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ISSN: 2329-6925
Journal of Vascular Medicine & Surgery
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Intraoperative Portal Vein Thrombosis after Pancreatic and Partial Portal Vein Resections

Hernandez AG1*, Munoz AN1, Tiliani OA2, Matamoros IS1, Sanchez AP1and Mompean FO3

1General and Digestive Surgery Unit of Hepatobiliopancreatic, Hospital Universitario Virgen Macarena, Spain

2Department of Cardiovascular Surgery, Hospital Universitario Virgen Macarena, Spain

3Chief of General Surgery Service, Hospital Universitario Virgen Macarena, Spain

*Corresponding Author:
Alejandra Gordillo Hernandez
Hospital Universitario Virgen Macarena
Avenida Doctor Fedriani 3
41071 Sevilla, Spain
Tel: 34-658- 154-289
Fax: 34-954-557-347
E-mail: [email protected]

Received Date: November 27, 2015; Accepted Date: December 22, 2015; Published Date: January 03, 2016

Citation: Hernandez AG, Munoz AN, Tiliani OA, Matamoros IS, Sanchez AP, et al. (2016) Intraoperative Portal Vein Thrombosis after Pancreatic and Partial Portal Vein Resections. J Vasc Med Surg 4:244. doi: 10.4172/2329-6925.1000244

Copyright: © 2016 Hernandez AG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

We report a case of intraoperative portal vein thrombosis in a patient with pancreatic head adenocarcinoma and tumor infiltration of the anterior wall of portal vein. Advances in surgery allow reparation of these vessels that can be infiltrated by the tumor. Currently we have a wide technical and prosthetic arsenal for this purpose. This case suggests that the use of patches is not a good choice and that the end to end suture is probably the most recommended in cases that require the portal reparation.

Keywords

Portal thrombosis; Pericardium patch; Tumour

Introduction

Advanced gastrointestinal tumors are aggressive and often invade blood vessels. Advances in surgical techniques allow their resection even in presence of vessel infiltration. In cases of portal vein involvement, it is not clear the way it should be reconstructed, some series report reconstruction with patch and few cases are reported for acute intraoperative portal trombosis, because of the patch employment. Here we report a case of such complication.

Presentation of Case

We report a 58-year-old patient with a history of hypertension, dyslipidemia, ovarian cystectomy and appendectomy that began with right upper quadrant pain and obstructive jaundice. The diagnostic was pancreatic head adenocarcinoma. Contrast Computed Tomography (CT) is performed where nodular hypo intense image is displayed on the rear margin of 2 cm succinate and is in intimate contact with the rear margin of the portal vein producing deformity thereof remaining permeable. Echo endoscopy - Fine needle aspiration (FNA) where diagnosis is confirmed. A 10F plastic stent is placed 5 cm + suprapapillary sphincterotomy. Subsequently she was admitted for elective surgery.

Bilateral subcostal incision is made. Intraoperative ultrasound without appreciating extension that contraindicates surgery, showing imprint / infiltration of the portal vein by the tumor. Dissection of the hepatic hilum, pyloric and gastro duodenal vessels, lymphadenectomy of the celiac trunk, Kocher maneuver and interaortocaval lymphadenectomy. Antral, pancreatic neck and 1st jejunal loop section. After ligation of Henle confluent, tumor infiltration of the anterior wall of portal vein is seen, resection of that portion with safety margins, performing repair with bovine pericardium, with previous heparinization with 5000 UI. The liver-jejunostomy, gastrojejunostomy transmesocolic handle and Y Roux are continuous with the pancreatic-jejunostomy with end to end anastomosis. We reviewed portal vein malfunction and observed formation of a thrombus proximal to the repair, so we decided heparinize with 5000 UI sodium heparin and remove the patch. Once stuffed the walls, portal, superior mesenteric and splenic proceeds to repair by transverse suture (Figures 1 and 2).

vascular-medicine-surgery-hepatic-pyloric-gastro

Figure 1: Dissection of the hepatic hilum, pyloric and gastro duodenal vessels, lymphadenectomy of the celiac trunk, Kocher maneuver and interaortocaval lymphadenectomy.

vascular-medicine-surgery-repaired-transverse-sutures

Figure 2: Walls repaired by transverse sutures.

Postoperative short and long term has been favorable and uncomplicated. Low molecular weight heparin administered at prophylactic doses from the first postoperative day. The patient was discharged with good result and is currently on track for oncology.

Discussion

Fukuda [1], noted that the pancreaticoduodedenectomy with resection of the portal vein may be only potential cure for patients with pancreatic duct adenocarcinoma and involvement of the portal vein. In our case, the portal vein was repaired with a pericardial patch. We present this case to show thrombosis as complication after intraoperative use of pericardial patch to close the defect secondary to vascular invasion by the tumor.

Yekebas [2], published the long-term survival perioperative results of 136 patients who underwent vascular resection for locally advanced pancreatic neoplasia. In 8 cases they had to resect more than one third of the lateral wall and the patches they used were from autologous venous (internal jugular, saphenous, inferior mesenteric) to prevent stenosis. In all patients prophylactic heparinization with low molecular weight is used. They recorded the portal vein thrombosis in 2 of venous resections.

Ravikumar [3], present a study comparing pancreaticoduodenectomy with resection of the portal vein or superior mesenteric, standard pancreaticoduodenectomy, and surgical bypass. Seven patients had portal vein thrombosis. Six patients had end to end anastomosis and one with graft interposition. Ho¨ing [4], have recently published a case report where they use a Polytetrafluoroethylene (PTFE) graft in endto- end technique.

In our case we used a bovine patch, the portal cossclamp time was as short as 10 minutes, and at the end of th surgery we observed portal vein trombosis, we hypothize that it has occured as a result of a combination of on one hand the prothrombotic status of the patient, and on the other the very low pressure and slow run off of the portal vein that may be prone for thrombosis if we use pericardial patches. So we believe that it is important to reconstruct the vein whenever is possible directly without any synthetic material.

Conclusion

Intraoperative thrombosis in this case may be due to slowness, low blood pressure and hypercoagulability factors. So we thought that the use of patches is not a good choice due to the lower pressure of the circulatory system at this level.

We conclude that the end to end suture is probably the most recommended in cases requiring portal resection to repair and intraoperative regimen heparinization with sodium heparin 5000 UI followed by postoperative heparinization.

Conflicts of Interest

The authors report no conflict of interest.

Funding

The authors have no funding to declare.

Consent

Written informed consent was obtained from the patient for publication of this case report and accompanying images.

References

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