alexa Bioprospecting and Drug Development, Parameters for a Rational Search and Validation of Biodiversity | OMICS International
ISSN: 1948-5948
Journal of Microbial & Biochemical Technology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Bioprospecting and Drug Development, Parameters for a Rational Search and Validation of Biodiversity

Juan B*


Bioprospecting Development and Consulting, Bogotá, Colombia

*Corresponding Author:
Juan B
Bioprospecting Development and Consulting
Bogotá, Colombia
E-mail: [email protected]

Received date: January 04, 2017; Accepted date: January 10, 2017; Published date: January 17, 2017

Citation: Juan B (2017) Bioprospecting and Drug Development, Parameters for a Rational Search and Validation of Biodiversity. J Microb Biochem Technol 9:e128. doi:10.4172/1948-5948.1000e128

Copyright: © 2017 Juan B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Microbial & Biochemical Technology


Bioprospecting describe the procedure of exploration, extraction, screening and trading of new products using biological diversity as source. Bioprospecting process is a multidisciplinary enterprise that involves various research actors and scientific subjects. Also a bioprospecting program investigates the indigenous understanding about practices and characteristics of medicinal plants and animals as well as the search for formerly unidentified compounds in natural sources that have never been used in folk medicine. The aim of this editorial is to give a rational approach for design a bioprospecting program for drug development, useful for to initiate a search on the primary screening of new drugs from biodiversity.


Bioprospecting; Drug development; Biodiversity


Natural products (NP) are defined as all substances produced by living organisms that include secondary metabolites defined as compounds produced by biological processes that are not necessary for primary or energy metabolism, but are important for ecological fitness. These molecules have been developed by the evolutionary pressure on biosynthetic pathways which results in a large and exuberant chemical diversity with potent biological activity [1] with high impact on chemical biology and pharmaceutical industry [2,3]. NPs are obtained from biological diversity defined in Article 2 of the Convention on Biological Diversity as “The variability among living organisms from all sources including, inter alia, terrestrial, marine, and other aquatic ecosystems and the ecological complexes of which they are part; this includes diversity within species, between species and of ecosystems” [4].

The prospective study of biodiversity looking for applications in agriculture, industry and medicine; known as bioprospecting, is defined as the process of looking for in natural sources new promising genetic resources and bioactive compounds as well as organisms with biotechnological uses [5]. In this way, NPs have important contributions in drug discovery as acetylsalicylic acid (ASA) (painkiller derived from willow bark, Salix alba), reserpine (antihypertensive from Rauwolfia serpentina, known as Indian snake root), d-tubocurarine (muscle relaxant used in anesthesia from Chondrodendron tomentosum), artemisin (derived from Artemisia annua used as an anti-malarial agent) and vincristine and vinblastine (anti-cancer drugs derived from Catharanthus roseus) [5].

Bioprospecting is constituted as scientific and economic activity with a high impact on sustainable development and poverty reduction as well as economic growth for developing countries. Because the establishment biodiversity based industries produce social appropriation of knowledge showing the benefits and applications of biodiversity [6]. Also, the revenue from royalties represented by the development of new medicines (have been estimated that a successful drug can generate $1 billion per year) derived from natural sources contribute to the conservation of biodiversity in mega diverse countries as well as the protection of traditional medical knowledge [7].

Also, bioprospecting programs have been reinforced by the emergence of metabolomics as scientific discipline specialized in to measure the dynamic metabolic response of living systems to biological stimuli or genetic manipulation is an important tool in the new trends in drug discovery from NPs. In this way, metabolomics seeks an analytical description of secondary metabolites production focused in the following areas: quantification of metabolites, obtention of metabolic profiles of compounds related to different metabolic pathways, development of a metabolomic fingerprinting that classify the biological sample and correlation of metabolite production with a specific genomic sequence [8,9].

Equally a rational bioprospecting program have to include new approaches that can improve the application of promising NPs in medicine, industry and agriculture, that is the case of nanotechnology which is an emerging and multidisciplinary field that integrate techniques and tools from biology, engineering, chemistry and medicine. In this order of ideas nanotechnology have been applied to design novel drug delivery systems (NDDS) for NPs, with the end of increase the bioavailability without adverse effects (increasing the therapeutic effect), as well as the treatment compliance and reducing the repeated administration [10,11].

Finally, a successful bioprospecting program depends of the clarification of several parameters and their coherent combination (Table 1). A correct and functional construction of bioprospecting efforts in mega diverse countries must be the result of a multidisciplinary study in where the principal aim is the sustainable growth of the communities in the benefit of the ecosystems conservation and the public health impact of the developed products.

Global health issues Sources Parameters of species selection Complementary approaches Products to obtain in a bioprospecting program
Terrestrial Antimicrobial resistance Plants Ethnopharmacology Metagenomics Pharmaceuticals
Freshwater origin Cardiovascular diseases Fungi Chemotaxonomy Protemics Chemical scaffolds
Marine Cancer Animals Ecological chemistry Metabolomics Bioprocesses
Polar regions Malnutrition Algae Random search Combinatorial chemistry Formulations
Extreme environments Mental diseases Insects Bioassay-guided isolation Medicinal chemistry Genetic modified organisms
  Pollution Ciliates   Organic synthesis  
  Emerging infectious diseases Bacteria      
    Microbial endophytes      
    Marine organisms      

Table 1: Parameters for to be considered in a rational bioprospecting program.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 1974
  • [From(publication date):
    February-2017 - Jun 21, 2018]
  • Breakdown by view type
  • HTML page views : 1796
  • PDF downloads : 178

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7