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Surgery: Current Research
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Current Advances for Aesthetic Improvement in Breast Reconstruction: Mimicking the Augmented Breast

Katherine A Rodby1, Karina P Quinn1, Babak Mehrara2 and Anuja K Antony1*

1Division of Plastic, Reconstructive and Cosmetic Surgery, University of Illinois at Chicago, Chicago, IL, USA

2Memorial Sloan-Kettering Cancer Center, New York, NY, USA

*Corresponding Author:
Anuja K Antony
Director of Breast Reconstruction
Division of Plastic and Reconstructive Surgery
University of Illinois at Chicago, Chicago, IL 60601, USA
Tel: 312-996-9313
Fax: 312-413-0496
E-mail: [email protected]

Received date: June 11, 2014; Accepted date: July 30, 2014; Published date: August 01, 2014

Citation: Rodby KA, Quinn KP, Mehrara B and Antony AK (2014) Current Advances for Aesthetic Improvement in Breast Reconstruction: Mimicking the Augmented Breast . Surgery Curr Res 4:202. doi:10.4172/2161-1076.1000202

Copyright: © 2014 Rodby KA et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Women seeking implant-based breast reconstruction increasingly request a round, projecting breast with an amplified upper pole that mimics the augmented breast. Two-stage reconstruction provides the opportunity to recreate a well-defined inframammary fold (IMF) with ptosis, to modify final implant characteristics (volume upsizing, high profile, gel implants) and correct contour irregularities with lipofilling at exchange to achieve this desired outcome. Methods/Technique: All patients completing two-stage breast reconstruction were added prospectively into a database. Patient demographics, oncologic phenotype and treatment, surgical details including IMF reconstruction, implant characteristics, and outcomes were reviewed. 2D and 3D photos and intraoperative videography were captured, further illustrating the technique. Results: 84 two-stage breast reconstructions were completed in 50 women between 5/2010– 11/2013. Mean age at the time of mastectomy was 42.8 years and mean BMI was 30. At the time of exchange, the majority of implants were typically upsized from the final expansion volume, with a volume increase ranging from 10-150cc (mean increase 46cc). Mean expander fill volume and final implant volume were 595cc and 618cc respectively. Fifty-nine reconstructions (70%) included inframammary fold reinforcement. Sixty-eight (81%) of reconstructions utilized high profile or extra-high profile implants. Selective use of fat grafting was implemented later in the series. Conclusion: Current advances in two-stage implant based breast reconstruction are outlined to achieve upper pole fullness, anterior projection of the breast, and definition of the inframammary fold. These strategies afford reconstructive outcomes that parallel the desired aesthetic features of the augmented breast.

Keywords

Two-stage reconstruction; Inframammary fold suspension; Aesthetic breast reconstruction; Tissue expander reconstruction

Introduction

Aesthetic breast reconstruction after mastectomy impacts a woman’s post-surgical confidence, sexuality, and overall well-being [1]. With increased patient awareness, expectations after breast reconstruction have increased manifold and assimilated towards that of the post-augmentation breast. The mainstay of breast reconstruction continues to be two stage tissue expander/implant (TE/I) based reconstructions, with aesthetic results hinging upon the creation of a natural breast shape with upper pole fullness, lower pole ptosis, and a well-defined inframammary fold (IMF) [2,3]. However, many surgeons fail to adequately address second stage procedures or the reconstruction process overall that can help achieve improved cosmesis [2,3].

Aesthetic breast reconstruction encompasses several aspects of breast symmetry and profile, including projection, ptosis, sulcus location, and lack of skin irregularities [3]. Adequate IMF reconstruction requires precise capsulotomy placement, tissue recruitment and dermal suspension to restore the blunted or eradicated fold. While IMF re-suspension is critical to achieve a natural breast shape, additional techniques to improve upper pole fullness, with creation of a round and projecting breast may be as important to achieve a successful reconstruction in patients desiring a construct which mimics the augmented breast. The exchange procedure in two-stage reconstruction provides the opportunity to modify final implant characteristics via upsizing volume and employing high profile, silicone implants to achieve the desired outcome. This paper describes current advances in aesthetic techniques utilized in a consecutive patient series, which focuses on two- stage reconstructions to simulate an augmented breast result.

Patients and Methods

Between May 2010 and November 2013, 84 consecutive two-stage breast reconstructions were completed in 50 women at the University of Illinois at Chicago and Mount Sinai Medical Center. All patients undergoing breast reconstruction were added prospectively into a database, recording patient demographics, oncologic phenotype, adjuvant treatment, reconstructive details, tissue expander and implant characteristics, and outcomes. Patients undergoing tissue expander reconstruction were identified; however, only those patients who completed second stage reconstruction were included in the analysis.

