alexa Histological Studies of the Effects of Monosodium Glutamate on the Stomach in Adult Rats | OMICS International
ISSN: 2157-7099
Journal of Cytology & Histology
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Histological Studies of the Effects of Monosodium Glutamate on the Stomach in Adult Rats

Zuhair M Mohammedsaleh1,2* and Gamal Abd El- Aziz2

1Faculty of Applied Medical Sciences, University Of Tabuk , Tabuk, Kingdom of Saudi Arabia

2Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author:
Zuhair Mohammedsaleh
Faculty of Applied Medical Sciences
University Of Tabuk, Tabuk
Kingdom of Saudi Arabia
Tel: +966504303999
Email: [email protected]

Received Date: August 12, 2014; Accepted Date: August 14, 2014; Published Date: August 23, 2014

Citation: Mohammedsaleh ZM,Abd El- Aziz G (2014) Histological Studies of the Effects of Monosodium Glutamate on the Stomach in Adult Rats Mohammedsaleh, J Cytol Histol 5:i102 doi: 10.4172/2157-7099.1000i102

Copyright: © 2014 Mohammedsaleh ZM. Thi s is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Cytology & Histology

Introduction

The safety of monosodium glutamate (MSG) usage as a food additive has generated much controversy locally and globally. The effect of MSG on the stomach of adult Wistar rat was investigated. Fifteen adult male Wistar rats of average weight of 175-200 grams were used in this study and randomly assigned into two treatments (n=6) and control (n=3) groups. The rats in the treatment groups received 3 and 6 gm/Kg body weight of MSG thorough oral route daily for seven days. The control rats received equal amounts of distilled water. The rats were sacrificed after seven days of the experiment. The stomach were carefully dissected out and quickly fixed in 10% formol saline for routine histological procedures. Regarding the stomach, the histological findings in the treated groups showed evidence of increased inflammatory cellular infiltration and cellular hypertrophy in animals given 3 gm of MSG, while degenerative, atrophic changes and increased amounts of connective tissues around the bases of the gastric glands and in the submucosa in the group with 6 gm. These findings indicate that MSG may have some deleterious effects on the microanatomy of the stomach of adult Wistar rats at higher doses. It is recommended that further studies aimed at corroborating these findings be carried out.

cytology-histology-photomicrograph

Figure 1: Photomicrograph of a section of the stomach of rats which received low dose of MSG showing multiple congested blood vessels (bv) in the gastric submucosa.

cytology-histology-section

Figure 2: Photomicrograph of a section of the body of stomach of rats which received large dose of MSG showing increase of connective tissues lamina propria and around the basal parts of the gastric gland. Masson’s trichrome 400X.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 11764
  • [From(publication date):
    September-2014 - Dec 16, 2017]
  • Breakdown by view type
  • HTML page views : 7941
  • PDF downloads : 3823
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version