alexa Hand-Foot and Mouth syndrome with Capecitabine | Open Access Journals
ISSN: 2327-5146
General Medicine: Open Access
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Hand-Foot and Mouth syndrome with Capecitabine

Issam Lalya* and Hamid Mansouri
Department of Radiation Oncology, Military Teaching Hospital of Rabat, Mohammed V University, Rabat-Morocco
*Corresponding Author : Issam Lalya
Department of Radiation Oncology
Military Teaching Hospital of Rabat
Mohammed V University, Rabat, Morocco
Tel: 00212661572770
E-mail: [email protected]
Received: February 21,2016 Accepted: February 24,2016 Published:  February 26,2016
Citation: Issam L, Mansouri H (2016) Hand-Foot and Mouth syndrome with Capecitabine. Gen Med (Los Angel) 4:i111. doi: 10.4172/2327-5146.1000i111
Copyright: © 2016 Issam L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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Clinical Image
A 33-year-old woman presented with anal squamous cell carcinoma staged T2N1M0, she underwent radiation therapy with concomitant Capecitabine administered orally at a dose of 825 mg/m2 twice a day throughout the course of radiation. Three weeks after initiation of treatment she presented with hyperpigmentation involving the dorsum and the bottom of both hands and feet, with reinforcement over the knuckles and toes (Figures 1,2).
Careful examination of the palms showed erythema underlying the hyperpigmentation. We retained the diagnosis of palmar–plantar erythrodysesthesia (the hand–foot syndrome). The peculiar case of this patient is the involvement of the dorsum of the tongue with patchy and confluent hyperpigmentation without ulceration (Figures 3,4).
Treatment with topical agents was initiated without interrupting Capecitabine.One month after the end of treatment, all of the above described lesions completely resolved. To the best of our knowledge this is the first case of Hand-Foot syndrome associated to hyperpigmentation of the tongue.

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