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Juvenile Granulosa Cell Tumor - A Rare Neoplasm in Newborns | OMICS International
ISSN: 2157-2518
Journal of Carcinogenesis & Mutagenesis

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Juvenile Granulosa Cell Tumor - A Rare Neoplasm in Newborns

Oral O1*, Ozer E2, Kaymaz E3 and Hucumenoglu S2

1Departments of Pathology, Viransehir Hospital, Sanlıurfa, Turkey

2Departments of Pathology, Ankara Education and Research Hospital, Ankara, Turkey

3Departments of Pathology, Bülent Ecevit University, Zonguldak, Turkey

*Corresponding Author:
Onur Oral
Department of Pathology
Viransehir Hospital, Sanlıurfa, Turkey
Tel: +905068106155
E-mail: [email protected]

Received date: July 19, 2016; Accepted date: July 21, 2016; Published date: July 22, 2016

Citation: Oral O, Ozer E, Kaymaz E, Hucumenoglu S (2016) Juvenile Granulosa Cell Tumor - A Rare Neoplasm in Newborns. J Carciong Mutagen 7:I101. doi:10.4172/2157-2518.1000I101

Copyright: © 2016 Oral O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Juvenile Granulosa Cell Tumor; Neoplasms


Juvenile granulosa cell tumor of the testis (JGCT) is a rare tumor although it is the one of the most common neoplasms of the infantile testis [1]. We here present an additional case of 5 months-old male with JGCT of testis.


At physical examination revealed a hard, mobile and painless mass suspicious for malignancy in his right testis. Serum AFP levels are within normal limits. Testicular ultrasonography revealed a right testicular mass of 1.7 × 1.1 cm diameters and regular lobulated borders.

After orchiectomy, the gross examination revealed a 2.8 × 1.8 × 1.5 cm testis with a white-grey, glistening lesion. It had an uninterrupted capsule which separated the mass from normal testis parenchyma (Figure 1). Microscopically, the tumor was composed of a prominent solid pattern with few cystic follicules (Figure 2).


Figure 1: Tumor had an uninterrupted capsule which separated the mass from normal testis parenchyma (H&E x40).


Figure 2: The tumor was composed of a prominent solid pattern with few cystic follicules (H&E x40) (H&E x100).

The follicules were lined by several cell layers; the inner cells having oval or round nuclei and eosinophilic cytoplasm whereas the outer had with spindle nuclei and scanty cytoplasm (Figure 3). A high mitotic rate was observed (Figure 4).


Figure 3: The view of follicules showing outer and inner cell layers (H&E x400).


Figure 4: The tumor cells have high mitotic rate (H&E x400).

Immunhistochemical stains were positive for inhibin, alpha-1 antitrypsin, CD99 and were negative for AFP in tumor cells (Figure 5). Also, Ki 67 immunostaining of tumor with a high proliferative rate (Figure 5). The tumor was diagnosed as juvenile granulosa cell tumor of the testis.


Figure 5: Immunhistochemical stains for various proteins within the tumors and their expression (A: Inhibin, B: Alpha-1 Antitrypsin, C: CD99, D: AFP, E: Ki-67, respectively).


Juvenile granulosa cell tumor is very rare with an incidence 1-2% of prepubertal testicular tumors [2]. It is considered as a benign neoplasm because no metastasis has been reported. Histopathological diagnosis is may be difficult, because yolk sac tumor, the better known tumor of young children, may present similar features. Contrary to USG images and gross examination, laboratory findings and immunohistochemical investigations are necessary to individuate between these tumors.


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