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Miniaturized Sensing Devices for Biomarker Detection | OMICS International
ISSN: 2155-6210
Journal of Biosensors & Bioelectronics

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Miniaturized Sensing Devices for Biomarker Detection

Ajeet Kaushika1*, Ariel Ruiza1, Shekhar Bhansalib2 and Madhavan Naira1

1Center of Personalized Nano Medicine, Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA

2BioMEMS Microsystems Laboratory, Department of Electrical and Computer Engineering, Florida International Laboratory, Miami, FL 33174, USA

*Corresponding Author:
Ajeet Kaushik
Center of Personalized Nanomedicine
Institute of Neuroimmune Pharmacology
Department of Immunology
Herbert Wertheim College of Medicine
Florida International University
Miami, FL 33199, USA
Tel: +1-305-348-1490
E-mail: [email protected]

Received Date: September 16, 2014; Accepted Date: September 17, 2014; Published Date: February 24, 2015

Citation: Kaushika A, Ruiza A, Bhansalib B and Naira1 M (2015) Miniaturized Sensing Devices for Biomarker Detection. J Biosens Bioelectron 6:e132. doi: 10.4172/2155-6210.1000e132

Copyright: © 2015 Kaushik A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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From the advent of glucose sensors, efforts have been made to design and develop new smaller sensors that are able to detect a wide variety of biomarkers. Miniature devices at point-of-care (POC) are becoming a trending subject for research and development in environment and healt monitoring and sensing. The information provided by such devices could revolutionize the fields of health informatics and novel treatment strategies by giving them a new basis. The development of these next generation devices, however, would also require a new class of assays and biosystems which can freely integrate itself into the environment of the analyte in order to retrieve the desired information both accurately and in real-time. The selection of sensing materials, transducer, electronic circuit, sensor design, easy operation, low power consumption, packaging, and automation of sample acquisition is crucial to the development of a desired sensor at POC applications. These challenges can be addressed using nanoenabling components in sensor design and development.

Nanomaterial’s have been shown capable of detecting biomarkers at the pM scale, when arranged in a 1D structure. These nano-sensing platforms are being integrated with Microelectromechanical Systems (MEMS) in order to avoid error and increase precisio through automation. To synthesize personalized treatments of particular diseases, the health informatics of each individual is crucial. Because of this, researchers were motivated to investigate and develop wearable POC biosensing systems to monitor personal health in an attempt to improve personalized diagnoses and treatments. For example, an LMP 91000 chip based miniaturized potentiostat has been reconfigured to be capable of performing electrochemical measurements. This potentiostat is further interfaced with a microfluidic manifold, consisting of an electrochemical sensor for the use of detecting biomarkers. The integrated sensing device (Figure 1) has successfully detected biomarkers down to the pM level and has potential to detect a variety of desired physiologically relevant biomarkers at on-site, infield, and POC [1,2].


Figure 1: Schematic illustration of electrochemical immunosensor integrated with microfluidic manifold. This sensing platform is interfaced with miniaturized potentiostat chip (reconfigured LMP 91000 board connected with BeagleBone microcontroller) connected with a microcontroller to detect cortisol using cyclic voltammetry techniques.

The aim of this editorial for journal of biosensors and bioelectronics is to attract researchers to explore the novel sensing platforms including design and development of novel sensing material, detection devices, and related nanostructures.


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