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ISSN: 2155-6148
Journal of Anesthesia & Clinical Research
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Intracranial Subdural Hematoma Following Spinal Anesthesia in a Pregnant Patient: Case Report and Review of the Literature

Khalid Al-zaben1, Aboud Al Ja’bari1*, Islam Massad1, Walid Zuabi1, Ahmed Tamimi2, Ayman Quatawneh3 and Osama Samara4

1Department of Anesthesia and Intensive Care, Jordan University Hospital, Jordan

2Department of Neurosurgery, Jordan University Hospital, Jordan

3Department of Obstetrics, Jordan University Hospital, Jordan

4Department of Radiology, Jordan University Hospital, Jordan

*Corresponding Author:
Aboud Al Ja’bari
Anesthesia and Intensive Care doctor
Department of Anesthesia and Intensive Care
Jordan University Hospital
Queen Rania Street 11942, Amman, Jordan
Tel: 962795143563
E-mail: [email protected]

Received date: May 28, 2014; Accepted date: August 02, 2014; Published date: August 12, 2014

Citation:Al-zaben K, Ja’bari AA, Massad I, Zuabi W, Tamimi A, et al. (2014) Intracranial Subdural Hematoma Following Spinal Anesthesia in a Pregnant Patient: Case Report and Review of the Literature. J Anesth Clin Res 5:430. doi: 10.4172/2155-6148.1000430

Copyright: ©2014 Al-zaben K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Postdural puncture headache is a well- known complication of spinal anesthesia, but the subsequent development of intracranial subdural hematoma is a serious life–threatening complication which should be urgently treated. We present the case of a 32-year-old pregnant woman who was scheduled for cesarean section. Spinal anesthesia was induced using a 25-gauge Quincke spinal needle. After 48 hours she developed postdural puncture headache which was treated conservatively and she was discharged home. On the 30th day post operatively, the patient developed intracranial subdural hematoma which was surgically evacuated in the operating room and the patient had full recovery. Our report reviews the literature on 49 patients who developed a postdural puncture headache complicated by intracranial subdural hematoma following spinal anesthesia. Careful follow up and good communication between the anesthesiologist, the obstetrician and the neurosurgeon is essential for early diagnosis and management of possible subdural hematoma for patients developing a postdural puncture headache.

Keywords

Spinal anesthesia; Post dural puncture headache; subdural hematoma

Introduction

Severe headache after spinal anesthesia in a pregnant patient has a broad differential diagnosis, including postdural puncture headache and intracranial pathologies [1]. Cerebral subdural hematoma is a serious life–threatening complication that may be misdiagnosed with postdural puncture headache [2]. It carries a high risk for morbidity and mortality if it is not detected and treated early [3]. We present a case that illustrates the importance of careful assessment of postspinal headache as it could be more serious than just benign postdural puncture headache.

Case Report

A 32 year old, 65-kg, 165-cm pregnant woman (G4 P3) was scheduled for cesarean section at 39 weeks gestation because of breech presentation. She was previously healthy. There was no history of hemorrhagic diathesis, use of anticoagulants or nonsteroidal anti-inflammatory drugs. She was taking iron and folic acid supplementation. Preoperative laboratory tests including complete blood count and coagulation parameters were within normal limits. The patient was consented for spinal anaesthesia.

Oxygen saturation, non-invasive arterial blood pressure and heart rate were continuously monitored in the operating room. On the first attempt, spinal anesthesia was performed with the patient in sitting position with a 25-gauge Quincke type spinal needle at the L3- L4 interspace using 12.5 mg of 0.5% isobaric bupivacaine. There was no blood or paraesthesia during insertion of the needle and she had adequate block. She had uneventful intraoperative course.

Twenty-four hours after surgery the patient experienced frontotemporal postural headache, which was treated as postdural puncture headache with bed rest, intravenous hydration and simple analgesics. Her headache was continuous even when she was discharged from the hospital on the fourth postoperative day. Following discharge her headache worsened to the point where she could no longer nurse her baby, her headache became non-postural, and not relieved with analgesia medications.

On the 30th day postoperatively, the patient presented to the emergency room complaining of severe non-postural headache accompanied with blurring of vision, nausea and dizziness. There was no history of trauma. Neurological examination demonstrated mild upper and lower left limb weakness. A computed tomography (CT) scan revealed a 15 mm thick acute subdural hematoma involving the right cerebral hemisphere convexity causing mass effect into the underlying hemisphere sulci (Figure 1).

anesthesia-clinical-research-Computed-tomography

Figure 1: Computed tomography (CT) of the head showing acute subdural hematoma involving the right cerebral hemisphere convexity measuring 15 mm in maximal width and causing mass effect into the underlying right hemisphere sulci.

