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Some titanium containing apatite (TMA) ceramics prepared by wet synthesis was superior to Hydroxyapatite (HAp) ceramics of mechanical property and cutting performance. In this study, we investigated chemical reaction of TMA in a body environment. Each TMA or commercial Hydroxyapatite powder (HAp) was formed to circular pellets by uniaxial pressing. The specimens were heated in muffle furnace by conventional sintering process. Some TMA specimens were dispensed by alkali and heat treatment. After the treatments, the specimens were soaked in simulated body fluid (SBF: Kokubo’s solution) at pH 7.25 at 37.0°C up to 7 days. Before and after soaking in SBF, the surfaces of the samples were characterized by XRD, SEM, and ICP. After soaking in SBF for 7days, some particles were precipitated on the surface of HAp ceramics and TMA ceramics with alkali and heat treatment. Ti-containing in the crystal structure of HAp affected apatite formation in the body environment.