alexa Leiomyosarcoma of the Ovary Mimicking Gastrointestinal Stromal Tumor Originating from Small Bowel: A Case Report and Literature Review | Open Access Journals
ISSN: 2161-0932
Gynecology & Obstetrics
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Leiomyosarcoma of the Ovary Mimicking Gastrointestinal Stromal Tumor Originating from Small Bowel: A Case Report and Literature Review

Bo Na Lee#, Yung Taek Ouh#, Hye Jin Choi, Sun Young Yang, Jae Kwan Lee and Jin Hwa Hong*

Department of Obstetrics and Gynecology, Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea

#Both authors contributed equally to this manuscript

*Corresponding Author:
Jin Hwa Hong, MD, PhD, Associate Professor
Department of Obstetrics and Gynecology, Guro Hospital
College of Medicine, Korea University, Seoul 152-703, Republic of Korea
Tel: 82-2-2626-3149
Fax: 82-2-838-1560
E-mail: [email protected]

Received Date: January 27, 2016;Accepted Date: February 08, 2016; Published Date: February 10, 2016

Citation: Lee BN, Ouh YT, Choi HJ, Yang SY, Lee JK, et al. (2016) Leiomyosarcoma of the Ovary Mimicking Gastrointestinal Stromal Tumor Originating from Small Bowel: A Case Report and Literature Review. Gynecol Obstet (Sunnyvale) 6:359.doi: 10.4172/2161-0932.1000359

Copyright: © 2016 Lee BN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Gynecology & Obstetrics

Abstract

Primary ovarian leiomyosarcoma is an extremely rare mesenchymal tumor that comprises less than 0.1% of all ovarian malignancies. Heterogeneous solid features on imaging and nonspecific bowel symptoms attributed to its close proximity to the gastrointestinal tract often cause confusion with a possible gastrointestinal tumor. We report a case of leiomyosarcoma of the ovary mimicking gastrointestinal stromal tumor from small bowel. Although rare, the possibility of primary ovarian leiomyosarcoma should be considered when the nature and location of a pelvic mass overlap with those of a gastrointestinal tract tumor.

Keywords

Leiomyosarcoma; Ovary; Gastrointestinal stromal tumor

Introduction

Leiomyosarcoma arising from the ovary is very rare, comprising less than 0.1% of all ovarian malignancies [1]. It usually affects postmenopausal women, with a few exceptions of cases in young women [2,3]. Because of its low prevalence and heterogeneous features on imaging, it is usually not diagnosed until pathologic examination following surgery. Vague digestive symptoms, such as lower abdominal discomfort, indigestion, and nausea, are also frequently encountered with tumors originating from the intestinal tract. These factors often lead to diagnostic confusion and therapeutic delay. However, not all ovarian leiomyosarcoma presents digestive symptoms, of which mainly presents urinary symptoms, or vaginal bleeding. Furthermore, there are no principal management recommendations for ovarian leiomyosarcoma due to absence of prospective studies [4]. Here, we present a rare case of primary ovarian leiomyosarcoma that was initially considered to be a gastrointestinal stromal tumor (GIST) originating from the small bowel.

We searched previous cases of primary ovarian leiomyosarcoma using PubMed system from 1965 to 2015 with the terms “primary ovarian leiomyosarcoma”. Then we analyzed and summarized the individual cases compared to our case.

Case Presentation

A 67-year-old, postmenopausal, multiparous woman presented to the gynecology clinic at Guro Hospital, College of Medicine, Korea University, with the complaint of a pelvic mass. Before visiting our hospital, she had undergone routine gynecologic checkup in a private clinic. At that time, transvaginal ultrasonography examination revealed an approximately 8-cm mixed echogenic solid mass of the right adnexa, which strongly suggested the presence of a malignant tumor. The patient had suffered from intermittent lower abdominal discomfort for 1 month.

Her menses had ceased at the age of 52. She had no complaints of vaginal bleeding or lower abdominal distension. The patient had regular gynecologic examinations, and her last Papanicolaou (Pap) smear was normal. She had been in good health except for hypertension. On pelvic examination, the cervix was small, and no specific abnormalities were observed. On physical examination, a hard mass with an irregular surface was palpable. Transvaginal ultrasonography examination revealed an approximately 8-cm mixed echogenic solid mass of the right adnexa, which strongly suggested the presence of a malignant tumor (Figure 1). However, serum carbohydrate antigen (CA) 125 (17.5 U/mL), CA 19-9 (27.95 U/mL), carcinoembryonic antigen (CEA) (3.95 ng/mL), alpha fetoprotein (AFP) (3.05 ng/mL), and beta-human chorionic gonadotropin (beta-hCG) (0.26 mIU/mL) levels were not elevated. Pelvic magnetic resonance imaging (MRI) revealed an approximately 8-cm, lobulated, well-enhancing solid mass with a cystic portion in the pelvic cavity (Figure 2). The mass showed apparent diffusion restriction on diffusion-weighted MRI image. It had an indistinguishable border with the distal ileum, but a fat plane was preserved between the mass and the sigmoid colon, uterus, and urinary bladder. Based on these findings, MRI suggested a mesenchymal tumor originating from the distal ileum, such as a GIST. However, a fibrotic tumor of right ovarian origin, such as a fibroma or fibrothecoma, was still possible. 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan also suggested a malignant mass. However, no lymph node enlargement or distant metastases were seen on imaging studies. Endoscopic examination of the stomach and colon showed no evidence of metastasis. Because MRI findings indicated GIST was likely, the patient was transferred to the general surgery department.

