alexa Cutaneous Field Cancerization on a Vitiligo Area | Open Access Journals
ISSN: 2471-9323
Journal of Cosmetology & Trichology
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Cutaneous Field Cancerization on a Vitiligo Area

Luciana Falivene Cará*, Julia de Ávila Fowler, André Cesar Antiori Freire Pessanha, Denise Steiner and Felipe Ribeiro da Silva

Department of Dermatology, University of Mogi das Cruzes, Mogi das Cruzes, Brasil

*Corresponding Author:
Luciana Falivene Cará
Department of Dermatology
University of Mogi das Cruzes
Mogi das Cruzes, Brasil
Tel: +55 12 997340810
E-mail: [email protected]

Received date: March 30, 2017; Accepted date: April 17, 2017; Published date: April 23, 2017

Citation: Cará LF, Fowler JA, Pessanha ACAF, Steiner D, Silva RD (2017) Cutaneous Field Cancerization on a Vitiligo Area. J Cosmo Trichol 3:119. doi: 10.4172/2471-9323.1000119

Copyright: © 2017 Cará LF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Cosmetology & Trichology

Abstract

Vitiligo is the most commom depigmentary disorder of the world, with probably an autoimmune cause. Studies reveal the presence of genes likely the emergence of Vitiligo, many of them involved in the synthesis of proteins related to the recognition and killing of melanocytes. The interaction of these genes may suggest protection and good prognosis for Vitiligo patients in relation to skin cancer. We describe the case of a patient with field cancerization in areas affected by Vitiligo, counteracting, therefore, the usual.

Keywords

Vitiligo; Skin neoplasms; Hypopigmentation; Pigmentation disorders; Pigmentation; Skin pigmentation; Melanoma

Introduction

Vitiligo is the most commom depigmentary disorder of the world. The oldest reports of a disease similar to Vitiligo known until today date from 1500 AC, present in sacred Hindu writings and in texts of ancient Egypt [1]. Classified as a disease of acquired character, in the most cases, with a prevalence of 0,5% all around the world [2], without predilection of gender, racial or age [3-5] although some studies reveal prevalence in females. Clinically, is expressed by patches and macules, achromic and rarely hypochromic, located mainly in the skin and mucous membranes, due to the decrease or absence of melanocytes, resulting from the autoantibodies produced by the own body that will eventually destroy them. These cells, besides granting the skin color through the melanin production, protect it from the effects of solar and chemicals carcinogens [6]. Recently, studies reveal the presence of susceptible genes related to the appearance of vitiligo, being a large part of them, involved in protein synthesis related to the recognition and death of melanocytes. The interaction of these genes suggests protection and good prognosis to patients with Vitiligo in relation to skin cancer [7].

The occurrence of malignant melanoma in skin areas affected by x is extremely rare, since it challenges the antagonistic relationship between these two pathologies.

It is reported a case of cutaneous field canceritazion in Vitiligo.

Case Report

We report on a 71-year-old female, housewife, brasilian, born and resident in the interior of Sao Paulo state, patient referenced to this service reporting red and scaly lesions all over the body 5 years ago. States that 15 years ago white spots appeared, initially in face and subsequently spreading to the rest of the body, being diagnosed with Vitiligo. In the dermatological examination, she presented disseminated achromic macules, with few not affected skin areas, besides small erythematous crusted plates lesions over her left forearm (Figures 1-3), face, back of hands and dorsum of the feet (sun-exposed regions). The initial hypothesis was generalized Vitiligo and actinic keratosis (KA). After surgical remove of some lesions, it was given the diagnosis by histopatholoy biopsy of: actinic keratosis with associated folliculitis, squamous cell carcinoma moderately differentiated in the left eyelid treated surgically by Mohs micrographic surgery.

cosmetology-trichology-Small-erythematous

Figure 1: Small erythematous crusted plates lesions on left forearm.

cosmetology-trichology-Expanded-vision

Figure 2: Expanded vision of lesions, allowing visualization of flaking and redness.

cosmetology-trichology-forearm-measuring

Figure 3: Lesions in the left forearm measuring about 2 cm.

Discussion

Studies report that there are genes that confer susceptibility to Vitiligo. Most of them encodes immunoregulatory proteins, especially to the pathways wich melanocytes can be recognized and killed. Besides that, there is an association between Vitiligo and polymorphism in the gene TYR, wich encodes tyrosinase, enzyme involved in melanin synthesis. Discrete allelic interactions in these genes related to different immunological recognition of tyrosinase in Vitiligo and melanoma, suggest that the intense expression of anti-tyrosinase protects patients with Vitiligo against melanoma. This gene interaction may also explain the frequent occurrence of Vitiligo in patient treated for melanoma, in wich the development of autoimmune disorder is a sign for positive prognosis, conferring increased survival of this patients [7].

Teulings et al. [5] analyzing 1.307 patients with and without Vitiligo noted that the probability of developing skin cancer in patients with Vitiligo it was considerably low. Besides that, among patients with Vitiligo that developed skin cancer, only 2 of them had basal cell carcinoma in Vitiligo’s affected area, illustrating this protection [6].

There are many mechanisms that attempt to explain the protection Vitiligo confers against skin cancer. Between then: patients with Vitiligo protect the skin more often from sun exposure [7-9]; the anti melanocytic autoimmune response of Vitiligo 10; theoretical impossibility of melanoma arising in the areas affected by Vitiligo, since the melanocytes were destroyed [6]; Vitiligo’s patients seem to have overexpression of p53, tumor suppressor gene, wich possibly explains the low risks for CBC and CEC7 [10]; due to autoimmune mechanism, Vitiligo patients have overproduction of proinflammatory cytokines IL-1 and TNF-α, that stimulates the production of superoxide dismutase and glutathione peroxidase, reducing the risk of skin cancer [10].

A research was made in Bireme and Scielo database, being found so far 10 case report and studies with large samples, between the years of 1991 and 2014 , in wich Vitiligo preceded the skin cancer, highlighting the rarity of this study and the importance of it to the scientific community.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 430
  • [From(publication date):
    June-2017 - Oct 24, 2017]
  • Breakdown by view type
  • HTML page views : 389
  • PDF downloads :41
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords