alexa Liver as a Target Organ for Eco-Toxicological Studies | OMICS International
ISSN: 2473-3350
Journal of Coastal Zone Management
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Liver as a Target Organ for Eco-Toxicological Studies

Aliakbar Hedayati*

Department of Fisheries, Faculty of Fisheries and Environment, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran

*Corresponding Author:
Aliakbar Hedayati
Faculty of Fisheries and Environment
Gorgan University of Agricultural Sciences and Natural Resources
Gorgan, Iran
Tel: +989131528572
E-mail: [email protected]

Received date June 23, 2016; Accepted date June 25, 2016; Published date July 02, 2016

Citation: Hedayati A (2016) Liver as a Target Organ for Eco-Toxicological Studies. J Coast Zone Manag 19: e118. doi:10.4172/2473-3350.1000e118

Copyright: ©2016 Hedayati A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Coastal Zone Management

Introduction

Liveris the primary target organs for many chemicals principally because of the role they serve within the body and serves as a suitable organ for the study of heavy metals effects due to its high metal accumulating capacity and susceptibility to histo-pathological damage by metals [1,2].

A range of contaminants including carcinogens, metals, bio-toxins, and persistent organic pollutants injure livers of fishes, and although some mechanisms of liver injury are unique to fish, most of the hepatic injury in these aquatic vertebrates arises from mechanisms similar to those observed in mammals [2]. An understanding of chemical hepato-toxicity requires an appreciation of anatomic and physiologic features of the liver. With respect to fish liver, although fish and mammalian liver are same in many features, there are some different futures between fish and mammals that may influence its interpretation [3].

Clearly, the liver is not an initial or primary organ expose to contaminant but it is a detoxifying organ which may accumulate various contaminants or their metabolites [3].

Gut is a important rout of contaminant uptake ones they are ingested by fish via this route the liver is a more direct target organ for uptake contaminants, however metabolism processes within the cell of intestine wall is prior to liver entry [4].

The three major functions of the liver essential for life of the organism are [3,4]:

Uptake, metabolism, storage, and redistribution of nutrients and other endogenous molecules

The synthetic and excretory functions of the liver maintain the homeostasis of the organism. To achieve this, specific molecules are synthesized in hepatocytes, packaged in the Golgi apparatus, transported in a specific direction for release into the intercellular spaces and to the bloodstream, where they are taken up by other organs and utilized.

Metabolism of lipophilic compounds, including xenobiotics

Biotransformation reactions catalyze the conversion of endogenous as well as exogenous compounds with poor water solubility to more hydrophilic metabolites that can be readily excreted. With respect to xenobiotics, the majority of hepatic biotransformation reactions may be considered as a detoxification process decreasing toxic body burden by enhancing excretion.

Formation and excretion of bile

Bile excretion is important for the elimination of degradation products of endogenous compounds such as heme or steroid hormones, as well as for the elimination of xenobiotics and their metabolites and some metals such as copper and mercury.

All of these hepatic functions have been shown to be involved not only in physiological states but also in processes leading to alterations in hepatic morphology and physiology. It is this great metabolic capacity of the liver that makes it both a target and an organ of defence. When toxic hits on the target occur, they may lead to alterations or injury in liver structure and function. Because of the multiple physiologic functions of the liver and its considerable plasticity, the liver responds to toxic insults in many different ways; thus, there appears to be no prototype single reaction classification of hepatotoxicity [5-8].

Conclusion

In Conclusion Liver is vital organ of fishes and due to various metabolism and different process. It is therefore a potential target for the toxic action of chemicals. It is important to differentiate between effects which are toxic for the liver cells and effects which do not harm the liver cells but disturb their support of peripheral tissues. We can chose liver as target organ of heavy metals and examined liver cell through histo-pathological analyses for possible effect of metals on liver tissue and also examined eventual role of xenobiotics on disturb liver support of peripheral tissues through enzymatic, hormonal and hematological analyses.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

  • 7th International Conference on Biodiversity Conservation and Ecosystem Management
    July 26-27, 2018 Melbourne, Australia
  • 2nd International Conference on Natural Hazards and Disaster Management
    July 26-27, 2018 Melbourne, Australia
  • 4th World Congress on Climate Change and Global Warming
    August 06-07, 2018 Osaka, Japan

Article Usage

  • Total views: 9339
  • [From(publication date):
    August-2016 - Jul 22, 2018]
  • Breakdown by view type
  • HTML page views : 9163
  • PDF downloads : 176
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7