alexa Editorial: Post-stroke Angiogenesis and Treatment Potential | Open Access Journals
ISSN: 2329-6925
Journal of Vascular Medicine & Surgery
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Editorial: Post-stroke Angiogenesis and Treatment Potential

Robert Perna*

The Institute of Rehabilitation Research, Houston, TX, USA

Corresponding Author:
Robert Perna
The Institute of Rehabilitation Research
RN, 5930 Kuldell Drive
Houston, Texas, USA
Tel: 706-750-2572
E-mail: [email protected]

Received Date: April 25, 2016; Accepted Date: April 26, 2016; Published Date: April 30, 2016

Citation: Perna R (2016) Editorial: Post-stroke Angiogenesis and Treatment Potential. Vasc Med Surg 4:e117. doi:10.4172/2329-6925.1000e117

Copyright: © 2016 Perna R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Vascular Medicine & Surgery

Editorial

Vascular science is progressing rapidly and current research methodologies are facilitating the testing of many potential treatments for vascular disease. One fascinating area of research with great potential for clinical implications is angiogenesis. It has long been observed that ischemia drives angiogenesis and this can be adaptive in promoting perfusion. Animal studies show that early post cerebral ischemia, angiogenesis genes are up regulated [1]. Angiogenesis may have great clinical potential if modifiable. For example, after stroke the effected brain region and long-term prognosis may be dependent on reinstitution of blood flow and potential angiogenesis [2]. Part of our current clinical challenge is to discern what variables and activities stimulate and modulate angiogenesis. Neo vascularization may be both adaptive and maladaptive so a thorough understanding of this process will be needed before clinical treatments can be fully developed. For example, evidence suggests that physical exercise [3] may induce slight hypoxia and thus stimulate angiogenesis; however, the details regarding which exercises, duration and intensity are not yet understood. Moreover, it is unclear if mental/cognitive exercise also stimulates these processes. In response to the ischemic injury vascular endothelial factors (VEGF) is released by endothelial cells and leads to angiogenesis and increased vascularization [4]. Many cytokines and growth factors have been shown to modulate VEGF gene expression. VEGF itself is up-regulated by other growth factors within hours of stroke and has a strong influence on growth of new blood vessels in the injured area of the brain [5]. Current research shows that various potential therapeutic interventions have the potential to stimulate cerebral angiogenesis [6]. Some research suggests that administration of exogenous Mesenchymal stem cells and various growth factors in an early post ischemic phase stimulate both angiogenesis and neurogenesis and lead to improved functional recovery after stroke. However vascular endothelial growth factor (VEGF) is a potent angiogenic factor for neuro vascularization and neurogenesis in ischemic injury and thus has great potential utility as therapy in stroke. We may be entering a time in medical history that may be laying the foundation for various new methods of treating cerebrovascular disease. It is likely that journals such as this will help foster the translational research that will be needed to facilitate much of the current cutting edge research into clinical treatments.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 8373
  • [From(publication date):
    April-2016 - Oct 17, 2017]
  • Breakdown by view type
  • HTML page views : 8283
  • PDF downloads :90
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords