alexa Benign Fibrous Histiocytoma Of Maxillary Gingiva | OMICS International
ISSN: 2161-1122
Dentistry

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Benign Fibrous Histiocytoma Of Maxillary Gingiva

George A*, Pynadath MK, Jayapalan CS, Noufal A, Manjunath GA and Nair RB

Department of Oral and Maxillofacial Pathology, MES Dental College, Perinthalmanna, Kerala, India

*Corresponding Author:
Antony George
Department of Oral and Maxillofacial Pathology
MES Dental College, Perinthalmanna
Malappuram District, 679338. Kerala, India
Tel: +919895889453
Email: [email protected]

Received date February 26, 2014; Accepted date March 26, 2014; Published date March 28, 2014

Citation: George A, Pynadath MK, Jayapalan CS, Noufal A, Manjunath GA, et al. (2014) Benign Fibrous Histiocytoma of Maxillary Gingiva. Dentistry 4:227. doi:10.4172/2161-1122.1000227

Copyright: © 2014 George A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Dentistry

Abstract

Background: Fibrohistiocytic lesions are heterogeneous group of mesenchymal tumours that are chiefly composed of fibroblastic and histiocytic elements. They occur commonly in the cutaneous soft tissue of the lower extremities and rarely in the non-cutaneous soft tissues of the head and neck.
Case Description: A 37yr old female reported with progressive difficulty in mouth opening. Intraoral examination revealed a large well-defined gingival swelling on the right maxillary tuberosity. The lesion had normal mucosal colouration, granular surface, was non-ulcerated, firm on palpation, and was not associated with tenderness or discharge.
Clinical Implication: Benign fibrous histiocytoma (BFH) are uncommon in the oral cavity but should be considered in the differential diagnosis of fibrous growth of gingiva and oral mucosa. Diagnosis of non-cutaneous BFH is difficult because of its non-specific clinical appearance, uncertain histogenesis, microscopic similarities, and lack of any specific immunohistochemical (IHC) marker. To the best of our knowledge this article describes the first case of BFH involving the maxillary posterior buccal gingiva. We also discuss the pathological and IHC characteristics of the lesion.

Keywords

Benign fibrous histiocytoma; Fibrohistiocytic; Noncutaneous; Maxillary; Gingiva; Immunohistochemistry; BFH

Introduction

Benign fibrous histiocytoma (BFH) are fibrohistiocytic tumours composed of biphasic cell population of fibroblasts and histiocytes [1-3]. The true histogenesis of this tumour is uncertain, and most authorities consider these tumours to be of fibroblastic differentiation without any relationship to true histiocytes [1-3]. World Health Organization (WHO) now recognizes the term “fibrohistiocytic” to merely denote a lesion that is composed of cells that resemble round histiocytic and spindled fibroblastic morphology [1-3]. BFH may originate in any part of the body [1,2]. They arise commonly in the sun-exposed cutaneous soft tissues of middle aged women [1,2]. About 1% of BFH arise in noncutaneous tissues, mainly in the deep tissues of the lower extremities [1,2]. BFH are uncommon in the head and neck region [1,2]. Skoulakis et al. states that on excluding fibrohistiocytic lesions of the facial bones, less than 10 cases of non-cutaneous BFH of the head and neck have been reported in the English literature [4]. BFH are rare in the oral cavity, with few reported cases in the buccal mucosa, vestibule, tongue, soft palate, jaw bones, floor of the mouth, and gingiva [1]. Arriving at a diagnosis of BFH is difficult as they appear clinically as non-specific, painless, solitary, slowly enlarging swelling that may affect the normal physiology and function of the area in which they arise [1,5]. The lesion is frequently reported after a scalpel-biopsy through a combination of light microscopic and immunohistochemical (IHC) examination. BFH has no known specific IHC marker and the diagnosis is usually based on absence of markers [1,4]. A search of English language medical literature returned a total of two case reports of BFH in the gingiva, both involving the lingual mandibular gingiva [3,5]. To the best of our knowledge this article describes the first case-report of BFH involving the maxillary posterior buccal gingiva. We also attempt to discuss the pathological and IHC characteristics of the lesion.

