alexa Current Practice in Low Vision Rehabilitation of Age-related Macular Degeneration and Usefulness of Virtual Reality as a Rehabilitation Tool

ISSN: 2329-8847

Journal of Aging Science

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Current Practice in Low Vision Rehabilitation of Age-related Macular Degeneration and Usefulness of Virtual Reality as a Rehabilitation Tool

Marine Raphanel1*, Gabrielle Shaughness2, William H. Seiple1,3 and Angelo Arleo1
1Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France
2University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI 48105, USA
3Lighthouse International, Arlene R. Gordon Research Institute, 111 E 59th St, New York NY 10022-1202, USA
*Corresponding Author: Marine Raphanel, Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012 Paris, France, Email: [email protected]

Received Date: Aug 06, 2018 / Accepted Date: Sep 05, 2018 / Published Date: Sep 10, 2018

Abstract

Purpose: This study surveys current low vision rehabilitation practice methodologies among French practitioners and it describes their opinions about the utility of using virtual reality as a tool for low vision rehabilitation training in patients with age-related macular degeneration.
Methods: An online questionnaire was distributed between October 2017 and February 2018. 471 orthoptists (110 students and 361 graduates) responded to the survey. Questions concerned the orthoptist’s educational and demographic background, extent of training in virtual reality as a reeducation tool, and mode of practice including frequency of patient visits, goals, and methods of rehabilitation training.
Results: Out of 361 practicing orthoptists, 47.75% were low vision rehabilitation providers, and 52.25% were not. A provider’s likelihood of using low vision rehabilitation immediately after graduating from university was positively correlated to his confidence in the training he had received. Most respondents were receptive to using virtual reality as a reeducation tool.
Conclusions: Analysis of current low vision rehabilitation practice demonstrates no standardization of treatment protocols among providers. Although orthoptists overall acknowledge the benefits of virtual reality as a rehabilitation tool, orthoptist curriculum varies greatly across universities, which thus affects a provider’s likelihood of offering low vision rehabilitation. Moreover, this lack of standardization is a problem worldwide, which suggests a need for better clinical guidelines in low vision rehabilitation practice.

Keywords: Low vision rehabilitation; Age-related macular degeneration; Training; Visual impairment; Virtual Reality

Introduction

Age-related Macular Degeneration (AMD) affects the central retina, resulting in a progressive loss of central vision. As the leading cause of acquired visual impairment in the Western world, AMD is responsible for 8.7% of all blindness worldwide. In individuals aged 65 to 75 years, AMD prevalence ranges between 9%-25%, and over 80% of those affected become legally blind after age 70 [1-8]. In France, AMD affects 8% of the population, and its frequency increases with age: 1% of people aged 50 to 55 years, 10% of those 65 to 75 years, and 25% to 30% of persons aged over 75 suffer from AMD [1,6,9-11].

Although treatment options exist to slow the progression of exudative (wet) AMD, currently there are no preventive or curative options for active pathology. As individuals lose their central vision and the ability to discriminate between fine spatial details, they become less autonomous in performing basic activities of daily living (ADLs, e.g., walking, feeding, dressing) as well as instrumental activities of daily living (IADLs, e.g., taking medications, independent mobility, managing money). This predisposes them to low self-esteem and it is correlated with a three times greater risk of developing depression [3,5-10]. Additionally, AMD patients are twice as likely to fall and four times more likely to fracture a hip [4,6,7,9,10-18]. Significant social and economic ramifications will thus ensue as the proportion of older adults in the general population continues to rise [1,19-21].

Because AMD is among the most common etiologies of vision loss, this disease accounts for a majority of patients enrolled in low vision rehabilitation [22]. By helping the patient adapt to, and optimize the use of, his residual visual function, this therapy increases autonomy and improves quality of life in people with vision loss. Current recommendations for the clinical management of patients with AMD, as outlined by the French High Health Authority, begin with pharmaceutical or surgical treatment, followed by referral to a low vision provider [23]. However, in actual clinical practice, only 10%- 15% of French visually impaired patients are referred to a low vision professional, while it is estimated that 90% of patients could benefit from this support [11]. The underuse of low vision rehabilitation is echoed globally, as for example, in India, only 30% of eligible patients are referred for low vision rehabilitation [24].

Furthermore, practices are not standardized among low vision providers, both in France and world-wide [25-29]. For example in the UK, there is no consistency between services that eye care professionals feel are available and reports by visually impaired patients of the service they receive [26]. In Canada, each Province or Territory is responsible for its own healthcare administration. This has resulted in discrepancies between urban and rural area funding for low vision rehabilitation with neither a published rehabilitation model nor a consistent referral system between regions [30,31]. A lack of consensus on terminology and management criteria among low vision practitioners is also described in the United States, which makes it difficult to even ascertain current practices [28]. Globally, practitioners tend to use empirical rather than evidence-based rehabilitation protocols and there is little agreement about how best to measure low-vision service outcomes [11,25]. The need to study and improve current methodologies is echoed by Markowitz et al. who conclude in a 2016 review of current global low vision practices that “the main challenge to low vision rehabilitation practice at the international level is the absence of standards for definitions of low vision rehabilitation and delivery models for low vision rehabilitation service” [29].

In this study, we investigated demographics and practice patterns of low vision rehabilitation providers in France, and identified barriers to the creation, development, dissemination, and implementation of Virtual Reality (VR) technology in low vision rehabilitation clinical practice. In this article, the term VR specifically refers to head-mounted displays that project interactive 3D worlds, providing highly immersive solutions that can be exploited in low vision rehabilitation.