Over a period of 46 months, 84 two-stage breast reconstructions were completed in 50 patients by the senior author (AKA). At the time of exchange, 59 reconstructions (70%) included inframammary fold reinforcement. At the time of mastectomy, mean age was 42.8 years old (range 23-63) and mean BMI was 30 (range 20-42). (Table 1) Thirty four patients elected to have bilateral mastectomies while 16 patients proceeded with unilateral mastectomies. Indications for mastectomy included prophylaxis to Stage 3B breast cancer. The majority of reconstructions were immediate (73 breasts) while nine patients (11 breasts) were delayed. For non-surgical oncologic treatment, seven patients (14%) received neoadjuvant chemotherapy, 24 patients (48%) received adjuvant chemotherapy, and 18 patients (36%) received radiation to the diseased breast.

Patients 50
Breast Reconstructions 84
Inframammary Fold Re-suspension 59 (70%)
Age 42.8
Ethnicity  
African American 28 (56%)
Caucasian 12 (24%)
Hispanic 9 (18%)
Asian 1 (2%)
Oncologic Treatment  
Bilateral Mastectomy 34 (68%)
Unilateral Mastectomy 16 (32%)
Neoadjuvant Chemotherapy 7 (14%)
Adjuvant Chemotherapy 24 (48%)
Radiation Therapy 18 (36%)

Table 1: Patient Demographics.

Surgical Technique

Immediate or delayed reconstruction was performed with Style 133MV textured tissue expanders (Allergan Inc, Irvine, CA) with inferolateral support via 1) total musculofascial coverage, 2) acellular dermal sling or 3) a latissimus flap if inadequate skin coverage due to radiation or scarring.

In the preoperative holding area, standard markings of the vertical midline, upper breast pole, and proposed and current inframammary fold position were performed with the patient standing. The expander is removed via excising the mastectomy scar, performing a limited elevation of the mastectomy flaps above the pectoralis muscle, and incising the pectoralis perpendicular to this incision, along the direction of the muscle fibers. A superior capsulotomy is completed in the supine position at the capsule reflection with re-elevation of the adherent pectoralis major. This allows the upper pole to fill with the upsized implant and drapes the skin over the superior portion of the implant, minimizing post-mastectomy contour defects.

The patient is then placed in the sitting position, and capsulotomies are carried out at the inferior, medial, and lateral aspects. Upright patient positioning is critical to promote accurate capsulotomy placement. The medial and limited lateral capsulotomies are placed 1-2 cm anterior to the reflection to support forward movement of the breast construct while maintaining the capsular edge to prevent medial and lateral implant dislodgement.

Complete IMF reconstruction requires an inferior capsule release, and the capsulotomy is placed with the intent to accurately reposition the IMF at the proposed level. It is critical to correctly position the inferior capsulotomy so that a dermal-capsule suture suspension can be performed without the need for suturing to the periosteum. Shifting the capsulotomy higher on the posterior segment effectively moves the IMF superiorly on the chest wall, while a more anterior capsulotomy shifts the dermal-capsular suspension of the IMF inferiorly. The inferior release includes parallel scoring with respect to the IMF, which continues into the fat of the anterior abdominal tissue and lower breast pocket to recruit additional breast ptosis as needed. At the inferior capsulotomy, the inferior edge of the posterior capsule is suspended to the dermis using 2-0 silk sutures. Silk sutures are placed (beginning at the midpoint and extending both medially and laterally with a slight curve) to recreate the IMF until the internal flap suspension demonstrates accurate contour and ptosis (Figure 1).

surgery-current-research-inframammary

Figure 1: Lateral placement of the inframammary fold suspension sutures

A saline sizer is used to estimate the optimal volume and projection. Final placement of any additional silk sutures can be carried out until desired symmetry and definition is achieved (Figure 2). The IMF should develop a dimpled appearance initially if the sutures are placed at the appropriate dermal level (Figure 3). The chest is reprepared and the silicone implants, prepared with antibiotic irrigation and placed with minimal handling, are selected based on the intraoperatively determined saline sizer volume (upsized when compared to the tissue expander volume) to assist with breast projection and upper pole fullness. Selection of higher projection implants will improve anterior projection and upper pole fullness. Muscle, subcutaneous tissues and skin are closed in a layered closure with 2-0 and 3-0 Vicryl and 4-0 Monocryl running sutures. Dermabond is applied to all incisions and the patient is covered with fluffs and a surgical bra. The dimpling of the IMF will resolve over the ensuing 2-3 months. Fat grafting into the upper pole will assist with softening post-mastectomy contour defects not improved by the superior capsulotomy and higher profile implants and can be performed at the time of exchange.

