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ISSN: 2157-7595
Journal of Yoga & Physical Therapy

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Efficacy and Tolerability of Pregabalin vs Sertralin in Generalised Anxiety Disorder Concise Communication

Mina Cvjetkovic-Bošnjak*

Psychiatry Clinic, Clinical Centre of Vojvodina, Novi Sad, Medicl faculty Novi Sad Hajduk Veljkova 1-7, Novi Sad, Serbia

Corresponding Author:
Mina Cvjetkovic-Bošnjak
Psychiatry Clinic, Clinical Centre of Vojvodina
Novi Sad, Medicl faculty Novi Sad Hajduk Veljkova 1-7
Novi Sad,Serbia
Tel: +381214843286, (063) 153 35 98
E-mail: [email protected]

Received date: October 26, 2015; Accepted date: December 19, 2015; Published date: December 27, 2015

Citation: Cvjetkovic-Bošnjak M (2015) Efficacy and Tolerability of Pregabalin vs Sertralin in Generalised Anxiety Disorder Concise Communication. J Yoga Phys Ther 5:221. doi:10.4172/2157-7595.1000221

Copyright: © 2015 Cvjetkovic-Bošnjak M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Generalised Anxiety Disorder(GAD) represent a chronic mental illness characterized with pathological fear,extremely persistant worry usually about minor everyday problems and with numerous of vegetative symptoms [1-17]. It represent difficult problem in Mental Health,as life occurance of GAD is 5-7% Symptoms of GAD, according to ICD-X and DSM-V even today can be misdiagnosed, and unadeqvatelly treated [8-24] . If the symptoms are long lasting and untreated, often comorbidity with depression,alcohol abuse,and high suicidality level make extremely serious mental problem [2-9]. GAD interfered significantly with everyday activities and causes substantional personall distres so proper diagnosis and adeqvate treatment have to become priority in medical practice. WFSBP (World Federation of Societes of Biological Psychiatry) recommend SSRI (Selective Serotonin Reutake Inhibitors), SNRI (Serotonin and Norepinefrin Reuptake Inhibiors) and pregabaline, atypical anxiolytc as first line treatment, in combination with psychotherapy [7-19]. In present study, efficacy and tolerability of pregabaline vs.sertraline in patient with diagnoses of GAD was observed.The study included 107 in-patients age 20-60,both gender. Duration of disorder was in average of 4,7+0,3 years in group of patients treated with sertraline and about 4,6+0,4 in group treated with pregabalin.In previous episodes, 98% of all included patients were treated with SSRI and SNRI, in adeqvately therapeutical doses. Actually, patients were admitted in daily treatment due to new episode of GAD. In included patients, washup period was one week. At the begining of the study, all patients were reqvired to have a Covi Anxiety Scale, total score >9 and total score on HAMA (Hamilton Anxiety Scale) >20.In first group, patients were treated with sertraline, (doses began from 50 mg up to mean value of 150 mg/die). Doses was titrated during one week.In second group patient were treated with pregabalin, doses at first day were 75 mg, and titrated to 225 mg/die during one week. In all included patients cognitive-behavioral therapy ,individual and group was performed, during investigation. The primary analysis was change in Hamilton Raiting Scale for Anxiety (HAMA), a total score from baseline to endpoint. Secondary indicator of efficacy was change in HAMA psychic (emotional) and somatic (physical) scores weekly till endpoint. Global clinical assessment was conducted by using the Clinical Global Impression change raiting (CGI).

HAMA was repeated every week to evaluate therapeutical effects used by two independent psychiatrist. Each patient was randomly assigned to 4 weeks treatment with pregabalin (n=47) or sertraline (n=60).Adverse events were reporte in 26% aff all patients, with no signifficante differences among two groups of patients.Among patients treated with sertraline most common adverse efvent was nausea (13%) and dizziness (5%), and in group there appear dizziness also ((13%) and somnolence (10%).In tis patients adverse events were short-lasting,dose-dependent and mild intensity.With reduction doses,adverse events dissepeared and therapeutical effects persist.There were no withdrawal eventts during this study.

Resultsof this study showed that both pregabalin and sertraline showed good effect in treating symptoms of Generalized Anxious Disorder. Time of acting onset was shorter in treatment with pregabalin compared to treatment with sertraline. In the patient treating with sertralin, anxiolytic effect was detectable after at least 14 days in present study, and pregabalin showed first good results during first week of treatment. Adverse effects were reported in 28 % patients treating with pregabalin and 27 % patient treated with sertraline,with no signifficant difference.

In present study, efficacy and tolerability of pregabalin were high. Compared to sertraline, pregabalin showed more rapid time of action and equal efficacy. Adverse events are short-lasting and dose depend our investigation showed that pregabalin, an atypic anxiolytic is efficacy and well tolerable in treatment of G.A.D.

In perspective, longer-term studieswill be reqvired to assess the long-term safety and efficacy of pregabalin in treatment of GAD.


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Review summary

  1. Marcelo
    Posted on Oct 31 2016 at 7:49 pm
    Authors have compared sertraline and pregabalin drug efficacy and tolerability in the treatment of G.A.D. Studies showed that pregabalin has more efficacy and rapid time of action. The finding of the study will be useful in development of more efficient drugs.

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