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ISSN: 2471-2671
Archives of Surgical Oncology
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Benign Fibrous Histiocytoma of the Left Tenth Rib

Mehta M1*, Brown R2, Tsui A3 and Antippa P4

1Thoracic Fellow, Royal Melbourne Hospital, VIC, Australia

2Cardiothoracic Surgeon, Royal Melbourne Hospital, VIC, Australia

3Pathologist, Royal Melbourne Hospital, VIC Australia

4Lung Tumour Services, Royal Melbourne Hospital, VIC Australia

*Corresponding Author:
Marzi Mehta
Thoracic Fellow
Royal Melbourne Hospital
VIC, Australia
Tel: +61 393427000
E-mail: [email protected]

Received Date: March 17, 2017; Accepted Date: April 13, 2017; Published Date: April 20, 2017

Citation: Mehta M, Brown R, Tsui A, Antippa P (2017) Benign Fibrous Histiocytoma of the Left Tenth Rib. Arch Surg Oncol 3:123. doi: 10.4172/2471-2671.1000123

Copyright: © 2017 Mehta M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

We report a case of benign fibrous Histiocytoma of the left tenth rib in a 40-year-old man. CT revealed an expanding lesion with calcification. An open biopsy of the lesion was performed and subsequently wide surgical resection of the left 10th rib was performed. Histological diagnosis was consistent with benign fibrous Histiocytoma of the rib.

Keywords

Benign Fibrous Histiocytoma (BFH); Giant cell tumour; Plasmacytoma; Malignancy

Introduction

Benign Fibrous Histiocytoma (BFH) of the bone is a rare tumor which most commonly involves the wing of the ilium and long bones. Patients range from 5 to 75 years in age and no sex predilection has been noticed. Until recently BFH was considered to be a variant of metaphyseal fibrous defect (including fibrous cortical defect, non-ossifying fibroma etc.).

BFH of the rib is an extremely rare entity, and very few reports have been published in literature.

Case Presentation

We present a case of a 40 year old male with history of left sided chest pain for two months. He did not have any history of trauma. Local examination did not suggest any skin changes and there was no palpable mass. The diagnostic imaging (X ray chest and CT Thorax) was suggestive of a solitary expansile lesion of the left 10th rib. Computed Tomography (CT) scan of thorax revealed a well-defined lytic bone lesion.

The tumour originated from the middle portion of the left 10th rib. The lung fields, mediastinum, and pleura were normal. The remaining scan did not show any other obvious bony abnormality. The differential (Figure 1) diagnosis made on CT scan was: Giant Cell Tumour (GCT); Plasmacytoma; and Benign Fibrous Histiocytoma (BFH).

surgical-oncology-tomography-scan

Figure 1: Computed tomography scan of thorax showing a well-defined, expansile lesion of the left 10th rib with breach of periosteum at places.

He underwent biopsy of the rib lesion to confirm pathology and rule out a metastatic lesion. The biopsy was BFH of the rib for which he subsequently underwent resection of the left 10th rib. Part of 10th rib containing (Figures 2 and 3) the residual tumour (BFH) was excised by achieving a 2 cm margin on either side. Grossly the tumour showed two fragments of a rib 45 × 20 × 10 mm and 40 × 35 × 17 mm.

surgical-oncology-punctate-foci

Figure 2: The left 10th rib is expanded by a firm white grey tumour with punctate foci of haemorrhage.

surgical-oncology-storiform-architecture

Figure 3: The tumour has storiform architecture with a proliferation of fibro-histiocytic cells and some multinucleated giant cells.

Histology Findings

Sections of the bone show a moderately cellular spindle cell tumour It has storiform pattern. No long fascicles are seen. There is entrapped woven bone within the lesion, along with scattered osteoclast-type giant cells. A breach of the cortex by tumour is identified but there is no local destruction of the adjacent soft tissue. The tumour cells have ovoid nuclei with no nuclear pleomorphism [1]. The cytoplasm is ill-defined and elongated. Mitoses are inconspicuous. No necrosis is noted. The stroma contains hemosiderin -laden macrophages. There is no evidence of malignancy. The tumour cells are smooth muscle actin and focally CD10 positive. The Ki-67 index is less than 1%. They are CD34, CD68, factor XIIIa and B-catenin negative. The features are those of Benign Fibrous Histiocytoma (BFH) of bone.

Discussion

Benign Fibrous Histiocytoma (BFH) of the bone is an uncommon entity and its occurrence in the rib being extremely rare [1,2]. Very few cases of benign fibrous Histiocytoma of the rib have been documented in literature (probably less than ten) [3].

Benign fibrous Histiocytoma is a condition of the bone, which does not have any specific age incidence, expect for the fact that it generally occurs in individuals greater than 20 years of age [4]. Differing opinion exists amongst pathologists as to the exact etiogenesis of the tumours. Opinions vary between calling it a true neoplasm, a developmental defect, or a reactive process.

The most common site involved is the Ilium, followed by the femur, the vertebrae, and tibia [5]. The importance of differentiating between Non Ossifying Fibroma (NOF) and BFH lies in the fact that BFH has a tendency to recur after curettage, while NOF does not. Additionally BFH has been known to behave in an aggressive manner with a potential for local spread and distant dissemination.

Clinically, it may be picked up as an asymptomatic finding while being investigated for other pathologies or patients report pain from the lesion, often of months or years duration [6]. Pain may be associated with pathological fracture. There may be some local tenderness, but no swelling or mass is seen, and there are no systemic symptoms. There is normally no impairment of the function of the nearby joint.

X ray image may show a lytic, loculated appearance with prominent sclerosis of the edges of the lesion. There is no matrix mineralization.

The zone of transition of the lesion is narrow. Cortical expansion and soft tissue invasion are rarely seen. On MRI scans, there is central low signal intensity with a surrounding rim of high signal on T1, and more uniform but somewhat variegated high signal intensity on T2 sequences, with the surrounding sclerotic bone having low signal intensity. Treatment options for benign fibrous Histiocytoma include wide resection of the tumour or curettage [7] and bone grafting.

Benign fibrous Histiocytoma is microscopically identical to metaphyseal fibrous defect, non-ossifying fibroma but benign fibrous Histiocytoma is usually seen in older age group and have low recurrence rates [8-10]. Occurrence of benign fibrous Histiocytoma of the rib is a very rare occurrence [11,12]. CT scan shows a moderately irregular lytic area with a prominent trabecular pattern and surrounding sclerotic bone [13].

Case reports still have a place in publication on account of their importance for clinical education and training of healthcare professionals. This rare case of benign [14,15] fibrous Histiocytoma being the case in point.

References

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