alexa Disease Closure through Opening Novel Chrono-Sciences: Bioprocessing of Intermediary Metabolism | Open Access Journals
ISSN: 2155-9821
Journal of Bioprocessing & Biotechniques
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Disease Closure through Opening Novel Chrono-Sciences: Bioprocessing of Intermediary Metabolism

Akbar Nikkhah*
Chief Highly Distinguished Professor, Department of Animal Sciences, University of Zanjan, Iran
Corresponding Author : Akbar Nikkhah
Chief Highly Distinguished Professor
Department of Animal Sciences, Faculty of Agricultural Sciences
University of Zanjan, Zanjan, Iran, National Elite Foundation, Tehran, Iran
Tel: +98-24-350- 328-01
Fax: +98-24-350-332-02
E-mail: [email protected]
Received December 29, 2014; Accepted December 30, 2014; Published January 02, 2015
Citation: Nikkhah A (2015) Disease Closure through Opening Novel Chrono- Sciences: Bioprocessing of Intermediary Metabolism. J Bioprocess Biotech 5:e118 doi: 10.4172/2155-9821.1000e118
Copyright: ©2015 Nikkhah A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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While deeply important, timing of nutrient intake and bioprocessing has been mostly overlooked in modern medical and nutritional sciences and public health policies. Glucose by humans is not well tolerated during evening and night times unlike morning and day time. From a chronophysiological standpoint, activity demands glucose and thus day - and not night - is the right time to bioprocess any glucose overflow [1,2]. This editorial authorizes a realistic recommendation to minimize evening and nocturnal eating and bioprocessing of especially sugars and starches to promote health through reducing risks from splanchnic and abdominal adiposity, metabolic syndrome, obesity, diabetes, hypertension, and cardiovascular abnormalities. The basis for such an advice includes the most recent discoveries on handling intermediary metabolism in sophisticated animal models.
A more profound understanding of human physiology is enabled by optimal understanding of comparative animal physiology. Ruminants as sophisticated working models for studying human metabolism possess adequately integrative systems ecology, serving postmodern investigations at gene, cell, organ and whole body levels [3-5]. Nocturnal vs. diurnal feed delivery to dairy cows can increase intake rate and postprandial rumen release of metabolites [4-6]. Night feeding, also, improves milk energy production and nutrient utilization efficiency in dairy and beef ruminants [6,7]. These findings underline the biological significance of eating timing in orchestration of nutrient partitioning and metabolic health [8-10].
The early morning glucose upsurge occurs usually in the expectation of the activity period and is called ‘dawn-phenomenon'. This glucose peak along with a rise in corticosterone helps to elevate glucose supply and bioprocessing, which in turn raises insulin demands [7]. Reduced glucose tolerance overnight may partially be due to higher melatonin that basically originates from lower glucose bioprocesing capacity and needs of the night. Avoiding large evening and night food meals can allow human endocrinology to better cope with the external circadian environment towards improved nutrient bioprocessing and general health [11-13].
The major philosophy is to help smoothly bioprocess and synchronize the internal rhythms of cell physiology with the shifting environment. Should effectively accomplished, this synchrony could largely ease brain and heart work and successfully reduce risks of metabolic disorders.
In brief, animals of particularly livestock provide appropriate metabolic models for testing innovative hypotheses in human medicine and nutrition [11]. This is increasingly important as the postmodern man is facing complicated issues such as diabetes, various cancer and nervous system related diseases. Farm animals could open novel horizons into closing such rising health hurricanes. This is certainly a practical tool to bioprocess intermediary metabolism to improve health.
The Iran’s Ministry of Science Research and Technology, National Elite Foundation, and University of Zanjan are gratefully acknowledged for supporting the author’s global programs of optimizing science edification in the new millennium.

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