gynecology-Transvaginal-ultrasound

Figure 1: Transvaginal ultrasound showing mixed echogenic, solid mass measuring 8.9 × 7.3 cm.

gynecology-Pelvic-magnetic

Figure 2: Pelvic magnetic resonance imaging scan of T2-weighted image. The mass shows iso- to slightly low signal intensity with heterogeneous enhancement. The border between the mass and distal ileum is indistinct.

Explorative laparotomy with midline incision was performed. The surgical team found that the pelvic mass originated from the right ovary and adhered to the right pelvic wall and ureter. A team in the Department of Obstetrics and Gynecology took over patient care at that point and continued to perform the surgery. An 8-cm, multi-lobulated, irregular mass was visible in the right ovary (Figure 3). The mass was well-encapsulated, but some necrotic portion was also present. The right ureter was completely dissected from the right common iliac artery to the level of right uterine artery to separate the mass from the right pelvic wall. After adhesiolysis, right salpingo-oophorectomy was performed and the specimen was sent to the Department of Pathology for frozen examination. The result was a benign tumor, such as a fibroma. The uterus, left ovary, and left tube were normal on gross appearance. Total hysterectomy and left salpingo-oophorectomy was then performed. The operation was uneventful.

gynecology-Gross-image

Figure 3: Gross image showing multi-lobulated, encapsulated, solid mass from the right ovary.

Histopathological analysis of the full specimen revealed a leiomyosarcoma, 9 × 7 × 5.6 cm3 in size, originating from the right ovary. The mitotic count was 12 per 10 high-power fields, and an area of necrosis was identified. The tumor cells had characteristically elongated, pleomorphic, and blunt-ended nuclei, and eosinophilic to pale cytoplasm (Figure 4). On immunohistochemical staining, tumor cells were positive for smooth muscle actin and desmin, but negative for calretinin, inhibin-alpha, and cluster of differentiation (CD) 34, consistent with a diagnosis of leiomyosarcoma. The uterus and left adnexa were free of metastasis. Postoperatively, the patient has been followed up for 3 months without any adjuvant treatment.

gynecology-Histopathological-features

Figure 4: Histopathological features of the tumor. Tumor cells had characteristically elongated, pleomorphic, and blunt-ended nuclei and eosinophilic to pale cytoplasm.

After excluding cases of leiomyosarcomas originating from ovarian vein, six cases of primary ovarian leiomyosarcomas were found by a PubMed search system (Table 1) [2,5-9]. Among them, only 2 cases showed elevated CA 125 level. Postoperative adjuvant chemotherapy was performed in 2 cases. Immunohistochemical studies revealed that smooth muscle actin was positive in most of cases, whereas inhibin was negative. During follow up, only 1 patient expired and 4 had no evidence of disease.

Author Year Age
(yr)
Size (cm) Tumor marker Type of surgery Adjuvant treatment Positive Weakly positive Negative Follow-up
(mo)
Current status
Monk et al. [5] 1993 12 17 × 13.5× 10.5 AFP (-), beta-hCG (-),
CEA (-)
BSO No further treatment SMA Desmin ND 20 NED
Seracchioli et al. [6] 2003 20 8×8 Negative, but type of marker was not described LSO No further treatment SMA, p53 ND ND ND NED
Bouie et al. [7] 2005 42 18 ×13 ×5 ND TAH LSO No further treatment SMA, Vimentin,
Ki-67
Desmin,
AE1/AE3, p53
Inhibin, HMB45,
S100
3 NED
Dai et al. [8] 2011 42 12 CA125 (39.4) Staging surgery cisplatin, etoposide,
bleomycin
ND ND ND 5 E×pired
Divya et al. [9] 2014 26 9 ×6 ×3 ND RSO No further treatment SMA, Vimentin ND Cytokeratin ND ND
Vijaya et al. [10] 2015 30 14.7 ×14.6 ×10.8 CA125 (69.9) RSO vincristine, epirubicin,
cyclophosphamide
SMA, Vimentin,
Desmin
ND Inhibin 6 NED
This case 2015 67 9 ×7 ×5.6 CA125 (-), CA 19-9 (-), CEA (-), AFP (-), beta-hCG (-) TAH BSO No further treatment SMA, Desmin ND Inhibin, Calretinin,
CD34
3 NED

Table 1: Summary of previous cases of primary ovarian leiomyosarcoma.

Before writing this case report, we obtained informed consent for the publication from the patient.

Discussion

Leiomyosarcomas account for 10–20% of all soft tissue sarcomas [10]. They most frequently arise from the uterus, gastrointestinal tract, and retroperitoneal region [11]. Those originating from the ovary are exceptionally rare, comprising less than 1% of ovarian sarcomas [1]. Other types of ovarian sarcomas include carcinosarcoma, rhabdomyosarcoma, stromal cell sarcoma, and fibrosarcoma [12].

