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Human Umbilical Cord Stem Cells Regulate the Surrounding Microenvironment through Active Secretion of Signaling Molecules | OMICS International
ISSN: 2168-975X
Brain Disorders & Therapy
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Human Umbilical Cord Stem Cells Regulate the Surrounding Microenvironment through Active Secretion of Signaling Molecules

Kiran Kumar Velpula1 and Jasti S Rao1,2*
1Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, USA
2Department of Neurosurgery, University of Illinois College of Medicine at Peoria, USA
Corresponding Author : Jasti S.Rao
Department of Cancer Biology and Pharmacology
University of Illinois College of Medicine at Peoria, IL 61605, USA
Tel: 309-671-3445
E-mail: [email protected]
Received May 19, 2012; Accepted May 21, 2012; Published May 24, 2012
Citation: Velpula KK, Rao JS (2012) Human Umbilical Cord Stem Cells Regulate the Surrounding Microenvironment through Active Secretion of Signaling Molecules. Brain Disord Ther 1:e102. doi:10.4172/2168-975X.1000e102
Copyright: © 2012 Velpula KK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Human umbilical cord blood, a rich source of hematopoietic and mesenchymal stem cells, provides an interesting therapeutic source of primitive cells. Specifically, human umbilical cord blood stem cells (hUCBSC) involve neither ethical issues related to embryonic stem cells nor common serious side-effects such as graft-versus-host disease, which may occur with bone marrow stem cells. In addition, hUCBSC exhibit higher proliferation and expansion potential than their adult bone marrow counterparts. Studies have demonstrated that hUCBSC influence their surrounding microenvironment in several ways: inhibiting neuronal death and apoptosis, controlling tumor proliferation and invasion, and inducing cell differentiation, neoangiogenesis, tissue repair and neuronal regeneration.

Kiran Kumar Velpula1 and Jasti S Rao1,2*
1Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, USA
2Department of Neurosurgery, University of Illinois College of Medicine at Peoria, USA
Corresponding Author : Jasti S.Rao
Department of Cancer Biology and Pharmacology
University of Illinois College of Medicine at Peoria, IL 61605, USA
Tel: 309-671-3445
E-mail: [email protected]
Received May 19, 2012; Accepted May 21, 2012; Published May 24, 2012
Citation: Velpula KK, Rao JS (2012) Human Umbilical Cord Stem Cells Regulate the Surrounding Microenvironment through Active Secretion of Signaling Molecules. Brain Disord Ther 1:e102. doi:10.4172/2168-975X.1000e102
Copyright: © 2012 Velpula KK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Kiran Kumar Velpula1 and Jasti S Rao1,2*
1Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, USA
2Department of Neurosurgery, University of Illinois College of Medicine at Peoria, USA
Corresponding Author : Jasti S.Rao
Department of Cancer Biology and Pharmacology
University of Illinois College of Medicine at Peoria, IL 61605, USA
Tel: 309-671-3445
E-mail: [email protected]
Received May 19, 2012; Accepted May 21, 2012; Published May 24, 2012
Citation: Velpula KK, Rao JS (2012) Human Umbilical Cord Stem Cells Regulate the Surrounding Microenvironment through Active Secretion of Signaling Molecules. Brain Disord Ther 1:e102. doi:10.4172/2168-975X.1000e102
Copyright: © 2012 Velpula KK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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