alexa Immunoinformatics: Implications on Reverse Vaccinology | OMICS International
ISSN: 2469-9756
Immunochemistry & Immunopathology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Immunoinformatics: Implications on Reverse Vaccinology

Mawadda Abd_Elraheem Awad _Elkareem1* and Mohammed Ahmed Salih2

1School of pharmacy, Department of Biotechnology, Ahfad university for women ,Omdurman, Khartoum ,Sudan

2School of pharmacy,Department of biotechnology, Africa city of technology, Khartoum,Sudan

*Corresponding Author:
Mawadda Abd_Elraheem Awad _Elkareem
School of pharmacy, Department of Biotechnology
Ahfad university for women ,Omdurman
Khartoum ,Sudan
Tel: 00249917313523/00249116869326
E-mail: [email protected]

Received Date: June 15, 2017; Accepted Date: June 20, 2017; Published Date: June 23, 2017

Citation: Awad_Elkareem MAE, Salih MA (2017) Immunoinformatics Implications on Reverse Vaccinology. Immunochem Immunopathol 3:127. doi: 10.4172/2469- 9756.1000127

Copyright: © 2017 Elneel MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Immunochemistry & Immunopathology


One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine [1]. Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease [2]. Then, Scientific progress has driven vaccine development from live attenuated and inactivated vaccines to purified recombinant one. The recent advances in bioinformatics, proteomics, immunoinformatics, structural biology and others have led to vaccinomics and reverse vaccinology as novel approaches for a generation of new vaccines [3]. Reverse vaccinology relies on the genomic information to identify relevant protein antigens and the design of algorithm for mapping potential B and T cell epitopes for diagnostic or vaccine purposes [4].


Vaccines; Immunological; Genome; Proteomics

Immunoinformatics is scientific setting that targets the use of mathematical and computational approaches to comprehend, produce, process, and develop immunological data [5]. Since the 1980s, different immunoinformatic tools were developed and used aiming for vaccine design (Figure 1) [6].


Figure 1: immunoinformatics implications on vaccine design.

As a result of sequencing human genome and other organism, huge amount of immunological data is accumulated. These wealthy data has been deposited in different database. The availability of different useful and user-friendly Web-based computational tools and searchable databases pave the way for predicting potential B, T cell epitopes in protein sequences. The main objective when predicting these epitopes is the determination of the binding affinity of MHC molecules and antigenic peptides.

The tools in this field are based on statistical and machine learning system and are used for studies modeling molecular interactions (such as antigen processing and presentation) and also plays a role in defining new hypotheses related to understand the immune system mechanisms [7].

The concept of reverse vaccinology is based on selecting specific epitope of interest that are capable of provoking cellular as well as humoral immune response. The peptide candidate could be selected based on several criteria including, sequence conservancy, binding affinity to both MHC classes allergenicity, etc.

Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others [3]. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. These approaches reducing the workload of experimentalists with higher probability of success. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise for reverse vaccinology.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

  • Antibody Engineering Meeting associated with 9th European Immunology Conference
    June 14-16 2018 Rome, Italy
  • International Conference on Clinical and Cellular Immunology
    August 6-7, 2018 Madrid, Spain
  • International Conference on Tumor & Cancer Immunology and Immunotherapy
    September 17-18, 2018 San Diego, USA
  • 12th International Conference on Allergy, Asthma & Clinical Immunology
    October 1-2, 2018 Moscow, Russia
  • World Congress and Expo on Immunology
    October 19-20, 2018 Baltimore, USA
  • 3rd International Conference on Autoimmunity
    November 26-27, 2018 Dublin, UK
  • 4th Antibodies, Antibiotics and Bio Therapeutics Congress
    December 05-06, 2018 Chicago, USA
  • 13th International Conference on Allergy and Clinical Immunology
    December 13-14 , 2018 Abu Dhabi, UAE

Article Usage

  • Total views: 758
  • [From(publication date):
    June-2017 - May 25, 2018]
  • Breakdown by view type
  • HTML page views : 668
  • PDF downloads : 90

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7