to the study period.

Variables Frequency Percent
Sex (n=1631)    
Male 553 33.9
Female 1078 66.1
Age Category (n=1608)    
15-24 years 107 6.7
25-34 years 560 34.8
35-44 years 549 34.1
45-54 years 277 17.2
>=55 years 115 7.2
Residence (n=1631)    
Urban 1342 82.3
Rural 289 17.7
Marital Status (n=1629)    
Single 228 14.0
Married or Cohabited 847 52.0
Divorced 179 11.0
Widowed 238 14.6
Others * 137 8.4
Ethnicity (n=1629)    
Oromo 1044 64.1
Amhara 451 27.7
Others ** 134 8.2
Religion (n=1629)    
Muslim 206 12.6
Orthodox 1051 64.5
Others *** 372 22.8
Educational status (n=1631)    
Unable to read and write 408 25.0
Read and write 82 5.0
Elementary (1-8th grade) 677 41.5
High school 326 20.0
Above high school 138 8.5
Occupation (n=1631)    
Day Laborer 439 26.9
Farmer 146 9.0
Housewife 262 16.1
Business owner 346 21.2
Employee (GO, NGO, etc.) 250 15.3
Others **** 188 11.5

Table 1: Socio-demographic characteristics of the study participants, Oromia Regional State, Ethiopia, 2015.

Knowledge and attitude of respondents towards ART

Respondents were asked about HIV/AIDS and ART related knowledge questions and those who scored above and including average were considered as having good knowledge. 1180 (72.3%) respondents had good knowledge. The study subjects were also asked attitude related questions and those who scored above and including average were considered as having favorable attitude. The score for the attitude was calculated and 1381 (84.7%) respondents have a favorable attitude (Figure 3).

More than one quarter (27.5%) of the respondents believed that HIV/AIDS is curable using ARV drugs. Similarly, about 26.6% and 9.6% of the respondents believed that HIV/AIDS is curable by worshiping and holy water respectively (Figure 4).

Factors associated with adherence to ART

Binary logistic regression analysis was used to identify the independent predictors of ART adherence. The outcome ART adherence variable is dichotomized (defined as 1=good adherence to ART: 0=fair to poor adherence to ART). Each independent variable was tested with the adherence status for the association. Some of the variables were significantly associated with good adherence (Table 4). Among socio-demographic variables residence, occupation and marital status were significantly associated with good adherence to ART (P<0.05). Use of addictive substances (consuming alcoholic beverages, chewing Khat and cigarette smoking), disclosure of HIV statuses to others and baseline CD4 count were significantly associated behavioral and clinical characteristics (P<0.05). Rural residents were more likely to have good adherence than urban counterparts (COR: 1.92; 95%CI: 1.06, 3.72). From the occupational status of respondents, housewives were more likely (COR: 4.77; 95%CI: 1.25, 18.29) to adhere to ARV treatment compared to day laborers. Similarly, Married and cohabiting respondents were more likely to adhere to ART as compared to singletons.

aids-clinical-Oromia-Regional

Figure 2: Percent of estimated average monthly income of the respondents, Oromia Regional State, Ethiopia, 2015.

Variables Frequency Percent
Living arrangement (n=1631)
  Live Alone 311 19.1
Live with Family 1119 68.6
Live with parents or others 201 12.3
HIV disclosure status (1607)
  Status not disclosed 212 13.2
Status Disclosed 1395 86.8
  Partner HIV status (n=919)    
  Negative test for HIV 176 19.2
  Positive but not on ART 93 10.1
  Positive and on ART 416 45.3
  HIV status unknown 106 11.5
  Partner not alive 128 13.9
Disclosure status about ART (n=1620)
  NO ART status disclosure to others than HW 213 13.1
Disclosed ART status to others 1407 86.9
Social Support (1606)
  Has no social 611 38.0
Has social Support 995 62.0
Use addictive substances (1528)
  Doesn't use addictive e drugs 1361 89.1
Uses addictive drugs 167 10.9
Types of addictive substances    
  Chew Khat 73 96.1
  Smoke cigarette 25 92.6
  Drink alcohol 56 96.6

Table 2: Economic and psycho-social characteristics of the study participants, Oromia Regional State, Ethiopia, 2015.

