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Digital Necrosis in Type I Cryoglobulinemia | OMICS International
ISSN: 2165-7831
Journal of Blood & Lymph
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Digital Necrosis in Type I Cryoglobulinemia

Sophie Georgin-lavialle1*, Emmanuel Lafont2, Audrey Stansal3and Jacques Pouchot2

1Department of Internal Medicine, Tenon Hospital, Pierre and Marie Curie University, France

2Department of Internal Medicine, Georges Pompidou European Hospital, Paris Descartes University, France

3Department of Vascular Medicine, Georges Pompidou European Hospital, Paris Descartes University, France

*Corresponding Author:
Sophie Georgin-lavialle
Department of Internal Medicine
Tenon hospital
Pierre and Marie Curie University, France
Tel: 33156017204
E-mail: [email protected]

Received date: date November 22, 2014; Accepted date: date November 24, 2014; Published date: date November 26, 2014

Citation: Georgin-lavialle S (2016) Digital Necrosis in Type I Cryoglobulinemia . J Blood Lymph 4:i102. doi:10.4172/2165-7831.1000i102

Copyright: © 2014 Faraj Sophie Georgin-lavialle et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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A 69-year-old man presented with severe pain in hands and feet related to necrosis. Extensive explorations revealed type I cyroglobulinemia associated to monoclonal IgG kappa. Unfortunately he died a few months after.


Digital necrosis; Type I Cryoglobulinemia; IgG Kappa

Clinical Image

A 69-year-old man presented with severe pain in hands and feet. The distal part of most fingers and toes were necrotic (Figure 1). Extensive diagnostic work-up was performed: physical examination was otherwise unremarkable, and a thoracic and abdominal CT-scan was non-contributive. Blood sampling demonstrated the presence of a type I cryoglobulinemia, constituted of a monoclonal immunoglobulin G kappa at a titer of 2.03 g/L. Bone marrow smear and biopsy were normal. Treatment with oral corticosteroids and rituximab was instituted, and necrotic lesions were surgically excised. Unfortunately, the patient was readmitted one month later for extension of digital necrosis and infectious pneumonia. Outcome was unfavorable and the patient died. Type I cryoglobulinemia represent 10 to 15% of all cryoglobulinemia [1]. They are frequently associated with malignant B cell proliferation and the production of a precipitating monoclonal immunoglobulin that may result in severe ischemic manifestations such as the one reported here.


Figure 1: Distal part of toes and fingers were necrotic


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