Although historically VR has mainly been used in the gaming industry, its application has recently expanded into healthcare for the medical education and for the treatment of a variety of conditions such as anxiety disorders, reducing fall risks in older adults, paincontrol, obesity-management, distraction during wound care, and as an adjunctive physical therapy tool [32-59]. However, despite an increasing awareness about the potential benefits of VR, this technology has not been fully developed for use in rehabilitation and it is only starting to be applied in the field of low vision rehabilitation. Understanding providers’ needs, concerns about effectiveness, ease-of-use, and accessibility of VR technology is critical to ensuring the success of VR interventions and rehabilitation.

Materials and Methods

Study population and data collection

All graduates of French orthoptist training programs (whether in practice or not) and all currently enrolled students were eligible to participate. An online questionnaire (Google Form) was used to collect data. This form was chosen for its ease of administration, data collection, and greater likelihood of soliciting participation, because respondents could complete the survey at their convenience. All respondents received the same questionnaire link. However, the questions varied depending on the respondent’s indication of whether he/she was a (a) graduate versus student, (b) low vision rehabilitation provider versus non-provider, or (c) low vision rehabilitation provider treating versus not treating AMD patients. A multiple-choice question format with an additional free-text option was used to survey practice methodology (including frequency and content of rehabilitation training), provider’s gender and educational background (year of graduation and university attended), sector, and geographic location of practice.

In order to solicit as many potential respondents as possible, a study participation invitation along with a link to the questionnaire was emailed twice to potential subjects of each orthoptic graduate school, all the various orthoptist labor unions, several large French teaching hospitals that have ophthalmology units, and posted three times (October 2017, December 2017, and January 2018) on a Facebook page called “2 Eyes”, which lists nearly 98% of all French orthoptists. In exhausting these channels, our advertisements theoretically reached nearly all 4,643 French orthoptists nationwide-both students still in training and orthoptists in practice. Online responses were accepted from October 2017 to February 2018 and they were recorded in a database for analysis.

Data analysis

The analysis of gathered data was stratified across three distinct demographics: graduates versus students; low vision rehabilitation providers versus non-providers; and among low vision rehabilitation providers, those whose practice comprises more than 10% versus less than 10% AMD patients.

All statistical analyses were performed on STATA (v. 14.2) and graphical representations were built on MS Excel (2016). Standard descriptive methods were used for demographic analysis with medians of 95% binomial-exact (conservative) confidence intervals and an alpha level of 0.05 considered statistically significant. Differences in demographic, training, and opinion regarding VR variables were compared in students versus graduates; and among graduates, low vision rehabilitation providers versus non-providers. Percentage and Pearson’s Chi-squared tests were used to assess the statistical significance among nominal variables. Continuous variables were analyzed using Student’s t-test. Those variables found to be statistically significant were then included in multiple logistic regression models to determine independent relationships.

Ethics

This study was conducted by the Silver Sight Chair at the Vision Institute (Paris, France) in accordance with the tenets of the Declaration of Helsinki and ethically approved by “CPP Ile de France V” (ID_RCB 2015-A01094-45, n. CPP: 16122 MSB). All participants gave informed consent approval for the de-identified publication of their data.

Results

Validity of the study population

Out of the 529 responses received, 471 met inclusion criteria (44 were rejected due to an invalid email and 14 replied more than once). The sample comprised 110 students and 361 graduates. Graduate orthoptists accounted for 7.78% of the 4643 French orthoptists nationwide, with a margin of error of 4.95% (CI=95%). As it is not possible to quantify how many orthoptists saw our advertisements soliciting study participation, we cannot calculate the response rate.

Gender and geographic demographics of respondents were representatives of the overall orthoptist population based on the 2017 consensus of French orthoptists [60]. However, the regions of Ile de France (comprising 29.28% of orthoptists in the sample vs. 22.57% of the general orthoptist population; p=0.0035) and Auvergne Rhone Alpes (accounting for 18.50% of orthoptists in the sample vs.12.66% of the general orthoptist population; p=0.0015) were slightly overrepresented, whereas the regions of Occitanie (comprising 8.56% of orthoptists in the sample vs. 13.22% of the general orthoptist population; p=0.0108) and Provence Alpes Cote d’Azur (6.07% of orthoptists in the sample vs. 9.69% of the general orthoptist population; p=0.0235) were slightly under-represented (Figure 1). Given that the title of our study included the term “low vision rehabilitation”, a possible self-selection bias exists favoring a higher proportion of low vision rehabilitation provider respondents.

aging-science-Geographic-distribution

Figure 2: Geographic distribution of sampled graduate orthoptist respondents. A total of n=471 orthoptists (110 students and 361 graduates) were sampled across France. The two most represented regions, Ile de France (greater metropolitan Paris) and Auvergne Rhone Alpes (greater metropolitan Lyon), are shown in red.

Demographic characteristics of the sample

The demographic characteristics of the sampled study population are reported in Table 1. The average date of orthoptist graduation was 2008 ± (SD) 3.27 years (n=361). Among the sampled graduates, 69.66% practice in an urban setting. Almost half of these (47.75%, n=171) reported having provided low vision rehabilitation at least once in the past year. Only 17.06% (n=29) of these providers (accounting for 8.03% of the total orthoptist sample) stated that low vision rehabilitation is the main therapeutic modality used in their practice.

Demographic Characteristic Total Students Graduates LVR Non-LVR
n % n % n % n % n %
Sex 471   110   361   17 47.75% 18 52.25%
Female 431 91.51% 100 90.91% 331 91.69% 16 97.06% 16 86.56%
Male 40 8.49% 10 9.09% 30 8.31% 5 2.94% 25 13.44%
University 471   110   361   17   18  
Paris 6 137 29.09% 31 28.18% 106 29.36% 38 22.35% 66 35.48%
Lyon 55 11.68% 7 6.36% 48 13.30% 20 11.76% 26 13.98%
Paris 5 39 8.28% 11 10.00% 28 7.76% 11 6.47% 17 9.14%
Montpellier 27 5.73% 2 1.82% 25 6.93% 19 11.18% 6 3.23%
Nantes 16 3.40% 9 8.18% 7 1.94% 2 1.18% 5 2.69%
Strasbourg 23 4.88% 8 7.27% 15 4.16% 6 3.53% 9 4.84%
Rennes 31 6.58% 9 8.18% 22 6.09% 13 7.65% 9 4.84%
Amiens 12 2.55% 8 7.27% 4 1.11% 1 0.59% 3 1.61%
Lille 16 3.40% 3 2.73% 13 3.60% 7 4.12% 6 3.23%
Bordeaux 25 5.31% 6 5.45% 19 5.26% 13 7.65% 6 3.23%
Toulouse 25 5.31% 1 0.91% 24 6.65% 17 10.00% 7 3.76%
Tours 16 3.40% 8 7.27% 8 2.22% 2 1.18% 5 2.69%
Marseille 16 3.40% 3 2.73% 13 3.60% 7 4.12% 6 3.23%
Clermont Ferrand 22 4.67% 4 3.64% 18 4.99% 9 5.29% 9 4.84%
Nancy 11 2.34%   0.00% 11 3.05% 5 2.94% 6 3.23%
Pursued Continuing Education After Graduation? 471   110   361   17   18  
Yes 137 29.09% 43 39.09% 94 26.04% 55 32.35% 37 19.89%
No 327 69.43% 60 54.55% 267 73.96% 11 67.65% 14 80.11%
Don’t know 7 1.49% 7 6.36%            
Sector of Practice 466   110   356   17   18  
Rural 68 14.59% 27 24.55% 41 11.52% 23 13.53% 18 9.68%
Urban 322 69.10% 74 67.27% 248 69.66% 10 63.53% 14 75.27%
Mixed 76 16.31% 9 8.18% 67 18.82% 39 22.94% 28 15.05%
Training Background                    
Did you practice LVR while a student? 471   110   361   17   18  
Never 174 36.94% 40 36.36% 134 37.12% 59 34.71% 74 39.78%
Basic Introduction 196 41.61% 46 41.82% 150 41.55% 66 38.82% 80 43.01%
Occasionally 74 15.71% 19 17.27% 55 15.24% 31 18.24% 24 12.90%
Regularly 27 5.73% 5 4.55% 22 6.09% 14 8.24% 8 4.30%
Did your training increase your desire to provide LVR? 297   70   227   11   11  
1 36 12.12% 8 11.43% 28 12.33% 7 6.31% 21 18.75%
2 57 19.19% 8 11.43% 49 21.59% 15 13.51% 33 29.46%
3 54 18.18% 8 11.43% 46 20.26% 16 14.41% 28 25.00%
4 64 21.55% 20 28.57% 44 19.38% 27 24.32% 16 14.29%
5 59 19.87% 20 28.57% 39 17.18% 30 27.03% 9 8.04%
6 27 9.09% 6 8.57% 21 9.25% 16 14.41% 5 4.46%
Did you study LVR? 471   110   361   17   18  
Never 80 16.99% 12 10.91% 68 18.84% 42 24.71% 26 13.98%
Basic Introduction 115 24.42% 11 10.00% 104 28.81% 52 30.59% 50 26.88%
Occasionally 192 40.76% 49 44.55% 143 39.61% 60 35.29% 82 44.09%
Regularly 84 17.83% 38 34.55% 46 12.74% 16 9.41% 28 15.05%
Did your courses increase your desire to provide LVR? 391   98   293   12   16  
1 43 11.00% 6 6.12% 37 12.63% 8 6.25% 29 18.13%
2 74 18.93% 17 17.35% 57 19.45% 20 15.63% 37 23.13%
3 104 26.60% 19 19.39% 85 29.01% 44 34.38% 37 23.13%
4 79 20.20% 21 21.43% 58 19.80% 23 17.97% 34 21.25%
5 62 15.86% 22 22.45% 40 13.65% 20 15.63% 20 12.50%
6 29 7.42% 13 13.27% 16 5.46% 13 10.16% 3 1.88%
Did you feel confident in your ability to practice LVR 471   110   361   17   18  
1 221 46.92% 24 21.82% 197 54.57% 80 47.06% 11 61.29%
2 97 20.59% 29 26.36% 68 18.84% 27 15.88% 39 20.97%
3 70 14.86% 22 20.00% 48 13.30% 30 17.65% 18 9.68%
4 52 11.04% 24 21.82% 28 7.76% 20 11.76% 8 4.30%
5 20 4.25% 7 6.36% 13 3.60% 8 4.71% 5 2.69%
6 11 2.34% 4 3.64% 7 1.94% 5 2.94% 2 1.08%

Table 1: Reports the demographic characteristics of the sampled study population

Similarly, only 39.61% of graduates reported having received a minimal level of training in low vision rehabilitation and 18.84% reported no exposure to low vision rehabilitation during their orthoptic curriculum. Even if they had wanted to train in low vision rehabilitation as a student, 37.12% of graduates stated that it was not offered during their internship year. Of the 227 graduates who were exposed to low vision rehabilitation during their internship, only 6.09% had the opportunity to regularly practice it during their training. Interestingly, we did not find any correlation between a practitioner’s extent of training in low vision rehabilitation and his willingness to provide it (chi squared theoretical 5%=7.82 Pearson chi squared calculated=4.852168; df=3, p=0.18296). 26.4% of graduates endorsed pursuing continuing education and 39.09% of students stated they intend to pursue further training upon graduation.