surgery-current-research-resuspended

Figure 2: Use of saline sizers to evaluate the resuspended inframammary fold and determine the volume for the implant

surgery-current-research-dimpling

Figure 3: Dimpling of the inframammary fold at case completion

Results

Mean time for tissue expansion was 84 days and mean time to exchange was 130 days. Mean mastectomy volume was 718 g, while mean expander fill volume and implant volume were 595cc and 618cc respectively. Sixty-six reconstructions (79%) had acellullar dermal matrix used at the first stage of reconstruction, while 14 reconstructions (17%) required latissimus flaps for additional tissue coverage. At the second stage, implants were typically upsized compared to the expander volume, with a mean volume increase of 47cc (range 10-155cc) (Table 2). Irradiated patients and post-latissimus patients were routinely over-filled during expansion to counter post-radiation skin changes and correct soft-tissue loss or scarring. These patients (n=25) were excluded from volume calculations as flap volume and differences in expansion techniques in the setting of radiation could not be accounted for when comparing final implant volume to filled expansion volume.

Breast Volume at Each Stage (average)  
Mastectomy Volume 718cc
Tissue Expander Fill Volume 595cc
Implant Volume 618cc
Tissue Coverage  
Acelluar Dermal Matrix 66 (79%)
Latissimus flaps 14 (17%)
Implant Styles used for Reconstruction  
Style 45 28 (33%)
Style 20 40 (48%)
Style 15 8 (10%)
Style 10 8 (10%)
Associated Procedures  
Contralateral augmentation 7 (14%)
Contralateral reduction or mastopexy 9 (18%)
Lipofilling 21 (25%)

Table 2: Reconstruction Demographics.

In this study, silicone implants were placed exclusively at the second-stage procedure. High profile Style 20 and extra-high profile Style 45 silicone implants (Allergan Inc, Irvine, CA) were the most commonly used implants in 81% of reconstructions, 40 (48%) and 28 (33%) respectively. Other styles incorporated included Style 15, moderate plus profile, and Style 10, moderate profile in eight breasts (10%) each.

Aesthetic outcomes were documented by two-dimensional and three-dimensional photography (Figures 4-6). Patients were followed for a mean of 21 months (range 4-48mo). Fifteen contralateral breast procedures were completed for symmetry, with seven augmentations and eight breast reductions or mastopexies. Post-reconstruction aesthetic procedures included lipofilling in 21 reconstructions, six scar revisions, and two cases of contouring liposuction. Three complications occurred during the second stage including two seromas (one resolved with drainage and one resulted in dehiscence requiring revision) and one hematoma necessitating evacuation and implant exchange. Capsular contracture requiring reoperation was documented in five reconstructions (10%), with four due to post-radiation changes. They were corrected with conversion to free flap reconstruction (n=1), latissimus flap (n=1), or acellular dermal matrix and revision (n=3). No patients have required revision of the IMF after reconstruction.

surgery-current-research-carcinoma

Figure 4: A 48 year old female with left breast ductal carcinoma in situ underwent bilateral simple mastectomies with and immediate tissue expander reconstruction. a) Preoperative imaging with a baseline breast volume of 278g and 305g. b) Post-expansion imaging with tissue expanders filled to 450cc bilaterally. c) Imaging at 6 weeks post exchange of tissue expander for the permanent implant, with upsizing by 50cc to a volume of 500cc bilaterally. Inframammary fold reconstruction and bilateral upper pole fat grafting was completed at the same surgery. d) Imaging at 4 months post IMF reconstruction, demonstrating resolution of the dimpling seen along the IMF

surgery-current-research-prophylactic

Figure 5: A 43 year old female with Stage 2A right breast infiltrating ductal carcinoma (IDC) underwent a right modified radical mastectomy with left prophylactic mastectomy and immediate tissue expander reconstruction. The patient desired increased volume and projection from her baseline breast volume of 350g and 324g. Tissue expanders were filled to 480cc, and the final implant volume was 550cc bilaterally. Images are taken 15 months after expander exchange and IMF reconstruction.

surgery-current-research-reconstruction

Figure 6: After positive BRCA testing, a 27 year old female underwent bilateral prophylactic mastectomies and immediate reconstruction. Tissue expanders were filled to 500cc bilaterally, and 550cc extra-high projection implants were placed. Two months later, the patient had bilaterally upper pole fat grafting with nipple reconstruction. Images are from 4 months after the IMF reconstruction.