Case Description

A 37 year old housewife presented to our teaching and research institute with a three month clinical history of progressive difficulty in mouth opening. She was otherwise healthy and gave no relevant medical history of any systemic disease or medication. No clinical history of trauma to the jaw, surgical intervention, or any recent dental procedures were given. A physical and extraoral examination revealed no relevant abnormal findings. Tempero-mandibular joint (TMJ) examination elicited no tenderness, clicking, or any other relevant findings. Her interincisal mouth opening was measured as 29 mm. Intraoral examination revealed a poor oral hygiene index and a high caries index with multiple decayed teeth including root-stumps of upper and lower posterior teeth. Soft tissue examinations revealed a large well-defined gingival swelling of 2×3 cm on the buccal aspect of right maxillary tuberosity extending to the first molar. The gingival mass had normal mucosal colouration, had granular surface, was non-ulcerated, firm to palpation, and was not associated with tenderness or discharge. The adjacent second molar was grossly decayed with pulpal exposure and grade II mobility with pain on horizontal and vertical percussion. Cervical lymph nodes were not palpable. Investigatory orthopentograph revealed multiple decayed teeth with pulpal exposure and few with periapical pathology. No TMJ or associated bony pathology was identified. A clinical diagnosis of gingival fibroma obstructing coronoid movement was given. She was advised and underwent surgical excision of the gingival mass under local anaesthesia along with removal of right maxillary third molar root-stump and the second molar. Post surgically her chief complaint was resolved. The haematoxylin and eosin (H&E) stained histopathological sections showed a non-infiltrating fibrohistiocytic lesion with grenz zone in relation to an overlying stratified squamous surface epithelium. The lesion was chiefly composed of interlacing fascicles of spindle cells having plump and vesicular nucleus with tapered and blunt ends arranged in a storiform pattern (Figure 1). Focal areas of few pleomorphic cells, round histiocytes, lipid laden macrophages, lymphocytes, and multinucleated giant cells were noted (Figure 2). No necrosis was present and the mitotic count was less than one per 10 high-power fields. A provisional diagnosis of BFH, pleomorphic undifferentiated sarcoma, fibrosarcoma, neurofibroma, solitary fibrous tumour (SFT), and leiomyoma was made and the tissue-blocks were forwarded for immunohistochemical (IHC) studies to arrive at a confirmatory diagnosis. The tumour cells showed strong immunoreactivity for vimentin (Figure 3) and CD 68 (Figure 4), focal immunoreactivity for smooth muscle actin (SMA) (Figure 5), and negative immunoreactivity for desmin, S-100, and Ki-67. Based on the H&E and IHC findings a final diagnosis of BFH was made. After 18 months of periodic follow-up, the patient is asymptomatic with no evidence of tumour recurrence. A written informed patient consent was obtained to publish her clinical details and investigatory findings for academic advancement without revealing her personal identity.

dentistry-Histopathological-section

Figure 1: Histopathological section (10x magnification) - fibrohistiocytic lesion with interlacing fascicles of spindle cells arranged in storiform pattern.

dentistry-pleomorphic-spindle-cells

Figure 2: Histopathological section (40x magnification) - fibrohistiocytic lesion with few pleomorphic spindle cells, xanthoma cells, and multinucleated giant cells.

dentistry-immunoreactivity-vimentin

Figure 3: Immunohistochemistry - positive immunoreactivity to vimentin.

dentistry-Immunohistochemistry-positive

Figure 4: Immunohistochemistry - positive immunoreactivity to CD 68.

dentistry-focal-immunoreactivity

Figure 5: Immunohistochemistry - focal immunoreactivity of blood vessels to smooth muscle actin (SMA).

Discussion

BFH was not known as a clinical entity before 1960 because of confusion over the natural history of this fibrohistiocytic lesion [1,4]. Electron microscopic studies have shown two distinct cell types in these tumours. One end of the spectrum has cells resembling fibroblasts with organized lamellae of rough endoplasmic reticulum, few or no lipid droplets, and no phagolysosomes [2]. The other end of the spectrum has rounded cells resembling histiocytes with numerous cell processes, mitochondria, and phagolysosomes [2]. BFH is academically separated into (1) cutaneous type (synonym: dermatofibroma), that arise in the sun-exposed areas of the skin, and the rare (2) non-cutaneous type which arises in the deep soft tissues of the extremities [1,4]. The rare oral BFH tend to occur in middle-aged and older adults with a mean age of 40yr and a male-female ratio of 2.5:1 [5,6]. They clinically appear as painless slow growing mass that cause progressive changes at the involved site [5,6]. They vary in size from few mm to several cm and have shown a pre-operative duration of 3-12 months [5,6]. The tumour is usually associated with a history of antecedent trauma or chronic infection, suggesting a reactive disease [1-4].

