alexa Ashwagandha: Ancient Medicine for Modern Times | OMICS International
ISSN: 2329-8731
Journal of Infectious Diseases & Preventive Medicine
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Ashwagandha: Ancient Medicine for Modern Times

Abbas K Samadi*

Neutriomix, San Diego, CA, USA

*Corresponding Author:
Abbas K Samadi
Pathway Genomics, San Diego, CA, USA
E-mail: [email protected]

Received date: July 01, 2013; Accepted date: July 01, 2013; Published date: July 03, 2013

Citation: Samadi AK (2013) Ashwagandha: Ancient Medicine for Modern Times. J Anc Dis Prev Rem 1:e108. doi: 10.4172/2329-8731.1000e108

Copyright: © 2013 Samadi AK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Infectious Diseases & Preventive Medicine

Ashwagandha (Withania somnifera Dunal) is a popular Indian medicinal plant and has been used for over 3000 years in Ayurvedic medicine to treat diverse range of diseases. Ashwagandha is a member of the class of herbs called rasayana, long prized for rejuvenating effects on health. It is believed that it assists body to respond appropriately to stressors, both acute and chronic [1]. The plant was first mentioned in English language text by Van Rheede in 1868, who described the use of its leavesin home ointments. Other parts of the Ashwagandha plant, including roots, shoots, seeds, and berries have also been used in daily tonics and various home remedy recipes to increase health and longevity [2]. The plant is a source of unique alkaloids and withanolides that have been shown to act as steroidal hormones and antioxidants with favorable impacts on human health [3]. Several recent studies have provided evidence for its anti-stress, antioxidant, analgesic, anti-inflammatory, anti-cancer, cardioprotective adaptogenic, anti spasmodic,immunomodulatory and immunostimulant activity [4-10].

Withaferin A (WA) is the most abundant compound in W. somnifera extract [11,12]. Recent studies reported that WA elicits strong anti-cancer activity in several cancer models. WA by specific binding to vimentin cytoskeleton protein promotes apoptosis of cancer cells [13-15]. A classical epithelial mesenchymal transition (EMT) protein, vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition and reduced patient survival. Several reports show increased expression of vimentin in invasive human tumors but are nearly undetectable in non-invasive, stationary tumors [16,17]. WA has vimentin-dependent proteosomal inhibitory activity that leads to anti-angiogenic effects [18-20]. Furthermore, WA induces apoptotic cell death and anti-tumor activity by targeting NF-κB [21-23], JAK-STAT [24], reactive oxygen species (ROS) activation [25,26], ROS-mediated autophagy [27], annexin [28], proteasome [29], Hsp90 [30-32], endoplasmic reticulum stress [33], RET protooncogene [34], Bcl-2 [26], and Par-4 tumor suppressor protein [35].

W. somnifera is one of the most important herbs used as a traditional remedy for several illnesses. Withanolides from W. somnifera inhibited the growth of human cancer cells. Therefore, it can be postulated that the consumption of W. somnifera leaves as a dietary supplement may prevent or decrease the growth of tumors in cancer patients as well as the formation of new tumors. Clinical trials using purified withanolides including WA as single therapy or in combination with standard cancer therapy is suggested.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 12367
  • [From(publication date):
    October-2013 - May 21, 2018]
  • Breakdown by view type
  • HTML page views : 8520
  • PDF downloads : 3847
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7