Primary ovarian leiomyosarcomas can be confused with leiomyosarcomas of extraovarian origin. For example, pedunculated uterine leiomyomas can attach to the ovary from which they draw their blood supply. In addition, leiomyosarcomas originating from broad ligaments, ovarian veins, and the gastrointestinal tract should be distinguished from primary ovarian leiomyosarcomas [5]. Identification of normal ovarian components in tumor tissue categorizes a tumor as a primary ovarian leiomyosarcoma. Low disease prevalence and non-specific radiological findings often hinder accurate diagnosis of this tumor preoperatively.

Interestingly, most leiomyosarcomas of ovary were provisionally misdiagnosed of another disease due to its rarity and diagnostic difficulty, which is consistent with our case. Bouie et al. initially considered the ovarian leiomyosarcoma as a fibrothecoma [2]. Divya et al. made a radiologic diagnosis of broad ligament fibroid because the mass was located ischial fossa displacing the rectum [8]. In addition, Vijaya et al. supposed the mass to be an ovarian leiomyoma on the basis of ultrasonography and MRI [9].

In this case, MRI initially suggested the tumor mass was a mesenchymal tumor originating from the distal ileum, such as a GIST. GIST is the most common mesenchymal tumor of the gastrointestinal tract [13]. It can originate at any site along the intestinal tract, including the stomach, jejunum, ileum, duodenum, rectum, colon, and esophagus. Radiologic features of GISTs vary depending on their size and anatomic location. Small (≤5 cm) GISTs are round and have strong homogeneous arterial and persistent enhancement. In contrast, larger GISTs (>5 cm) are frequently lobulated and have mild, heterogeneous, gradual enhancement and heterogeneity with intratumoral hemorrhage, necrosis, or cystic change [14]. Unfortunately, these findings are also commonly encountered in patients with ovarian leiomyosarcoma, as in this case. For these reasons, preoperative radiological differentiation between ovarian leiomyosarcoma and GIST is difficult. A large tumor mass abutting the gastrointestinal tract, as in this case, makes the diagnosis more challenging. In this case, preoperative endoscopic evaluation of the stomach and colon did not identify any mass lesion. However, these negative findings cannot completely rule out the presence of GIST because these two tests do not cover the small intestine. If barium swallow studies such as small bowel series are performed, the possibility of small bowel GIST could easily be eliminated.

Another important point in this case was subsequent management according to intraoperative frozen examination. The result indicated a benign mass, such as a fibroma. Although the uterus, left ovary, and left tube were normal on gross appearance, total hysterectomy and left salpingo-oophorectomy were performed due to the possibility of malignant findings on final pathologic examination. At present, the main treatment modality for ovarian leiomyosarcoma is surgery. This ranges from fertility preserving surgery to debulking surgery including total hysterectomy, bilateral salpingo-oophorectomy, and excision of any suspicious masses. In this case, the patient was postmenopausal and had no need to preserve fertility, so debulking surgery was performed.

Given the very poor prognosis of leiomyosarcoma, misdiagnosis may have a detrimental effect on patient outcome. In this case, all preoperative evaluations, including serum tumor markers, identified GIST as the most probable diagnosis. Unfortunately, no specific tumor markers have exhibited clinical utility for detecting leiomyosarcomas. Pathologically, leiomyosarcomas can be distinguished from leiomyomas by the following features: larger tumor cells, cytologic atypia, increased mitotic activity, area of necrosis, and nuclear pleomorphism, consistent with our case [3,15]. Immunohistochemical markers including desmin, vimentin, and smooth muscle actin are used to diagnose leiomyosarcoma, whereas CD117 and CD34 are wellknown specific markers for GIST [16].

Given the rarity of this disease, the benefit of adjuvant chemotherapy or radiation therapy has not been established. Vijaya et al. reported that chemotherapy with vincristine, epirubicin, and cyclophosphamide was beneficial to prolong progression-free survival [9]. Hensley et al. used a combined gemcitabine and docetaxel regimen, frequently used for uterine leiomyosarcoma, and demonstrated disease-free interval for 22 months [17]. Radiotherapy has been shown as temporarily effective for local control, but it failed to prevent distant metastasis [18].

In this study, we presented a case of primary ovarian leiomyosarcoma initially confused with GIST originating from the distal ileum. This case report suggests an important lesson. When a pelvic mass is suggestive of GIST on radiological evaluation but could still be ovarian cancer based on anatomic location or imaging features, ovarian sarcoma should be suspected. Another way to differentiate between these entities is to perform a barium swallow study to examine the entire intestinal tract. Appropriate surgical treatment should not be delayed solely on the basis of normal tumor marker levels. Because of its dismal prognosis, early diagnosis and prompt surgical removal are crucial for patients with primary ovarian leiomyosarcoma.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 7931
  • [From(publication date):
    February-2016 - Aug 18, 2017]
  • Breakdown by view type
  • HTML page views : 7877
  • PDF downloads :54
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords