alexa Heterotopic Ossification after Lung Transplantation | OMICS International
ISSN: 2161-105X
Journal of Pulmonary & Respiratory Medicine

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Heterotopic Ossification after Lung Transplantation

Stephan Keusch1* and Christian Benden2

1Division of Pulmonary Medicine, Zürcher Höhenklinik Wald, Switzerland

2Division of Pulmonary Medicine, Lung Transplant Unit, University Hospital Zurich, Switzerland

*Corresponding Author:
Stephan Keusch
Division of Pulmonary Medicine
Zürcher Höhenklinik Wald
Faltigbergstrasse 7, 8636 Wald, Switzerland
Tel: +41552566830
Fax: +41552566899
E-mail: [email protected]

Received date: January 12, 2015; Accepted date: January 16, 2015; Published date: January 18, 2015

Citation: Keusch S (2015) Heterotopic Ossification after Lung Transplantation. J Pulm Respir Med 5:i011. doi: 10.4172/2161-105X.1000i011

Copyright: © 2015 Keusch S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Lung transplantation; Heterotopic ossification

Image Article

A 40-year-old man who underwent lung transplantation for alpha-1-antitrypsine deficient emphysema showed in an abdominal x-ray, performed for the clinical suspicion of coprostasis, an unclear bone formation in the pelvis. He reported no complaints and clinical examination showed no tenderness, movement limitation or neurological deficits. In the computer tomography of the pelvis, surprisingly extraskeletal, heterotopic ossification of the gluteus minimus muscle of both sides were detected. No known risk factors for this pathology such as trauma, surgery, neurological or thermal injuries, or prolongued immobilization after transplantation could be established. It remains unclear if transplantation with start of triple immunosuppression or other unknown factors triggered this uncommon complication. In literature a case series (n=5) on heterotopic bone formation after transplantation (orthotopic liver and lung) [1] and a single case-report after lung transplantation [2] have been reported. Established treatment options are surgical excision or radiotherapy if symptoms are burdensome necessitating an intervention.


Figure 1 : Heterotopic ossification of the pelvis. Arrows mark the extraskeletal bone formation in the gluteus minimus muscle on both sides. Panel A: axial view, Panel B: coronal view, Panel C and D: sagittal view.


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