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FMT-PET for the Early Diagnosis of Parkinsonand#195;and#162;and#194;and#8364;and#194;and#8482;s Disease | OMICS International
ISSN: 2329-6895
Journal of Neurological Disorders
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FMT-PET for the Early Diagnosis of Parkinson’s Disease

Sayaka Ono1,2*, Yuko Nara1, Toshihiko Sato3 and Shin-ichi Muramatsu1*
1Division of Neurology, Jichi Medical University, Tochigi, Japan
2Division of Neurology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
3Utsunomiya Central Clinic, Tochigi, Japan
Corresponding Authors : Sayaka Ono
Division of Neurology
Department of Medicine
Jichi Medical University
3311-1 Yakushiji, Shimotsuke
Tochigi 329-0498, Japan
Tel: +81-285-58-7352
Fax: +81-285-44-5118
E-mail: [email protected]
  Shin-ichi Muramatsu
Division of Neurology
Department of Medicine
Jichi Medical University
3311-1 Yakushiji, Shimotsuke
Tochigi 329-0498, Japan
Tel: +81-285-58-7352
Fax: +81-285-44-5118
E-mail: [email protected]
Received October 30, 2014; Accepted October 31, 2014; Published November 02, 2014
Citation: Ono S (2014) FMT-PET for the Early Diagnosis of Parkinson’s Disease . J Neurol Disord 2:i104. doi:10.4172/2329-6895.1000i104
Copyright: © 2014 Ono S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

A 56-year-old woman complained of a three-month history of progressive clumsiness in her left hand. She reported fine hand movements to have become slow and uncoordinated, thus leading to moderate difficulty in dressing and working as a beautician. A neurological examination revealed rigidity in her left limb. No obvious tremors were noted. She was treated with L-dopa (300 mg/day), which provided substantial symptomatic benefits. MRI showed the putamen to have a normal morphology and size, and no areas of any altered signals were observed in the brain parenchyma (Figure 1A). Positron emission tomography (PET) with an aromatic L-amino acid decarboxylase (AADC) tracer, 6-[18F] fluoro-L-m-tyrosine (FMT) showed a reduced uptake in the posterior part of the right putamen.

Description
A 56-year-old woman complained of a three-month history of progressive clumsiness in her left hand. She reported fine hand movements to have become slow and uncoordinated, thus leading to moderate difficulty in dressing and working as a beautician. A neurological examination revealed rigidity in her left limb. No obvious tremors were noted. She was treated with L-dopa (300 mg/day), which provided substantial symptomatic benefits. MRI showed the putamen to have a normal morphology and size, and no areas of any altered signals were observed in the brain parenchyma (Figure 1A). Positron emission tomography (PET) with an aromatic L-amino acid decarboxylase (AADC) tracer, 6-[18F] fluoro-L-m-tyrosine (FMT) showed a reduced uptake in the posterior part of the right putamen (Figure 1B).
In Parkinson’s disease (PD), the activity of AADC in the striatum is reduced to 5%–20% of normal levels before cardinal motor symptoms become apparent [1]. High-resolution FMT-PET images can clearly demonstrate a reduction of the subregional AADC activities, and the lowest FMT uptake values tend to be observed in the posterior part of the putamen contralateral to the more affected limbs, even in the early stage of the disease [2]. This case therefore demonstrated the diagnostic value of using FMT-PET in the diagnosis of mild PD, particularly when encountering patients that do not show any remarkable tremors while at rest.
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