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Commentary on Visual Acuity, Contrast Sensitivity and Color Vision Three Years after Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma | OMICS International
ISSN: 2155-9570
Journal of Clinical & Experimental Ophthalmology

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Commentary on Visual Acuity, Contrast Sensitivity and Color Vision Three Years after Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma

Irena Tsui, Tara A McCannel, and Bradley R. Straatsma*
Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA
*Corresponding Author : Bradley R. Straatsma
Jules Stein Eye Institute, 100 Stein Plaza
UCLA, Los Angeles, CA 90095-7000, USA
Tel: (310) 825-5051
Fax: (310) 206-4293
E-mail: [email protected]
Received: January 30, 2016 Accepted: January 30, 2016 Published: February 02, 2016
Citation: Tsui I, McCannel TA, Straatsma BR (2016) Commentary on Visual Acuity, Contrast Sensitivity and Color Vision Three Years after Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma. J Clin Exp Ophthalmol 7:520. doi:10.4172/2155-9570.1000520
Copyright: © 2015 Tsui I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Commentary
This prospective interventional case series of 37 patients (37 eyes) that received iodine-125 brachytherapy for choroidal and ciliary body melanoma reports best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy. The 37 patients (19 men and 18 women) with a mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years after and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20/32), 65 letters (20/50), 56 letters (20/80) and 47 letters (20/125); contrast sensitivity of 30, 26, 22 and 19 letters; and color vision of 26, 20, 17 and 14 test figures, respectively (Table 1). Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from baseline at 1 year, at 2 years and at 3 years after brachytherapy. Greater decrease in visual acuity 3 years after brachytherapy was associated with midchoroid and macula melanoma location, ≥ 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy.
In this study, assessment of best-corrected visual acuity was systematically combined with contrast sensitivity and color vision measurement to document the extent of central vision impairment following brachytherapy for choroidal and ciliary body melanoma. Snellen visual acuity alone is insufficient for full understanding of visual performance [1-3]. Decrease in contrast sensitivity and color perception measure distinctly different properties of vision and combine with impairment of visual acuity to interfere with activities of daily living such as mobility at low levels of illumination, perception of stairs and curbs, driving, reading, using tools and sewing.
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Review summary

  1. V. Zhydomov
    Posted on Jul 15 2016 at 4:45 pm
    The article reports a case series of 37 patients that were treated with iodine-125 brachytherapy for choroidal and ciliary body melanoma. The assessment of the recovery was done up to a period of 3 years. The visual activity, contrast sensitivity and color perception was studied and it was found that there was an overall impairment of visual activity due to brachytherapy. The patients faced many difficulties in carrying on their daily activities at low levels of illumination.

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