School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan, Republic of China
Received: May 05, 2015; Accepted: August 13, 2015; Published: August 15, 2015
Citation: Lee HH (2015) Modifying Other’s Originality without Quote is an Act of Piracy. Human Genet Embryol 5:128. doi:10.4172/2161-0436.1000128
Copyright:© 2015 Lee HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Human Genetics & Embryology
A defective CYP21A2 gene downstream of the TNXB gene in congenital adrenal hyperplasia (CAH) falls into three categories: (a) small-scale conversions of CYP21A1P, (b) spontaneous mutations, and (c) chimeric RCCX modules that include the chimeric CYP21A1P/ CYP21A2 and TNXA/TNXB genes . Most of the CYP21A2 mutations identified so far were a result of small-scale conversions of the CYP21A1P (up to 11 for CYP21A1P) during both meiosis and mitosis , which account for about 70%-80% of all CAH cases. The Chimeric CYP21A1P/CYP21A2 and TNXA/TNXB genes, which result from unequal cross-over (or deletions) during meiosis  and occur in ~20% of CAH alleles in most populations [1,3] respectively reflect the deletion of the 1/XCYP21A1P - XA - RP2 - C4B - 1/XCYP21A2 gene array (1/X indicates an uncertain fraction of the gene sequence)  and a deletion of the RP2 - C4B - CYP21A2 - 1/XTXNB gene array . Their deletion range is about a 26- or 32-kb gene sequence which depends on whether C4B is the long or short gene (more commonly shown in the literature as being 30 kb). In fact, these different types of large-gene deletions in the RCCX region are generally considered to represent one event in many studies.
I read with interest the recent article by New et al. , in which the authors described an analysis of 1,507 CAH families. They showed CYP21A2 gene deletion with 9 phenotypes of the chimeras, designating them CH1, CH2, CH3, CH4, CH5, CH6, CH7, CH8, and CH9  in figure configuration (as attached Figure 1 in the context). However, by examining the figure, the word abbreviation of “CH” representing “Chimeric CYP21A1P/CYP21A2” was originally used by the Lee’s study [1,5-8]. Furthermore, there were more modifications of the figure configuration from Lee’s studies such as font including “CH-1” style (Lee’s study) (Figure 1A) having been changed into “CH1” (Figure 1B) and configuration of exons representation for the CYP21A1P and CYP21A2 genes as black boxes and white boxes respectively (in Lee’s study) (Figure 1A) having been modified into CYP21A1P and CYP21A2 genes as white boxes and black boxes respectively (Figure 1B). Moreover, the figure legend’s statement “To date, nine types of chimera (CH1-CH9) with different junction site have been identified”. did not cite its origin from the paper published by Chen et al’s study . Most seriously, I have found out that they did not do chimera study and there was no citation for these two references. Therefore, these point-out issues (Table 1) do not seem to be created or studied by the New et al’s group  and may have been perceived mistakenly as the New et al’s originality thereafter.
Figure 1: Diagram of the representation of the chimeric CYP21A1P/CYP21A2 genes used by Lee and New et al. studies. (A) The structure of the functional CYP21A2 gene containing ten exons indicated by a white box [1,5-9]. The solid arrows indicate mutations which exist in CYP21A1P which showed the black box. CH-1 represents a chimeric CYP21A1P/CYP21A2s as described in Lee studies [1,5-9]. 707-714delGAGACTAC in CYP21A1P is marked by an asterisk (*). (B) The structure of the functional CYP21A2 gene indicated by a black box and the white box represents a nonfunctional CYP21A1P gene in New et al. study .
|Study||Publication||Designation for chimericCYP21A1P/CYP21A2||Ref.|
|Lee HH*||+||CH-1 to CH-5||[1,5-9]|
|Chen et al.||+||CH-1 to CH-9|||
|New et al.||_||CH1 to CH9|||
*There were more than 10 articles related with chimeric CYP21A1P/CYP21A2 gene study in the past 10 years.
Table 1: Study on chimeric CYP21A1P/CYP21A2 gene in congenital adrenal hyperplasia.
A writer who does not cite the sources in h/h feature article is committing piracy. Piracy is plagiarism, and it is legally and morally wrong. Because the Journal policy of the Proceedings of the National Academy of Sciences of the United States of America (PNAS U.S.A) with high level quality requires originality and creativity, these inattentions whether caused by the unintentional or not should be strongly condemned and prohibited. Accordingly, the originally contributing author may preserve the honor worthily and endeavor to further contribution in scientific study.