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Functional Dyspepsia | OMICS International
ISSN: 2165-7920
Journal of Clinical Case Reports
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Functional Dyspepsia

Abdullah M Nasrat1,2*, Eman Al-Ayoubi1 and Yasir Raza3
1Department of General Surgery, Balghsoon Clinic, Jeddah, Saudi Arabia
2Department of Nutritional Therapy, Damak Center, Jeddah, Saudi Arabia
3Stem Cell Research Laboratory, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
Corresponding Author : Abdullah M Nasrat
Department of General Surgery
Balghsoon Clinic, Jeddah
KSA, Saudi Arabia
Tel: + 966 (012) 667 3645
E-mail: [email protected]
Received March 28, 2015; Accepted April 25, 2015; Published April 27, 2015
Citation: Nasrat AM, Al-Ayoubi E, Raza Y (2015) Functional Dyspepsia. J Clin Case Rep 5:516. doi:10.4172/2165-7920.1000516
Copyright: ©2015 Nasrat AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Functional dyspepsia is a clinical syndrome defined by chronic or recurrent pain or discomfort in the upper abdomen of a variable origin. A general agreement exists on the irrelevant role played by Helicobacter pylori in the pathophysiology of most cases of functional dyspepsia worldwide.

Letter to Editor
Functional dyspepsia is a clinical syndrome defined by chronic or recurrent pain or discomfort in the upper abdomen of a variable origin. A general agreement exists on the irrelevant role played by Helicobacter pylori in the pathophysiology of most cases of functional dyspepsia worldwide [1].
Diagnosis of H. pylori is based on the clinical symptoms and detection of H. pylori serum antibodies. Specific sensitive diagnostic tests are available but H. pylori serum antibodies, though non-specific, is suggested for screening of patients because of being cost effective as the matter of H. pylori dyspepsia is a typical subject of cost-effectiveness [2,3].
The efficacy of antibiotic treatment for non-ulcer dyspepsia is controversial, different trails have given conflicting results. Overall, antibiotic eradication treatment for non-ulcer dyspepsia symptoms had no significant effect on quality of life compared with placebo and was found more costly if compared to antacid treatment [4,5]. Bio-organic acids; lactic and acetic, have been proved effective in symptomatic and clinical cure of dyspepsia due to interference with H. pylori energy metabolism or its respiratory chain metabolism as the main sources of energy for H. pylori are via pyruvate and the activity of the pyruvate dehydrogenase complex is controlled by the rules of feedback regulation and product inhibition; lactate and acetate are demonstrated among the end products of pyruvate metabolism [6,7].
H. pylori is not just a bad bug in all instances; the juxta-mucosal ammonia produced by H. pylori protects the gastric wall from its acid if it goes in excess. The residual ammonia inside the lumen of the stomach resulting from the buffering process between the ammonia and the gastric acid is not toxic, it is even beneficial; as it functions as smooth muscle tonic maintaining the integrity of the gastro-esophageal sphincter and hence preventing reflux [2,7].
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