|Ryoma Michishita1*, Hiroaki Tanaka1,2, Hideaki Kumahara3, Makoto Ayabe4, Takuro Tobina5, Eiichi Yoshimura6, Takuro Matsuda2,7, Yasuki Higaki1,2 and Akira Kiyonaga1,2|
|1Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka, Japan|
|2Institute for Physical Activity, Fukuoka University, Fukuoka, Japan|
|3Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan|
|4Faculty of Computer Science and Systems Engineering, Okayama Prefectural University, Okayama, Japan|
|5Faculty of Nursing and Nutrition, Laboratory of Exercise Physiology, University of Nagasaki, Nagasaki, Japan|
|6Department of Food and Health Science, Prefectural University of Kumamoto, Kumamoto, Japan|
|7Department of Physical Medicine and Rehabilitation, Fukuoka University Hospital, Fukuoka, Japan|
|Corresponding Author :||Michishita R
Laboratory of Exercise Physiology
Faculty of Health and Sports Science
Fukuoka University, Fukuoka, Japan
E-mail: [email protected]
|Received May 28, 2014; Accepted June 25, 2014; Published June 28, 2014|
|Citation: Michishita R, Tanaka H, Kumahara H, Ayabe M, Tobina T, Yoshimura E, Matsuda T, Higaki Y, Kiyonaga A (2014) Effects of Lifestyle Modifications on Improvement in the Blood Lipid Profiles in Patients with Dyslipidemia. J Metabolic Synd 3:150. doi:10.4172/2167-0943.1000150|
|Copyright: © 2014 Michishita R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Aim: This study was designed to clarify the difference in the effects of aerobic exercise training and diet on the improvement in the blood lipid profiles in patients with dyslipidemia.
Subjects and Methods: The study enrolled 86 patients with dyslipidemia [34 males and 52 females; age, 55 ± 10 years (33 to 71 years); low-density lipoprotein cholesterol (LDL-C), 150 ± 33 mg/dl (74 to 206 mg/dl); high-density lipoprotein cholesterol (HDL-C), 54 ± 12 mg/dl (35 to 87 mg/dl) and triglycerides, 165 ± 65 mg/dl (68 to 318 mg/dl)]. The subjects were randomly allocated to exercise training (n=42) or diet (n=44) group. These patients in the exercise training group were instructed to exercise for more than 300 min per week at the lactate threshold intensity. In the diet group, the target caloric intake was 25 kcal/kg of ideal body weight [height (m)2 × 22] according to the guideline of the Japan Society for the Study of Obesity.
Results: After the 12-week intervention, the LDL-C, triglyceride level and body weight decreased in both the exercise training and diet groups (p<0.05). There was no significant interaction effect for group × time on the LDL-C, fasting triglyceride level or body weight between the groups. The HDL-C increased only in the exercise training group, and a significant interaction effect for group × time was seen between the exercise training and diet groups for the HDL-C levels (p<0.05).
Conclusions: Based on our results, an improvement in the HDL-C level was observed in the exercise training group, but not in the diet group, despite the fact that the reductions in the LDL-C, triglycerides and body weight were not significantly different between the two groups. Therefore, these results suggest that lifestyle modification, especially exercise training, is considered to be important to reduce the risk of cardiovascular disease through by increasing the HDL-C.
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