alexa Effects of Pineal Gland Neurohormone Melatonin on Cancer Cells in the Human Central Nervous System | Open Access Journals
Journal of Cancer Science and Research
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Effects of Pineal Gland Neurohormone Melatonin on Cancer Cells in the Human Central Nervous System

Yiğit Uyanıkgil1,2, Kubilay Doğan Kılıç1 and Mehmet Turgut3*

1Department of Histology and Embryology, Ege University, School of Medicine, Turkey

2Cord Blood, Cell-Tissue Research and Application Center, Ege University, İzmir, Turkey

3Department of Neurosurgery, Adnan Menderes University School of Medicine, Aydın, Turkey

*Corresponding Author:
Mehmet Turgut
Cumhuriyet Mahallesi
Adnan Menderes Bulvarı, Turkey
Tel: +90 256 2134874
Fax: +90. 256.2120146
E-mail: [email protected]

Received date: March 26, 2016; Accepted date: March 27, 2016; Published date: March 30, 2016

Citation: Uyanıkgil Y, Doğan Kılıç K, Turgut M(2016) Effects of Pineal Gland Neurohormone Melatonin on Cancer Cells in the Human Central Nervous System. Cancer Med Anticancer Drug 1:e102.

Copyright: © 2016 Uyanıkgil Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Cancer Science and Research

Editorial

Melatonin (MLT), N-acetyl-5-methoxytryptamine, an endogenous compound synthesized by pineal gland and it was discovered nearly 50 years ago [1,2]. It was recognized with reproductive and neuroendocrine physiology [3]. Studies on mammalians showed that MLT’s acute and chronic toxicity is low. Even in human studies, there was not any significant negative effect. MLT is one of the members of regulatory factors which control proliferation and cell loss [4]. Up to now it is the only molecule known to hormonal regulator of neoplastic cell growth. Recently, it has been suggested that MLT inhibits cancer cell proliferation at physiological concentration, also exhibits cancer cell’s cytotoxicity at pharmacologic concentration. Furthermore, at both concentrations MLT lowers invasive and metastatic status of cancer cells [5]. Also, there are in vivo and in vitro studies shows that MLT has a regressive role in tumors [6]. Studies of effects of MLT on brain tumors focus on two different cell types of the nerve system, glial and neuronal.

Brain tumours are of different cell types, the commonest being tumours of glia called gliomas. Cruz-Machado et al. [7] reported that rat pineal gland responds to lipopolysaccharide (LPS). LPS triggers tumor necrosis factor (TNF) production in vitro. TNF is recognized by TNF R1 expressed on astrocytes, microglia and pinealocytes, but the source of TNF production in cultured pineal glands is unknown at present [8]. Not only MLT’s positive effect on regressing tumor but also a lack of MLT is linking with electromagnetic fields on MLT production by the pineal gland, to tumors. It is also known that pinealectomy causes increasing incidence of tumours [9].

Studies show that one of the major concepts of MLT is increasing apoptotic cell death in cancer cells. In general, research concerning the role of MLT in apoptosis focused on immune cells and neurons. In contrast with the certain, MLT inhibits apoptosis in normal cell [10]. However, there are prooves that in cancer cells, MLT increases apoptosis. Fukuda et al. [11] studied in the previous step of MLT, hydroxy indole-O-methyltransferase (HIOMT) which catalyzes the terminal reaction of MLT. The proportions of HIOMT-immunoreactive cells successively regressed the pineocytoma, pineal parenchymal tumor of intermediate differentiation, and pineoblastoma. Their results indicated new way through the diagnosis of the parenchymal pineal tumor.

In spite of these studies, there is no clear evidence which suggests the obvious positive effect of MLT on brain carcinoma treatment. Nevertheless, we strongly believe that new studies will demonstrate MLT’s therapeutical potential in future. In the following years, further studies to be published in the Journal of Brain Tumors & Neurooncology will reveal its way of effect clearly and combined clinical trials will increase the frequency of applications. Moreover, the outcomes of new studies may facilitate the experimental studies on MLT and attract more researchers into this field to make novel investigations in future.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Journals

Article Usage

  • Total views: 8424
  • [From(publication date):
    March-2016 - Oct 18, 2017]
  • Breakdown by view type
  • HTML page views : 8342
  • PDF downloads :82

Review summary

  1. Stuart
    Posted on Aug 12 2016 at 6:04 pm
    This paper reports about the pineal gland neurohomone melatonin and its effects on cancer cells present in human nervous system. Authors have clearly mentioned the concepts involved and new way of diagnosis measures. In future this experimental study opens new field for investigations.
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords