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Hypocholesterolemia in Sickle Cell Anemia: What is the Reason behind it? | OMICS International
ISSN: 2167-0501
Biochemistry & Pharmacology: Open Access
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Hypocholesterolemia in Sickle Cell Anemia: What is the Reason behind it?

Yesim Er Oztas*
Department of Biochemistry, Medical Faculty, Hacettepe University, Ankara, Turkey
Corresponding Author : Yesim Er Oztas
Department of Biochemistry, Medical Faculty
Hacettepe University, Ankara, Turkey
E-mail: [email protected]
Received March 03, 2012; Accepted March 09, 2012; Published March 12, 2012
Citation: Er Oztas Y (2012) Hypocholesterolemia in Sickle Cell Anemia: What is the Reason behind it? Biochem Pharmacol (Los Angel) 1:e110. doi:10.4172/2167-0501.1000e110
Copyright: © 2012 Er Oztas Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Editorial
Sickle cell anemia (SCA) is in fact a hemoglobinapathy complicated with vasoocclusion, inflammation and organ pathology. Hypocholesterolemia is a common laboratory finding in the plasma of SCA patients [1-4]. Till now the underlying pathology of this hypocholesterolemia has not been clarified in addition to the uncertainty of its clinical consequences.
There are some possibilities to explain the hypocholesterolemia of SCA patients. First comes the hemolytical stress where chronic hemolysis and increased erythropoietic activity are important in the consumption of plasma pool of cholesterol and development of hypocholesterolemia in SCA patients [5]. Oxidative stress can be another reason for hypocholesterolemia in SCA. In a recent study of our group a significant negative correlation was found between plasma cholesterol and hemolysate MDA levels of steady state SCA patients [6]. This data may indicate a decrease of either erythrocyte or plasma lipoprotein cholesterol perhaps due to a hypermetabolic state in response to oxidative stress.
Inflammatory stress is another character of SCA where chronic vasoocclusion results with a stimulation of inflammation [7]. Inflammation may possibly alter lipid balance that may result with hypocholesterolemia.
Although there are various reasons that may cause hypocholesterolemia, the clinical consequences of this laboratory finding have not been well established. Hypocholesterolemia is associated with depression and decreased immunity especially in elderly. Therefore, we are, as researchers, responsible to find the underlying metabolic events in this hypocholesterolemia and to determine the clinical correlations of hypocholesterolemia in SCA patients.
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