A statistically significant correlation between the year of graduation, or anticipated graduation, and whether the respondent had received training in low vision rehabilitation was observed (n=471, r=0.425347; p<0.0000001). There was no significant correlation between the year of graduation, or anticipated graduation, and the opportunity for a respondent to obtain low vision training during his/her internship if desired (N=471, r=0.082606; p=0.073285). Only 1.93% of graduates reported that they were confident in their ability to provide low vision rehabilitation upon graduation, whereas 86.71% were either neutral or not at all confident (Figure 2).

aging-science-vision-rehabilitation

Figure 2: Confidence score with respect to low vision rehabilitation practice upon graduation. Both low vision rehabilitation providers and non-providers responded to the question: “Upon graduation, did you feel confident in your ability to practice low vision rehabilitation?” with a scale of 1 to 6 (1=not all confident; 6=fully confident). The score distribution is significantly biased towards 1, with 47.06% of current low vision rehabilitation providers and 61.29% of non-providers that were not at all confident in their ability to practice low vision rehabilitation upon graduation.

Differences between low vision rehabilitation providers and non-providers

An orthoptist’s likelihood of providing low vision rehabilitation was correlated to the university where he/she trained (chi squared theoretical 5%=23.69<Pearson chi squared calculated=27.5925; df=14, p=0.016117) (Figure 3). The quality of an orthoptist’s training may thus contribute to his/her confidence in being able to perform low vision rehabilitation (Figure 4). Women are 5.13 times more likely to practice low vision training than men (odds ratio=5.13, IC=[1.9153;13.7187]; Pearson chi squared=17.57787; df=6; p=0.00738). Half of all female providers offered low vision rehabilitation upon graduation compared to only 20% of male providers (chi squared theoretical 5%=3.84<Pearson chi squared calculated=12.68894; df=1, p=0.00037). Reasons cited by respondents for not providing low vision rehabilitation are described in Table 2. Almost half of non-providers (49.46%) attribute their reticence to lack of confidence in their low vision rehabilitation training. Approximately two thirds (66.67%) report that it is not in their scope of practice, whether because they are employed by an ophthalmologist under whom they cannot provide these services, or because they work in a hospital that does not have a low vision rehabilitation department.

aging-science-vision-rehabilitation

Figure 3: Likelihood of providing low vision rehabilitation as a function of the university where the orthoptist respondent graduated. The diagram shows a clear relation between the University of Origin and the probability of becoming a low vision rehabilitation provider upon graduation. Interestingly, this relation is not determined by the number of orthoptist that graduate from a given university. For instance, only 36.54% of graduated from the University of Paris 6 (which trained about one third of all French orthoptists) were likely to provide low vision rehabilitation, whereas a majority of orthoptists that graduated from the University of Montpellier and from the University of Toulouse (76% and 70.83%, respectively), did practice low vision rehabilitation (despite the small number of the orthoptists trained by these universities).

aging-science-median-score

Figure 4: Willingness score with respect to low vision rehabilitation practice upon internship training in low vision rehabilitation. Both low vision rehabilitation providers and non-providers responded to the question: “Did your internship in low vision rehabilitation increase your desire to practice it?” with a scale of 1 to 6 (1=completely disagree; 6=totally agree). For the majority of providers, their training internship in low vision rehabilitation increased their desire to practice it (mode score=5, with 27.03% of the respondents; median score=4, with 58.56% of the respondents). The opposite holds for non-providers (mode score=2, with 29.46% of respondents; median score=3, with 73, 21% of respondent with a score of 3 or less).

Non-LVR providers (n=186) n Percent
Not enough demand. 32 17.20%
Not requested by my patients or prescribers and I wish it were. 10 5.38%
Not requested by my patients or prescribers and I am satisfied with it not being requested. 22 11.83%
I am not confident enough in my ability to perform this modality. 92 49.46%
My work does not permit it. 124 66.67%
And I wish it were. 49 26.34%
No occasion to practice it and I wish it were. 13 6.99%
And I am satisfied with it not being requested. 62 33.33%
I don’t like LVR. 42 22.58%
No interest in LVR. 2 1.08%
I don’t believe LVR is effective. 3 1.61%
Takes too long. 15 8.06%
Too much emotional investment. 22 11.83%
Financial reasons. 24 12.90%
This activity does not pay enough. 6 3.23%
Equipment too expensive. 18 9.68%

Table 2: Reasons cited by respondents for not providing low vision rehabilitation.

As shown in Table 3, 61.18% (n=170) of low vision providers report that rehabilitation represents less than 10% of their work. 45.25% of these providers complete additional training before rehabilitating their first low vision patient and 53.25% of practitioners state this is due to insufficient training in their orthoptic curriculum. 17.20% of orthoptists who do not pursue additional training cite lack of funds and 36.56% report they prefer instead to refer to colleagues. Only 11.83% of orthoptists report sufficiently confident in their prior training to not require additional training. A majority (63%) of providers do not regularly read international scientific papers on low vision rehabilitation, although they are slightly more apt to read French peer-reviewed articles (Figure 5). In addition to orthoptists, opticians (77.93%) are the primary other practitioners specializing in low vision rehabilitation. However, only one third of orthoptist low vision providers coordinate care with a psychomotor, occupational, or mobility therapist. Only 29.76% of providers report a positive working relationship with the prescribing ophthalmologist and 20.83% report no interaction at all.

Questions n %
What percentage of your work includes LVR? N=170
0% to10% 104 61.18%
10% to30% 30 17.65%
30% to 50 % 7 4.12%
50% to 70% 10 5.88%
70% to 90% 4 2.35%
90% to 100% 15 8.82%
   Did you complete additional continuing education in LVR before offering this to a patient? N=170
No 93 54.71%
Yes 77 45.29%
   If you answered yes, why? N=77
I did not feel comfortable enough with my level of training in orthoptic school. 41 53.25%
I feel continuing education is necessary to maintain a level of professional competency. 27 35.06%
I had already been in practice for a long time before receiving my first low vision patient and I needed a refresher. 5 6.49%
I wanted to have the most up-to-date training. 4 5.19%
    Did your training in LVR before graduation meet your expectations? N=77
Yes 65 84.42%
No (not enough opportunities to practice) 12 15.58%
   If you did not pursue additional training in LVR, why? N=93
I can ask advices to my colleagues to provide LVR. 34 36.56%
I can’t afford the training fees. 16 17.20%
I don’t have enough time. 12 12.90%
Not enough patient demand to justify the cost of training. 12 12.90%
My theoretical training has already sufficiently prepared me clinically. 11 11.83%
I already feel competent. 5 5.38%
I don’t know of any programs that meet my expectations. 3 3.23%
   Do you regularly read international scientific articles on LVR? N=170 (1=never; 6=very regularly)
1 28 16%
2 33 19%
3 48 28%
4 31 18%
5 19 11%
6 11 6%
Do you regularly read French professional journals on LVR? (For example, Le journal français d'orthoptie) N=170 (1=never; 6=very regularly)
1 2 1.18%
2 13 7.65%
3 38 22.35%
4 40 23.53%
5 42 24.71%
6 35 20.59%
Interaction with other healthcare providers
Interaction with ophthalmologist n=170
They don’t believe in the effectiveness of LVR 8 4.76%
Non-existent 35 20.83%
Difficult initially, but now they accept LVR 4 2.38%
Cordial 70 41.67%
Excellent 50 29.76%
Do you work with other LVR providers? N=170
Yes 145 85.29%
No 25 14.71%
   With which LVR providers do you work? N=145 (multiple answers possible)
Optician specialized in low vision 113 77.93%
LVR orthoptists 85 58.62%
Psychomotor therapist 48 33.10%
Occupational therapist 44 30.34%
Mobility instructors 43 29.66%
A specialized institute 7 4.83%
Therapist specialized in ADLs 6 4.14%
Therapist 2 1.38%
Teacher 2 1.38%
Transcriptor 2 1.38%

Table 3: The online questionnaire and their responses from orthoptists.

aging-science-scientific-articles

Figure 5: Providers’ aptitude to read international scientific articles versus French professional articles on low vision rehabilitation practice. The distribution of responses (with a scale of 1 to 6:1=never reading; 6=reading very regularly) shows that a majority (63%) of providers do not regularly read international scientific papers on low vision rehabilitation (median score=3, with 28.24% of respondents), whereas they are slightly more apt to read French professional articles (median score=5, with 24.71% of respondents).

Low vision rehabilitation of AMD patients

As described in Table 4, 123 of 171 graduate low vision rehabilitation providers reported an AMD patient population representing more than 10% of their practice. In general, more than half of these practitioners saw an AMD patient once per week (55.28%) for an average of 15 ± 8 sessions (min=5; max=50). The initial intake averaged 77 ± 29 minutes (n=123; min=30; max=180), most often divided over two sessions. Follow-up visits averaged 54 ± 9 minutes (n=123, min=25; max=60). Almost half (53.66%) of all patients were classified as meeting WHO stage 1 criteria for visual impairment, whereas 13.82% of patients met pre-stage 1 criteria (no visual impairment) and 22.76% met stage 2 criteria. Almost half (44.72%) of providers reported not offering rehabilitation once patients reach stage 3 criteria due to consensus that at this point, visual loss is too far progressed to benefit from therapy. Factors influencing which therapeutic modality these providers employed in the treatment of AMD patients included their colleagues’ recommendations (51.22%), past training in a given modality (48.78%), and personal professional experience (45.53%).

Methodology LVR
n %
How often do you see your AMD patients? N=123
Once per trimester 1 0.0081
Once per month 15 0.122
2 times per week 33 0.2683
Once per week initially, then twice per month 4 0.0325
Once per week 68 0.5528
More than once per week 2 0.0163
   At what WHO clinical stage of low vision do you start LVR? N=123
Before Stage 1 17 13.82%
Stage 1 66 53.66%
Stage 2 28 22.76%
Stage 3 10 8.13%
Stage 4 1 0.81%
Stage 5 1 0.81%
   At what WHO clinical stage of low vision do you stop LVR? n=123
Stage 1 7 5.69%
Stage 2 10 8.13%
Stage 3 22 17.89%
Stage 4 55 44.72%
Stage 5 29 23.58%
   How do you choose your methodology? N=123
Recommendation of my colleagues 63 51.22%
My past training 60 48.78%
My own methodology based on my experience 56 45.53%
Textbook 42 34.15%
Internship 42 34.15%
Articles 26 21.14%
Internet 13 10.57%
Do you identify the patient’s PRL?
Yes 80 65.04%
No 43 34.96%
   How do you identify the patient’s PRL?    
Goldman visual field test 57 71.25%
Observation of pupillary reflections 35 43.75%
MP1 9 11.25%
Retinophotography 8 10.00%
Clock test 2 2.50%
Amsler 1 1.25%
   Do you train hand-eye coordination? N=123
Yes 11 92.68%
No 9 7.32%
   How do you train hand-eye coordination? N=114
Étoile de thomas 92 81%
Test de barrage 90 78.95%
Fixation balls 75 65.79%
E de weiss 51 44.74%
Home-made creation or turning game 20 17.54%
Computer tablet 2 1.75%
   Do you test facial recognition? N=123
Yes 63 50.81%
No 60 48.39%
   Do you test postural stability? N=123
Yes 40 32.26%
No 83 66.94%
   Do you test reading speed? N=123
Yes 10 86.18%
No 17 13.82%
   How do you test reading speed? N=106
French Mn Read (TEVL) 90 84.91%
Stopwatch with any text 9 8.49%
I don’t time the patient, but I assess general speed (quick, slow). 4 3.77%
Mr Petit 2 1.89%
Computer test 1 0.94%
   Do you believe your methodology is effective? N=123
1 0 0.00%
2 5 4.03%
3 30 24.19%
4 62 50.00%
5 23 18.55%
6 3 2.42%

