Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation
Received Date: Jul 26, 2017 / Accepted Date: Jul 27, 2017 / Published Date: Aug 01, 2017
Nano catalytic hydrogenation is the useful and widely applicable method for the reduction of chemical substances and belongs to the basic processes of modern medicinal and pharmaceutical chemistry. It has found numerous applications in biological networks for emerging roles of proteomics, genomics and transcriptomics in the discovery and validation of human colorectal cancer biomarkers from DNA/RNA sequencing data under synchrotron radiation. Majority of medicinal and pharmaceutical nano catalytic hydrogenations is still carried out using heterogeneous nano catalysts due to the process advantages such as ability, easy separation, and wide range of applicable reaction conditions. The homogenous nano catalysts, which have been further developed during the past years, have extended the scope of nano catalytic hydrogenation especially in the field of highly stereo selective transformations in biological networks for emerging roles of proteomics, genomics and transcriptomics in the discovery and validation of human colorectal cancer biomarkers from DNA/ RNA sequencing data under synchrotron radiation. However, new developments continue to appear also in the field of heterogeneous nano catalysis, particularly in cases where a high chemo-, region-, or stereo selectivity must be achieved.
The selectivity aspects of nano catalytic hydrogenation over heterogeneous nano catalysts will be discussed and documented with several examples. All three types of selectivity (chemo-, region-, and stereo selectivity) will be addressed with especial emphasis on the applicability of the nano catalytic procedure in biological networks for emerging roles of proteomics, genomics and transcriptomics in the discovery and validation of human colorectal cancer biomarkers from DNA/RNA sequencing data under synchrotron radiation. The scope of chemo selective hydrogenation will be demonstrated by selective hydrogenation of unsaturated nitriles. It was found that the C≡N group can be hydrogenated prior to the C=C bond [1–34]. Hydrogenation of (E,E)–2,4–hexadienoic acid methyl ester; methyl (E,E)–2,4– hexadienoate; 2,4–hexadienoic acid, methyl ester, (E,E)–; sorbic acid, methyl ester, (E,E)–; methyl trans, trans–sorbate; 2–trans– 4–trans– methyl sorbate; methyl (E,E)–sorbate; sorbic acid, methyl ester; methyl (2E,4E)- hexadienoate; methyl (2E,4E)–2,4–hexadienoate; methyl (E,E)–hexa–2,4–dienoate; 2,4– hexadienoic acid, methyl ester, (2E,4E)– will represent examples of regio selective hydrogenation [35–45]. In this case, only one of the two C=C bonds present in the nanomolecules should be reduced to obtain desired products. Finally, two examples will be given on stereo selective hydrogenation in biological networks for emerging roles of proteomics, genomics and transcriptomics in the discovery and validation of human colorectal cancer biomarkers from DNA/RNA sequencing data under synchrotron radiation. One example will describe the diastereo selective hydrogenation applied in the synthesis of (±)–piperazine-2-carboxylic acid dihydrochloride and 1-Boc-piperazine-2–carboxylic acid [46–76] while the other one will focus on enantio selective hydrogenation of prochiral α- and β- ketoesters over chirally-modified gold and silver nano catalysts, respectively.
- Heidari A, Brown C (2015) Study of composition and morphology of cadmium oxide (cdo) nanoparticles for eliminating cancer cells. J Nanomedicine Res 2: 5-20
- Heidari A, Brown C (2015) Study of surface morphological, phytochemical and structural characteristics of rhodium (iii) oxide (rh2o3) nanoparticles. Int J Pharmacol Phytochem Ethno 1: 15-19
- Heidari A (2016) An experimental biospectroscopic study on seminal plasma in determination of semen quality for evaluation of male infertility. Int J Adv Technol 7: e007.
- Heidari A (2016) Extraction and preconcentration of n–tolyl–sulfonyl–phosphoramid–saeure–dichlorid as an anti– cancer drug from plants: A pharmacognosy study. J Pharmacogn Nat Prod 2: e103
- Heidari A (2016) A thermodynamic study on hydration and dehydration of dna and rna−amphiphile complexes. J Bioeng Biomed Sci 002
- Heidari A (2016) Computational studies on molecular structures and carbonyl and ketene groups’ effects of singlet and triplet energies of azidoketene o=c=ch–nnn and isocyanatoketene o=c=ch–n=c=o. J Appl Computat Math 5: e142.