The patient was admitted to the hospital. A right fronto-temporal craniotomy was performed and the hematoma was evacuated. Her symptoms resolved entirely and the patient did not develop any further symptoms. She was discharged home after one week and had uneventful postoperative course during her follow up for six months.

Discussion

Spinal anesthesia has become very popular for pregnant patients undergoing cesarean section. It has the advantage of avoidance of complications of general anesthesia and its consequences but it has its complications like hypotension, postdural puncture headache, nerve damage, meningitis, intracerebral hemorrhage, spinal and cranial hematoma [3,4].

Postdural puncture headache (PDPH) is a frequent, unpleasant complication of lumbar puncture and spinal anesthesia. The mechanism that is proposed for this phenomenon is the persistent leakage of cerebrospinal fluid through the dural puncture site, leading to the caudal displacement of the brain with traction on pain-sensitive structures and the thin subdural bridging veins, possibly causing a slow and constant blood leakage from these veins [5]. The blood can accumulate over time causing subdural hematoma and leading to symptoms of high intracranial pressure.

PDPH has certain features which can help in diagnosis and management; it usually appears within the first 24-48 hours after puncture, located on the frontal or occipital regions or both worsening significantly upon assuming the upright position and improving significantly upon lying down. It may persist up to 2 weeks and generally responds well to conservative management (hydration, bed rest, simple analgesics and epidural blood patch). Additional symptoms may include neck pain, nausea, emesis, interscapular pain, photophobia, diplopia, dizziness, and change in hearing, visual blurring, cranial nerve palsies and radicular upper extremity symptoms [6].

The occurrence of subdural hematoma increases the intracranial pressure which can be associated with non-postural headache, vomiting, convulsions, hemiplegia, confusion, sleepiness and coma. The main problem is that the differentiation between the neurological symptoms of intracranial hypotension and subdural hematoma can be difficult, but the most important warning sign is the change in headache characteristics from postural to non-postural.

Our patient developed postural headache in the first few days which was treated conservatively before discharge from the hospital. She was lost to follow up for about 14 days when she started to have a change in the characteristics of her headache to more severe nonpostural headache. At that time we thought that the patient may have an intracranial pathology which should be investigated but she refused to be admitted to the hospital due to social reasons despite the clear clinical advice which delayed the diagnosis. She did not present to the hospital until her headache became intolerable and associated with other neurological symptoms.

Predisposing factors for PDPH and subsequent development of subdural hematoma include, pregnancy, dehydration, multiple dural punctures, using thick needles, coagulopathy, cerebral vascular abnormalities, brain atrophy and alcohol consumption [3]. The only contributing factor in our case was pregnancy as we used a 25 Gauge spinal needle (the smallest needle in our province), and CSF flow was detected at first attempt. However using fine needles does not eliminate the possibility of occurrence of this complication as reported here and in other literature cases [7,8].

It seems that venous congestion during pregnancy can make bridging veins more susceptible to rupture. Sudden increases in venous pressure of these dilated veins by coughing or abdominal compression during labor and delivery can lead to an augmentation of tension, especially at the subdural portion of bridging veins [9]. It is widely believed that pregnancy increases the risk of stroke. Reports have shown that the incidence of intracerebral hemorrhage is increased in the six weeks after delivery [10]. There are also reported cases of spontaneous spinal epidural hematoma during pregnancy [11].

Review of the literature disclosed 49 cases of intracranial subdural hematoma after spinal anesthesia (Table 1). In 15 patients the only predisposing factor was pregnancy. There was no predisposing factor in 20 patients. Headache was present in 37 patients. A 27 gauge needle was used in 6 patients. The age of patients ranged between 20 to 88 years. The earliest diagnosis of subdural hematoma was six hours after spinal anesthesia and the latest was 12 weeks. Two patients were on anticoagulants, one patient had brain aneurysm, nine patients had multiple punctures and four patients died.