Variables Frequency Percent
Baseline functional status (n=1620)    
 Ambulatory 71 4.5
 Bedridden 8 0.5
 Working 1550 95.0
WHO clinical stage (n=1605)    
  WHO stage I 175 10.9
WHO stage II 542 33.8
WHO stage III 562 35.0
WHO stage IV 326 20.3
Baseline CD4 (n=1480)    
  <350 cells/ml 988 66.8
>=350 cells/ml 492 33.2
Number of pills taken per day in the last one month (1596)    
  One pill 511 32.0
Two pills 637 39.9
Three pills 369 23.1
>=Four pills 79 4.9
Missed dose in the last one month (n=1631)    
  No 1460 89.5
Yes 171 10.5
Registered side effect (n=1505)    
  Side effect present 246 16.3
Side effect Absent 1259 83.7

Table 3: Medical history and adherence of the study participants, Oromia Regional State, Ethiopia, 2015.

Variables Category Adherence status COR 95%CI AOR 95%CI
Good
No (%)
Fair to poor
No (%)
       
Residence Urban 1310 (82.6) 32 (71.1) 1.00   1.00  
Rural 276 (17.4) 13 (28.9) 1.92 1.06, 3.72* 1.42 0.66, 3.05
Occupation Day laborer 424 (26.7) 15 (33.3) 1.00   1.00  
Farmer 138 (8.7) 8 (17.8) 2.91 0.84, 10.16 2.34 0.62, 8.81
Housewife 255 (16.1) 7 (15.6) 4.77 1.25, 18.29* 5.10 1.30, 19.98
Business owner 339 (21.4) 7 (15.6) 2.26 0.58, 8.84 1.34 0.31, 5.76
Employee 247 (15.6) 3 (6.7) 1.70 0.44, 6.64 1.13 0.25, 5.20
Others 183 (11.5) 5 (11.1) 2.25 0.53, 9.53 1.47 0.24, 9.17
Marital Status Single 227 (14.3) 1 (2.2) 1.00   1.00  
  Married 817 (51.6) 30 (66.7) 8.34 1.13, 61.45* 2.19 1.13, 4.26*
Divorced 175 (11.0) 4 (8.9) 5.19 0.58, 46.83 6.02 0.64, 56.60  
Widowed 231 (14.6) 7 (15.6) 6.88 0.84, 56.36 7.96 0.93, 68.36  
Others 134 (8.6) 3 (6.7) 5.08 0.52, 49.35 5.90 0.58, 59.86  
Use Addictive substance Yes 158 (10.6) 9 (21.4) 1.00   1.00  
  No 1328 (89.4) 33 (78.6) 2.29 1.10, 4.88* 7.42 1.46, 37.81*
Disclosure of ART status Yes 1337 (87.2) 34 (75.6) 2.20 1.10, 4.41* - -
No 202 (12.8) 11 (24.4) 1.00   1.00  
Baseline CD4 Count <350 cells/ml 971 (67.2) 17 (48.6) 2.17 1.11, 4.21* 2.21 1.13, 4.34*
>=350 cells/ml 474 (32.6) 18 (51.4) 1.00   1.00  

Table 4: Factors associated with adherence to ART among patients living with HIV/AIDS, Oromia Regional State, Ethiopia, 2015.

aids-clinical-Regional-State

Figure 3: Knowledge and attitude of respondents towards HIV/AIDS and ARV, Oromia Regional State, Ethiopia, 2015.

In addition, no use of addictive substances was likely to increase adherence by odds of more than seven times (AOR: 7.42; 95% CI: 1. 46. 37.81). Those respondents who disclosed their ART status were (COR: 2.20; 95% CI: 1. 10.4.41) more likely to adhere to ART than their counterparts. Baseline CD4 Count <350 cells/ml were two times more likely to adhere as compared to respondents with CD4 count >350cell/ mm3.

However, no statistically significant relationships were observed between the sex of the respondents, religion, age, estimated monthly income, education, knowledge score, attitudes score, distance from a health facility, travel cost, social support, baseline functional status, WHO staging and other related variables. Stratified analysis using these factors also didn’t show statistical significance with ART adherence.