- Heidari A (2016) Study of irradiations to enhance the induces the dissociation of hydrogen bonds between peptide chains and transition from helix structure to random coil structure using atr–ftir, raman and 1hnmr spectroscopies. J Biomol Res Ther 5: e146
- Heidari A (2016) Future prospects of point fluorescence spectroscopy, fluorescence imaging and fluorescence endoscopy in photodynamic therapy (pdt) for cancer cells. J Bioanal Biomed 8: e135
- Heidari A (2016) A bio–spectroscopic study of DNA density and color role as determining factor for absorbed irradiation in cancer cells. Adv Cancer Prev 1: e102
- Heidari A (2016) Manufacturing process of solar cells using cadmium oxide (cdo) and rhodium (iii) oxide (rh2o3) nanoparticles. J Biotechnol Biomater 6: e125
- Heidari A (2016) A novel experimental and computational approach to photobiosimulation of telomeric dna/rna: Abiospectroscopic and photobiological study. J Res Development 4: 144.
- Heidari A (2016) Biochemical and pharmacodynamical study of microporous molecularly imprinted polymer selective for vancomycin, teicoplanin, oritavancin, telavancin and dalbavancin binding. Biochem Physiol 5: e146
- Heidari A (2016) Anti–cancer effect of uv irradiation at presence of cadmium oxide (cdo) nanoparticles on dna of cancer cells: A photodynamic therapy. Study Arch Cancer Res 4: 1
- Heidari A (2016) Biospectroscopicstudy on multi–component reactions (mcrs) in two a–type and b–type conformations of nucleic acids to determine ligand binding modes, binding constant and stability of nucleic acids in cadmium oxide (cdo) nanoparticles–nucleic acids complexes as anti–cancer drugs. Arch Cancer Res. 4: 2
- Heidari A (2016) Simulation of temperature distribution of DNA/RNA of human cancer cells usingtime– dependent bio–heat equation and lasers. Arch Cancer Res 4: 2
- Heidari A (2016) Quantitative structure–activity relationship (qsar) approximation for cadmium oxide (cdo) and rhodium (iii) oxide (rh2o3) nanoparticles as anti–cancer drugs for the catalytic formation of proviral DNA from viral RNA using multiple linear and non–linear correlation approach.Ann Clin Lab Res 4: 1
- Heidari A (2016) Biomedical study of cancer cells DNA therapy using laser irradiations at presence of intelligent nanoparticles. J Biomedical Sci 5: 2
- Heidari A (2016) Measurement the amount of vitamin D2 (ergocalciferol), vitamin D3 (cholecalciferol) and absorbable calcium (ca2+), iron (ii) (fe2+), magnesium (mg2+), phosphate (po4–) and zinc (zn2+) in apricot using high–performanceliquidchromatography(hplc)andspectroscopictechniques. J Biom Biostat 7: 292
- Heidari A (2016) Spectroscopy and quantum mechanics of the helium dimer (he2+), neon dimer (ne2+), argon dimer (ar2+), krypton dimer (kr2+), xenon dimer (xe2+), radon dimer (rn2+) and ununoctium dimer (uuo2+) molecular cations. Chem Sci J 7: e112
- Heidari A (2016) Human toxicity photodynamic therapy studies on DNA/RNA complexes as a promising new sensitizer for the treatment of malignant tumors using bio–spectroscopic techniques. J Drug Metab Toxicol 7: e129
- Heidari A (2016) Novel and stable modifications of intelligent cadmium oxide (cdo) nanoparticles as anti– cancer drug in formation of nucleic acids complexes for human cancer cells’ treatment. Biochem Pharmacol (Los Angel) 5: 207
- Heidari A (2016) A combined computational and qm/mm molecular dynamics study on boron nitride nanotubes (bnnts), amorphous boron nitride nanotubes (a–bnnts) and hexagonal boron nitride nanotubes (h–bnnts) as hydrogen storage. Struct Chem Crystallogr Commun 2: 1
- Heidari A (2016) Pharmaceutical and analytical chemistry study of cadmium oxide (cdo) nanoparticlessynthesis methods and properties as anti–cancer drug and its effect on human cancer cells. Pharm Anal Chem Open Access 2: 113
- Heidari A (2016) A chemotherapeutic and biospectroscopic investigation of the interaction of double–standard DNA/RNA–binding molecules with cadmium oxide (cdo) and rhodium (iii) oxide (rh2o3) nanoparticles as anti–cancer drugs for cancer cells treatment. Chemo Open Access 5: e129
- Heidari A (2016) Pharmacokinetics and experimental therapeutic study of DNA and other biomolecules using lasers: advantages and applications. J Pharmacokinet Exp Ther 1: e005
- Heidari A (2016) Determination of ratio and stability constant of DNA/RNA in human cancer cells and cadmium oxide (cdo) nanoparticles complexes using analytical electrochemical and spectroscopic techniques. Insights Anal Electrochem 2: 1
- Heidari A (2016) Discriminate between antibacterial and non–antibacterial drugs artificial neutral networks of a multilayerperceptron(mlp)typeusingasetoftopologicaldescriptors. J Heavy Met Toxicity Dis 1: 2.
