|Jin Young Kim1,2, Yong Jin Jeong3,4 and Sung Pyo Park3,4*|
|1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea|
|2Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea|
|3Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea|
|4Department of Ophthalmology, Kangdong Sacred Heart Hospital, Seoul, Korea|
|Corresponding Author :||Sung Pyo Park
Department of Ophthalmology
Hallym University College of Medicine
Kangdong Sacred Heart Hospital, Gil-dong
Gangdonggu,Seoul, 134-701; Republic of Korea
E-mail: [email protected]
|Received November 22, 2014; Accepted December 23, 2014; Published December 29, 2014|
|Citation: Kim JY, Jeong YJ, Park SP (2014) Different Concentrations of Aqueous Cytokines According to Diabetic Macular Edema Patterns as Determined Optical Coherence Tomography. J Clin Exp Ophthalmol 5:380. doi:10.4172/2155-9570.1000380|
|Copyright: © 2014 Kim JY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: To evaluate the relationship between various cytokine levels in aqueous humor and diabetic macular edema (DME) types as determined by optical coherence tomographic (OCT) patterns.
Methods: The study examined 76 patients with DME at early phase. Ten patients who underwent cataract surgery served as controls. Eyes with DME were divided into four groups, based on OCT patterns of DME, prior to intravitreal bevacizumab injection (IVB). Patterns included sponge-like diffuse retinal thickening (SDRT) (n=27), cystoid macular edema (CME) (n=18), serous retinal detachment (SRD) (n=15), and combined CME and SRD (n=16). Visual acuity, central macular thickness (CMT) through OCT, and aqueous cytokine concentrations of interleukin (IL)-6, IL-8, IL-10, IL-13, monocyte chemo attractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF) were measured in all subjects. The odds ratio (OR) between aqueous cytokines and each DME pattern were calculated using multivariate regression analysis.
Results: After IVB, CMT was reduced in all groups, but the highest reduction ratio occurred in eyes with SDRT and CME. Aqueous analyses showed that VEGF was associated with development of SDRT (P=0.003, OR=1.043, 95% CI=1.015-1.072). IL-6, MCP-1 were related with CME (P<0.001, OR=1.025, 95% CI=1.011-1.039; P<0.001, OR=1.003, 95% CI=1.001-1.004, respectively). IL-6 was also associated with SRD (P=0.045, OR=1.018, 95% CI=1.006-1.030). Furthermore, IL-6, VEGF were related with Combined pattern (P=0.031, OR=1.013, 95% CI=1.002-1.024; P=0.038, OR=1.014, 95% CI=1.014-1.043, respectively).
Conclusion: Specific aqueous cytokines may play an important role in developing each DME pattern based on OCT.
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