Table 4: The questions related to their methodology of handling of AMD patients.

We observed a large variability in the functional capacities rehabilitated through low vision training (Figure 6). 93% of practitioner’s trained hand-eye coordination, 65% sought to identify a patient’s preferred retinal locus (PRL), and 32.26% tested postural stability. Marked disparities between rehabilitation methodologies are also evident. For example, to identify a patient’s PRL, practitioners varied between using subjective measures (71.25% of providers use a Goldman field test and 43.75% use pupillary reflection) and objectives measures (11.25% use microperimetry MP1, and 10% employ retinography).

aging-science-Eye-hand

Figure 6: Distribution of AMD patients’ functional capabilities trained through low vision re-habilitation. Eye-hand coordination, reading speed, and preferential retinal locus are most often rehabilitated by orthoptists (92.68%, 86.18%, and 65.04%, respectively), whereas the evaluation others functional capacities such as postural stability is significantly less frequently provided (32.26%).

Usefulness of virtual reality for low vision rehabilitation of AMD patients

Finally, we inquired about practitioners’ willingness to try new methodologies for low vision rehabilitation (Figure 7). In general, orthoptists (both graduates and students) were receptive to new technologies (mean=4.568 ± 0.981; n=470) such as VR (mean=4.417 ± 1.1847; n=470). On a scale of 1 to 6 (1=completely disagree, 6=completely agree) the mean willingness score among orthoptic students was 4.582 ± 1.1036 (n=110, min=2; max=6), among graduates it was 4.367 ± 1.2054 (n=361; min=1; max=6), and for the total sample (both students and graduates) it was 4.417 ± 1.1847 (n=471; min=1; max=6).

aging-science-Eye-hand

Figure 7: Usefulness of VR for low vision rehabilitation of AMD patients. Both low vision rehabilitation providers and non-providers were asked to what extent they were in favor of the use of VR as a low vision rehabilitation tool (scale of 1 to 6: 1=completely disagree; 6=completely agree). In general, orthoptists (both providers and non-providers) were receptive to this new technology. Differences between groups were not statistically significant. Even when low vision rehabilitation providers reported excellent confidence in their current preferred methodology, differences in willingness between groups remained not significant (70% reported a willingness of 4 or more).

Differences between groups were not statistically significant. Even when low vision rehabilitation providers reported excellent confidence in their current preferred methodology, differences in willingness between groups remained not significant (70% reported a willingness of 4 or more). However, there was a significant difference in the proportion of non-providers and providers who were willing to use VR (23.04% and 14.04%, respectively). No correlation was found between the year of graduation (in both students and graduates) and one’s familiarity with VR as a rehabilitation modality (n=470; r=0.084653 p=0.066708). Very few non-providers believed that VR would increase their desire to practice low vision rehabilitation (on a scale of 1 to 6, mean 3.445 ± 1.3361; n=186).

Among those providers not willing to use VR, we then used openended questions to identify their reservations. The following themes emerged out of the 38 respondents: skepticism regarding its usefulness with older patients (n=12), belief that the equipment is too expensive (n=7), concern that a loss of binocular vision due to a scotoma will prevent the patient from attaining 3D vision with the HMD (n=6), assumption that VR does not accurately depict real life (n=6), the practitioner’s own lack of confidence in using such technology (n=4), and opinion that this modality is too exhausting for the participant (n=2). Additional unique responses (n=1) included: “There are already enough rehabilitation tools”; “The technology has not yet been perfected”; “I am too close to retirement to invest in this tool”; “It’s a gadget”; “It does not guarantee a good relationship between the patient and provider”; “We can’t see patient’s eye when using it”; “I don’t think this technology has progressed far enough”; and “It is not suitable for patients with severe visual impairment”.

Discussion

This survey reflects a representative sample of French orthoptists and their current low vision rehabilitation practices. Half of all French orthoptists practice in either Ile de France (greater metropolitan Paris) or Auvergne Rhone Alpes (greater metropolitan Lyon). This demographic is consistent with a corresponding greater population density in these areas. Similarly, there are fewer orthoptists in areas where ophthalmology and medical personnel in general, are in shortage (“medical deserts”). Given that an orthoptist can only provide low vision rehabilitation when prescribed by an ophthalmologist, these medical deserts pose a real concern. Current measures underway to address these issues include possible expansion of orthoptist scope of practice in medical desert areas.

Half of all orthoptists reported lacking confidence in their ability to practice low vision rehabilitation upon graduation due to insufficient training. Almost 40% of practitioners never practiced low vision rehabilitation before graduation and 45% of providers chose to pursue this training after graduation. Given that a provider’s confidence is correlated with his likelihood of offering low vision rehabilitation, these findings clearly highlight the need to increase university-sponsored internships in this modality. If this is infeasible, other avenues of training must be explored such as continuing education workshops.