- Heidari A (2016) Combined theoretical and computational study of the belousov–zhabotinsky chaoticreaction and curtius rearrangement for synthesis of mechlorethamine, cisplatin, streptozotocin, cyclophosphamide, melphalan, busulphan and bcnu as anti–cancer drugs. Insights Med Phys 1: 2
- Heidari A (2016) A translational biomedical approach to structural arrangement of amino acids complexes: A combined theoretical and computational study. Transl Biomed 7: 2
- Heidari A (2016) Ab initio and density functional theory (dft) studies of dynamic NMR shielding tensors and vibrational frequencies of DNA/RNA and cadmium oxide (cdo) nanoparticles complexes in human cancer cells. J Nanomedine Biotherapeutic Discov 6: e144
- Heidari A (2016) Molecular dynamics and monte–carlo simulations for replacement sugars in insulin resistance, obesity, ldl cholesterol, triglycerides, metabolic syndrome, type 2 diabetes and cardiovascular disease: A glycobiological study. J Glycobiol 5: e111
- Heidari A (2016) Synthesis and study of 5–[(phenylsulfonyl)amino]–1,3,4–thiadiazole–2–sulfonamide as potential anti–pertussis drug using chromatography and spectroscopy techniques. Transl Med (Sunnyvale) 6: e138
- Heidari A (2016) Nitrogen, oxygen, phosphorus and sulphur heterocyclic anti–cancer nano drugs separation in the supercritical fluid of ozone (o3) using soave–redlich–kwong (srk) and pang–robinson (pr) equations. Electronic J Biol 12: 4
- Heidari A (2016) An analytical and computational infrared spectroscopic review of vibrational modes in nucleic acids. Austin J Anal Pharm Chem 3: 1058.
- Heidari A, Brown C (2016) Phase, composition and morphology study and analysis of os–PD/HFC nanocomposites. Nano Res Appl. 2: 1
- Heidari A, Brown C (2016)Vibrational spectroscopic study of intensities and shifts of symmetric vibration modes of ozone diluted by cumene. IntJ Adv Chem 4: 5-9
- Heidari A (2016) Study of the role of anti–cancer molecules with different sizes for decreasing corresponding bulk tumor multiple organs or tissues. Arch Can Res 4: 2
- Heidari A (2016) Genomics and proteomics studies of zolpidem, necopidem, alpidem, saripidem, miroprofen, zolimidine, olprinone and abafungin as anti–tumor, peptide antibiotics, antiviral and central nervous system (cns) drugs. J Data Mining Genomics & Proteomics 7: e125.
