Can Nutraceuticals a Day Keep the Doctor Away?
Received Date: Feb 11, 2019 / Accepted Date: Feb 13, 2019 / Published Date: Feb 18, 2019
'’So where do we go from here? Well, I think, again I'm not sure, that the quest to demonstrate whether chronic administration, long‐term diet, long‐term supplementation, can prevent serious diseases like cancer, heart disease, dementia, arthritis has come to an end’’. -Stephen L. DeFelice, 2014; said the man who lectured about the term ‘Nutraceutical’ in a scientific session 2014 . The reputation of the Nutraceuticals and its evidence of efficiency is vague and every so often conflicting because of their meagre trial designs and inflated popularity for profitable drives [2,3].
Stephen DeFelice a renowned physician, the founder of ‘Foundation for Innovation in Medicine’ (FIM; Cranford, NJ, USA) coined the term 'Nutraceutical' in 1989 and defined Nutraceuticals as “a food or portion of a food substance that delivers health or medical benefits, which includes the treatment as well as the prevention of occurrence and progression of disease .
Various nutraceuticals tested or being tested
|Soy protein (genistein)||Coronary heart disease (reduces low-density lipoproteins)||Yes||–|
|Omega-3 oil||Coronary heart disease||Yes||–|
|Black cohosh||Menopausal hot flashes (serotonin modulation)||–||Yes|
|Stanol/sterol esters||Coronary heart disease (reduces low-density lipoproteins)||Yes||–|
|Soy isoflavones||Breast, prostate and bone cancer||Yes||–|
|Phytoestrogens||Cognition in post-menopausal women||Yes||–|
|Cranberry||Urinary tract infections||Yes||–|
|Red clover||Hormonal actions||Yes||–|
|Chasteberry (vitex)||Menstrual disorders||–||Yes|
|Black haw (Virburnum prunifolium)||Premenstrual tension||–||Yes|
|Chinese mushrooms||Prostate and bladder cancer||Yes||–|
Table 1: List of various Nutraceuticals tested or being tested.
Source of Nutraceuticals
Commonly used Nutraceuticals are Curcumin which is extracted from the Indian spice turmeric, GAGs (Glucosamine Sulfate, Chondroitin Sulfate, and Hyaluronic Acid), ASU (Avocado/soy unsaponifiable (ASU) are plant extracts with a sterol-rich hydrolyzed lipid fraction that is extracted from soybean, avocado. Bioflavonoids,phytoflavonoids are polyphenols components that are extracted from vegetables and plants. Bromelain and ginger are obtained from immature fruits of pineapple and stems (Table 1).
Recently Nutraceutical interventions are used as a tactical means for prevention and management of geriatric diseases like osteoarthritis, Alzheimer’s because of its risk-benefit ratio, low cost. Furthermore, the recent research data reveals the fact that this kind of intervention ropes not only functional improvement, clinical symptoms, but also it helps in disease regression .
As we are in the era where the treatments are expensive and are incessantly increasing, the Nutraceuticals approaches have evolved as a novel, more effective and inexpensive intervention technique. The use of these agents can be increased by the appropriate formulations, improvised knowledge of selected Nutraceuticals with inclined bioavailability will certainly widen, the existing large group of population using the Nutraceuticals. Nevertheless, evidence-based data regarding the usage and its effects on the body systems is still deficient. More clinical trials are required to illuminate their role and ideal way and dosage administration are still needed to be studied.
- DeFelice SL. Nutrition stymied: The neutraceutical solution. Plenary Lecture September 9, 2014. XXV National congress of the Italian chemical society‐SCI‐The University of Calabria.
- Schmitt J, Ferro A (2013) Nutraceuticals: Is there good science behind the hype? Br J Clin Pharmacol 75: 585-587.
- Ioannidis JP (2013) Implausible results in human nutrition research. BMJ 347: 6698.
- Vicki BA (2005) Nutraceutical a day may keep the doctor away. EMBO Rep 6: 708-711.
- Paola C, Francesca M, Carla L, Houda N, Marta A, et al. (2016) Neutraceutical supplements in the management and prevention of osteoarthritis. Int J Mol Sci 17: 2042.
Citation: Divya R, Ashok V, Rajajeyakumar M (2019) Can Nutraceuticals a Day Keep the Doctor Away?. Altern Integr Med 8: e122. DOI: 10.4172/2327-5162.1000e122
Copyright: © 2019 Divya R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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