Multivariate logistic regression was run to identify predictors of ART adherence and showed that being house wife (occupation) (AOR: 5.10; 95% CI: 1.30, 19.98), Married (AOR: 2.19; 95% CI: 1.13, 4.26), Baseline CD4 Count <350 cells/ml (AOR: 2.21; 95% CI: 1.13, 4.34) and no use of addictive substances (AOR: 7.42; 95% CI: 1.46, 37.81) were predictors of ART adherence.

Discussion

This study used both primary and secondary data. It showed that 97.2% of the patients took more than 95% of the prescribed doses correctly one month prior to the survey (good adherence status). This is in line with the study conducted by Tiyou et al. based on self report of missed doses of one-week recall before the actual interview indicating 95% of the participants had good adherence (dose adherence) [13]. However, the level of adherence in this study is higher than the report from the Hospital based study from south and central Ethiopia in 2009 that indicted an adherence rate of 88.1%, [7]. But, it is comparable with the studies done by Ayele et al. that showed adherence rate of 95% [13]. Another study done by Mekonnen et al. in the South West part of Ethiopia showed an overall adherence rate of 98.8% (98.1% among males and 99.5 % among females) [31]. A systematic review by Mills and colleagues showed a pooled adherence estimate of 77% (95% confidence interval, 68–85%; based on a total of 12,116 patients) by sub-Saharan African patients [32]. One possible reason for these disparities could be that these studies used different methods to measure ART adherence; some used self report of missed doses from few weeks to months while others used pill count. The other reason for these variations could be attributed to the recent ART service decentralization to health centers which brings the service closer to the beneficiaries.

This study showed that housewives were found to be at increased likelihood of having good adherence to ART compared to the daily laborers. This could be due to the fact that daily laborers might be travelers and have no residential stability as compared to housewives.

Our study showed that no use of addictive substances was likely to increase adherence to ART. This result goes with the study done in Ethiopia that showed nonusers of addictive substances were more likely to adhere to ART than their counterparts. Drinking alcohol (AOR, 0.21; 95% CI: 0.07, 0.62) was also associated with poor adherence in the study done by Simoni et al. [7]. This might be due to the fact that addictive substance users are prone to forget their medication schedules and have impaired social life. ART disclosure status was significantly associated with good adherence to ART in the current study.

aids-clinical-curable-worshiping

Figure 4: Respondents believing HIV/AIDS is curable by worshiping and holy water, respectively.

This study also showed that patients with baseline CD4 count of less than 350 cells/ml were more likely to adhere to ART. This may be attributed to the focus of attention given by patients for they already experienced the illnesses. Health care workers also may give less attention for those patients who look apparently healthy.

The knowledge level of respondents was not adequate (72.3%), although it was not found to be statistically significant association with adherence. Similarly, the attitude of the respondents towards ARV drugs was favorable for 84% of them. This gap might have contributed for seeking other options than ART like worshiping (26.6%) and holy water (9.6%).

This study identified some patient characteristics (use of addictive substances, base line CD4 count more than 350/mm3 and being unmarried) that directly affects ART adherence. These set of patients need to be given special attention during adherence preparation.

Conclusion

The level of adherence to ART was very high (97.2%). Married respondents and those who do not use the addictive substance adhere more to ART. CD4 count less than 350 cell/mm3 and those respondents who disclosed their ART status had optimum adherence to ART. Moreover, significant proportions of patients believe that use of worshiping and holy water can cure HIV/AIDS. Health education should be provided for ART clients to increase their knowledge and attitude towards HIV/AIDS. The study finding showed optimal ART adherence in the region and this achievement should be maintained. The pre ART adherence preparation should be given due attention for day laborers, addictive substance users and unemployed people by all stakeholders. Also, the knowledge and attitude of the patients towards the course of HIV/AIDS should be given due emphasis.

Author’s Contribution

All the authors were responsible for the design and conduct of the study. Analysis, interpretation of findings and drafting of the manuscript were done by the authors. The authors have read and approved the final content of the manuscript.

Acknowledgement

We would like to thank RHB for financial support to conduct this study and for giving relevant enrichments of the research ideas. We also acknowledge AHMC for facilitating forthe research process. The study facilities, data collectors and supervisors are acknowledged for their unreserved cooperation without whom this study would not have been realized. Last but not least, we would like to extend our gratitude to our study participants.

Funding

This study was sponsored by ORHB.

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