Discussion

Over the past decade, the rates of post-mastectomy breast reconstruction continue to rise, improving body image and quality of life [4]. Considering the recent trend towards implant-based reconstruction, non-autologus reconstruction provides several challenges to achieve good cosmetic results [5,6]. Aesthetic results are based on the essential features of a natural breast, including size, projection, upper pole contouring, lower pole fullness, ptosis, fold location, and symmetry [2,3,7]. Attaining superior cosmesis bears impact, as post-reconstruction analysis has linked patients’ aesthetic scores and symmetry with patient satisfaction [7]. With recent advances in breast cancer reconstruction, expectations have also increased and paralleled that of the augmented breast. Achieving these aesthetic results typically focus on the creation of upper pole fullness, optimal projection, lower pole ptosis, and a well-defined IMF.

As the breast develops, the IMF plays a crucial role to anchor the inferior pole of the breast to the chest wall and provide the classic shape to the breast itself [8]. However, in patients undergoing mastectomy, most if not all of the IMF is sacrificed during the oncologic resection and closure. Previous studies have documented only 0.7-1.7% of breast cancers arising in the IMF, however 28% of IMF specimens studied contained breast or lymphatic tissues, supporting the thought that the area should be resected in oncologic cases [9]. Despite the ongoing debate regarding IMF excision, this area commonly is destroyed during mastectomy and tissue expansion [10]. The IMF system can be challenging to recreate since histologic evaluation shows it is a dense collagen network in the dermis and not a simple ligamentous structure to mimic [11]. External bolsters attempt to create the IMF through scarring, but still lack true definition with ptosis, highlighting the need for a true reconstructive technique [12].

Early inframammary fold reconstruction was highlighted in 1977 by Pennisi, who used a dermal-superficial fascia flap anchored to the chest wall muscular fascia [13]. Although the external approaches were reliable, the overall fold was bulky and still did not allow for much ptosis. Current internal techniques are adapted from Handel’s description in a small series, where an elevated capsulotomy is performed and the upper abdominal flap is fixed at the new IMF to increase the pocket and provide fold definition [14]. Nava has modified this to perform the capsulotomy at the desired level for increased precision, eliminated the dissection along the chest wall creating the upper abdominal lipofascial flap, and used a running suture between the superficial fascia and posterior capsule [13]. While this produced improved aesthetic results, there was still loss of definition in 5% of cases in the immediate postoperative period [13]. These procedures use an upper abdominal flap or superficial fascia sutured to the deep fascia, but this can lead to loss of fold definition. Thus, our technique anchors the dermis to the posterior capsule to create lasting definition and employs a silk suture to promote scarring and fixation.

While several factors aid in determining the aesthetics of the female breast, the inframammary fold is an important aspect. Few criteria exist regarding fold reconstruction, although a small series performed IMF re-suspension if the fold was undermined more than 1 cm [15]. Since the IMF can lose definition at a rate of 50% within 5 years, reconstructive surgeons should strive to redefine even acceptable folds [16]. Incorporating Acellular Dermal Matrix (ADM) can permit a more precise definition of the IMF, if the coverage is needed [17]. Therefore, achieving an improved aesthetic result hinges on the appearance of the inframammary and lateral mammary folds [12,15].

Our procedure for inframammary fold reconstruction employs several techniques not previously used. First, applying capsulotomies along each edge of the breast allows for the skin release described by Bogetti. However, these are not carried out at the reflection to the posterior capsule but anteriorly into the breast in order to maintain implant placement without migration and improve anterior projection. Using the specific placement of the inferior capsulotomy to determine the fold’s final position in addition to IMF re-suspension in the upright position has not been previously described; this important step allows for accurate placement of the IMF. Many authors then anchor the lower mastectomy dermis or subcutaneous fascia of the upper abdominal flap to the rib periostium [3,15]. While this stabilizes the lower pole, it can generate extreme and unnecessary postoperative discomfort. We have found that the early scalloping seen with dermal-capsular suspension resolves over the ensuing 6-8 weeks, and recovery is rapid with minimal to no discomfort.