Furthermore, courses vary greatly across universities. Training in low vision rehabilitation is not a required component of orthoptic curriculum and it is thus offered at the school’s individual discretion. Due to this lack of standardization, patients have no way of knowing whether their provider is trained in low vision rehabilitation. Additional factors limiting the number of practitioners include lack of time or funding to pursue continuing education certification. Consequently, there is a shortage of providers, particularly in rural communities. These deficits highlight the need to standardize low vision rehabilitation training among universities.

In an effort to ameliorate this deficit, in the United States, the Michigan Optometric Association encourages optometrists to complete a low vision rehabilitation certification. However, Carlson and Hinkley (2011) found that while 26% of providers offer low vision rehabilitation, only 6.4% of them are actually certified. As in our survey, reasons cited for not obtaining this certification include: low vision care not comprising a significant portion of their practice, lack of support from their current practice environment, no legal requirement to be certified in or-der to offer low vision rehabilitation, insufficient time to become certified, complexity of the certification process, and no direct increase in practice revenues [61]. A 2015 survey of Canadian optometrists reticent to providing low vision rehabilitation similarly cited lack of knowledge, equipment, or experience; that low vision assessment is too time consuming; and that the cost is too prohibitive [62].

In the absence of sufficient incentives to pursue post-graduate low vision rehabilitation certification, we propose alternative avenues. One option might be to increase the length of orthoptic training in France to ensure better training in all orthoptic sub-specialties. Indeed, in France, orthoptists train for only 3 years. Yet, their scope of practice almost nearly approaches that of their colleagues in Canada or the United States who train for 5 years. Given the breadth of study required in an abbreviated course of time, it is difficult to guarantee a high degree of educational quality. Additionally, governing boards could require a national licensing exam, including competence in low vision rehabilitation, for all orthoptists, similar to the national exams required of other professional degrees.

Our survey findings, as well as a review of the literature, reveal there is no gold standard consensus for low vision rehabilitation among providers [2,27,28,62]. Although half of orthoptists report practicing low vision rehabilitation, only 8% incorporate this modality in the majority of their AMD treatment plans. Not only do the tools and techniques used in AMD reeducation vary widely from one practitioner to another, but, furthermore, there is no standardization between which functional capacity a practitioner chooses to train (hand-eye coordination, reading speed, facial recognition, postural stability, visual exploration, fixation stability, etc.).

Particularly in rural areas, the majority of low vision rehabilitation therapy is provided by non-specialized orthoptists using an empirical approach or recommendations from colleagues. Even when evidencebased tools exist in the literature, practitioners tend to improvise with their own methods. For example, 85% of orthoptists measure a patient’s reading speed using random text in a book, whereas only 8.49% employ the MNREAD test that has been validated by strong scientific literature. Similarly, many practitioners still use “pencil and paper” tests to reeducate hand-eye coordination despite a large body of literature demonstrating poor transfer of learning. The tendency of providers to create their own methodologies indicates a lack of accepted protocol in the field, or at least a poor awareness of clinical guidelines. Moreover, the dearth of evidence-based practice within orthoptics and optometry is not limited to France, as many other countries suffer from the same gap in low vision rehabilitation [2,4,22,25-27,29,31,61-72]. This extends further into little agreement about how best to measure low-vision rehabilitation outcomes [25].

Finally, this survey explored the feasibility of incorporating virtual reality (VR) techniques in low vision rehabilitation. One such application utilizes wall-mounted screens depicting various city scenes. These are positioned around a visually impaired patient who must then learn to safely cross a street [32]. Similarly, in patients with anisometropic amblyopia, VR head mounted displays have been used in dichoptic training to increase visual and stereoacuity [35]. Although used as an optic aid rather than a rehabilitative tool, eSight is yet another ex-ample of a head-mounted device that enables visually impaired patients to better navigate daily life scenarios by augmenting their perceived environment [73].

The particular advantages of a tool such as VR are many. First, this completely immersive environment can be customized to the individual’s progress. For example, for patients hesitant to enter challenging scenarios (i.e., crossing a busy street) the environment can be graded beginning with easier conditions (no traffic) and increasing in complexity (more cars, other pedestrians, cyclists) as the patient gains confidence. This allows the therapist to coach the patient through these psychologically distressing situations [74]. Furthermore, study of this technique by Bowman et al. found a good transfer of learning to the real world. Particularly in older populations, immersive environments have been shown to increase cognitive learning plasticity [33,40,50]. Additionally, since the patient knows the exercise is only a simulation, he/she may feel safer and therefore more willing to explore different navigation techniques [74]. This customization further allows the medical provider to transform rehabilitation into a more entertaining and empowering experience for the patient. Finally, unlike video or computer games that require learning how to use the software, VR headsets demand no active manipulation by the patient. Treatment sessions can even be automated so that a therapist need not necessarily be present, thereby increasing cost efficiency and large-scale accessibility.

Given the success of these prior applications, we propose VR could be expanded to rehabilitation of AMD patients. For example, when central vision is lost, one must shift one’s visual point of fixation and attention. By simulating real life scenarios with VR, we can then train a patient to best exploit his remaining visual capacities and to discover new visual exploration strategies. Similar to the study described by Bowman et al., as the patient gains comfort in navigating relatively simple simulated environments, he/she would then transition to increasingly complex scenarios, i.e. urban streets with moving pedestrians and vehicles.

