alexa Commentary on Covalent Tethering of Photo-responsive Superficial Layers on Hydrogel Surfaces | OMICS International
ISSN: 2379-1764
Advanced Techniques in Biology & Medicine
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Commentary on Covalent Tethering of Photo-responsive Superficial Layers on Hydrogel Surfaces

Lie Chen1 and Mingjie Liu1,2*

1Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China

2International Research Institute for Multidisciplinary Science, Beihang University, Beijing, 100191, P. R. China

Corresponding Author:
Mingjie Liu, Professor
Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education
School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China
E-mail: [email protected]

Received date: June 01, 2017; Accepted date: June 14, 2017; Published date: June 21, 2017

Citation: Chen L, Liu M (2017) Commentary on Covalent Tethering of Photoresponsive Superficial Layers on Hydrogel Surfaces. Adv Tech Biol Med 5:229. doi:10.4172/2379-1764.1000229

Copyright: © 2017 Chen L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Advanced Techniques in Biology & Medicine

Hydrogels are widely used in the field related to biological medicine, such as drug carrier and drug delivery vehicle due to their excellent biocompatibility [1]. In the last two decades, hydrogels with diverse stimuli responsiveness were developed and utilized to construct the controlled release systems. However, conventionally strategies that are reported to prepare stimuli-responsive hydrogels usually suffer from complex preparation procedures [2-4] and the using of sol-gel transition process of the hydrogel to realize the controlled release would inevitably lead to the burst release [5-7]. Overcoming these limitations, we report a post-modified hydrogel with photo-controlled release property by covalent tethering of photo-responsive superficial layers on hydrogel surfaces in Chemical Science [8].

Despite the great efforts in the development of controlled release of hydrogels, the fabrication of stimuli-responsive hydrogels for controlled release without changing the intrinsic superhydrophilicity and biocompatibility of the hydrogel network remains challenging. The focus for us is the development of superhydrophobicity on hydrogel surfaces, creating asymmetric wettability across the surface and the inner network. To achieve this goal, the n-alkylation reaction is introduced in our work to modify hydrogel surfaces. By taking advantage of the oil/ water repulsive interaction, the surface modification was confined at the hydrogel/oil interface. The introduction of photo-responsive molecule 1-(4-Iodobutyl)-3,3-dimethylindoline-6-nitrobenzospiropyran (IBSP) as modifier endows the as prepared hydrogel with photo-responsive tunable surface wettability.

The as prepared IBSP-modified hydrogel was superhydrophobic. “It was supposed that the superhydrophobicity of the hydrogel was attributed to its surface composition and surface roughness”, explains in the original article. Besides, the IBSP was not just formed a monomolecular layer on hydrogel surfaces after modification as we through. The results showed that a photo-responsive superficial layer with limited thickness (within 1.3 μM) was formed on the hydrogel surfaces, which was explained as “The oil phase (dichloromethane) used in this work was not perfectly immiscible with water and give rise to the modifiers dissolved in oil being able to penetrate into the hydrogel and graft onto the polymer network.”

This superhydrophobic photo-responsive superficial layer that generated on hydrogel surface showed significant influence on diffusion and exchange of substances across the surfaces of hydrogel. Most importantly, the IBSP-modified hydrogel was demonstrated can be used as drug carrier for controlled release, from which the diffusion rate of substances can be controlled by light illumination.

It is worth to point out that the method used in this work is a universal strategy to functionalize the surfaces of synthetic hydrogels [9]. Consequently, the development of other functional modifiers will further broaden the list of functional hydrogel and expand into diverse complicated biomedical and practical applications that may not be appropriate for the classical homogeneous bulk hydrogel.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 235
  • [From(publication date):
    July-2017 - Dec 13, 2017]
  • Breakdown by view type
  • HTML page views : 200
  • PDF downloads : 35
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version