- Heidari A (2016) Pharmacogenomics and pharmacoproteomics studies of phosphodiesterase–5 (pde5) inhibitors and paclitaxel albumin–stabilized nanoparticles as sandwiched anti–cancer nano drugs between two DNA/RNA molecules of human cancer cells. J Pharmacogenomics Pharmacoproteomics 7: e153
- Heidari A (2016) Biotranslationalmedical and biospectroscopic studies of cadmium oxide (cdo) nanoparticles–DNA/RNA straight and cycle chain complexes as potent anti–viral, anti–tumor and anti–microbial drugs: A clinical approach. Transl Biomed 7: 2
- Heidari A (2016) A comparative study on simultaneous determination and separation of adsorbed cadmium oxide (CDO) nanoparticles on DNA/RNA of human cancer cells using biospectroscopic techniques and dielectrophoresis (DEP) method. Arch Can Res 4: 2
- Heidari A (2016) Cheminformatics and system chemistry of cisplatin, carboplatin, nedaplatin, oxaliplatin, heptaplatin and lobaplatin as anti–cancer nano drugs: A combined computational and experimental study. J Inform Data Min 1: 3
- Heidari A (2016) linear and non–linear quantitative structure–anti–cancer–activity relationship (qsacar) study of hydrous ruthenium (iv) oxide (ruo2) nanoparticles as non–nucleoside reverse transcriptase inhibitors (nnrtis) and anti–cancer nano drugs. J IntegrOncol 5: e110
- Heidari A (2016) Synthesis, characterization and biospectroscopic studies of cadmium oxide (cdo) nanoparticles–nucleic acids complexes absence of soluble polymer as a protective agent using nucleic acids condensation and solution reduction method. J Nanosci Curr Res 1: e101
- Heidari A (2016) Coplanarity and collinearity of 4’–dinonyl–2,2’–bithiazole in one domain of bleomycin and pingyangmycin to be responsible for binding of cadmium oxide (cdo) nanoparticles to DNA/RNA bidentate ligands as anti–tumor nano drugs. Int J Drug Dev & Res 8: 007–008
- Heidari A (2016) A Pharmacovigilance study on linear and non–linear quantitative structure (chromatographic) retention relationships (qsrr) models for the prediction of retention time of ant i–cancer nano drugs under synchrotron radiations. J Pharmacovigil 4: e161
- Heidari A (2016) Nanotechnology in preparation of semipermeable polymers. J Adv Chem Eng 6: 157
- Heidari A (2016) A gastrointestinal study on linear and non–linear quantitative structure (chromatographic) retention relationships (qsrr) models for analysis 5–aminosalicylatesnano particles as digestive system nano drugs under synchrotron radiations. J Gastrointest Dig Syst 6: e119
- Heidari A (2016) DNA/RNA fragmentation and cytolysis in human cancer cells treated with diphthamide nano particles derivatives. Biomedical Data Mining 5: e102
- Heidari A (2016) A successful strategy for the prediction of solubility in the construction of quantitative Structure–Activity Relationship (QSAR) and quantitative structure–property relationship (qspr) under synchrotron radiations using genetic function approximation (gfa) algorithm. J Mol Biol Biotechnol 1: 1
- Heidari A (2016) Computational study on molecular structures of C20, C60, C240, C540, C960, C2160 and C3840fullerene nano molecules under synchrotron radiations using fuzzy logic. J Material Sci Eng 5: 282
- Heidari A (2016) Graph theoretical analysis of zigzag polyhexamethylene biguanide, polyhexamethylene adipamide, polyhexamethylene biguanide gauze and polyhexamethylene biguanide hydrochloride (phmb) boron nitride nanotubes (bnnts), amorphous boron nitride nanotubes (a–bnnts) and hexagonal boron nitride nanotubes (h–bnnts). J Appl Computat Math 5: e143
- Heidari A (2016)The impact of high resolution imaging on diagnosis.Int J Clin Med Imaging 3: 1000e101
- Heidari A (2016) A Comparative study of conformational behavior of isotretinoin (13–cis retinoic acid) and tretinoin (all–trans retinoic acid (atra)) nano particles as anti–cancer nano drugs under synchrotron radiations using hartree–fock (hf) and density functional theory (dft) methods.Insights in Biomed 1: 2.
