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ISSN: 2329-9088
Tropical Medicine & Surgery
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Mesenteric Lipoma in a Goat

Ghasem Farjanikish1* and Hossein Mohammadi2

1Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran

2Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Khuzestan, Iran

Corresponding Author:
Ghasem Farjanikish
DVM, PhD, Assistant Professor of Veterinary Pathology
Department of Pathobiology, Faculty of Veterinary Medicine
Lorestan University, Khorramabad, Iran
Tel: +98 -066-33302033
E-mail: [email protected]

Received date: April 30, 2016; Accepted date: June 20, 2016; Published date: June 27, 2016

Citation: Farjanikish G, Mohammadi H (2016) Mesenteric Lipoma in a Goat. Trop Med Surg 5:213. doi:10.4172/2329-9088.1000213

Copyright: ©2016 Farjanikish G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

A 5 years old female, mixed-breed goat was presented to clinic for evaluation of postmortem lesions because it showed evidence of paratuberculosis. At necropsy examination, whitish-yellow lobulated mass (11 × 8 × 4 cm) was found on the ileal mesentery. Histopathologically, the tumor consisted of well-differentiated fat cells with no pleomorphism and anaplasia. The cells have monovacuolated and multivacuolated cytoplasm. Mitotic figures were not observed in the mature adipocytes. On the basis of the gross and microscopical findings, the mesenteric lipoma was diagnosed.

Keywords

Goat; Mesenteric lipoma; Histopathologically

Introduction

Neoplasms of adipocytes are classified as lipomas, infiltrative lipomas, angiolipomas, and liposarcomas. Lipomas are benign fatty tumors composed of mature fat cells. These neoplasms are commonly encountered in dogs, occasionally identified in cats and horses, and rarely observed in other domestic species [1,2].

Lipomas are common benign tumors that are composed of lobules of well-differentiated adipocytes. They may arise in any anatomical location, but commonly occur in the subcutis of the chest, abdomen, legs and axillae [3-5]. Lipomas are usually found in older animal and the incidence of neoplasms increase with age [1,4,5]. In the present report, we describe pathological characteristics of a mesenteric lipomain a goat.

Case Presentation

A 5 years old female, mixed-breed goat with history of lethargy, diarrhea, progressive weight loss and emaciation was necropsied and postmortem examination was conducted. In accordance to gross findings, it was concluded that significant findings in the goat were related to flock problems and showed evidence of paratuberculosis.

At the examination of the abdominal cavity, ileal mesentery in the lower abdominal cavity was covered by a whitish-yellow tumoral mass, which was coarsely lobulated and soft, with 11 × 8 × 4 cm dimensions (Figure 1). In addition, thickening and corrugation of the intestinal mucosa and enlargement of mesenteric lymph nodes were more evident in the ileum than other parts of the intestine.

tropical-medicine-Whitish-yellow

Figure 1: Lipoma. Whitish-yellow lobulated tumoral mass is in the abdominal cavity.

For microscopic investigations, histopathological specimens were obtained from the tumoral mass and, fixed in 10% neutral-buffered formalin, dehydrated in graded ethanol, cleared in xylene, and embedded in paraffin wax. Sections in 5-μm thicknesses were stained by hematoxylin and eosin, and studied microscopically.

Histopathologically, the mass was composed of variable sized lobules separated by fibrous septa. The lobules were composed of relatively mature adipocytes with significant variation in cell size, with no pleomorphism and anaplasia (Figure 2). The adipocytes were well differentiated and contained a large, monovacuolated and multivacuolated cytoplasm (Figure 3). Mitoses were not observed in the mature adipocytes. Based on gross and microscopical findings giant mesenteric lipoma was diagnosed.

tropical-medicine-well-differentiated

Figure 2:Lipoma. The mass is composed of well-differentiated fat cells with no pleomorphism and anaplasia (HE, Bar= 100 µm).

tropical-medicine-cytoplasmic-cytoplasmic

Figure 3:Lipoma. The adipocytes have variably sized and clear cytoplasmic vacuoles (HE, Bar=100, 25 µm).

In the ileum, diffuse granulomatous enteritis and lymphadenitis with infiltration of mononuclear inflammatory cells such as lymphocytes and epitheloid macrophages were prominent. The mesenteric lymph nodes were shown multifocal granulomas distributed throughout the cortex and paracortex.

Discussion

Lipomas are neoplasms of well-differentiated lipocytes and lipoblasts [1]. These tumors are most common in dogs and are uncommon in other species [5-7]. Intrapericardial lipoma and infiltrative lipoma in the heart have been reported in horses [8,9].

In this case, because most neoplastic cells resembled neoplastic adipocytes and contained clear lipid vacuoles, the neoplasm was classified as a lipoma. It is difficult to define the origin of the mass in the present case, but mesenteric adipose tissue would be most likely.

Mesenteric lipomas are usually asymptomatic and create a clinical picture that depends on the localization and size of the lipoma. The tumors can cause symptoms consistent with a partial bowel obstruction, such as intermittent abdominal pain, abdominal distention, and vomiting, with very few resulting in intestinal volvulus or complete intestinal obstruction due to torsion [10-15]. However, most mesenteric lipomas are of no clinical consequence. Although rare, intestinal strangulation by pedunculated lipomas has been reported in the dog. Pedunculated lipomas in horses can also cause strangulation, colic, ischemia and death [16,17].

In human, lipomas may show a familial tendency and an increased incidence in people who are obese, have diabetes mellitus or hypercholesterolemia, and experience a traumatic injury [18]. These tumors commonly recur after excision, but metastasis is rare.

The histologic characteristics of the present case were similar to those of other cases reported in humans and animals [14,16,19,20].

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