In order to standardize and assess the effectiveness of such training, we suggest pre- and post- therapy assessment of visual capabilities. Reading speed and discrimination can be measured with the MNREAD test. This is currently the gold standard in research [17,67,75,76], yet is not often applied in actual clinical practice. However, reading is not the only visual function affected by AMD, and so we further recommend evaluating a patient’s hand-eye coordination, steadiness of visual fixation, postural stability (using a force platform), ability to ambulate, and perceived quality of life and autonomy. Although not practical in clinical practice, EEG and brain imaging (such as functional and anatomical magnetic resonance imaging, fMRI and aMRI, respectively), could further be used in research to objectively measure and validate the effectiveness of such training, and to better understand the cognitive impact of this care.

Our study found that a majority of orthoptists would be willing to incorporate virtual reality as a therapeutic tool for AMD patients if studies prove its effectiveness. This is in concordance with a 2017 survey by Keller et al. that used social media posts (Facebook) to solicit public opinion on the use of VR in healthcare [77]. However, within the general population, Keller also found a positive correlation between a person’s age and his skepticism of VR’s utility. In another study, Schmid et al., found a similar positive correlation among physio and occupational therapists regarding their reservation of VR’s utility in stroke rehabilitation [47]. This might be explained by a greater familiarity with VR, and new technology in general, among younger physiotherapists who have gradually integrated this modality into therapy [41,47,74]. In our study, we did not find this correlation, perhaps because our sample of older practitioners was underpowered. As new and innovative VR tools emerge, providers must be able to adapt to these advances in technology in order to better serve their patients.

Among practitioners who remain skeptical, one concern is whether VR is suitable for older people and how they will interact with new technology. Additionally, some orthoptists worry that in patients who have binocular vision deficits, such as in AMD, a lack of 3D perception will render a head-mounted device ineffective. However, this is not the case as head-mounted devices exploit a combination of binocular disparity, dynamic stereoscopy, and perspective distortion to generate images. Therefore, even if a patient lacks one of these three facilities, he/she can still compensate by using the other two. In addition, head mounted displays are able to track both head position and rotation (using accelerometers, gyroscopes, and magnetometer sensors), thus guaranteeing excellent visual immersion and precision. Currently, one company (Tobii Pro) offers an advanced option that incorporates an eye tracker to enhance visual simulation. At the moment, this model remains too expensive for general clinical practice, but as more brands further develop this technology, it may enhance the attractiveness of VR head mounted displays as a rehabilitation tool in the future.

Additional concerns voiced by some orthoptists include the quality of peripheral visual fields in a head-mounted VR. They wonder whether peripheral distortion could compromise the re-adaptation ability of a person with central vision loss. We anticipate that any such peripheral distortions will be improved as technology rapidly advances in the coming years. Other objections stressed the current (over)use of technology in society, cost, accessibility, and uncertainty of social security reimbursement leading to reluctance to incorporate new technology in healthcare settings, despite the potential clinical benefits. Conversely, those orthoptists who favorably view VR cite that its use may lend greater credibility to the profession by reducing the technological gap between ophthalmologists and orthoptists. We propose that if practitioners could be reassured that these tools will not detract from their own professional expertise and value, and if their fears regarding dependency on the overuse of new technology could be assuaged, they would become more receptive to the adoption of VR.

Of encouragement, most recently graduated orthoptists hail from a younger generation born into the digital world, and who therefore fluently speak the language of technology. As new and innovative VR tools emerge, providers must adapt to these advances in technology in order to best serve their patients. Additionally, as the current population ages, the next generation of older adults will not be technologically naive. These retirees will have become accustomed to using a variety of computerized devices such as smartphones or tablets and they will likely be more willing to try new technological tools in the future.

Conclusion

Evidence-based practice is poorly employed in the paramedical field, and in particular in low vision rehabilitation. To address this deficit, further studies of current practice methodologies among low vision rehabilitation providers are necessary. A better understanding of the factors contributing to the success or failure of a given rehabilitation technique will enable improvement measures to increase its effectiveness in the future.

The development of an effective, validated, and standardized training protocol for AMD patients that transfers to real-life conditions is an important goal of low vision rehabilitation practice. Currently, AMD rehabilitation mainly focuses on reading speed and discrimination tasks [17,18,67,75,76,78]. However, vision loss has consequences on a person’s activities of daily living beyond reading difficulties. Changes in postural stability, hand-eye coordination, mobility, autonomy, and perceived quality of life are equal considerations in any successful rehabilitation program.

Active visual exploration strategies using both static and dynamic body movement, as well as hand-eye coordination training (as it can be accomplished using an additional sensor on the patient’s hand) made possible by VR may offer AMD patients excellent transfer of learning from simulated scenarios to real-world experiences. Additionally, VR can be tailored to create increasingly dynamic and visually complex environments for the patient to navigate. Improved provider training, using evidence-based protocols as established by the literature, is needed to establish an effective, cost-efficient model for providing standardized low vision rehabilitation to persons diagnosed with AMD. Such a VR program offers the opportunity to thereby create an entertaining, immersive environment that promotes better real-world transfer of learning.

Acknowledgements

This research was supported by ANR - Essilor Silver Sight Chair ANR-14- CHIN-0001 and by the Institute Universities d’Ingénierie en Santé (IUIS) of Sorbonne Université.

Conflict of Interest

The authors declare no competing interests.

References

Citation: Raphanel M, Shaughness G, Seiple WH, Arleo A (2018) Current Practice in Low Vision Rehabilitation of Age-related Macular Degeneration and Usefulness of Virtual Reality as a Rehabilitation Tool. Aging Sci 6: 194 DOI: 10.4172/2329-8847.1000194

Copyright: © 2018 Raphanel M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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