- Heidari A (2016) Advances in logic, operations and computational mathematics. J Appl Computat Math 5: 5
- Heidari A (2016) Mathematical equations in predicting physical behavior. J Appl Computat Math 5: 5
- Heidari A (2016) Chemotherapy a last resort for cancer treatment. Chemo Open Access 5: 4
- Heidari A (2016) Separation and pre–concentration of metal cations–DNA/RNA chelates using molecular beam mass spectrometry with tunable vacuum ultraviolet (VUV) synchrotron radiation and various analytical methods. Mass Spectrom Purif Tech 2: e101
- Heidari A (2016) Yoctosecondquantitative structure–activity relationship (qsar) and quantitative structure– property relationship (qspr) under synchrotron radiations studies for prediction of solubility of anti–cancer nano drugs in aqueous solutions using genetic function approximation (gfa) algorithm. Insight Pharm Res. 1: 1
- Heidari A (2016) Cancer risk prediction and assessment in human cells under synchrotron radiations using quantitative structure activity relationship (qsar) and quantitative structure properties relationship (QSPR) studies. Int J Clin Med Imaging 3: 516
- Heidari A (2016) A novel approach to biology. Electronic J Biol 12: 4
- Heidari A (2016) Innovative biomedical equipment’s for diagnosis and treatment.J Bioengineer & Biomedical Sci 6: 2
- Heidari A (2016) Integrating precision cancer medicine into healthcare, medicare reimbursement changes and the practice of oncology: Trends in oncology medicine and practices.J Oncol Med & Pract 1: 2
- Heidari A (2016) Promoting convergence in biomedical and biomaterials sciences and silk proteins for biomedical and biomaterials applications: an introduction to materials in medicine and bioengineering perspectives. J Bioengineer & Biomedical Sci 6: 3
- Heidari A (2017) X–Ray fluorescence and X–ray diffraction analysis on discrete element modeling of nanopowder metallurgy processes in optimal container design. J Powder Metall Min 6: 1
- Heidari (2017) Biomolecular spectroscopy and dynamics of nano–sized molecules and clusters as cross– linking–induced anti–cancer and immune–oncology nano drugs delivery in DNA/RNA of human cancer cells’ membranes under synchrotron radiations: A payload–based perspective. Arch Chem Res 1: 2
- Heidari A (2017) Deficiencies in repair of double–standard DNA/RNA–binding molecules identified in many types of solid and liquid tumors oncology in human body for advancing cancer immunotherapy using computer simulations and data analysis. J Appl Bioinforma Comput Biol 6: 1
- Heidari A (2017) Electronic coupling among the five nanomolecules shuts down quantum tunneling in the presence and absence of an applied magnetic field for indication of the dimer or other provide different influences on the magnetic behavior of single molecular magnets (SMMS) as qubits for quantum computing. Glob J Res Rev 4: 2
- Heidari A (2017) Polymorphism in nano–sized graphene ligand–induced transformation of Au38– xAgx/xCux(SPh–tBu)24 to Au36–xAgx/xCux(SPh–tBu)24 (x=1–12) nanomolecules for synthesis of Au144– xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p–MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] nano clusters as anti–cancer nano drugs. J Nanomater Mol Nanotechnol 6: 3
- Heidari A (2017) Biomedical resource oncology and data mining to enable resource discovery in medical, medicinal, clinical, pharmaceutical, chemical and translational research and their applications in cancer research.Int J Biomed Data Min 6: e103
- Heidari A (2017) Study of synthesis, pharmacokinetics, pharmacodynamics, dosing, stability, safety and efficacy of olympiadane nanomolecules as agent for cancer enzymotherapy, immunotherapy, chemotherapy, radiotherapy,hormone therapy and targeted therapy under synchrotorn radiation. J Dev Drugs 6: e154.
- Heidari A (2017) A novel approach to future horizon of top seven biomedical research topics to watch in 2017: Alzheimer's, Ebola, hypersomnia, Human Immunodeficiency Virus (hiv), Tuberculosis (tb), microbiome/antibiotic resistance and endovascular stroke. J Bioengineer & Biomedical Sci 7: e127
- Heidari A (2017) Opinion on computational fluid dynamics (cfd) technique. Fluid Mech Open Acc 4: 157
- Heidari A (2017) Concurrent diagnosis of oncology influence outcomes in emergency general surgery for colorectal cancer and multiple sclerosis (MS) treatment using magnetic resonance imaging (MRI) and Au329(SR)84, Au329–xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 nano clusters. J Surgery Emerg Med 1: 21
- Heidari A (2017) Developmental cell biology in adult stem cells death and autophagy to trigger a preventive allergic reaction to common airborne allergens under synchrotron radiation using nanotechnology for therapeutic goals in particular allergy shots (immunotherapy). Cell Biol (Henderson, NV) 6: 1
- Heidari A (2017) Changing metal powder characteristics for elimination of the heavy metals toxicity and diseases in disruption of extracellular matrix (ECM) proteins adjustment in cancer metastases induced by osteosarcoma, chondrosarcoma, carcinoid, carcinoma, ewing’s sarcoma, fibrosarcoma and secondary hematopoietic solid or soft tissue tumors.J Powder Metall Min 6: 170
Citation: Heidari A (2017) Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation. Transcriptomics 5: e117. Doi: 10.4172/2329-8936.1000e117
Copyright: ©2017 Heidari A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 879
- [From(publication date): 0-2017 - Dec 14, 2018]
- Breakdown by view type
- HTML page views: 829
- PDF downloads: 50