The inframammary fold is an important aspect of an aesthetic reconstruction, yet it is not the only element needed to improve breast symmetry, projection, and shape. Placement of high and extra-high profile implants will assist in achieving upper pole fullness as we have found patient expectations tend towards that of an augmented breast. There is limited discussion in the literature regarding implant selection; however, surgeon variability persists. Although one author described using lower-profile, anatomic implants to minimize projection in the upper pole; still another author indicated high and extra-high profile implants as more optimal in breast reconstruction [3,18]. The BREAST-Q survey, a validated instrument to assess patient satisfaction, demonstrated higher patient satisfaction with silicone implants, since the newer silicone implants generate a more natural feel and less rippling with no discernable difference between anatomic and round implants [19]. In our practice, the majority of patients request increased anterior projection with upper pole fullness and prefer higher profile implants to achieve the desired outcome. We have attained this by upsizing the implant volume from the final tissue expander volume at the second-stage procedure. In addition, symmetry is confirmed during intraoperative evaluation of the patient in the sitting position during the reconstruction procedure.

Implant-based breast reconstruction is primarily comprised of single-stage and two-stage reconstructions, and several studies compare aesthetic outcomes and surgical revision rates. A prospective study comparing the two techniques noted a 70% reoperation rate in the single stage cohort when compared with the two-stage cohort (10%) [20]. While patient satisfaction in the one-stage cohort was statically lower, this difference equalized after surgical revision of this cohort [20]. Bonomi et al. have found two-stage reconstructions achieve good results across a variety of patients, while single-stage reconstructions are best utilized in small, nonptotic breasts [21]. We have found staging affords an opportunity to apply these strategies in a stepwise and thoughtful manner and correlates with high patient satisfaction. In addition, we have found that two-stage reconstruction allows for increased patient involvement and a shared understanding of the patient’s reconstructive goals during the expansion phase.

An additional strategy that has found new applications is the use of lipofilling in reconstructive surgery. Fat grafting can be applied to mastectomy flaps and the upper pole region to improve contour deformities, decrease implant rippling, reduce hollowing, and create a smooth transition from the chest wall to the implant. The timing of lipofilling can vary based on the desired objective. In a small case series, when structural fat grafting was applied to the mastectomy flaps of irradiated tissue prior to expander exchange, there were no reported cases of wound infection or ulceration [22]. Further studies have shown an aesthetic improvement when lipofilling is employed after permanent implant placement to correct reconstruction asymmetries [23,24]. In one study, patient aesthetic scores improved from 5.2 to 7.2 (scale 1-10), while surgeon scores increased from 4.9 to 7.1 at six months postoperatively [23]. We routinely employ lipofilling to mask implant visibility and correct rippling or contour defects. Additionally, we have found anecdotally that lipofilling tends to improve the quality of irradiated tissue and provides a softer pole. We have found lipofilling to be best tolerated when combined as an adjunctive procedure during the exchange procedure or nipple reconstruction.

Recreating the IMF through precise capsulotomy, abdominal flap recruitment/release, and suture suspension achieves improved breast positioning and definition against the chest wall with natural lower pole ptosis. Similarly, upsizing the implant at the second stage surgery allows the increased volume to adequately fill the expanded pocket and generate the desired upper pole fullness and anterior projection. This can be further enhanced with higher profile implants and use of lipofilling. While there are many different techniques to recreate the inframmary fold, we highlighted key elements from the original procedure as described by Pennisi, Nava and Bogetti. We do not discuss the muitlple minor modifications available to limit repetition in the manuscript. In regards to implant upsizing and the technique to mimic the augmented breast, this is the first paper to describe this procedure to our knowledge. As demonstrated in 2D and 3D photography, this technique highlights improved aesthetic outcomes mimicking the augmented breast. Further evaluation of patient satisfaction using the BREAST-Q survey, a validated instrument to assess patient satisfaction in breast reconstruction, is needed in this unique, urban population.

Conclusion

Current advances in two-stage implant based breast reconstruction are outlined to achieve upper pole fullness, anterior projection of the breast, and definition of the inframammary fold. . These results can be further enhanced with higher profile implants and the use of lipofilling, however further studies in patient satisfaction using the BREAST-Q survey are warranted. These strategies afford reconstructive outcomes that parallel the desired aesthetic features of the augmented breast.

Conflicts/ disclosures

A portion of this work was sponsored by the Warren and Clara Cole Foundation / American College of Surgeons Early Career Development Award, received by Dr. Anuja Antony. The remaining authors have no reportable conflicts or disclosures.

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