Symptoms Needle Predisposing  factors Time for diagnosis Age/Sex Ref
HC and visual disturbances 25 G Quincke MP 12 weeks 49/M 12
HC and tinnitus 25 G Quincke ? ? 24/M 13
Diplopia ? Pregnancy 4 weeks 25/F 14
HC, right upper limb paresis 27 G Quincke None 48 hours 48/F 15
HC, vomiting and hemiparesis 25 whitacre Pregnancy 13 days 27/F 16
HC, ptosis and hemiparesis 25 whitacre None 24 hours 49/F
HC and vomiting 26 G None 5 days 73/F 17
HC, vomiting and confusion 24 Quincke None 4 days 70/F 18
Coma ? ? 24 hours 53/F 19
HC 25 G Quincke None 21 days 39/F 20
HC and vomiting 27 G Quincke Double puncture 42 days 39/F 8
HC 27 G Quincke Pregnancy/MP 40 days 32/F
Hemiparesis and coma ? MP < 1 day 69/M 21
HC, nausea and vomiting 24 G Quincke Pregnancy < 1 day 26/F 22
HC and diplopia 26 G Pregnancy/MP 8 days 31/F 23
HC and dysphasia 26 G Pregnancy 20 days 29/F 24
HC and hemiparesis 26 whitacre None 3 weeks 38/M 25
HC 24 G Sprotte None 40 days 68/M 26
HC and diplopia 19 G None 25 days 41/F 27
Confusion and sleepiness 25 G Quincke Brain atrophy 3 days 88/F 28
HC 22 G Quincke None 40 days 38/M 29
Diplopia 27 G None 2 weeks 38/F 30
HC and confusion 27 G whitacre Brain aneurysm 2 days 59/M 31
HC and hemiparesis 24 G Pregnancy 6 hours 28/F 32
HC and vomiting 24 G Sprotte Pregnancy 1 day 29/F 33
HC and vomiting 23 G Quincke None 1 week 20/M 34
HC, vomiting and coma 27 G whitacre Anticoagulants 10 days 42/M 35
Hemiparesis 22 G Pregnancy 14 days 31/F 36
Left hemiparesis and aphasia 26 G Pregnancy 5 days 27/F 37
HC and vomiting 22 G Quincke None 5 days 71/M 38
HC and vomiting 25 G Quincke MP 6 days 39/F 39
HC and hemiparesis 22 G Anticoagulants 11 days 63/F 40
HC and confusion 22 G None 30 days 68/M 41
HC and left orbital pain 25 G Quincke MP 2 weeks 68/M 42
Coma 22 G Quincke None 6 days 67/M 43
Frontal HC and confusion 25 G MP 3 weeks 67/M 44
HC and confusion ? None 30 days 50/M 45
HC and confusion 21 G Pregnancy 26 days 33/F 46
Dysphasia and hemiplegia 24 G None 29 days 63/M 47
HC, vomiting and confusion 22 G None 21 days 70/M 48
HC and left hemiparesis 26 G Pregnancy 30 days 39/F 3
Disorientation and hyperreflexia 22 G None 10 days 67/M 49
Coma 25 G Quincke MP 6 days 37/M 50
HC, diplopia and confusion 22 G None 48 days 69/M 51
HC,tinnitus 26 G Pencil-point Pregnancy 5 days 33/F 52
HC,seizures ? Pregnancy ? days 27/F 53
HC,photophobia ? Pregnancy 42 days 18/F 54
HC ? None 6 weeks 28/M 55
HC, tinnitus 25G Qunicke ? 2 days 24/F 56

Table 1: Reported cases of intracranial subdural hematoma after spinal anesthesia.

In the 49 cases reported here, 41patients required surgical drainage. Conservative treatment is indicated for small blood collections without deviation of the structures in the intracranial midline that do not cause relevant clinical repercussions. Our patient had surgical evacuation of the hematoma due to the mass effect into the underlying hemisphere sulci which caused her neurological symptoms (headache, right-sided weakness, blurring of vision, nausea and dizziness).

The delayed diagnosis, in many cases, implies that subdural hematoma wasn’t taken into consideration as a complication of spinal anesthesia. Fortunately our patient had complete recovery despite the delay in diagnosis and the surgical evacuation of the hematoma. As a result of this case, we have modified our practice so that every patient is instructed regarding this possible complication and asked to contact the anesthesiologist in the case of a change in the characteristics of the headache, that is, from postural to non-postural.

The true incidence of subdural hematoma after spinal anesthesia may be greater than the published case reports. This suggests that headaches following spinal anesthesia can be a diagnostic challenge for the clinician. Subdural hematoma must be suspected when headache persists despite conservative treatment or when a non-postural character appears. The presences of neurological deficits, seizures, signs of intracranial hypertension, or alterations of consciousness are additional late warning signs.

In conclusion, patients developing PDPH unrelieved by conservative measures, as well as the change of PDPH from postural to non-postural, require careful follow-up for early diagnosis and management of possible subdural hematoma. Investigation with a head CT or MRI is mandatory. Pregnant women seem to be more susceptible to the formation of subdural hematoma after spinal anesthesia.

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