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Left Atrial Mass in a Patient with Rheumatic Mitral Stenosis and Atrial Fibrillation-Thrombus or Myxoma? | OMICS International
ISSN: 2329-9517
Journal of Cardiovascular Diseases & Diagnosis
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Left Atrial Mass in a Patient with Rheumatic Mitral Stenosis and Atrial Fibrillation-Thrombus or Myxoma?

Neeraj Ganju, Arvind Kandoria, Kunal Mahajan*, Sudhir Mehta, Anchana Gulati, and Sanjay Rathore

Indira Gandhi Medical College, Shimla, India

*Corresponding Author:
Kunal Mahajan
Indira Gandhi Medical College
Shimla, India
Tel: 8628864820
E-mail: [email protected]

Received Date: May 23, 2017; Accepted Date: May 24, 2017; Published Date: May 26, 2017

Citation: Ganju N, Kandoria A, Mahajan K, Mehta S, Gulati A, et al. (2017) Left Atrial Mass in a Patient with Rheumatic Mitral Stenosis and Atrial Fibrillation-Thrombus or Myxoma? J Cardiovasc Dis Diagn 5:i106. doi: 10.4172/2329-9517.1000i106

Copyright: © 2017 Ganju N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Atrial myxoma; Rheumatic Mitral Valve Disease; Echocardiography


A 38-year-old female presented for evaluation of dyspnea on exertion. She also complained of palpitations but gave no history of edema, chest pain, cardioembolism, fever, arthralgia or weight loss. She was in atrial fibrillation (AF) with a controlled ventricular rate. Cardiac auscultation revealed a loud S1 with an opening snap and a mid-diastolic rumbling murmur at the apex. There was no presystolic accentuation and no postural variations. Transthoracic echocardiogram revealed thickening and restricted motion of mitral valve leaflets associated with doming of anterior mitral leaflet and severe subvalvular deformity. Mitral valve area was 0.8 cm2. These findings were consistent with severe rheumatic mitral stenosis (MS). Left atrium (LA) was dilated with a large spherical mass (50 mm × 46 mm) originating from the interatrial septum, occupying more than two-third of LA (Figure 1). This mass was immobile and non-pedunculated with no stalk visible even on transesophageal echocardiography. It was characterized by multiple echolucent areas interspersed in an echogenic background. LA appendage was clear. The size, location and echogenecity suggested it to be a myxoma while the mobility and absence of stalk in the presence of rheumatic severe MS and AF suggested it to be a thrombus. We gave a trial of oral anticoagulation for 6 weeks but there was no regression in the size. Mitral valve replacement with surgical excision of mass was eventually performed. Gross examination of the resected LA mass revealed soft, gelatinous tissue with areas of haemorrhage (Figure 2). Histopathology confirmed it to be a myxoma (Figure 3). A cardiac mass in association of rheumatic MS and AF is much more suggestive for a thrombus than a myxoma. This case highlights the diagnostic dilemmas in such a rare co-existence of atrial myxoma and rheumatic MS [1]. Histopathology will always be the gold standard in such situations [2].


Figure 1: Transthoracic Echocardiogram-modified parasternal long axis view, showing a large left atrial mass measuring 50 mm × 46 mm, attached to the interatrial septum. Note the multiple echolucent areas (largest one represented by an arrow) in the background of an echogenic mass. Thickened mitral valve leaflets and fused chordae tendinae are also visible.


Figure 2: Gross examination of the surgically resected mass revealed a soft, gelatinous structure with multiple areas of haemorrhage.


Figure 3: Histopathological pphotomicrograph showing hyalinization, hemorrhage and focus of myxoid area. (H&E x 100).

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Competing Interest




Contributorship Statement

NG and AK made the diagnosis. SM and AG performed the investigations and were involved in the management of the patient. KM wrote the manuscript and performed the literature search. SR corrected the manuscript and gave conceptual advice. All authors read and approved the final version of the manuscript.


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