Reach Us +44-1202-068036
Brain Structural and Functional Changes in Cocaine Users during Abstinence | OMICS International
ISSN: 2329-6488
Journal of Alcoholism & Drug Dependence
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Brain Structural and Functional Changes in Cocaine Users during Abstinence

Suchismita Ray*

Center of Alcohol Studies, Rutgers, The State University of New Jersey, USA

*Corresponding Author:
Suchismita Ray
Center of Alcohol Studies, Rutgers, The State University of New Jersey
607 Allison Road, Piscataway, NJ 08854, USA
Tel: 848-445-9391
Fax: 732-445-3500
E-mail: [email protected]

Received date: October 14, 2016; Accepted date: October 17, 2016; Published date: October 24, 2016

Citation: Ray S (2016) Brain Structural and Functional Changes in Cocaine Users during Abstinence. J Alcohol Drug Depend 4:e134. doi:10.4172/2329-6488.1000e134

Copyright: © 2016 Ray S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Visit for more related articles at Journal of Alcoholism & Drug Dependence



Stimulant abuse, particularly cocaine abuse is an important public health concern, as according to 2013 National Survey on Drug Use and Health (SAMHSA, 2013) [1], there are 1.5 million current cocaine users in the United States and costs to the society for drug abuse including cocaine abuse are calculated to be $62 billion (NDCS, 1997) [2]. Utilizing brain imaging techniques and neuropsychological tests, earlier studies have shown reduced anterior and posterior cingulate activation, attenuated inferior frontal and dorsolateral prefrontal cortex activation and altered posterior parietal activation, and impaired learning, memory, attention, reaction time and cognitive executive function in chronic cocaine users [3-5]. Long-term stimulant abuse has been associated with brain’s structural abnormalities [6,7], as well as functional abnormalities characterized in terms of an enhanced neural reactivity to appetitive drug cues [8-12] enhanced neural response during craving [10], and an impaired neural response in paradigms that measure cognitive control [13-16]. A continuing problem with cocaine dependence is that the majority of cocaine users will frequently resume drug use after a period of abstinence [17]. However, there is relatively little empirical research on how the brain’s structural and functional abnormalities change while a stimulant user maintains drug abstinence.

Studies using Diffusion Tensor Imaging (DTI; Beaulieu, 2002) [18] technique have shown that current users of cocaine have reductions in white matter (WM) integrity compared to controls [19,20]. However a fundamental question is whether these white matter differences are present following abstinence from cocaine use. To address this question, a limited number of DTI studies have been conducted that utilized a cross sectional design [21-23]. For example, Bell et al. [21] examined WM integrity in cocaine-abstinent individuals and nonusing controls. Cocaine-abstinent individuals showed lower fractional anisotropy (FA) in the left anterior callosal fibers, left genu of the corpus callosum, right superior longitudinal fasciculus, right callosal fibers and the superior corona radiata bilaterally compared to controls. Differences between the cocaine abstinent sub-groups were observed bilaterally in the inferior longitudinal fasciculus, right anterior thalamic radiation, and right ventral posterolateral nucleus of the thalamus, left superior corona radiata, superior longitudinal fasciculus bilaterally, right cingulum and the WM of the right precentral gyrus. Similarly, Xu et al. [23] found that the long-term abstinence group had significantly higher FA than the short-term abstinence group in corpus callosum, frontal, parietal, temporal, occipital and cerebellar regions. Using structural MRI analyzed with voxel based morphometry (VBM). Hanlon et al. [22] showed that the one-month abstinent cocaine users had significantly higher gray matter density than current cocaine users in neocortical areas including the frontal and temporal cortex. Using a VBM technique, a reduced gray matter volume in the prefrontal cortex, lateral and medial aspects of the orbitofrontal cortex and right cingulate gyrus in 20-day abstinent cocaine users compared to controls was reported by Matochik et al. [24]. Thus, although a limited number of cross sectional studies have examined structural changes in abstinent cocaine users, no longitudinal data exist on this topic. The cross sectional studies are limited in that they fail to reveal if the structural and functional brain changes in substance users during abstinence are due to dynamic intra-individual changes that characterize successful abstinence, or if they manifest pre-existing differences between substance users.

A more recent focus of neuroimaging studies is understanding not just which individual brain areas are activated by a cognitive task, but how individual brain regions are integrated, i.e., functional connectivity. Functional connectivity has been examined in current cocaine users in the resting state [25-28] as well as while they performed a finger-tapping and an attention task [22,29]. However, earlier studies on functional connectivity in individuals who have abstained from cocaine use are limited with only a handful of imaging studies examining this topic [30-32]. For example, Adinoff et al. [30] assessed alterations in regional cerebral blood flow (rCBF) and related resting state functional connectivity (rsFC) to prospectively predict relapse in cocaine users following treatment for cocaine use disorder. Results showed an enhanced rCBF only in the left posterior hippocampus in the group who relapsed compared with the early remission (Individuals who did not use cocaine within 30 days following discharge) and control groups. Also, the left posterior hippocampus had an increased rsFC strength with the posterior cingulate cortex/precuneus in the relapsed versus early remission subgroups. Differences in measures of intrinsic connectivity during functional magnetic resonance imaging (fMRI) stroop performance were examined by Mitchell et al. [32]. Results demonstrated a relatively greater intrinsic connectivity in the ventral striatum, putamen, inferior frontal gyrus, anterior insula, thalamus and substantia nigra for abstinent cocaine users compared to controls.

To date, only two fMRI effective connectivity studies which reveal the influence that one brain region exerts over another have been conducted with cocaine users. Effective connectivity studies provide enhanced information on the consequences of chronic drug use on the brain compared to functional connectivity studies. My colleagues and I have assessed effective connectivity among brain regions while chronic cocaine users viewed cocaine-related picture cues (Ray et al. [33]). And Ma et al. [34] examined effective connectivity in cocaine users during an immediate and delayed working memory task. I am not aware of any effective connectivity study involving abstinent cocaine users. Thus, although a few studies have examined functional connectivity in cocaine-dependent individuals who are abstinent, no studies implemented a longitudinal design.

In order to move the field forward, I propose that a longitudinal fMRI study should be conducted to examine dynamic structural and functional changes in treatment-seeking abstinent cocaine dependent individuals by scanning them at multiple time points during abstinence. Structural and functional brain changes should be examined using structural, functional and effective connectivity analysis approaches. Specifically, the focus should be on the cognitive control network (CCN) [35] which have been associated with impulsive drug seeking behaviour. This study may have implications to develop therapies that have potentials to change the neuroplasticity within the CCN which may promote abstinence from cocaine use.


This research was supported by a National Institute on Drug Abuse grant (K01DA029047) to Dr. Suchismita Ray.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 8761
  • [From(publication date):
    October-2016 - Jan 19, 2019]
  • Breakdown by view type
  • HTML page views : 8687
  • PDF downloads : 74

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version