Histopathologically BFH show a dual population of histiocytic and fibrous elements, with most researchers now believing that the histiocyte-like cells originate from undifferentiated mesenchymal stem-cells and are of fibroblastic origin [1-4]. BFH is characterised by cellular proliferation of spindle shaped fibroblasts with vesicular nucleus arranged in short intersecting fascicles of storiform pattern [1-6]. Round histiocyte-like cells, lipid-containing xanthoma cells, multinucleated giant cells, and scattered lymphocytes are frequently seen [1-6]. Our case showed similar microscopic features, with positive immunoreactivity for vimentin (Figure 3) and CD 68 (Figure 4) demonstrating that the lesion is composed of fibroblastic and histiocyte-like cells. The negativity for S-100 differentiated the lesion from neurogenic tumours, and the negativity for Ki-67 demonstrated that the lesion was not aggressive or proliferative. It is important to differentiate BFH from aggressive neoplasms including the more frequent undifferentiated pleomorphic sarcoma (synonym: malignant fibrous histiocytoma) and fibrosarcoma [5]. Undifferentiated pleomorphic sarcoma was excluded due to lack of pleomorphic sarcomatous cells, lack of typical and atypical mitotic figures, and lack of bizarre giant cells, necrosis, and prominent areas of haemorrhage [7]. Fibrosarcoma was excluded by the lack of obvious malignant features, invasive margins, and the characteristic herring-bone pattern [6]. SFT was excluded as they pathologically appear as monomorphic spindle cells organised into interlacing fascicles and ‘pattern-less’ pattern with hemangiopericytoma-like vascular spaces [8]. They show positive immunoreactivity to vimentin and negative immunoreactivity to desmin and SMA [8]. Our case showed SMA immunoreactivity for the blood vessels associated with the tumour, the true lesional cells showed negative immunoreactivity (Figure 5). We excluded AFH as it occurs in children and young adults, is characterized predominantly by sheets of histiocytic cells arranged in serpentine pattern having cystic areas of haemorrhage [2,9,10]. The lesion is characteristically surrounded by dense lymphocytic stroma and plasma cells, and lack giant cells and xanthoma cells [2,9,10]. According to Weiss et al. SMA may occasionally be positive in BFH and their sporadic immunoreactivity should not considered as evidence of smooth muscle neoplasm [2]. Leiomyoma was excluded as they have a more distinct fascicular arrangement with blunt-ended plumper nucleus and cytoplasm showing longitudinal striations corresponding to myofilamentous material [2]. They strongly express SMA unlike the focal immunoreactivity noted in BFH [2].

The treatment of choice for oral BFH is en-block surgical excision. The prognosis is good and is without recurrence when completely excised [4,5]. However, it is recommended to have regular periodic follow-up because of the difficulty in arriving at the diagnosis and of the few reported cases of recurrence, possibly due to inadequate margins of resection [4,5]. Our case underwent complete surgical excision and post 18 months follow-up the patient is asymptomatic.

Conclusion

We have reported the clinical, microscopic, and immunohistochemical aspects of non-cutaneous BFH afflicting the maxillary posterior buccal gingiva. Oral BFH mimics many clinical oral lesions and may often be misdiagnosed initially. It may represent a pathologist’s nightmare since the histopathological and morphological patterns are common to many other soft tissue tumours. As there are no known specific IHC marker BFH essentially represents a diagnosis of exclusion. Oral BFH are rare but it should be considered in the differential diagnosis of fibrous growth of gingiva and oral mucosa.

Authors Contributions

AG performed the pathological examination of the lesion and along with MKP was the major contributor in writing the manuscript. CSJ and AN contributed by reviewing the literature and helped in drafting the manuscript. GAM and RBN performed the surgical procedure and contributed to the expatiation of the clinical data. All the authors read and approved the final manuscript.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 12136
  • [From(publication date):
    May-2014 - May 21, 2018]
  • Breakdown by view type
  • HTML page views : 8303
  • PDF downloads : 3833
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7