|Rana M1, Shah S1*, Quinlan M2, Gupta A2, Masood I1 and Nessim M1,2|
|1Birmingham and Midland Eye centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom|
|2Sandwell and Dudley Hospital, Sandwell and West Birmingham Hospitals NHS Trust, United Kingdom|
|Corresponding Author :||Prof Sunil Shah
Consultant Ophthalmologist and Cornea Lead
Birmingham Midlands Eye Centre, Birmingham, UK
Tel: 0044- 121 507 6807
Email: [email protected]
|Received: November 22, 2014; Accepted: December 23, 2014; Published: December 26, 2014|
|Citation:Rana M, Shah S, Quinlan M, Gupta A, Masood I, et al. (2014) Effect of Ocular Biomechanics on Intraocular Pressure Measurement in Mucopolysaccharidosis I-S (Scheie’s Syndrome). J Clin Exp Ophthalmol 5:378. doi:10.4172/2155-9570.1000378|
|Copyright: © 2014 Shah S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: To study the effect of biomechanical properties of the cornea on the intraocular pressure in eyes affected with Mucopolysaccharidosis type I-S (Scheie's syndrome).
Methods: Four eyes of two patients in their mid-fifties diagnosed with Scheie's syndrome were investigated for corneal biomechanical properties. The corneal biomechanical profile was assessed by the use of Ocular response analyzer (ORA, Reichert Inc., of Buffalo, NY). Intraocular pressures were also checked using various tonometry devices to check for variability in the readings due to the corneal changes.
Results: The intraocular pressure (IOP) measurements were noted to be high in both the patients at their initial presentation. Both the patients were put on topical anti glaucoma treatment and one underwent glaucoma filteration surgery as well for IOP control. Both the patients underwent successful bilateral deep anterior lamellar keratoplasty (DALK) procedures. The post procedure IOP measurement had a dramatic improvement in both the patients. Corneal biomechanical profile was noted to be high pre DALK and reduced significantly after the lamellar surgery. The intraocular pressure readings were also measured using different tonometry devices and were noted to be lower after graft surgeries.
Conclusion: Corneal rigidity and hysteresis is high in patients with MPS type I-S. This is reflected in the raised intraocular pressures checked by use of applanation or indentation tonometry. Use of the ocular response analyzer has helped study the biomechanical properties of such corneas and helped in assessment of true values of intraocular pressures thus preventing inappropriate intervention options especially surgical options.
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